arXiv subjects

Xiaogen Zhou

Publications and source records attributed to Xiaogen Zhou.

4 recordsLinked to original sources

arXiv2026

Seed Hijacking of LLM Sampling and Quantum Random Number Defense

Large language models (LLMs) rely on deterministic pseudorandom number generators (PRNGs) for autoregressive sampling, creating a critical supply-chain attack surface overlooked by existing defenses. We present SeedHijack, a backdoor attack that manipulates PRNG outputs to force attacker-specified token selection without altering model logits. In a 540-trial benchmark on GPT-2 (124M), the attack achieves 99.6% exact token injection across 9 sampling configurations; it reaches 100% success on four aligned models (1.5B-7B, RLHF/SFT/reasoning distillation) and bypasses all alignment methods tested in this work. We further propose a defense based on a hardware quantum random number generator (QRNG), which neutralizes the attack in our evaluated threat model with negligible median overhead (+0.6% latency, +7.7 MB memory). Our work identifies a critical sampling-layer vulnerability and provides a practical, deployable QRNG-based defense.

cs.CR↗

arXiv2026

3D Modality-Aware Pre-training for Vision-Language Model in MRI Multi-organ Abnormality Detection

Vision-language models (VLMs) show strong potential for complex diagnostic tasks in medical imaging. However, applying VLMs to multi-organ medical imaging introduces two principal challenges: (1) modality-specific vision-language alignment and (2) cross-modal feature fusion. In this work, we propose MedMAP, a Medical Modality-Aware Pretraining framework that enhances vision-language representation learning in 3D MRI. MedMAP comprises a modality-aware vision-language alignment stage and a fine-tuning stage for multi-organ abnormality detection. During the pre-training stage, the modality-aware encoders implicitly capture the joint modality distribution and improve alignment between visual and textual representations. We then fine-tune the pre-trained vision encoders (while keeping the text encoder frozen) for downstream tasks. To this end, we curated MedMoM-MRI3D, comprising 7,392 3D MRI volume-report pairs spanning twelve MRI modalities and nine abnormalities tailored for various 3D medical analysis tasks. Extensive experiments on MedMoM-MRI3D demonstrate that MedMAP significantly outperforms existing VLMs in 3D MRI-based multi-organ abnormality detection. Our code is available at https://github.com/RomantiDr/MedMAP.

cs.CV↗

arXiv2024

Robust Semi-supervised Multimodal Medical Image Segmentation via Cross Modality Collaboration

Multimodal learning leverages complementary information derived from different modalities, thereby enhancing performance in medical image segmentation. However, prevailing multimodal learning methods heavily rely on extensive well-annotated data from various modalities to achieve accurate segmentation performance. This dependence often poses a challenge in clinical settings due to limited availability of such data. Moreover, the inherent anatomical misalignment between different imaging modalities further complicates the endeavor to enhance segmentation performance. To address this problem, we propose a novel semi-supervised multimodal segmentation framework that is robust to scarce labeled data and misaligned modalities. Our framework employs a novel cross modality collaboration strategy to distill modality-independent knowledge, which is inherently associated with each modality, and integrates this information into a unified fusion layer for feature amalgamation. With a channel-wise semantic consistency loss, our framework ensures alignment of modality-independent information from a feature-wise perspective across modalities, thereby fortifying it against misalignments in multimodal scenarios. Furthermore, our framework effectively integrates contrastive consistent learning to regulate anatomical structures, facilitating anatomical-wise prediction alignment on unlabeled data in semi-supervised segmentation tasks. Our method achieves competitive performance compared to other multimodal methods across three tasks: cardiac, abdominal multi-organ, and thyroid-associated orbitopathy segmentations. It also demonstrates outstanding robustness in scenarios involving scarce labeled data and misaligned modalities.

cs.CV↗

arXiv2020

Protein structure and sequence re-analysis of 2019-nCoV genome does not indicate snakes as its intermediate host or the unique similarity between its spike protein insertions and HIV-1

As the infection of 2019-nCoV coronavirus is quickly developing into a global pneumonia epidemic, careful analysis of its transmission and cellular mechanisms is sorely needed. In this report, we re-analyzed the computational approaches and findings presented in two recent manuscripts by Ji et al. (https://doi.org/10.1002/jmv.25682) and by Pradhan et al. (https://doi.org/10.1101/2020.01.30.927871), which concluded that snakes are the intermediate hosts of 2019-nCoV and that the 2019-nCoV spike protein insertions shared a unique similarity to HIV-1. Results from our re-implementation of the analyses, built on larger-scale datasets using state-of-the-art bioinformatics methods and databases, do not support the conclusions proposed by these manuscripts. Based on our analyses and existing data of coronaviruses, we concluded that the intermediate hosts of 2019-nCoV are more likely to be mammals and birds than snakes, and that the "novel insertions" observed in the spike protein are naturally evolved from bat coronaviruses.

q-bio.GN↗