arXiv subjects

Wenrui Wu

Publications and source records attributed to Wenrui Wu.

5 recordsLinked to original sources

arXiv2026

A Correlation-Free Test for High-Dimensional Elliptical Distributions

Elliptical distributions provide a flexible and widely used extension of multivariate normal distribution. They play a critical role in many statistical procedures when dealing with high-dimensional data. However, goodness-of-fit testing for elliptical distributions remains challenging when the dimension is comparable to or larger than the sample size. In this work, we propose a correlation-free test for high-dimensional elliptical distributions. We establish high-dimensional Gaussian approximation for the test statistic under general correlation structures, allowing the dimension to grow as $\log p=o(n^{1/14})$ under finite moment conditions, without using the inverse sample covariance matrix. We further develop Gaussian multiplier bootstrap test procedure and prove its theoretical validity. Numerical studies demonstrate stable finite-sample behavior and favorable power against a range of alternatives. Applications to real datasets illustrate practical utility of the proposed test.

stat.ME↗

arXiv2025

A Foundation Model for Spatial Proteomics

Foundation models have begun to transform image analysis by acting as pretrained generalist backbones that can be adapted to many tasks even when post-training data are limited, yet their impact on spatial proteomics, imaging that maps proteins at single-cell resolution, remains limited. Here, we introduce KRONOS, a foundation model built for spatial proteomics. KRONOS was trained in a self-supervised manner on over 47 million image patches covering 175 protein markers, 16 tissue types, and 8 fluorescence-based imaging platforms. We introduce key architectural adaptations to address the high-dimensional, multi-channel, and heterogeneous nature of multiplex imaging. We demonstrate that KRONOS learns biologically meaningful representations across multiple scales, ranging from cellular and microenvironment to tissue levels, enabling it to address diverse downstream tasks, including cell phenotyping, region classification, and patient stratification. Evaluated across 11 independent cohorts, KRONOS achieves state-of-the-art performance across cell phenotyping, treatment response prediction, and retrieval tasks, and is highly data-efficient. KRONOS also introduces the paradigm of segmentation-free patch-level processing for efficient and scalable spatial proteomics analysis, allowing cross-institutional comparisons, and as an image reverse search engine for spatial patterns. Together, these results position KRONOS as a flexible and scalable tool for spatial proteomics. The model is publicly accessible at https://github.com/mahmoodlab/KRONOS.

cs.CV↗

arXiv2023

iEDA: An Open-Source Intelligent Physical Implementation Toolkit and Library

Open-source EDA shows promising potential in unleashing EDA innovation and lowering the cost of chip design. This paper presents an open-source EDA project, iEDA, aiming for building a basic infrastructure for EDA technology evolution and closing the industrial-academic gap in the EDA area. iEDA now covers the whole flow of physical design (including Floorplan, Placement, CTS, Routing, Timing Optimization etc.), and part of the analysis tools (Static Timing Analysis and Power Analysis). To demonstrate the effectiveness of iEDA, we implement and tape out three chips of different scales (from 700k to 1.5M gates) on different process nodes (110nm and 28nm) with iEDA. iEDA is publicly available from the project home page http://ieda.oscc.cc.

cs.AR↗

arXiv2016

Path discovery by Querying the federation of Relational Database and RDF Graph

The class of queries for detecting path is an important as those can extract implicit binary relations over the nodes of input graphs. Most of the path querying languages used by the RDF community, like property paths in W3C SPARQL 1.1 and nested regular expressions in nSPARQL are based on the regular expressions. Federated queries allow for combining graph patterns and relational database that enables the evaluations over several heterogeneous data resources within a single query. Federated queries in W3C SPARQL 1.1 currently evaluated over different SPARQL endpoints. In this paper, we present a federated path querying language as an extension of regular path querying language for supporting RDF graph integration with relational database. The federated path querying language is absolutely more expressive than nested regular expressions and negation-free property paths. Its additional expressivity can be used for capturing the conjunction and federation of nested regular path queries. Despite the increase in expressivity, we also show that federated path queries are still enjoy a low computational complexity and can be evaluated efficiently.

cs.DB↗

arXiv2016

Context-Free Path Queries on RDF Graphs

Navigational graph queries are an important class of queries that canextract implicit binary relations over the nodes of input graphs. Most of the navigational query languages used in the RDF community, e.g. property paths in W3C SPARQL 1.1 and nested regular expressions in nSPARQL, are based on the regular expressions. It is known that regular expressions have limited expressivity; for instance, some natural queries, like same generation-queries, are not expressible with regular expressions. To overcome this limitation, in this paper, we present cfSPARQL, an extension of SPARQL query language equipped with context-free grammars. The cfSPARQL language is strictly more expressive than property paths and nested expressions. The additional expressivity can be used for modelling graph similarities, graph summarization and ontology alignment. Despite the increasing expressivity, we show that cfSPARQL still enjoys a low computational complexity and can be evaluated efficiently.

cs.DB↗