arXiv subjects

Wolfgang Maass

Publications and source records attributed to Wolfgang Maass.

At least 19 recordsLinked to original sources

arXiv2026

INCLAIR: Inception-Based Longitudinal Clinical Anomaly Detection with Informed Reasoning

Detecting anomalies in longitudinal clinical profiles is clinically important but difficult: abnormal evidence is often sparse, patient histories have unequal length, and expert explanations are costly. We propose INCLAIR, a framework that scores each observation against multiple historical contexts, aggregates evidence at the profile level, and generates grounded natural-language explanations under limited expert supervision. Under stated within-profile exchangeability assumptions, the complete mean subsequence score takes an order-$l$ U-statistic form, yielding a variance decomposition and an incomplete-subset approximation that controls combinatorial inference cost independently of profile length. The same analysis shows that mean aggregation attenuates localized anomalies by a factor set by the anomaly support and profile length, motivating validation-selected top-$k$ pooling. Across three clinical datasets, INCLAIR consistently outperforms state-of-the-art baselines. We further validate practical relevance through a case study on longitudinal steroid profiles, comparing INCLAIR's predictions and explanations against domain-expert assessments supported by DNA analysis. The results show that INCLAIR enables clinically actionable anomaly detection under limited expert supervision.

cs.AI↗

arXiv2026

MedLLM: An Open Medical Language Model at the Sub-Billion Scale

Open medical language models have converged on a single scale: every widely used system runs at 7B parameters or more, leaving the sub-billion regime uncharacterized. We present MedLLM, an open 0.1B-parameter medical language model trained through a fully open three-phase pipeline: general pretraining with curriculum sequence-length scheduling, domain fine-tuning on MedFineWeb, a reference-guided medical corpus we release that is selected from general web data by embedding similarity to medical question-answering (QA) data, and preference-aligned fine-tuning combining SFT with direct preference optimization (DPO). Across medical benchmarks, MedLLM shows a pattern visible only at sub-billion scale: medical competence does not degrade uniformly under compression but splits by task type. On context-grounded QA it comes within $2.9$pp of a medically adapted 7B model and surpasses the instruction-tuned and general-purpose 7B baselines; on knowledge-recall QA it stays near the task floor on clinical-vignette MedQA yet significantly exceeds every 7B and sub-7B baseline on MedMCQA, indicating that where recall fails the constraint is model capacity rather than adaptation. This dissociation is masked at 7B, where both capabilities are present, and surfaces only when capacity is scarce.

cs.AI↗

arXiv2026

LongMoE: Longitudinal Multimodal Learning via Trajectory-Aware Mixture-of-Experts

Multimodal clinical learning is increasingly important for integrating diverse patient data, including imaging, text, and personalised health records. However, it faces two fundamental challenges: i) modality missingness, where arbitrary subsets of modalities are unavailable at a given patient visit, ii) longitudinal dynamics, where the diagnostic significance of an observation depends on the patient's evolving disease trajectory over time. Existing methods address these challenges in isolation: missing-modality frameworks treat each visit as an independent static snapshot and discard temporal context, while longitudinal models often assume complete modality availability and degrade under systematic modality incompleteness. We propose LongMoE (Longitudinal Mixture-of-Experts), the unified framework to jointly address both challenges. LongMoE combines a context-aware imputation module with an attentional tokenization module that captures frequency-domain temporal patterns across irregular visit sequences, a trajectory-aware encoder for modeling disease progression, and context-conditioned Sparse MoE routing for patient-specific expert selection. Experiments on ADNI, OASIS-3, and MIMIC-IV show that LongMoE improves robustness under missing or weak contemporaneous modalities and remains competitive in full-modality settings, establishing a strong foundation for longitudinally-aware multimodal clinical learning.

cs.LG↗

arXiv2026

Completion vs Optimality: Policy Gradient in Long-Horizon Cumulative-Damage Problems

Long-horizon decision problems with cumulative damage couple locally attractive actions to globally adverse outcomes. We identify two orthogonal failure modes for policy-gradient methods on this class and propose a decomposition that separates them: \emph{completion} (reaching the terminal horizon rather than exiting via an implicit terminal constraint) and \emph{optimality} (matching the dynamic-programming reference given completion). Under PPO with a linear soft penalty, granting horizon access alone reduces the completion rate: the penalty's equilibrium drives the dominant-activity share to zero, while action-space restriction combined with horizon access achieves completion but leaves an optimality gap ($ΔM_{\text{final}} = 0.271$) that we trace to first-phase greedy commitment at the damage origin. We derive four testable predictions and evaluate them in two separately calibrated environments that share the same abstract structure but differ in domain, horizon, activity set, and calibration data: a 49-step bricklayer career and a 20-season NBA power-forward career. All four predictions replicate qualitatively. The horizon-invariance prediction is met at three of four tested horizons, with the exception at $H = 15$ consistent with the $H^*$ boundary ($H^* \in [6, 14]$ under the NBA parameters).

cs.AI↗

arXiv2026

DiGAN: Diffusion-Guided Attention Network for Early Alzheimer's Disease Detection

Early diagnosis of Alzheimer's disease (AD) remains a major challenge due to the subtle and temporally irregular progression of structural brain changes in the prodromal stages. Existing deep learning approaches require large longitudinal datasets and often fail to model the temporal continuity and modality irregularities inherent in real-world clinical data. To address these limitations, we propose the Diffusion-Guided Attention Network (DiGAN), which integrates latent diffusion modelling with an attention-guided convolutional network. The diffusion model synthesizes realistic longitudinal neuroimaging trajectories from limited training data, enriching temporal context and improving robustness to unevenly spaced visits. The attention-convolutional layer then captures discriminative structural-temporal patterns that distinguish cognitively normal subjects from those with mild cognitive impairment and subjective cognitive decline. Experiments on the ADNI dataset demonstrate that DiGAN outperforms existing state-of-the-art baselines, showing its potential for early-stage AD detection.

cs.CV↗

arXiv2026

Evolving Afferent Architectures: Biologically-inspired Models for Damage-Avoidance Learning

We introduce Afferent Learning, a framework that produces Computational Afferent Traces (CATs) as adaptive, internal risk signals for damage-avoidance learning. Inspired by biological systems, the framework uses a two-level architecture: evolutionary optimization (outer loop) discovers afferent sensing architectures that enable effective policy learning, while reinforcement learning (inner loop) trains damage-avoidance policies using these signals. This formalizes afferent sensing as providing an inductive bias for efficient learning: architectures are selected based on their ability to enable effective learning (rather than directly minimizing damage). We provide theoretical convergence guarantees under smoothness and bounded-noise assumptions. We illustrate the general approach in the challenging context of biomechanical digital twins operating over long time horizons (multiple decades of the life-course). Here, we find that CAT-based evolved architectures achieve significantly higher efficiency and better age-robustness than hand-designed baselines, enabling policies that exhibit age-dependent behavioral adaptation (23% reduction in high-risk actions). Ablation studies validate CAT signals, evolution, and predictive discrepancy as essential. We release code and data for reproducibility.

cs.LG↗

arXiv2024

RAG for Effective Supply Chain Security Questionnaire Automation

In an era where digital security is crucial, efficient processing of security-related inquiries through supply chain security questionnaires is imperative. This paper introduces a novel approach using Natural Language Processing (NLP) and Retrieval-Augmented Generation (RAG) to automate these responses. We developed QuestSecure, a system that interprets diverse document formats and generates precise responses by integrating large language models (LLMs) with an advanced retrieval system. Our experiments show that QuestSecure significantly improves response accuracy and operational efficiency. By employing advanced NLP techniques and tailored retrieval mechanisms, the system consistently produces contextually relevant and semantically rich responses, reducing cognitive load on security teams and minimizing potential errors. This research offers promising avenues for automating complex security management tasks, enhancing organizational security processes.

cs.LG↗

arXiv2024

Incorporating Metabolic Information into LLMs for Anomaly Detection in Clinical Time-Series

Anomaly detection in clinical time-series holds significant potential in identifying suspicious patterns in different biological parameters. In this paper, we propose a targeted method that incorporates the clinical domain knowledge into LLMs to improve their ability to detect anomalies. We introduce the Metabolism Pathway-driven Prompting (MPP) method, which integrates the information about metabolic pathways to better capture the structural and temporal changes in biological samples. We applied our method for doping detection in sports, focusing on steroid metabolism, and evaluated using real-world data from athletes. The results show that our method improves anomaly detection performance by leveraging metabolic context, providing a more nuanced and accurate prediction of suspicious samples in athletes' profiles.

q-bio.QM↗

arXiv2024

Quantum Computing Enhanced Service Ecosystem for Simulation in Manufacturing

Quantum computing (QC) and machine learning (ML), taken individually or combined into quantum-assisted ML (QML), are ascending computing paradigms whose calculations come with huge potential for speedup, increase in precision, and resource reductions. Likely improvements for numerical simulations in engineering imply the possibility of a strong economic impact on the manufacturing industry. In this project report, we propose a framework for a quantum computing-enhanced service ecosystem for simulation in manufacturing, consisting of various layers ranging from hardware to algorithms to service and organizational layers. In addition, we give insight into the current state of the art of applications research based on QC and QML, both from a scientific and an industrial point of view. We further analyse two high-value use cases with the aim of a quantitative evaluation of these new computing paradigms for industrially-relevant settings.

quant-ph↗

arXiv2023

How can neuromorphic hardware attain brain-like functional capabilities?

Research on neuromorphic computing is driven by the vision that we can emulate brain-like computing capability, learning capability, and energy-efficiency in novel hardware. Unfortunately, this vision has so far been pursued in a half-hearted manner. Most current neuromorphic hardware (NMHW) employs brain-like spiking neurons instead of standard artificial neurons. This is a good first step, which does improve the energy-efficiency of some computations, see \citep{rao2022long} for one of many examples. But current architectures and training methods for networks of spiking neurons in NMHW are largely copied from artificial neural networks. Hence it is not surprising that they inherit many deficiencies of artificial neural networks, rather than attaining brain-like functional capabilities. Of course, the brain is very complex, and we cannot implement all its details in NMHW. Instead, we need to focus on principles that are both easy to implement in NMHW and are likely to support brain-like functionality. The goal of this article is to highlight some of them.

cs.NE↗

arXiv2022

2022 Roadmap on Neuromorphic Computing and Engineering

Modern computation based on the von Neumann architecture is today a mature cutting-edge science. In the Von Neumann architecture, processing and memory units are implemented as separate blocks interchanging data intensively and continuously. This data transfer is responsible for a large part of the power consumption. The next generation computer technology is expected to solve problems at the exascale with 1018 calculations each second. Even though these future computers will be incredibly powerful, if they are based on von Neumann type architectures, they will consume between 20 and 30 megawatts of power and will not have intrinsic physically built-in capabilities to learn or deal with complex data as our brain does. These needs can be addressed by neuromorphic computing systems which are inspired by the biological concepts of the human brain. This new generation of computers has the potential to be used for the storage and processing of large amounts of digital information with much lower power consumption than conventional processors. Among their potential future applications, an important niche is moving the control from data centers to edge devices. The aim of this Roadmap is to present a snapshot of the present state of neuromorphic technology and provide an opinion on the challenges and opportunities that the future holds in the major areas of neuromorphic technology, namely materials, devices, neuromorphic circuits, neuromorphic algorithms, applications, and ethics. The Roadmap is a collection of perspectives where leading researchers in the neuromorphic community provide their own view about the current state and the future challenges. We hope that this Roadmap will be a useful resource to readers outside this field, for those who are just entering the field, and for those who are well established in the neuromorphic community. https://doi.org/10.1088/2634-4386/ac4a83

cs.ET↗

arXiv2022

Current State and Future Directions for Learning in Biological Recurrent Neural Networks: A Perspective Piece

We provide a brief review of the common assumptions about biological learning with findings from experimental neuroscience and contrast them with the efficiency of gradient-based learning in recurrent neural networks. The key issues discussed in this review include: synaptic plasticity, neural circuits, theory-experiment divide, and objective functions. We conclude with recommendations for both theoretical and experimental neuroscientists when designing new studies that could help bring clarity to these issues.

q-bio.NC↗

arXiv2021

A Long Short-Term Memory for AI Applications in Spike-based Neuromorphic Hardware

Spike-based neuromorphic hardware holds the promise to provide more energy efficient implementations of Deep Neural Networks (DNNs) than standard hardware such as GPUs. But this requires to understand how DNNs can be emulated in an event-based sparse firing regime, since otherwise the energy-advantage gets lost. In particular, DNNs that solve sequence processing tasks typically employ Long Short-Term Memory (LSTM) units that are hard to emulate with few spikes. We show that a facet of many biological neurons, slow after-hyperpolarizing (AHP) currents after each spike, provides an efficient solution. AHP-currents can easily be implemented in neuromorphic hardware that supports multi-compartment neuron models, such as Intel's Loihi chip. Filter approximation theory explains why AHP-neurons can emulate the function of LSTM units. This yields a highly energy-efficient approach to time series classification. Furthermore it provides the basis for implementing with very sparse firing an important class of large DNNs that extract relations between words and sentences in a text in order to answer questions about the text.

cs.NE↗

arXiv2021

Pairing Conceptual Modeling with Machine Learning

Both conceptual modeling and machine learning have long been recognized as important areas of research. With the increasing emphasis on digitizing and processing large amounts of data for business and other applications, it would be helpful to consider how these areas of research can complement each other. To understand how they can be paired, we provide an overview of machine learning foundations and development cycle. We then examine how conceptual modeling can be applied to machine learning and propose a framework for incorporating conceptual modeling into data science projects. The framework is illustrated by applying it to a healthcare application. For the inverse pairing, machine learning can impact conceptual modeling through text and rule mining, as well as knowledge graphs. The pairing of conceptual modeling and machine learning in this this way should help lay the foundations for future research.

cs.SE↗

arXiv2021

Optimized spiking neurons classify images with high accuracy through temporal coding with two spikes

Spike-based neuromorphic hardware promises to reduce the energy consumption of image classification and other deep learning applications, particularly on mobile phones or other edge devices. However, direct training of deep spiking neural networks is difficult, and previous methods for converting trained artificial neural networks to spiking neurons were inefficient because the neurons had to emit too many spikes. We show that a substantially more efficient conversion arises when one optimizes the spiking neuron model for that purpose, so that it not only matters for information transmission how many spikes a neuron emits, but also when it emits those spikes. This advances the accuracy that can be achieved for image classification with spiking neurons, and the resulting networks need on average just two spikes per neuron for classifying an image. In addition, our new conversion method improves latency and throughput of the resulting spiking networks.

cs.NE↗

arXiv2020

Online Spatio-Temporal Learning in Deep Neural Networks

Biological neural networks are equipped with an inherent capability to continuously adapt through online learning. This aspect remains in stark contrast to learning with error backpropagation through time (BPTT) applied to recurrent neural networks (RNNs), or recently to biologically-inspired spiking neural networks (SNNs). BPTT involves offline computation of the gradients due to the requirement to unroll the network through time. Online learning has recently regained the attention of the research community, focusing either on approaches that approximate BPTT or on biologically-plausible schemes applied to SNNs. Here we present an alternative perspective that is based on a clear separation of spatial and temporal gradient components. Combined with insights from biology, we derive from first principles a novel online learning algorithm for deep SNNs, called online spatio-temporal learning (OSTL). For shallow networks, OSTL is gradient-equivalent to BPTT enabling for the first time online training of SNNs with BPTT-equivalent gradients. In addition, the proposed formulation unveils a class of SNN architectures trainable online at low time complexity. Moreover, we extend OSTL to a generic form, applicable to a wide range of network architectures, including networks comprising long short-term memory (LSTM) and gated recurrent units (GRU). We demonstrate the operation of our algorithm on various tasks from language modelling to speech recognition and obtain results on par with the BPTT baselines. The proposed algorithm provides a framework for developing succinct and efficient online training approaches for SNNs and in general deep RNNs.

cs.LG↗

arXiv2020

Embodied Synaptic Plasticity with Online Reinforcement learning

The endeavor to understand the brain involves multiple collaborating research fields. Classically, synaptic plasticity rules derived by theoretical neuroscientists are evaluated in isolation on pattern classification tasks. This contrasts with the biological brain which purpose is to control a body in closed-loop. This paper contributes to bringing the fields of computational neuroscience and robotics closer together by integrating open-source software components from these two fields. The resulting framework allows to evaluate the validity of biologically-plausibe plasticity models in closed-loop robotics environments. We demonstrate this framework to evaluate Synaptic Plasticity with Online REinforcement learning (SPORE), a reward-learning rule based on synaptic sampling, on two visuomotor tasks: reaching and lane following. We show that SPORE is capable of learning to perform policies within the course of simulated hours for both tasks. Provisional parameter explorations indicate that the learning rate and the temperature driving the stochastic processes that govern synaptic learning dynamics need to be regulated for performance improvements to be retained. We conclude by discussing the recent deep reinforcement learning techniques which would be beneficial to increase the functionality of SPORE on visuomotor tasks.

cs.NE↗

arXiv2020

Recognizing Images with at most one Spike per Neuron

In order to port the performance of trained artificial neural networks (ANNs) to spiking neural networks (SNNs), which can be implemented in neuromorphic hardware with a drastically reduced energy consumption, an efficient ANN to SNN conversion is needed. Previous conversion schemes focused on the representation of the analog output of a rectified linear (ReLU) gate in the ANN by the firing rate of a spiking neuron. But this is not possible for other commonly used ANN gates, and it reduces the throughput even for ReLU gates. We introduce a new conversion method where a gate in the ANN, which can basically be of any type, is emulated by a small circuit of spiking neurons, with At Most One Spike (AMOS) per neuron. We show that this AMOS conversion improves the accuracy of SNNs for ImageNet from 74.60% to 80.97%, thereby bringing it within reach of the best available ANN accuracy (85.0%). The Top5 accuracy of SNNs is raised to 95.82%, getting even closer to the best Top5 performance of 97.2% for ANNs. In addition, AMOS conversion improves latency and throughput of spike-based image classification by several orders of magnitude. Hence these results suggest that SNNs provide a viable direction for developing highly energy efficient hardware for AI that combines high performance with versatility of applications.

cs.NE↗