arXiv subjects

Wouter Weeda

Publications and source records attributed to Wouter Weeda.

3 recordsLinked to original sources

arXiv2026

Principal Covariate Regression with Nuclear Norm Penalty

In high-dimensional data settings, dimensionality reduction or variable selection are key steps when using statistical learning techniques. Principal Covariate Regression-type methods aim to perform both dimensionality reduction and (regularized) regression steps in one analysis. However, existing PCovR methods cannot simultaneously select dimensionalities and estimate regularized coefficients, forcing researchers to make ad-hoc choices in the order of these steps. In this study, we propose a novel method called Principal Covariate Regression with Nuclear Norm Penalty (PcovRnnp) that allows simultaneous dimension reduction and estimation of regularized coefficients.

stat.ME↗

arXiv2022

Cluster extent inference revisited: quantification and localization of brain activity

Cluster inference based on spatial extent thresholding is the most popular analysis method for finding activated brain areas in neuroimaging. However, the method has several well-known issues. While powerful for finding brain regions with some activation, the method as currently defined does not allow any further quantification or localization of signal. In this paper we repair this gap. We show that cluster-extent inference can be used (1.) to infer the presence of signal in anatomical regions of interest and (2.) to quantify the percentage of active voxels in any cluster or region of interest. These additional inferences come for free, i.e. they do not require any further adjustment of the alpha-level of tests, while retaining full familywise error control. We achieve this extension of the possibilities of cluster inference by an embedding of the method into a closed testing procedure, and solving the graph-theoretic k-separator problem that results from this embedding. The new method can be used in combination with random field theory or permutations. We demonstrate the usefulness of the method in a large-scale application to neuroimaging data from the Neurovault database.

stat.ME↗

arXiv2020

Permutation-based true discovery proportions for functional Magnetic Resonance Imaging cluster analysis

We propose a permutation-based method for testing a large collection of hypotheses simultaneously. Our method provides lower bounds for the number of true discoveries in any selected subset of hypotheses. These bounds are simultaneously valid with high confidence. The methodology is particularly useful in functional Magnetic Resonance Imaging cluster analysis, where it provides a confidence statement on the percentage of truly activated voxels within clusters of voxels, avoiding the well-known spatial specificity paradox. We offer a user-friendly tool to estimate the percentage of true discoveries for each cluster while controlling the family-wise error rate for multiple testing and taking into account that the cluster was chosen in a data-driven way. The method adapts to the spatial correlation structure that characterizes functional Magnetic Resonance Imaging data, gaining power over parametric approaches.

stat.AP↗