arXiv subjects

Xiang Wan

Publications and source records attributed to Xiang Wan.

At least 109 records · Page 6Linked to original sources

arXiv2022

Graph Enhanced Contrastive Learning for Radiology Findings Summarization

The impression section of a radiology report summarizes the most prominent observation from the findings section and is the most important section for radiologists to communicate to physicians. Summarizing findings is time-consuming and can be prone to error for inexperienced radiologists, and thus automatic impression generation has attracted substantial attention. With the encoder-decoder framework, most previous studies explore incorporating extra knowledge (e.g., static pre-defined clinical ontologies or extra background information). Yet, they encode such knowledge by a separate encoder to treat it as an extra input to their models, which is limited in leveraging their relations with the original findings. To address the limitation, we propose a unified framework for exploiting both extra knowledge and the original findings in an integrated way so that the critical information (i.e., key words and their relations) can be extracted in an appropriate way to facilitate impression generation. In detail, for each input findings, it is encoded by a text encoder, and a graph is constructed through its entities and dependency tree. Then, a graph encoder (e.g., graph neural networks (GNNs)) is adopted to model relation information in the constructed graph. Finally, to emphasize the key words in the findings, contrastive learning is introduced to map positive samples (constructed by masking non-key words) closer and push apart negative ones (constructed by masking key words). The experimental results on OpenI and MIMIC-CXR confirm the effectiveness of our proposed method.

cs.CL↗

arXiv2022

A Simple yet Effective Relation Information Guided Approach for Few-Shot Relation Extraction

Few-Shot Relation Extraction aims at predicting the relation for a pair of entities in a sentence by training with a few labelled examples in each relation. Some recent works have introduced relation information (i.e., relation labels or descriptions) to assist model learning based on Prototype Network. However, most of them constrain the prototypes of each relation class implicitly with relation information, generally through designing complex network structures, like generating hybrid features, combining with contrastive learning or attention networks. We argue that relation information can be introduced more explicitly and effectively into the model. Thus, this paper proposes a direct addition approach to introduce relation information. Specifically, for each relation class, the relation representation is first generated by concatenating two views of relations (i.e., [CLS] token embedding and the mean value of embeddings of all tokens) and then directly added to the original prototype for both train and prediction. Experimental results on the benchmark dataset FewRel 1.0 show significant improvements and achieve comparable results to the state-of-the-art, which demonstrates the effectiveness of our proposed approach. Besides, further analyses verify that the direct addition is a much more effective way to integrate the relation representations and the original prototypes.

cs.CL↗

arXiv2022

Hero-Gang Neural Model For Named Entity Recognition

Named entity recognition (NER) is a fundamental and important task in NLP, aiming at identifying named entities (NEs) from free text. Recently, since the multi-head attention mechanism applied in the Transformer model can effectively capture longer contextual information, Transformer-based models have become the mainstream methods and have achieved significant performance in this task. Unfortunately, although these models can capture effective global context information, they are still limited in the local feature and position information extraction, which is critical in NER. In this paper, to address this limitation, we propose a novel Hero-Gang Neural structure (HGN), including the Hero and Gang module, to leverage both global and local information to promote NER. Specifically, the Hero module is composed of a Transformer-based encoder to maintain the advantage of the self-attention mechanism, and the Gang module utilizes a multi-window recurrent module to extract local features and position information under the guidance of the Hero module. Afterward, the proposed multi-window attention effectively combines global information and multiple local features for predicting entity labels. Experimental results on several benchmark datasets demonstrate the effectiveness of our proposed model.

cs.CL↗

arXiv2022

Generating Radiology Reports via Memory-driven Transformer

Medical imaging is frequently used in clinical practice and trials for diagnosis and treatment. Writing imaging reports is time-consuming and can be error-prone for inexperienced radiologists. Therefore, automatically generating radiology reports is highly desired to lighten the workload of radiologists and accordingly promote clinical automation, which is an essential task to apply artificial intelligence to the medical domain. In this paper, we propose to generate radiology reports with memory-driven Transformer, where a relational memory is designed to record key information of the generation process and a memory-driven conditional layer normalization is applied to incorporating the memory into the decoder of Transformer. Experimental results on two prevailing radiology report datasets, IU X-Ray and MIMIC-CXR, show that our proposed approach outperforms previous models with respect to both language generation metrics and clinical evaluations. Particularly, this is the first work reporting the generation results on MIMIC-CXR to the best of our knowledge. Further analyses also demonstrate that our approach is able to generate long reports with necessary medical terms as well as meaningful image-text attention mappings.

cs.CL↗

arXiv2022

Cross-modal Memory Networks for Radiology Report Generation

Medical imaging plays a significant role in clinical practice of medical diagnosis, where the text reports of the images are essential in understanding them and facilitating later treatments. By generating the reports automatically, it is beneficial to help lighten the burden of radiologists and significantly promote clinical automation, which already attracts much attention in applying artificial intelligence to medical domain. Previous studies mainly follow the encoder-decoder paradigm and focus on the aspect of text generation, with few studies considering the importance of cross-modal mappings and explicitly exploit such mappings to facilitate radiology report generation. In this paper, we propose a cross-modal memory networks (CMN) to enhance the encoder-decoder framework for radiology report generation, where a shared memory is designed to record the alignment between images and texts so as to facilitate the interaction and generation across modalities. Experimental results illustrate the effectiveness of our proposed model, where state-of-the-art performance is achieved on two widely used benchmark datasets, i.e., IU X-Ray and MIMIC-CXR. Further analyses also prove that our model is able to better align information from radiology images and texts so as to help generating more accurate reports in terms of clinical indicators.

cs.CL↗

arXiv2021

Word Graph Guided Summarization for Radiology Findings

Radiology reports play a critical role in communicating medical findings to physicians. In each report, the impression section summarizes essential radiology findings. In clinical practice, writing impression is highly demanded yet time-consuming and prone to errors for radiologists. Therefore, automatic impression generation has emerged as an attractive research direction to facilitate such clinical practice. Existing studies mainly focused on introducing salient word information to the general text summarization framework to guide the selection of the key content in radiology findings. However, for this task, a model needs not only capture the important words in findings but also accurately describe their relations so as to generate high-quality impressions. In this paper, we propose a novel method for automatic impression generation, where a word graph is constructed from the findings to record the critical words and their relations, then a Word Graph guided Summarization model (WGSum) is designed to generate impressions with the help of the word graph. Experimental results on two datasets, OpenI and MIMIC-CXR, confirm the validity and effectiveness of our proposed approach, where the state-of-the-art results are achieved on both datasets. Further experiments are also conducted to analyze the impact of different graph designs to the performance of our method.

cs.CL↗

arXiv2021

Hepatocellular Carcinoma Segmentation from Digital Subtraction Angiography Videos using Learnable Temporal Difference

Automatic segmentation of hepatocellular carcinoma (HCC) in Digital Subtraction Angiography (DSA) videos can assist radiologists in efficient diagnosis of HCC and accurate evaluation of tumors in clinical practice. Few studies have investigated HCC segmentation from DSA videos. It shows great challenging due to motion artifacts in filming, ambiguous boundaries of tumor regions and high similarity in imaging to other anatomical tissues. In this paper, we raise the problem of HCC segmentation in DSA videos, and build our own DSA dataset. We also propose a novel segmentation network called DSA-LTDNet, including a segmentation sub-network, a temporal difference learning (TDL) module and a liver region segmentation (LRS) sub-network for providing additional guidance. DSA-LTDNet is preferable for learning the latent motion information from DSA videos proactively and boosting segmentation performance. All of experiments are conducted on our self-collected dataset. Experimental results show that DSA-LTDNet increases the DICE score by nearly 4% compared to the U-Net baseline.

eess.IV↗

arXiv2021

USCL: Pretraining Deep Ultrasound Image Diagnosis Model through Video Contrastive Representation Learning

Most deep neural networks (DNNs) based ultrasound (US) medical image analysis models use pretrained backbones (e.g., ImageNet) for better model generalization. However, the domain gap between natural and medical images causes an inevitable performance bottleneck. To alleviate this problem, an US dataset named US-4 is constructed for direct pretraining on the same domain. It contains over 23,000 images from four US video sub-datasets. To learn robust features from US-4, we propose an US semi-supervised contrastive learning method, named USCL, for pretraining. In order to avoid high similarities between negative pairs as well as mine abundant visual features from limited US videos, USCL adopts a sample pair generation method to enrich the feature involved in a single step of contrastive optimization. Extensive experiments on several downstream tasks show the superiority of USCL pretraining against ImageNet pretraining and other state-of-the-art (SOTA) pretraining approaches. In particular, USCL pretrained backbone achieves fine-tuning accuracy of over 94% on POCUS dataset, which is 10% higher than 84% of the ImageNet pretrained model. The source codes of this work are available at https://github.com/983632847/USCL.

cs.CV↗

arXiv2021

Medical-VLBERT: Medical Visual Language BERT for COVID-19 CT Report Generation With Alternate Learning

Medical imaging technologies, including computed tomography (CT) or chest X-Ray (CXR), are largely employed to facilitate the diagnosis of the COVID-19. Since manual report writing is usually too time-consuming, a more intelligent auxiliary medical system that could generate medical reports automatically and immediately is urgently needed. In this article, we propose to use the medical visual language BERT (Medical-VLBERT) model to identify the abnormality on the COVID-19 scans and generate the medical report automatically based on the detected lesion regions. To produce more accurate medical reports and minimize the visual-and-linguistic differences, this model adopts an alternate learning strategy with two procedures that are knowledge pretraining and transferring. To be more precise, the knowledge pretraining procedure is to memorize the knowledge from medical texts, while the transferring procedure is to utilize the acquired knowledge for professional medical sentences generations through observations of medical images. In practice, for automatic medical report generation on the COVID-19 cases, we constructed a dataset of 368 medical findings in Chinese and 1104 chest CT scans from The First Affiliated Hospital of Jinan University, Guangzhou, China, and The Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, China. Besides, to alleviate the insufficiency of the COVID-19 training samples, our model was first trained on the large-scale Chinese CX-CHR dataset and then transferred to the COVID-19 CT dataset for further fine-tuning. The experimental results showed that Medical-VLBERT achieved state-of-the-art performances on terminology prediction and report generation with the Chinese COVID-19 CT dataset and the CX-CHR dataset. The Chinese COVID-19 CT dataset is available at https://covid19ct.github.io/.

cs.CV↗

arXiv2021

Structured Sparse Non-negative Matrix Factorization with L20-Norm for scRNA-seq Data Analysis

Non-negative matrix factorization (NMF) is a powerful tool for dimensionality reduction and clustering. Unfortunately, the interpretation of the clustering results from NMF is difficult, especially for the high-dimensional biological data without effective feature selection. In this paper, we first introduce a row-sparse NMF with $\ell_{2,0}$-norm constraint (NMF_$\ell_{20}$), where the basis matrix $W$ is constrained by the $\ell_{2,0}$-norm, such that $W$ has a row-sparsity pattern with feature selection. It is a challenge to solve the model, because the $\ell_{2,0}$-norm is non-convex and non-smooth. Fortunately, we prove that the $\ell_{2,0}$-norm satisfies the Kurdyka-Ł{ojasiewicz} property. Based on the finding, we present a proximal alternating linearized minimization algorithm and its monotone accelerated version to solve the NMF_$\ell_{20}$ model. In addition, we also present a orthogonal NMF with $\ell_{2,0}$-norm constraint (ONMF_$\ell_{20}$) to enhance the clustering performance by using a non-negative orthogonal constraint. We propose an efficient algorithm to solve ONMF_$\ell_{20}$ by transforming it into a series of constrained and penalized matrix factorization problems. The results on numerical and scRNA-seq datasets demonstrate the efficiency of our methods in comparison with existing methods.

cs.LG↗

arXiv2021

Semi-Supervised Active Learning for COVID-19 Lung Ultrasound Multi-symptom Classification

Ultrasound (US) is a non-invasive yet effective medical diagnostic imaging technique for the COVID-19 global pandemic. However, due to complex feature behaviors and expensive annotations of US images, it is difficult to apply Artificial Intelligence (AI) assisting approaches for lung's multi-symptom (multi-label) classification. To overcome these difficulties, we propose a novel semi-supervised Two-Stream Active Learning (TSAL) method to model complicated features and reduce labeling costs in an iterative procedure. The core component of TSAL is the multi-label learning mechanism, in which label correlations information is used to design multi-label margin (MLM) strategy and confidence validation for automatically selecting informative samples and confident labels. On this basis, a multi-symptom multi-label (MSML) classification network is proposed to learn discriminative features of lung symptoms, and a human-machine interaction is exploited to confirm the final annotations that are used to fine-tune MSML with progressively labeled data. Moreover, a novel lung US dataset named COVID19-LUSMS is built, currently containing 71 clinical patients with 6,836 images sampled from 678 videos. Experimental evaluations show that TSAL using only 20% data can achieve superior performance to the baseline and the state-of-the-art. Qualitatively, visualization of both attention map and sample distribution confirms the good consistency with the clinic knowledge.

cs.CV↗

arXiv2020

Regularity and finite element approximation for two-dimensional elliptic equations with line Dirac sources

We study the elliptic equation with a line Dirac delta function as the source term subject to the Dirichlet boundary condition in a two-dimensional domain. Such a line Dirac measure causes different types of solution singularities in the neighborhood of the line fracture. We establish new regularity results for the solution in a class of weighted Sobolev spaces and propose finite element algorithms that approximate the singular solution at the optimal convergence rate. Numerical tests are presented to justify the theoretical findings.

math.NA↗

arXiv2020

Multi-Modal Active Learning for Automatic Liver Fibrosis Diagnosis based on Ultrasound Shear Wave Elastography

With the development of radiomics, noninvasive diagnosis like ultrasound (US) imaging plays a very important role in automatic liver fibrosis diagnosis (ALFD). Due to the noisy data, expensive annotations of US images, the application of Artificial Intelligence (AI) assisting approaches encounters a bottleneck. Besides, the use of mono-modal US data limits the further improve of the classification results. In this work, we innovatively propose a multi-modal fusion network with active learning (MMFN-AL) for ALFD to exploit the information of multiple modalities, eliminate the noisy data and reduce the annotation cost. Four image modalities including US and three types of shear wave elastography (SWEs) are exploited. A new dataset containing these modalities from 214 candidates is well-collected and pre-processed, with the labels obtained from the liver biopsy results. Experimental results show that our proposed method outperforms the state-of-the-art performance using less than 30% data, and by using only around 80% data, the proposed fusion network achieves high AUC 89.27% and accuracy 70.59%.

cs.CV↗

arXiv2020

Named Entity Recognition for Social Media Texts with Semantic Augmentation

Existing approaches for named entity recognition suffer from data sparsity problems when conducted on short and informal texts, especially user-generated social media content. Semantic augmentation is a potential way to alleviate this problem. Given that rich semantic information is implicitly preserved in pre-trained word embeddings, they are potential ideal resources for semantic augmentation. In this paper, we propose a neural-based approach to NER for social media texts where both local (from running text) and augmented semantics are taken into account. In particular, we obtain the augmented semantic information from a large-scale corpus, and propose an attentive semantic augmentation module and a gate module to encode and aggregate such information, respectively. Extensive experiments are performed on three benchmark datasets collected from English and Chinese social media platforms, where the results demonstrate the superiority of our approach to previous studies across all three datasets.

cs.CL↗

arXiv2020

Improving Named Entity Recognition with Attentive Ensemble of Syntactic Information

Named entity recognition (NER) is highly sensitive to sentential syntactic and semantic properties where entities may be extracted according to how they are used and placed in the running text. To model such properties, one could rely on existing resources to providing helpful knowledge to the NER task; some existing studies proved the effectiveness of doing so, and yet are limited in appropriately leveraging the knowledge such as distinguishing the important ones for particular context. In this paper, we improve NER by leveraging different types of syntactic information through attentive ensemble, which functionalizes by the proposed key-value memory networks, syntax attention, and the gate mechanism for encoding, weighting and aggregating such syntactic information, respectively. Experimental results on six English and Chinese benchmark datasets suggest the effectiveness of the proposed model and show that it outperforms previous studies on all experiment datasets.

cs.CL↗

arXiv2018

Long-Time Behavior of Quasilinear Thermoelastic Kirchhoff-Love Plates with Second Sound

We consider an initial-boundary-value problem for a thermoelastic Kirchhoff & Love plate, thermally insulated and simply supported on the boundary, incorporating rotational inertia and a quasilinear hypoelastic response, while the heat effects are modeled using the hyperbolic Maxwell-Cattaneo-Vernotte law giving rise to a 'second sound' effect. We study the local well-posedness of the resulting quasilinear mixed-order hyperbolic system in a suitable solution class of smooth functions mapping into Sobolev $H^{k}$-spaces. Exploiting the sole source of energy dissipation entering the system through the hyperbolic heat flux moment, provided the initial data are small in a lower topology (basic energy level corresponding to weak solutions), we prove a nonlinear stabilizability estimate furnishing global existence & uniqueness and exponential decay of classical solutions.

math.AP↗

arXiv2018

Joint Analysis of Individual-level and Summary-level GWAS Data by Leveraging Pleiotropy

A large number of recent genome-wide association studies (GWASs) for complex phenotypes confirm the early conjecture for polygenicity, suggesting the presence of large number of variants with only tiny or moderate effects. However, due to the limited sample size of a single GWAS, many associated genetic variants are too weak to achieve the genome-wide significance. These undiscovered variants further limit the prediction capability of GWAS. Restricted access to the individual-level data and the increasing availability of the published GWAS results motivate the development of methods integrating both the individual-level and summary-level data. How to build the connection between the individual-level and summary-level data determines the efficiency of using the existing abundant summary-level resources with limited individual-level data, and this issue inspires more efforts in the existing area. In this study, we propose a novel statistical approach, LEP, which provides a novel way of modeling the connection between the individual-level data and summary-level data. LEP integrates both types of data by \underline{LE}veraing \underline{P}leiotropy to increase the statistical power of risk variants identification and the accuracy of risk prediction. The algorithm for parameter estimation is developed to handle genome-wide-scale data. Through comprehensive simulation studies, we demonstrated the advantages of LEP over the existing methods. We further applied LEP to perform integrative analysis of Crohn's disease from WTCCC and summary statistics from GWAS of some other diseases, such as Type 1 diabetes, Ulcerative colitis and Primary biliary cirrhosis. LEP was able to significantly increase the statistical power of identifying risk variants and improve the risk prediction accuracy from 63.39\% ($\pm$ 0.58\%) to 68.33\% ($\pm$ 0.32\%) using about 195,000 variants.

q-bio.GN↗

arXiv2018

Testing normality using the summary statistics with application to meta-analysis

As the most important tool to provide high-level evidence-based medicine, researchers can statistically summarize and combine data from multiple studies by conducting meta-analysis. In meta-analysis, mean differences are frequently used effect size measurements to deal with continuous data, such as the Cohen's d statistic and Hedges' g statistic values. To calculate the mean difference based effect sizes, the sample mean and standard deviation are two essential summary measures. However, many of the clinical reports tend not to directly record the sample mean and standard deviation. Instead, the sample size, median, minimum and maximum values and/or the first and third quartiles are reported. As a result, researchers have to transform the reported information to the sample mean and standard deviation for further compute the effect size. Since most of the popular transformation methods were developed upon the normality assumption of the underlying data, it is necessary to perform a pre-test before transforming the summary statistics. In this article, we had introduced test statistics for three popular scenarios in meta-analysis. We suggests medical researchers to perform a normality test of the selected studies before using them to conduct further analysis. Moreover, we applied three different case studies to demonstrate the usage of the newly proposed test statistics. The real data case studies indicate that the new test statistics are easy to apply in practice and by following the recommended path to conduct the meta-analysis, researchers can obtain more reliable conclusions.

stat.ME↗