arXiv subjects

Wenbin Guan

Publications and source records attributed to Wenbin Guan.

3 recordsLinked to original sources

arXiv2025

Boosting Pathology Foundation Models via Few-shot Prompt-tuning for Rare Cancer Subtyping

Rare cancers comprise 20-25% of all malignancies but face major diagnostic challenges due to limited expert availability-especially in pediatric oncology, where they represent over 70% of cases. While pathology vision-language (VL) foundation models show promising zero-shot capabilities for common cancer subtyping, their clinical performance for rare cancers remains limited. Existing multi-instance learning (MIL) methods rely only on visual features, overlooking cross-modal knowledge and compromising interpretability critical for rare cancer diagnosis. To address this limitation, we propose PathPT, a novel framework that fully exploits the potential of vision-language pathology foundation models through spatially-aware visual aggregation and task-specific prompt tuning. Unlike conventional MIL, PathPT converts WSI-level supervision into fine-grained tile-level guidance by leveraging the zero-shot capabilities of VL models, thereby preserving localization on cancerous regions and enabling cross-modal reasoning through prompts aligned with histopathological semantics. We benchmark PathPT on eight rare cancer datasets(four adult and four pediatric) spanning 56 subtypes and 2,910 WSIs, as well as three common cancer datasets, evaluating four state-of-the-art VL models and four MIL frameworks under three few-shot settings. Results show that PathPT consistently delivers superior performance, achieving substantial gains in subtyping accuracy and cancerous region grounding ability. This work advances AI-assisted diagnosis for rare cancers, offering a scalable solution for improving subtyping accuracy in settings with limited access to specialized expertise.

cs.CV↗

arXiv2024

Knowledge-enhanced Pretraining for Vision-language Pathology Foundation Model on Cancer Diagnosis

Vision-language foundation models have shown great promise in computational pathology but remain primarily data-driven, lacking explicit integration of medical knowledge. We introduce KEEP (KnowledgE-Enhanced Pathology), a foundation model that systematically incorporates disease knowledge into pretraining for cancer diagnosis. KEEP leverages a comprehensive disease knowledge graph encompassing 11,454 diseases and 139,143 attributes to reorganize millions of pathology image-text pairs into 143,000 semantically structured groups aligned with disease ontology hierarchies. This knowledge-enhanced pretraining aligns visual and textual representations within hierarchical semantic spaces, enabling deeper understanding of disease relationships and morphological patterns. Across 18 public benchmarks (over 14,000 whole-slide images) and 4 institutional rare cancer datasets (926 cases), KEEP consistently outperformed existing foundation models, showing substantial gains for rare subtypes. These results establish knowledge-enhanced vision-language modeling as a powerful paradigm for advancing computational pathology.

eess.IV↗

arXiv2024

Efficient Meta-Learning Enabled Lightweight Multiscale Few-Shot Object Detection in Remote Sensing Images

Presently, the task of few-shot object detection (FSOD) in remote sensing images (RSIs) has become a focal point of attention. Numerous few-shot detectors, particularly those based on two-stage detectors, face challenges when dealing with the multiscale complexities inherent in RSIs. Moreover, these detectors present impractical characteristics in real-world applications, mainly due to their unwieldy model parameters when handling large amount of data. In contrast, we recognize the advantages of one-stage detectors, including high detection speed and a global receptive field. Consequently, we choose the YOLOv7 one-stage detector as a baseline and subject it to a novel meta-learning training framework. This transformation allows the detector to adeptly address FSOD tasks while capitalizing on its inherent advantage of lightweight. Additionally, we thoroughly investigate the samples generated by the meta-learning strategy and introduce a novel meta-sampling approach to retain samples produced by our designed meta-detection head. Coupled with our devised meta-cross loss, we deliberately utilize "negative samples" that are often overlooked to extract valuable knowledge from them. This approach serves to enhance detection accuracy and efficiently refine the overall meta-learning strategy. To validate the effectiveness of our proposed detector, we conducted performance comparisons with current state-of-the-art detectors using the DIOR and NWPU VHR-10.v2 datasets, yielding satisfactory results.

cs.CV↗