arXiv subjects
Publications and source records attributed to Wenqi Li.
We study the behavior of asymptotic cohomological functions on proper schemes over a field. We prove a formula for how asymptotic cohomological functions behave under perturbation by an object in the bounded derived category. Using the same method, we also prove that the volume of a line bundle on any proper scheme over a field always exists as a limit.
Characteristic linguistic behaviors associated with Social Language Disorder (SLD) in autism spectrum disorder, including echoic repetition, pronoun displacement, and stereotyped media quoting, are largely absent from spontaneous conversation and only emerge under specific conversational conditions. In structured clinical assessments, this latency means that questioning strategy selection is a critical yet underappreciated determinant of how much diagnostic information a conversation yields. Whether large language models (LLMs) can be guided to proactively select questioning strategies that systematically surface these latent traits remains largely unexplored. Here we present TPA (Think, Plan, Ask), a proactive multi-agent dialogue framework applied to the language assessment component of the Autism Diagnostic Observation Schedule Module 4 (ADOS-2), in which a doctor agent explicitly reasons about which traits remain unobserved before selecting a clinically grounded strategy and generating a targeted question. A patient agent grounded in real ADOS-2 clinical data enables reproducible evaluation without real patient participation, validated across three independent experiments confirming adequate fidelity to real patient language. Evaluated on 484 episodes from 35 patients, TPA outperforms six competitive dialogue planning baselines across all primary metrics, achieving 82.1% SLD trait coverage, 16.6% higher than automated replay of real clinical dialogues conducted by trained clinicians (65.5%), with substantially greater per-turn diagnostic efficiency (AUCC: 0.628 vs. 0.458, absolute gain +0.170). These results demonstrate that proactive questioning strategy selection substantially improves the efficiency of automated SLD trait assessment, with direct implications for scalable AI-assisted clinical screening.
Large language models can be continually pre-trained or fine-tuned to improve performance in specific domains, languages, or skills, but this specialization often degrades other capabilities and may cause catastrophic forgetting. We investigate how abilities are distributed within LLM parameters by analyzing module activations under domain- and language-specific inputs for closely related models. Across layers and modules, we find that ability-related activations are highly concentrated in a small set of channels (typically <5\%), and these channels are largely disentangled with good sufficiency and stability. Building on these observations, we propose ACT (Activation-Guided Channel-wise Ability Transfer), which localizes ability-relevant channels via activation differences and selectively transfers only the corresponding parameters, followed by lightweight fine-tuning for compatibility. Experiments on multilingual mathematical and scientific reasoning show that ACT can recover forgotten abilities while preserving retained skills. It can also merge multiple specialized models to integrate several abilities into a single model with minimal interference. Our code and data will be publicly released.
In this study, we conducted semi-structured interviews with 21 IIR researchers to investigate their data reuse practices. This study aims to expand upon current findings by exploring IIR researchers' information-obtaining behaviors regarding data reuse. We identified the information about shared data characteristics that IIR researchers need when evaluating data reusability, as well as the sources they typically consult to obtain this information. We consider this work to be an initial step toward revealing IIR researchers' data reuse practices and identifying what the community needs to do to promote data reuse. We hope that this study, as well as future research, will inspire more individuals to contribute to ongoing efforts aimed at designing standards, infrastructures, and policies, as well as fostering a sustainable culture of data sharing and reuse in this field.
The development of digital humanities necessitates scholars to adopt more data-intensive methods and engage in multidisciplinary collaborations. Understanding their collaborative data behaviors becomes essential for providing more curated data, tailored tools, and a collaborative research environment. This study explores how interdisciplinary researchers collaborate on data activities by conducting focus group interviews with 19 digital humanities research groups. Through inductive coding, the study identified seven primary and supportive data activities and found that different collaborative modes are adopted in various data activities. The collaborative modes include humanities-driven, technically-driven, and balanced, depending on how team members naturally adjusted their responsibilities based on their expertise. These findings establish a preliminary framework for examining collaborative data behavior and interdisciplinary collaboration in digital humanities.
As personalized recommendation algorithms become integral to social media platforms, users are increasingly aware of their ability to influence recommendation content. However, limited research has explored how users provide feedback through their behaviors and platform mechanisms to shape the recommendation content. We conducted semi-structured interviews with 34 active users of algorithmic-driven social media platforms (e.g., Xiaohongshu, Douyin). In addition to explicit and implicit feedback, this study introduced intentional implicit feedback, highlighting the actions users intentionally took to refine recommendation content through perceived feedback mechanisms. Additionally, choices of feedback behaviors were found to align with specific purposes. Explicit feedback was primarily used for feed customization, while unintentional implicit feedback was more linked to content consumption. Intentional implicit feedback was employed for multiple purposes, particularly in increasing content diversity and improving recommendation relevance. This work underscores the user intention dimension in the explicit-implicit feedback dichotomy and offers insights for designing personalized recommendation feedback that better responds to users' needs.
Pancreatic NEuroendocrine Tumors (pNETs) are very rare endocrine neoplasms that account for less than 5% of all pancreatic malignancies, with an incidence of only 1-1.5 cases per 100,000. Early detection of pNETs is critical for improving patient survival, but the rarity of pNETs makes segmenting them from CT a very challenging problem. So far, there has not been a dataset specifically for pNETs available to researchers. To address this issue, we propose a pNETs dataset, a well-annotated Contrast-Enhanced Computed Tomography (CECT) dataset focused exclusively on Pancreatic Neuroendocrine Tumors, containing data from 469 patients. This is the first dataset solely dedicated to pNETs, distinguishing it from previous collections. Additionally, we provide the baseline detection networks with a new slice-wise weight loss function designed for the UNet-based model, improving the overall pNET segmentation performance. We hope that our dataset can enhance the understanding and diagnosis of pNET Tumors within the medical community, facilitate the development of more accurate diagnostic tools, and ultimately improve patient outcomes and advance the field of oncology.
Sharing and reusing research data can effectively reduce redundant efforts in data collection and curation, especially for small labs and research teams conducting human-centered system research, and enhance the replicability of evaluation experiments. Building a sustainable data reuse process and culture relies on frameworks that encompass policies, standards, roles, and responsibilities, all of which must address the diverse needs of data providers, curators, and reusers. To advance the knowledge and accumulate empirical understandings on data reuse, this study investigated the data reuse practices of experienced researchers from the area of Interactive Information Retrieval (IIR) studies, where data reuse has been strongly advocated but still remains a challenge. To enhance the knowledge on data reuse behavior and reusability assessment strategies within IIR community, we conducted 21 semi-structured in-depth interviews with IIR researchers from varying demographic backgrounds, institutions, and stages of careers on their motivations, experiences, and concerns over data reuse. We uncovered the reasons, strategies of reusability assessments, and challenges faced by data reusers within the field of IIR as they attempt to reuse researcher data in their studies. The empirical finding improves our understanding of researchers' motivations for reusing data, their approaches to discovering reusable research data, as well as their concerns and criteria for assessing data reusability, and also enriches the on-going discussions on evaluating user-generated data and research resources and promoting community-level data reuse culture and standards.
Generalist vision language models (VLMs) have made significant strides in computer vision, but they fall short in specialized fields like healthcare, where expert knowledge is essential. In traditional computer vision tasks, creative or approximate answers may be acceptable, but in healthcare, precision is paramount.Current large multimodal models like Gemini and GPT-4o are insufficient for medical tasks due to their reliance on memorized internet knowledge rather than the nuanced expertise required in healthcare. VLMs are usually trained in three stages: vision pre-training, vision-language pre-training, and instruction fine-tuning (IFT). IFT has been typically applied using a mixture of generic and healthcare data. In contrast, we propose that for medical VLMs, a fourth stage of specialized IFT is necessary, which focuses on medical data and includes information from domain expert models. Domain expert models developed for medical use are crucial because they are specifically trained for certain clinical tasks, e.g. to detect tumors and classify abnormalities through segmentation and classification, which learn fine-grained features of medical data$-$features that are often too intricate for a VLM to capture effectively especially in radiology. This paper introduces a new framework, VILA-M3, for medical VLMs that utilizes domain knowledge via expert models. Through our experiments, we show an improved state-of-the-art (SOTA) performance with an average improvement of ~9% over the prior SOTA model Med-Gemini and ~6% over models trained on the specific tasks. Our approach emphasizes the importance of domain expertise in creating precise, reliable VLMs for medical applications.
In this study, we present a quantitative and comprehensive analysis of social gaze in people with autism spectrum disorder (ASD). Diverging from traditional first-person camera perspectives based on eye-tracking technologies, this study utilizes a third-person perspective database from the Autism Diagnostic Observation Schedule, 2nd Edition (ADOS-2) interview videos, encompassing ASD participants and neurotypical individuals as a reference group. Employing computational models, we extracted and processed gaze-related features from the videos of both participants and examiners. The experimental samples were divided into three groups based on the presence of social gaze abnormalities and ASD diagnosis. This study quantitatively analyzed four gaze features: gaze engagement, gaze variance, gaze density map, and gaze diversion frequency. Furthermore, we developed a classifier trained on these features to identify gaze abnormalities in ASD participants. Together, we demonstrated the effectiveness of analyzing social gaze in people with ASD in naturalistic settings, showcasing the potential of third-person video perspectives in enhancing ASD diagnosis through gaze analysis.
Since the release of Segment Anything 2 (SAM2), the medical imaging community has been actively evaluating its performance for 3D medical image segmentation. However, different studies have employed varying evaluation pipelines, resulting in conflicting outcomes that obscure a clear understanding of SAM2's capabilities and potential applications. We shortly review existing benchmarks and point out that the SAM2 paper clearly outlines a zero-shot evaluation pipeline, which simulates user clicks iteratively for up to eight iterations. We reproduced this interactive annotation simulation on 3D CT datasets and provided the results and code~\url{https://github.com/Project-MONAI/VISTA}. Our findings reveal that directly applying SAM2 on 3D medical imaging in a zero-shot manner is far from satisfactory. It is prone to generating false positives when foreground objects disappear, and annotating more slices cannot fully offset this tendency. For smaller single-connected objects like kidney and aorta, SAM2 performs reasonably well but for most organs it is still far behind state-of-the-art 3D annotation methods. More research and innovation are needed for 3D medical imaging community to use SAM2 correctly.
Foundation models for interactive segmentation in 2D natural images and videos have sparked significant interest in building 3D foundation models for medical imaging. However, the domain gaps and clinical use cases for 3D medical imaging require a dedicated model that diverges from existing 2D solutions. Specifically, such foundation models should support a full workflow that can actually reduce human effort. Treating 3D medical images as sequences of 2D slices and reusing interactive 2D foundation models seems straightforward, but 2D annotation is too time-consuming for 3D tasks. Moreover, for large cohort analysis, it's the highly accurate automatic segmentation models that reduce the most human effort. However, these models lack support for interactive corrections and lack zero-shot ability for novel structures, which is a key feature of "foundation". While reusing pre-trained 2D backbones in 3D enhances zero-shot potential, their performance on complex 3D structures still lags behind leading 3D models. To address these issues, we present VISTA3D, Versatile Imaging SegmenTation and Annotation model, that targets to solve all these challenges and requirements with one unified foundation model. VISTA3D is built on top of the well-established 3D segmentation pipeline, and it is the first model to achieve state-of-the-art performance in both 3D automatic (supporting 127 classes) and 3D interactive segmentation, even when compared with top 3D expert models on large and diverse benchmarks. Additionally, VISTA3D's 3D interactive design allows efficient human correction, and a novel 3D supervoxel method that distills 2D pretrained backbones grants VISTA3D top 3D zero-shot performance. We believe the model, recipe, and insights represent a promising step towards a clinically useful 3D foundation model. Code and weights are publicly available at https://github.com/Project-MONAI/VISTA.
With impressive achievements made, artificial intelligence is on the path forward to artificial general intelligence. Sora, developed by OpenAI, which is capable of minute-level world-simulative abilities can be considered as a milestone on this developmental path. However, despite its notable successes, Sora still encounters various obstacles that need to be resolved. In this survey, we embark from the perspective of disassembling Sora in text-to-video generation, and conducting a comprehensive review of literature, trying to answer the question, \textit{From Sora What We Can See}. Specifically, after basic preliminaries regarding the general algorithms are introduced, the literature is categorized from three mutually perpendicular dimensions: evolutionary generators, excellent pursuit, and realistic panorama. Subsequently, the widely used datasets and metrics are organized in detail. Last but more importantly, we identify several challenges and open problems in this domain and propose potential future directions for research and development.
Diagnosing language disorders associated with autism is a complex challenge, often hampered by the subjective nature and variability of traditional assessment methods. Traditional diagnostic methods not only require intensive human effort but also often result in delayed interventions due to their lack of speed and precision. In this study, we explored the application of ChatGPT, a large language model, to overcome these obstacles by enhancing sensitivity and profiling linguistic features for autism diagnosis. This research utilizes ChatGPT natural language processing capabilities to simplify and improve the diagnostic process, focusing on identifying autism related language patterns. Specifically, we compared ChatGPT performance with that of conventional supervised learning models, including BERT, a model acclaimed for its effectiveness in various natural language processing tasks. We showed that ChatGPT substantially outperformed these models, achieving over 10% improvement in both sensitivity and positive predictive value, in a zero shot learning configuration. The findings underscore the model potential as a diagnostic tool, combining accuracy and applicability. We identified ten key features of autism associated language disorders across scenarios. Features such as echolalia, pronoun reversal, and atypical language usage play a critical role in diagnosing ASD and informing tailored treatment plans. Together, our findings advocate for adopting sophisticated AI tools like ChatGPT in clinical settings to assess and diagnose developmental disorders. Our approach promises enhanced diagnostic precision and supports personalized medicine, potentially transforming the evaluation landscape for autism and similar neurological conditions.
Diagnosing autism spectrum disorder (ASD) by identifying abnormal speech patterns from examiner-patient dialogues presents significant challenges due to the subtle and diverse manifestations of speech-related symptoms in affected individuals. This study presents a comprehensive approach to identify distinctive speech patterns through the analysis of examiner-patient dialogues. Utilizing a dataset of recorded dialogues, we extracted 40 speech-related features, categorized into frequency, zero-crossing rate, energy, spectral characteristics, Mel Frequency Cepstral Coefficients (MFCCs), and balance. These features encompass various aspects of speech such as intonation, volume, rhythm, and speech rate, reflecting the complex nature of communicative behaviors in ASD. We employed machine learning for both classification and regression tasks to analyze these speech features. The classification model aimed to differentiate between ASD and non-ASD cases, achieving an accuracy of 87.75%. Regression models were developed to predict speech pattern related variables and a composite score from all variables, facilitating a deeper understanding of the speech dynamics associated with ASD. The effectiveness of machine learning in interpreting intricate speech patterns and the high classification accuracy underscore the potential of computational methods in supporting the diagnostic processes for ASD. This approach not only aids in early detection but also contributes to personalized treatment planning by providing insights into the speech and communication profiles of individuals with ASD.
We experimentally demonstrate the optical frequency tuning of a squeezed vacuum state generated from an optical parametric oscillator by using an acousto-optic modulator based bi-frequency interferometer. The systematic efficiency of the frequency tuning device is $91\%$, which is only confined by the optical transmission efficiency of the acousto-optic modulators. The amount of frequency tuning is 80 MHz, which is orders of magnitude larger than the line-width of the laser used to generate the squeezed state, and can in principle be further extended to GHz range. Our investigation shows the interferometric enhanced Bragg diffraction effect can be applied to a variety of other quantum optical states as well, and will serve as a handy tool for quantum network.
We demonstrate a high performance AOM based bi-frequency interferometer, which can realize either beating or beating free interference for single photon level quantum state. Visibility and optical efficiency of the interferometer are (99.5 +- 0.2)% and (95 +- 1)%, respectively. The phase of the interferometer is actively stabilized by using dithering phase locking scheme, where the phase dithering is realized by directly driving the AOMs with specially designed electronic signal. We further demonstrate applications of the interferometer in quantum technology, including bi-frequency coherent combination, frequency tuning and optical switching. These result show the interferometer is a versatile device for multiple quantum technologies.
Harnessing the power of pre-training on large-scale datasets like ImageNet forms a fundamental building block for the progress of representation learning-driven solutions in computer vision. Medical images are inherently different from natural images as they are acquired in the form of many modalities (CT, MR, PET, Ultrasound etc.) and contain granulated information like tissue, lesion, organs etc. These characteristics of medical images require special attention towards learning features representative of local context. In this work, we focus on designing an effective pre-training framework for 3D radiology images. First, we propose a new masking strategy called local masking where the masking is performed across channel embeddings instead of tokens to improve the learning of local feature representations. We combine this with classical low-level perturbations like adding noise and downsampling to further enable low-level representation learning. To this end, we introduce Disruptive Autoencoders, a pre-training framework that attempts to reconstruct the original image from disruptions created by a combination of local masking and low-level perturbations. Additionally, we also devise a cross-modal contrastive loss (CMCL) to accommodate the pre-training of multiple modalities in a single framework. We curate a large-scale dataset to enable pre-training of 3D medical radiology images (MRI and CT). The proposed pre-training framework is tested across multiple downstream tasks and achieves state-of-the-art performance. Notably, our proposed method tops the public test leaderboard of BTCV multi-organ segmentation challenge.