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William Denault

Publications and source records attributed to William Denault.

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Inverse Probability Weighting in a Post-Bayesian World

We present a justification of the use of Inverse Probability Weighting (IPW) in a post-Bayesian framework, in which the bias-correction provided by IPW in a frequentist context is reframed as a reweighting of the Kullback-Leibler (KL) divergence between the statistical model and the true data-generating parameter value. We provide a coherent argument in support of this approach, including theoretical results concerning convergence and properties of the generalised belief posteriors. We present examples demonstrating the utility of post-Bayesian IPW in practice: these include two simulated examples of inference under selection bias in the observed data, and a large-scale real-data example concerning systematic biases present in registry data when using prostate-specific antigen (PSA) to predict prostate cancer mortality. The empirical and theoretical results together show the utility of IPW to address classes of problems previously intractable within a Bayesian approach.

stat.ME

Wavelet Screaming: a novel approach to analyzing GWAS data

We present an alternative method for genome-wide association studies (GWAS) that is more powerful than the regular GWAS method for locus detection. The regular GWAS method suffers from a substantial multiple-testing burden because of the millions of single nucleotide polymorphisms (SNPs) being tested simultaneously. Furthermore, it does not consider the functional genetic effect on the response variable; i.e., it ignores more complex joint effects of nearby SNPs within a region. Our proposed method screens the entire genome for associations using a sequential sliding-window approach based on wavelets. A sequence of SNPs represents a genetic signal, and for every screened region, we transform the genetic signal into the wavelet space. We then estimate the proportion of wavelet coefficients associated with the phenotype at different scales. The significance of a region is assessed via simulations, taking advantage of a recent result on Bayes factor distributions. Our new approach reduces the number of independent tests to be performed. Moreover, we show via simulations that the Wavelet Screaming method provides a substantial gain in power compared to the classic GWAS modeling when faced with more complex signals than just single-SNP associations. To demonstrate feasibility, we re-analyze data from the large Norwegian HARVEST cohort. Keywords: Bayes factors, GWAS, SNP, Multiple testing, Polygenic

stat.AP