arXiv subjects

Xiangjian He

Publications and source records attributed to Xiangjian He.

At least 19 recordsLinked to original sources

arXiv2026

DistMedVL: Distributional Vision-Language Alignment for Uncertainty-Aware Medical Image Segmentation

Cross-modal alignment of visual and textual representations is fundamental to multimodal medical image understanding, yet remains hindered by uncertainty in both modalities under real-world clinical conditions. Existing vision-language segmentation methods rely on deterministic cross-modal matching, which overlooks aleatoric uncertainty from ambiguous boundaries and epistemic uncertainty from limited training data, leading to fragile performance under domain shift. To address this issue, we propose DistMedVL, a probabilistic vision-language framework that introduces a lightweight Probabilistic Cross-Modal Adapter (PCM-Adapter) upon frozen encoders to explicitly model representational uncertainty. Specifically, the PCM-Adapter comprises two sequential modules for progressive probabilistic alignment. We first devise a Mahalanobis Alignment Module (MAM) that models textual tokens as Gaussian distributions and computes patch-text compatibility via Mahalanobis distance, yielding variance-conditioned matching that downweights unreliable feature dimensions. Moreover, we devise a Distribution Flow Module (DFM) that estimates modality-wise confidence parameters and performs vision-guided refinement of textual distributions, accommodating distributional variation across imaging modalities. Extensive experiments across eight medical segmentation benchmarks demonstrate that DistMedVL outperforms state-of-the-art methods with only 6.3M trainable parameters, exhibiting superior data efficiency, perturbation robustness and cross-dataset generalization.

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arXiv2026

Rethinking the Adaptation of Vision Foundation Models for Efficient Cell Segmentation

Cell segmentation is critical for computational pathology and biomedical discovery. While recent Vision Foundation Models (VFMs) have demonstrated remarkable universal feature representations, unlocking their full potential for cellular imaging is currently bottlenecked by resource-intensive adaptation paradigms. Existing methods typically rely on fine-tuning heavy visual encoders, leading to extensive computational overhead and a dependency on large-scale annotations. To address this, we propose the EffiCell-Seg framework for highly efficient cell segmentation without re-training the visual encoder. Our core insight is that pretrained VFMs intrinsically encode complementary structural priors: global saliency for localizing potential cells, and local morphological patterns for delineating cellular structures. To harness these priors, we devise a Cell Structure Prompt Encoder (CSP-Encoder) that synthesizes semantic-aware saliency and principal morphological features from frozen VFM representations into explicit structural prior maps. Moreover, we propose a Synergistic Mask Decoder (SM-Decoder) that enforces contextual consistency by jointly predicting geometric distance fields and semantic maps via mutual cross-guidance. Extensive experiments demonstrate that EffiCell-Seg outperforms state-of-the-art methods across diverse cell imaging modalities while requiring only ~5M trainable parameters, over 130x fewer than fully fine-tuned VFM counterparts. The code is available at https://github.com/xq141839/EffiCell-Seg.

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arXiv2026

Cesarean Scar Defect Segmentation in Transvaginal Ultrasound Images: a Dataset and Benchmark

Cesarean Scar Defect (CSD) is one of the most prevalent complications following cesarean delivery. Transvaginal ultrasonography is widely used for primary CSD screening. Accurate determination of CSD outline and dimensions is crucial for treatment. However, CSDs are frequently overlooked by sonographers due to small size and irregular morphology, suboptimal image quality, and limited clinical awareness in resource-constrained settings. Despite artificial intelligence advances in medical imaging, no public dataset exists for transvaginal ultrasound CSD segmentation. To address this gap, we present a comprehensive CSD dataset comprising 1,111 images and 16 videos, yielding 501 positive samples with confirmed CSD and precise pixel-level manual annotations. Annotations are performed following standardized clinical guidelines through collaboration between experienced sonographers and trained PhD students. This work provides high-quality benchmark resources for advancing medical image segmentation algorithms and promoting clinical innovation. Ultimately, improved CSD diagnosis and subsequent treatment strategies can enhance the quality of life in women of reproductive age, representing significant value for both medical research and clinical practice.

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arXiv2026

TAFG-MAN: Timestep-Adaptive Frequency-Gated Latent Diffusion for Efficient and High-Quality Low-Dose CT Image Denoising

Low-dose computed tomography (LDCT) reduces radiation exposure but also introduces substantial noise and structural degradation, making it difficult to suppress noise without erasing subtle anatomical details. In this paper, we present TAFG-MAN, a latent diffusion framework for efficient and high-quality LDCT image denoising. The framework combines a perceptually optimized autoencoder, conditional latent diffusion restoration in a compact latent space, and a lightweight Timestep-Adaptive Frequency-Gated (TAFG) conditioning design. TAFG decomposes condition features into low- and high-frequency components, predicts timestep-adaptive gates from the current denoising feature and timestep embedding, and progressively releases high-frequency guidance in later denoising stages before cross-attention. In this way, the model relies more on stable structural guidance at early reverse steps and introduces fine details more cautiously as denoising proceeds, improving the balance between noise suppression and detail preservation. Experiments show that TAFG-MAN achieves a favorable quality-efficiency trade-off against representative baselines. Compared with its base variant without TAFG, it further improves detail preservation and perceptual quality while maintaining essentially the same inference cost, and ablation results confirm the effectiveness of the proposed conditioning mechanism.

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arXiv2026

RoLID-11K: A Dashcam Dataset for Small-Object Roadside Litter Detection

Roadside litter poses environmental, safety and economic challenges, yet current monitoring relies on labour-intensive surveys and public reporting, providing limited spatial coverage. Existing vision datasets for litter detection focus on street-level still images, aerial scenes or aquatic environments, and do not reflect the unique characteristics of dashcam footage, where litter appears extremely small, sparse and embedded in cluttered road-verge backgrounds. We introduce RoLID-11K, the first large-scale dataset for roadside litter detection from dashcams, comprising over 11k annotated images spanning diverse UK driving conditions and exhibiting pronounced long-tail and small-object distributions. We benchmark a broad spectrum of modern detectors, from accuracy-oriented transformer architectures to real-time YOLO models, and analyse their strengths and limitations on this challenging task. Our results show that while CO-DETR and related transformers achieve the best localisation accuracy, real-time models remain constrained by coarse feature hierarchies. RoLID-11K establishes a challenging benchmark for extreme small-object detection in dynamic driving scenes and aims to support the development of scalable, low-cost systems for roadside-litter monitoring. The dataset is available at https://github.com/xq141839/RoLID-11K.

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arXiv2025

FreqDINO: Frequency-Guided Adaptation for Generalized Boundary-Aware Ultrasound Image Segmentation

Ultrasound image segmentation is pivotal for clinical diagnosis, yet challenged by speckle noise and imaging artifacts. Recently, DINOv3 has shown remarkable promise in medical image segmentation with its powerful representation capabilities. However, DINOv3, pre-trained on natural images, lacks sensitivity to ultrasound-specific boundary degradation. To address this limitation, we propose FreqDINO, a frequency-guided segmentation framework that enhances boundary perception and structural consistency. Specifically, we devise a Multi-scale Frequency Extraction and Alignment (MFEA) strategy to separate low-frequency structures and multi-scale high-frequency boundary details, and align them via learnable attention. We also introduce a Frequency-Guided Boundary Refinement (FGBR) module that extracts boundary prototypes from high-frequency components and refines spatial features. Furthermore, we design a Multi-task Boundary-Guided Decoder (MBGD) to ensure spatial coherence between boundary and semantic predictions. Extensive experiments demonstrate that FreqDINO surpasses state-of-the-art methods with superior achieves remarkable generalization capability. The code is at https://github.com/MingLang-FD/FreqDINO.

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arXiv2025

UniUltra: Interactive Parameter-Efficient SAM2 for Universal Ultrasound Segmentation

The Segment Anything Model 2 (SAM2) demonstrates remarkable universal segmentation capabilities on natural images. However, its performance on ultrasound images is significantly degraded due to domain disparities. This limitation raises two critical challenges: how to efficiently adapt SAM2 to ultrasound imaging while maintaining parameter efficiency, and how to deploy the adapted model effectively in resource-constrained clinical environments. To address these issues, we propose UniUltra for universal ultrasound segmentation. Specifically, we first introduce a novel context-edge hybrid adapter (CH-Adapter) that enhances fine-grained perception across diverse ultrasound imaging modalities while achieving parameter-efficient fine-tuning. To further improve clinical applicability, we develop a deep-supervised knowledge distillation (DSKD) technique that transfers knowledge from the large image encoder of the fine-tuned SAM2 to a super lightweight encoder, substantially reducing computational requirements without compromising performance. Extensive experiments demonstrate that UniUltra outperforms state-of-the-arts with superior generalization capabilities. Notably, our framework achieves competitive performance using only 8.91% of SAM2's parameters during fine-tuning, and the final compressed model reduces the parameter count by 94.08% compared to the original SAM2, making it highly suitable for practical clinical deployment. The source code is available at https://github.com/xq141839/UniUltra.

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arXiv2025

TM-UNet: Token-Memory Enhanced Sequential Modeling for Efficient Medical Image Segmentation

Medical image segmentation is essential for clinical diagnosis and treatment planning. Although transformer-based methods have achieved remarkable results, their high computational cost hinders clinical deployment. To address this issue, we propose TM-UNet, a novel lightweight framework that integrates token sequence modeling with an efficient memory mechanism for efficient medical segmentation. Specifically, we introduce a multi-scale token-memory (MSTM) block that transforms 2D spatial features into token sequences through strategic spatial scanning, leveraging matrix memory cells to selectively retain and propagate discriminative contextual information across tokens. This novel token-memory mechanism acts as a dynamic knowledge store that captures long-range dependencies with linear complexity, enabling efficient global reasoning without redundant computation. Our MSTM block further incorporates exponential gating to identify token effectiveness and multi-scale contextual extraction via parallel pooling operations, enabling hierarchical representation learning without computational overhead. Extensive experiments demonstrate that TM-UNet outperforms state-of-the-art methods across diverse medical segmentation tasks with substantially reduced computation cost. The code is available at https://github.com/xq141839/TM-UNet.

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arXiv2025

CoMA: Complementary Masking and Hierarchical Dynamic Multi-Window Self-Attention in a Unified Pre-training Framework

Masked Autoencoders (MAE) achieve self-supervised learning of image representations by randomly removing a portion of visual tokens and reconstructing the original image as a pretext task, thereby significantly enhancing pretraining efficiency and yielding excellent adaptability across downstream tasks. However, MAE and other MAE-style paradigms that adopt random masking generally require more pre-training epochs to maintain adaptability. Meanwhile, ViT in MAE suffers from inefficient parameter use due to fixed spatial resolution across layers. To overcome these limitations, we propose the Complementary Masked Autoencoders (CoMA), which employ a complementary masking strategy to ensure uniform sampling across all pixels, thereby improving effective learning of all features and enhancing the model's adaptability. Furthermore, we introduce DyViT, a hierarchical vision transformer that employs a Dynamic Multi-Window Self-Attention (DM-MSA), significantly reducing the parameters and FLOPs while improving fine-grained feature learning. Pre-trained on ImageNet-1K with CoMA, DyViT matches the downstream performance of MAE using only 12% of the pre-training epochs, demonstrating more effective learning. It also attains a 10% reduction in pre-training time per epoch, further underscoring its superior pre-training efficiency.

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arXiv2025

Synergistic Modality-and-Slice Memory Framework for Cross-Modal 3D Brain Tumor Segmentation

The 3D multi-modal brain tumor segmentation is critical to multi-modal healthcare, and it requires accurate identification of distinct internal anatomical subregions. While the recent prompt-based segmentation paradigms enable interactive experiences for clinicians, existing methods ignore cross-modal correlations and rely on labor-intensive category-specific prompts, limiting their applicability in real-world scenarios. To address these issues, we propose the MSM-Seg, a synergistic framework for multi-modal brain tumor segmentation. The MSM-Seg introduces a dual-memory segmentation paradigm that synergistically integrates multi-modal and inter-slice information with an efficient category-agnostic prompt for brain tumor understanding. To this end, we first devise a modality-and-slice memory attention (MSMA) to exploit the complex cross-modal correlations and spatial-slice dependencies among the input scans. \cz{Then, we propose a multi-scale category-agnostic prompt encoder (MCP-Encoder) to provide whole tumor region guidance for decoding.} Moreover, we devise a modality-adaptive fusion decoder (MF-Decoder) that leverages the complementary decoding information across different modalities to improve segmentation accuracy. Extensive experiments on different MRI datasets demonstrate that our MSM-Seg framework outperforms state-of-the-art methods in multi-modal metastases and glioma tumor segmentation. The code is available at https://github.com/xq141839/MSM-Seg.

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arXiv2025

MAN: Latent Diffusion Enhanced Multistage Anti-Noise Network for Efficient and High-Quality Low-Dose CT Image Denoising

While diffusion models have set a new benchmark for quality in Low-Dose Computed Tomography (LDCT) denoising, their clinical adoption is critically hindered by extreme computational costs, with inference times often exceeding thousands of seconds per scan. To overcome this barrier, we introduce MAN, a Latent Diffusion Enhanced Multistage Anti-Noise Network for Efficient and High-Quality Low-Dose CT Image Denoising task. Our method operates in a compressed latent space via a perceptually-optimized autoencoder, enabling an attention-based conditional U-Net to perform the fast, deterministic conditional denoising diffusion process with drastically reduced overhead. On the LDCT and Projection dataset, our model achieves superior perceptual quality, surpassing CNN/GAN-based methods while rivaling the reconstruction fidelity of computationally heavy diffusion models like DDPM and Dn-Dp. Most critically, in the inference stage, our model is over 60x faster than representative pixel space diffusion denoisers, while remaining competitive on PSNR/SSIM scores. By bridging the gap between high fidelity and clinical viability, our work demonstrates a practical path forward for advanced generative models in medical imaging.

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arXiv2025

WSI-LLaVA: A Multimodal Large Language Model for Whole Slide Image

Recent advancements in computational pathology have produced patch-level Multi-modal Large Language Models (MLLMs), but these models are limited by their inability to analyze whole slide images (WSIs) comprehensively and their tendency to bypass crucial morphological features that pathologists rely on for diagnosis. To address these challenges, we first introduce WSI-Bench, a large-scale morphology-aware benchmark containing 180k VQA pairs from 9,850 WSIs across 30 cancer types, designed to evaluate MLLMs' understanding of morphological characteristics crucial for accurate diagnosis. Building upon this benchmark, we present WSI-LLaVA, a novel framework for gigapixel WSI understanding that employs a three-stage training approach: WSI-text alignment, feature space alignment, and task-specific instruction tuning. To better assess model performance in pathological contexts, we develop two specialized WSI metrics: WSI-Precision and WSI-Relevance. Experimental results demonstrate that WSI-LLaVA outperforms existing models across all capability dimensions, with a significant improvement in morphological analysis, establishing a clear correlation between morphological understanding and diagnostic accuracy.

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arXiv2025

MambaVesselNet++: A Hybrid CNN-Mamba Architecture for Medical Image Segmentation

Medical image segmentation plays an important role in computer-aided diagnosis. Traditional convolution-based U-shape segmentation architectures are usually limited by the local receptive field. Existing vision transformers have been widely applied to diverse medical segmentation frameworks due to their superior capabilities of capturing global contexts. Despite the advantage, the real-world application of vision transformers is challenged by their non-linear self-attention mechanism, requiring huge computational costs. To address this issue, the selective state space model (SSM) Mamba has gained recognition for its adeptness in modeling long-range dependencies in sequential data, particularly noted for its efficient memory costs. In this paper, we propose MambaVesselNet++, a Hybrid CNN-Mamba framework for medical image segmentation. Our MambaVesselNet++ is comprised of a hybrid image encoder (Hi-Encoder) and a bifocal fusion decoder (BF-Decoder). In Hi-Encoder, we first devise the texture-aware layer to capture low-level semantic features by leveraging convolutions. Then, we utilize Mamba to effectively model long-range dependencies with linear complexity. The Bi-Decoder adopts skip connections to combine local and global information of the Hi-Encoder for the accurate generation of segmentation masks. Extensive experiments demonstrate that MambaVesselNet++ outperforms current convolution-based, transformer-based, and Mamba-based state-of-the-arts across diverse medical 2D, 3D, and instance segmentation tasks. The code is available at https://github.com/CC0117/MambaVesselNet.

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arXiv2025

HER-Seg: Holistically Efficient Segmentation for High-Resolution Medical Images

High-resolution segmentation is critical for precise disease diagnosis by extracting fine-grained morphological details. Existing hierarchical encoder-decoder frameworks have demonstrated remarkable adaptability across diverse medical segmentation tasks. While beneficial, they usually require the huge computation and memory cost when handling large-size segmentation, which limits their applications in foundation model building and real-world clinical scenarios. To address this limitation, we propose a holistically efficient framework for high-resolution medical image segmentation, called HER-Seg. Specifically, we first devise a computation-efficient image encoder (CE-Encoder) to model long-range dependencies with linear complexity while maintaining sufficient representations. In particular, we introduce the dual-gated linear attention (DLA) mechanism to perform cascaded token filtering, selectively retaining important tokens while ignoring irrelevant ones to enhance attention computation efficiency. Then, we introduce a memory-efficient mask decoder (ME-Decoder) to eliminate the demand for the hierarchical structure by leveraging cross-scale segmentation decoding. Extensive experiments reveal that HER-Seg outperforms state-of-the-arts in high-resolution medical 2D, 3D and video segmentation tasks. In particular, our HER-Seg requires only 0.59GB training GPU memory and 9.39G inference FLOPs per 1024$\times$1024 image, demonstrating superior memory and computation efficiency. The code is available at https://github.com/xq141839/HER-Seg.

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arXiv2025

WSI-Agents: A Collaborative Multi-Agent System for Multi-Modal Whole Slide Image Analysis

Whole slide images (WSIs) are vital in digital pathology, enabling gigapixel tissue analysis across various pathological tasks. While recent advancements in multi-modal large language models (MLLMs) allow multi-task WSI analysis through natural language, they often underperform compared to task-specific models. Collaborative multi-agent systems have emerged as a promising solution to balance versatility and accuracy in healthcare, yet their potential remains underexplored in pathology-specific domains. To address these issues, we propose WSI-Agents, a novel collaborative multi-agent system for multi-modal WSI analysis. WSI-Agents integrates specialized functional agents with robust task allocation and verification mechanisms to enhance both task-specific accuracy and multi-task versatility through three components: (1) a task allocation module assigning tasks to expert agents using a model zoo of patch and WSI level MLLMs, (2) a verification mechanism ensuring accuracy through internal consistency checks and external validation using pathology knowledge bases and domain-specific models, and (3) a summary module synthesizing the final summary with visual interpretation maps. Extensive experiments on multi-modal WSI benchmarks show WSI-Agents's superiority to current WSI MLLMs and medical agent frameworks across diverse tasks.

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arXiv2025

CFFormer: Cross CNN-Transformer Channel Attention and Spatial Feature Fusion for Improved Segmentation of Heterogeneous Medical Images

Medical image segmentation plays an important role in computer-aided diagnosis. Existing methods mainly utilize spatial attention to highlight the region of interest. However, due to limitations of medical imaging devices, medical images exhibit significant heterogeneity, posing challenges for segmentation. Ultrasound images, for instance, often suffer from speckle noise, low resolution, and poor contrast between target tissues and background, which may lead to inaccurate boundary delineation. To address these challenges caused by heterogeneous image quality, we propose a hybrid CNN-Transformer model,called CFFormer, which leverages effective channel feature extraction to enhance the model' s ability to accurately identify tissue regions by capturing rich contextual information. The proposed architecture contains two key components: the Cross Feature Channel Attention (CFCA) module and the X-Spatial Feature Fusion (XFF) module. The model incorporates dual encoders, with the CNN encoder focusing on capturing local features and the Transformer encoder modeling global features. The CFCA module filters and facilitates interactions between the channel features from the two encoders, while the XFF module effectively reduces the significant semantic information differences in spatial features, enabling a smooth and cohesive spatial feature fusion. We evaluate our model across eight datasets covering five modalities to test its generalization capability. Experimental results demonstrate that our model outperforms current state-of-the-art methods and maintains accurate tissue region segmentation across heterogeneous medical image datasets. The code is available at https://github.com/JiaxuanFelix/CFFormer.

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arXiv2025

NuSegDG: Integration of Heterogeneous Space and Gaussian Kernel for Domain-Generalized Nuclei Segmentation

Domain-generalized nuclei segmentation refers to the generalizability of models to unseen domains based on knowledge learned from source domains and is challenged by various image conditions, cell types, and stain strategies. Recently, the Segment Anything Model (SAM) has made great success in universal image segmentation by interactive prompt modes (e.g., point and box). Despite its strengths, the original SAM presents limited adaptation to medical images. Moreover, SAM requires providing manual bounding box prompts for each object to produce satisfactory segmentation masks, so it is laborious in nuclei segmentation scenarios. To address these limitations, we propose a domain-generalizable framework for nuclei image segmentation, abbreviated to NuSegDG. Specifically, we first devise a Heterogeneous Space Adapter (HS-Adapter) to learn multi-dimensional feature representations of different nuclei domains by injecting a small number of trainable parameters into the image encoder of SAM. To alleviate the labor-intensive requirement of manual prompts, we introduce a Gaussian-Kernel Prompt Encoder (GKP-Encoder) to generate density maps driven by a single point, which guides segmentation predictions by mixing position prompts and semantic prompts. Furthermore, we present a Two-Stage Mask Decoder (TSM-Decoder) to effectively convert semantic masks to instance maps without the manual demand for morphological shape refinement. Based on our experimental evaluations, the proposed NuSegDG demonstrates state-of-the-art performance in nuclei instance segmentation, exhibiting superior domain generalization capabilities. The source code is available at https://github.com/xq141839/NuSegDG.

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arXiv2024

TAVP: Task-Adaptive Visual Prompt for Cross-domain Few-shot Segmentation

While large visual models (LVM) demonstrated significant potential in image understanding, due to the application of large-scale pre-training, the Segment Anything Model (SAM) has also achieved great success in the field of image segmentation, supporting flexible interactive cues and strong learning capabilities. However, SAM's performance often falls short in cross-domain and few-shot applications. Previous work has performed poorly in transferring prior knowledge from base models to new applications. To tackle this issue, we propose a task-adaptive auto-visual prompt framework, a new paradigm for Cross-dominan Few-shot segmentation (CD-FSS). First, a Multi-level Feature Fusion (MFF) was used for integrated feature extraction as prior knowledge. Besides, we incorporate a Class Domain Task-Adaptive Auto-Prompt (CDTAP) module to enable class-domain agnostic feature extraction and generate high-quality, learnable visual prompts. This significant advancement uses a unique generative approach to prompts alongside a comprehensive model structure and specialized prototype computation. While ensuring that the prior knowledge of SAM is not discarded, the new branch disentangles category and domain information through prototypes, guiding it in adapting the CD-FSS. Comprehensive experiments across four cross-domain datasets demonstrate that our model outperforms the state-of-the-art CD-FSS approach, achieving an average accuracy improvement of 1.3\% in the 1-shot setting and 11.76\% in the 5-shot setting.

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