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Xiaobo Xia

Publications and source records attributed to Xiaobo Xia.

At least 73 records · Page 4Linked to original sources

VisionFM: a Multi-Modal Multi-Task Vision Foundation Model for Generalist Ophthalmic Artificial Intelligence

We present VisionFM, a foundation model pre-trained with 3.4 million ophthalmic images from 560,457 individuals, covering a broad range of ophthalmic diseases, modalities, imaging devices, and demography. After pre-training, VisionFM provides a foundation to foster multiple ophthalmic artificial intelligence (AI) applications, such as disease screening and diagnosis, disease prognosis, subclassification of disease phenotype, and systemic biomarker and disease prediction, with each application enhanced with expert-level intelligence and accuracy. The generalist intelligence of VisionFM outperformed ophthalmologists with basic and intermediate levels in jointly diagnosing 12 common ophthalmic diseases. Evaluated on a new large-scale ophthalmic disease diagnosis benchmark database, as well as a new large-scale segmentation and detection benchmark database, VisionFM outperformed strong baseline deep neural networks. The ophthalmic image representations learned by VisionFM exhibited noteworthy explainability, and demonstrated strong generalizability to new ophthalmic modalities, disease spectrum, and imaging devices. As a foundation model, VisionFM has a large capacity to learn from diverse ophthalmic imaging data and disparate datasets. To be commensurate with this capacity, in addition to the real data used for pre-training, we also generated and leveraged synthetic ophthalmic imaging data. Experimental results revealed that synthetic data that passed visual Turing tests, can also enhance the representation learning capability of VisionFM, leading to substantial performance gains on downstream ophthalmic AI tasks. Beyond the ophthalmic AI applications developed, validated, and demonstrated in this work, substantial further applications can be achieved in an efficient and cost-effective manner using VisionFM as the foundation.

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Multi-Label Noise Transition Matrix Estimation with Label Correlations: Theory and Algorithm

Noisy multi-label learning has garnered increasing attention due to the challenges posed by collecting large-scale accurate labels, making noisy labels a more practical alternative. Motivated by noisy multi-class learning, the introduction of transition matrices can help model multi-label noise and enable the development of statistically consistent algorithms for noisy multi-label learning. However, estimating multi-label noise transition matrices remains a challenging task, as most existing estimators in noisy multi-class learning rely on anchor points and accurate fitting of noisy class posteriors, which is hard to satisfy in noisy multi-label learning. In this paper, we address this problem by first investigating the identifiability of class-dependent transition matrices in noisy multi-label learning. Building upon the identifiability results, we propose a novel estimator that leverages label correlations without the need for anchor points or precise fitting of noisy class posteriors. Specifically, we first estimate the occurrence probability of two noisy labels to capture noisy label correlations. Subsequently, we employ sample selection techniques to extract information implying clean label correlations, which are then used to estimate the occurrence probability of one noisy label when a certain clean label appears. By exploiting the mismatches in label correlations implied by these occurrence probabilities, we demonstrate that the transition matrix becomes identifiable and can be acquired by solving a bilinear decomposition problem. Theoretically, we establish an estimation error bound for our multi-label transition matrix estimator and derive a generalization error bound for our statistically consistent algorithm. Empirically, we validate the effectiveness of our estimator in estimating multi-label noise transition matrices, leading to excellent classification performance.

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Regularly Truncated M-estimators for Learning with Noisy Labels

The sample selection approach is very popular in learning with noisy labels. As deep networks learn pattern first, prior methods built on sample selection share a similar training procedure: the small-loss examples can be regarded as clean examples and used for helping generalization, while the large-loss examples are treated as mislabeled ones and excluded from network parameter updates. However, such a procedure is arguably debatable from two folds: (a) it does not consider the bad influence of noisy labels in selected small-loss examples; (b) it does not make good use of the discarded large-loss examples, which may be clean or have meaningful information for generalization. In this paper, we propose regularly truncated M-estimators (RTME) to address the above two issues simultaneously. Specifically, RTME can alternately switch modes between truncated M-estimators and original M-estimators. The former can adaptively select small-losses examples without knowing the noise rate and reduce the side-effects of noisy labels in them. The latter makes the possibly clean examples but with large losses involved to help generalization. Theoretically, we demonstrate that our strategies are label-noise-tolerant. Empirically, comprehensive experimental results show that our method can outperform multiple baselines and is robust to broad noise types and levels.

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HumanMAC: Masked Motion Completion for Human Motion Prediction

Human motion prediction is a classical problem in computer vision and computer graphics, which has a wide range of practical applications. Previous effects achieve great empirical performance based on an encoding-decoding style. The methods of this style work by first encoding previous motions to latent representations and then decoding the latent representations into predicted motions. However, in practice, they are still unsatisfactory due to several issues, including complicated loss constraints, cumbersome training processes, and scarce switch of different categories of motions in prediction. In this paper, to address the above issues, we jump out of the foregoing style and propose a novel framework from a new perspective. Specifically, our framework works in a masked completion fashion. In the training stage, we learn a motion diffusion model that generates motions from random noise. In the inference stage, with a denoising procedure, we make motion prediction conditioning on observed motions to output more continuous and controllable predictions. The proposed framework enjoys promising algorithmic properties, which only needs one loss in optimization and is trained in an end-to-end manner. Additionally, it accomplishes the switch of different categories of motions effectively, which is significant in realistic tasks, e.g., the animation task. Comprehensive experiments on benchmarks confirm the superiority of the proposed framework. The project page is available at https://lhchen.top/Human-MAC.

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Dynamics-Aware Loss for Learning with Label Noise

Label noise poses a serious threat to deep neural networks (DNNs). Employing robust loss functions which reconcile fitting ability with robustness is a simple but effective strategy to handle this problem. However, the widely-used static trade-off between these two factors contradicts the dynamics of DNNs learning with label noise, leading to inferior performance. Therefore, we propose a dynamics-aware loss (DAL) to solve this problem. Considering that DNNs tend to first learn beneficial patterns, then gradually overfit harmful label noise, DAL strengthens the fitting ability initially, then gradually improves robustness. Moreover, at the later stage, to further reduce the negative impact of label noise and combat underfitting simultaneously, we let DNNs put more emphasis on easy examples than hard ones and introduce a bootstrapping term. Both the detailed theoretical analyses and extensive experimental results demonstrate the superiority of our method. Our source code can be found in https://github.com/XiuchuanLi/DAL.

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Making Binary Classification from Multiple Unlabeled Datasets Almost Free of Supervision

Training a classifier exploiting a huge amount of supervised data is expensive or even prohibited in a situation, where the labeling cost is high. The remarkable progress in working with weaker forms of supervision is binary classification from multiple unlabeled datasets which requires the knowledge of exact class priors for all unlabeled datasets. However, the availability of class priors is restrictive in many real-world scenarios. To address this issue, we propose to solve a new problem setting, i.e., binary classification from multiple unlabeled datasets with only one pairwise numerical relationship of class priors (MU-OPPO), which knows the relative order (which unlabeled dataset has a higher proportion of positive examples) of two class-prior probabilities for two datasets among multiple unlabeled datasets. In MU-OPPO, we do not need the class priors for all unlabeled datasets, but we only require that there exists a pair of unlabeled datasets for which we know which unlabeled dataset has a larger class prior. Clearly, this form of supervision is easier to be obtained, which can make labeling costs almost free. We propose a novel framework to handle the MU-OPPO problem, which consists of four sequential modules: (i) pseudo label assignment; (ii) confident example collection; (iii) class prior estimation; (iv) classifier training with estimated class priors. Theoretically, we analyze the gap between estimated class priors and true class priors under the proposed framework. Empirically, we confirm the superiority of our framework with comprehensive experiments. Experimental results demonstrate that our framework brings smaller estimation errors of class priors and better performance of binary classification.

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Harnessing Out-Of-Distribution Examples via Augmenting Content and Style

Machine learning models are vulnerable to Out-Of-Distribution (OOD) examples, and such a problem has drawn much attention. However, current methods lack a full understanding of different types of OOD data: there are benign OOD data that can be properly adapted to enhance the learning performance, while other malign OOD data would severely degenerate the classification result. To Harness OOD data, this paper proposes a HOOD method that can leverage the content and style from each image instance to identify benign and malign OOD data. Particularly, we design a variational inference framework to causally disentangle content and style features by constructing a structural causal model. Subsequently, we augment the content and style through an intervention process to produce malign and benign OOD data, respectively. The benign OOD data contain novel styles but hold our interested contents, and they can be leveraged to help train a style-invariant model. In contrast, the malign OOD data inherit unknown contents but carry familiar styles, by detecting them can improve model robustness against deceiving anomalies. Thanks to the proposed novel disentanglement and data augmentation techniques, HOOD can effectively deal with OOD examples in unknown and open environments, whose effectiveness is empirically validated in three typical OOD applications including OOD detection, open-set semi-supervised learning, and open-set domain adaptation.

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Robust Generalization against Photon-Limited Corruptions via Worst-Case Sharpness Minimization

Robust generalization aims to tackle the most challenging data distributions which are rare in the training set and contain severe noises, i.e., photon-limited corruptions. Common solutions such as distributionally robust optimization (DRO) focus on the worst-case empirical risk to ensure low training error on the uncommon noisy distributions. However, due to the over-parameterized model being optimized on scarce worst-case data, DRO fails to produce a smooth loss landscape, thus struggling on generalizing well to the test set. Therefore, instead of focusing on the worst-case risk minimization, we propose SharpDRO by penalizing the sharpness of the worst-case distribution, which measures the loss changes around the neighbor of learning parameters. Through worst-case sharpness minimization, the proposed method successfully produces a flat loss curve on the corrupted distributions, thus achieving robust generalization. Moreover, by considering whether the distribution annotation is available, we apply SharpDRO to two problem settings and design a worst-case selection process for robust generalization. Theoretically, we show that SharpDRO has a great convergence guarantee. Experimentally, we simulate photon-limited corruptions using CIFAR10/100 and ImageNet30 datasets and show that SharpDRO exhibits a strong generalization ability against severe corruptions and exceeds well-known baseline methods with large performance gains.

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Pluralistic Image Completion with Probabilistic Mixture-of-Experts

Pluralistic image completion focuses on generating both visually realistic and diverse results for image completion. Prior methods enjoy the empirical successes of this task. However, their used constraints for pluralistic image completion are argued to be not well interpretable and unsatisfactory from two aspects. First, the constraints for visual reality can be weakly correlated to the objective of image completion or even redundant. Second, the constraints for diversity are designed to be task-agnostic, which causes the constraints to not work well. In this paper, to address the issues, we propose an end-to-end probabilistic method. Specifically, we introduce a unified probabilistic graph model that represents the complex interactions in image completion. The entire procedure of image completion is then mathematically divided into several sub-procedures, which helps efficient enforcement of constraints. The sub-procedure directly related to pluralistic results is identified, where the interaction is established by a Gaussian mixture model (GMM). The inherent parameters of GMM are task-related, which are optimized adaptively during training, while the number of its primitives can control the diversity of results conveniently. We formally establish the effectiveness of our method and demonstrate it with comprehensive experiments.

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Selective-Supervised Contrastive Learning with Noisy Labels

Deep networks have strong capacities of embedding data into latent representations and finishing following tasks. However, the capacities largely come from high-quality annotated labels, which are expensive to collect. Noisy labels are more affordable, but result in corrupted representations, leading to poor generalization performance. To learn robust representations and handle noisy labels, we propose selective-supervised contrastive learning (Sel-CL) in this paper. Specifically, Sel-CL extend supervised contrastive learning (Sup-CL), which is powerful in representation learning, but is degraded when there are noisy labels. Sel-CL tackles the direct cause of the problem of Sup-CL. That is, as Sup-CL works in a \textit{pair-wise} manner, noisy pairs built by noisy labels mislead representation learning. To alleviate the issue, we select confident pairs out of noisy ones for Sup-CL without knowing noise rates. In the selection process, by measuring the agreement between learned representations and given labels, we first identify confident examples that are exploited to build confident pairs. Then, the representation similarity distribution in the built confident pairs is exploited to identify more confident pairs out of noisy pairs. All obtained confident pairs are finally used for Sup-CL to enhance representations. Experiments on multiple noisy datasets demonstrate the robustness of the learned representations by our method, following the state-of-the-art performance. Source codes are available at https://github.com/ShikunLi/Sel-CL

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Objects in Semantic Topology

A more realistic object detection paradigm, Open-World Object Detection, has arisen increasing research interests in the community recently. A qualified open-world object detector can not only identify objects of known categories, but also discover unknown objects, and incrementally learn to categorize them when their annotations progressively arrive. Previous works rely on independent modules to recognize unknown categories and perform incremental learning, respectively. In this paper, we provide a unified perspective: Semantic Topology. During the life-long learning of an open-world object detector, all object instances from the same category are assigned to their corresponding pre-defined node in the semantic topology, including the `unknown' category. This constraint builds up discriminative feature representations and consistent relationships among objects, thus enabling the detector to distinguish unknown objects out of the known categories, as well as making learned features of known objects undistorted when learning new categories incrementally. Extensive experiments demonstrate that semantic topology, either randomly-generated or derived from a well-trained language model, could outperform the current state-of-the-art open-world object detectors by a large margin, e.g., the absolute open-set error is reduced from 7832 to 2546, exhibiting the inherent superiority of semantic topology on open-world object detection.

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Kernel Mean Estimation by Marginalized Corrupted Distributions

Estimating the kernel mean in a reproducing kernel Hilbert space is a critical component in many kernel learning algorithms. Given a finite sample, the standard estimate of the target kernel mean is the empirical average. Previous works have shown that better estimators can be constructed by shrinkage methods. In this work, we propose to corrupt data examples with noise from known distributions and present a new kernel mean estimator, called the marginalized kernel mean estimator, which estimates kernel mean under the corrupted distribution. Theoretically, we show that the marginalized kernel mean estimator introduces implicit regularization in kernel mean estimation. Empirically, we show on a variety of datasets that the marginalized kernel mean estimator obtains much lower estimation error than the existing estimators.

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Class2Simi: A Noise Reduction Perspective on Learning with Noisy Labels

Learning with noisy labels has attracted a lot of attention in recent years, where the mainstream approaches are in pointwise manners. Meanwhile, pairwise manners have shown great potential in supervised metric learning and unsupervised contrastive learning. Thus, a natural question is raised: does learning in a pairwise manner mitigate label noise? To give an affirmative answer, in this paper, we propose a framework called Class2Simi: it transforms data points with noisy class labels to data pairs with noisy similarity labels, where a similarity label denotes whether a pair shares the class label or not. Through this transformation, the reduction of the noise rate is theoretically guaranteed, and hence it is in principle easier to handle noisy similarity labels. Amazingly, DNNs that predict the clean class labels can be trained from noisy data pairs if they are first pretrained from noisy data points. Class2Simi is computationally efficient because not only this transformation is on-the-fly in mini-batches, but also it just changes loss computation on top of model prediction into a pairwise manner. Its effectiveness is verified by extensive experiments.

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Sample Selection with Uncertainty of Losses for Learning with Noisy Labels

In learning with noisy labels, the sample selection approach is very popular, which regards small-loss data as correctly labeled during training. However, losses are generated on-the-fly based on the model being trained with noisy labels, and thus large-loss data are likely but not certainly to be incorrect. There are actually two possibilities of a large-loss data point: (a) it is mislabeled, and then its loss decreases slower than other data, since deep neural networks "learn patterns first"; (b) it belongs to an underrepresented group of data and has not been selected yet. In this paper, we incorporate the uncertainty of losses by adopting interval estimation instead of point estimation of losses, where lower bounds of the confidence intervals of losses derived from distribution-free concentration inequalities, but not losses themselves, are used for sample selection. In this way, we also give large-loss but less selected data a try; then, we can better distinguish between the cases (a) and (b) by seeing if the losses effectively decrease with the uncertainty after the try. As a result, we can better explore underrepresented data that are correctly labeled but seem to be mislabeled at first glance. Experiments demonstrate that the proposed method is superior to baselines and robust to a broad range of label noise types.

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Instance Correction for Learning with Open-set Noisy Labels

The problem of open-set noisy labels denotes that part of training data have a different label space that does not contain the true class. Lots of approaches, e.g., loss correction and label correction, cannot handle such open-set noisy labels well, since they need training data and test data to share the same label space, which does not hold for learning with open-set noisy labels. The state-of-the-art methods thus employ the sample selection approach to handle open-set noisy labels, which tries to select clean data from noisy data for network parameters updates. The discarded data are seen to be mislabeled and do not participate in training. Such an approach is intuitive and reasonable at first glance. However, a natural question could be raised "can such data only be discarded during training?". In this paper, we show that the answer is no. Specifically, we discuss that the instances of discarded data could consist of some meaningful information for generalization. For this reason, we do not abandon such data, but use instance correction to modify the instances of the discarded data, which makes the predictions for the discarded data consistent with given labels. Instance correction are performed by targeted adversarial attacks. The corrected data are then exploited for training to help generalization. In addition to the analytical results, a series of empirical evidences are provided to justify our claims.

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Part-dependent Label Noise: Towards Instance-dependent Label Noise

Learning with the \textit{instance-dependent} label noise is challenging, because it is hard to model such real-world noise. Note that there are psychological and physiological evidences showing that we humans perceive instances by decomposing them into parts. Annotators are therefore more likely to annotate instances based on the parts rather than the whole instances, where a wrong mapping from parts to classes may cause the instance-dependent label noise. Motivated by this human cognition, in this paper, we approximate the instance-dependent label noise by exploiting \textit{part-dependent} label noise. Specifically, since instances can be approximately reconstructed by a combination of parts, we approximate the instance-dependent \textit{transition matrix} for an instance by a combination of the transition matrices for the parts of the instance. The transition matrices for parts can be learned by exploiting anchor points (i.e., data points that belong to a specific class almost surely). Empirical evaluations on synthetic and real-world datasets demonstrate our method is superior to the state-of-the-art approaches for learning from the instance-dependent label noise.

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Extended T: Learning with Mixed Closed-set and Open-set Noisy Labels

The label noise transition matrix $T$, reflecting the probabilities that true labels flip into noisy ones, is of vital importance to model label noise and design statistically consistent classifiers. The traditional transition matrix is limited to model closed-set label noise, where noisy training data has true class labels within the noisy label set. It is unfitted to employ such a transition matrix to model open-set label noise, where some true class labels are outside the noisy label set. Thus when considering a more realistic situation, i.e., both closed-set and open-set label noise occurs, existing methods will undesirably give biased solutions. Besides, the traditional transition matrix is limited to model instance-independent label noise, which may not perform well in practice. In this paper, we focus on learning under the mixed closed-set and open-set label noise. We address the aforementioned issues by extending the traditional transition matrix to be able to model mixed label noise, and further to the cluster-dependent transition matrix to better approximate the instance-dependent label noise in real-world applications. We term the proposed transition matrix as the cluster-dependent extended transition matrix. An unbiased estimator (i.e., extended $T$-estimator) has been designed to estimate the cluster-dependent extended transition matrix by only exploiting the noisy data. Comprehensive synthetic and real experiments validate that our method can better model the mixed label noise, following its more robust performance than the prior state-of-the-art label-noise learning methods.

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Multi-Class Classification from Noisy-Similarity-Labeled Data

A similarity label indicates whether two instances belong to the same class while a class label shows the class of the instance. Without class labels, a multi-class classifier could be learned from similarity-labeled pairwise data by meta classification learning. However, since the similarity label is less informative than the class label, it is more likely to be noisy. Deep neural networks can easily remember noisy data, leading to overfitting in classification. In this paper, we propose a method for learning from only noisy-similarity-labeled data. Specifically, to model the noise, we employ a noise transition matrix to bridge the class-posterior probability between clean and noisy data. We further estimate the transition matrix from only noisy data and build a novel learning system to learn a classifier which can assign noise-free class labels for instances. Moreover, we theoretically justify how our proposed method generalizes for learning classifiers. Experimental results demonstrate the superiority of the proposed method over the state-of-the-art method on benchmark-simulated and real-world noisy-label datasets.

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