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Xiaohong Liu

Publications and source records attributed to Xiaohong Liu.

At least 19 recordsLinked to original sources
arXiv2026

QoNext: Towards Next-generation QoE for Foundation Models

Existing evaluations of foundation models predominantly focus on output correctness, treating interaction as a static exchange of information. However, such perspectives overlook the essence of the LLM-driven conversational experience, which is determined not only by content quality but, crucially, by dynamic service attributes such as generation velocity and latency patterns. To address this gap, we introduce QoNext, the first framework that adapts Quality of Experience (QoE) principles from networking and multimedia to the holistic assessment of human-AI interaction. QoNext identifies experiential factors that shape user experience and incorporates them into controlled experiments in simulated interaction scenarios, where human ratings are collected under diverse configurations. From these studies we construct the QoNext Database and train the QoNext Model, a neural predictor that estimates user experience directly from measurable system parameters. Our results demonstrate that QoNext effectively decodes the underlying mechanisms of user satisfaction and enables precise prediction of human sentiment across varied service conditions.

cs.CL↗
arXiv2026

Towards World Models in Biomedical Research

A central goal of biomedicine is to understand, predict and ultimately control the dynamic mechanisms by which biological systems respond to perturbations, disease progression and therapeutic intervention. Although foundation models and large language models have accelerated biomedical data interpretation, most current systems remain focused on static pattern recognition rather than prospective simulation of biological futures. Here we propose biomedical world models as a paradigm for AI-driven discovery. These models learn latent representations of molecular, cellular, tissue and clinical states, together with intervention-conditioned dynamics that allow future trajectories to be simulated before actions are taken. We discuss how biomedical world models could function as data engines, environment simulators and scientific planning substrates across applications including virtual cells, organoids, virtual patients and surgical simulation. We outline the data infrastructure, evaluation benchmarks, safety constraints and governance frameworks required. Biomedical world models may provide a foundation for simulation-guided, closed-loop and experimentally actionable biomedical discovery.

cs.AI↗
arXiv2026

Expert-level vision-language foundation model for real-world radiology and comprehensive evaluation

Radiology is a vital and complex component of modern clinical workflow and covers many tasks. Recently, vision-language (VL) foundation models in medicine have shown potential in processing multimodal information, offering a unified solution for various radiology tasks. However, existing studies either pre-trained VL models on natural data or did not fully integrate vision-language architecture and pretraining, often neglecting the unique multimodal complexity in radiology images and their textual contexts. Additionally, their practical applicability in real-world scenarios remains underexplored. Here, we present RadFound, a large and open-source vision-language foundation model tailored for radiology, that is trained on the most extensive dataset of over 8.1 million images and 250,000 image-text pairs, covering 19 major organ systems and 10 imaging modalities. To establish expert-level multimodal perception and generation capabilities, RadFound introduces an enhanced vision encoder to capture intra-image local features and inter-image contextual information, and a unified cross-modal learning design tailored to radiology. To fully assess the models' capability, we construct a benchmark, RadVLBench, including radiology interpretation tasks like medical vision-language question-answering, as well as text generation tasks ranging from captioning to report generation. We also propose a human evaluation framework. When evaluated on the real-world benchmark involving three representative modalities, 2D images (chest X-rays), multi-view images (mammograms), and 3D images (thyroid CT scans), RadFound significantly outperforms other VL foundation models on both quantitative metrics and human evaluation. In summary, the development of RadFound represents an advancement in radiology generalists, demonstrating broad applicability potential for integration into clinical workflows.

cs.CV↗
arXiv2026

ClinicalGPT-R1: Pushing reasoning capability of generalist disease diagnosis with large language model

Recent advances in reasoning with large language models (LLMs)has shown remarkable reasoning capabilities in domains such as mathematics and coding, yet their application to clinical diagnosis remains underexplored. Here, we introduce ClinicalGPT-R1, a reasoning enhanced generalist large language model for disease diagnosis. Trained on a dataset of 20,000 real-world clinical records, ClinicalGPT-R1 leverages diverse training strategies to enhance diagnostic reasoning. To benchmark performance, we curated MedBench-Hard, a challenging dataset spanning seven major medical specialties and representative diseases. Experimental results demonstrate that ClinicalGPT-R1 outperforms GPT-4o in Chinese diagnostic tasks and achieves comparable performance to GPT-4 in English settings. This comparative study effectively validates the superior performance of ClinicalGPT-R1 in disease diagnosis tasks. Resources are available at https://github.com/medfound/medfound.

cs.CL↗
arXiv2026

FAR-DPO: Feasibility-Aware and Robust Direct Preference Optimization for Cyclic Peptide Design

Cyclic peptides are emerging as promising molecular scaffolds in drug discovery due to their high binding affinity and structural stability. However, extending generative models from linear to cyclic peptide design remains challenging, as cyclization sharply restricts the feasible design space through coupled geometric and biophysical constraints. Moreover, limited training data has led existing approaches to rely largely on zero-shot generation or post hoc filtering, resulting in low yields of feasible designs and limited control over multi-objective trade-offs. To address these limitations, we propose FAR-DPO (Feasibility-Aware and Robust Direct Preference Optimization), an architecture-agnostic framework that steers generative models toward structurally and biophysically feasible cyclic peptide designs, particularly for challenging targets. FAR-DPO integrates feasibility-aware preference construction with difficulty-aware group-robust optimization. Specifically, it constructs within-target preference pairs through feasibility-gated multi-objective dominance and adaptively reweights predefined difficulty groups according to their current preference losses. On the CPSea LNR benchmark, under a fixed generation budget, FAR-DPO increases overall success rate from 46.89% to 57.79% on PepGLAD and from 47.96% to 49.57% on PepFlow. These gains also extend to the hardest target quartile and are accompanied by more favorable best-per-target binding scores. Together, these results demonstrate FAR-DPO's effectiveness in improving feasibility and target-wise robustness.

cs.LG↗
arXiv2026

InsertFuse: A Unified Framework for Multi-Category Reference-Guided Image Insertion

We present InsertFuse, a unified framework for multi-category reference-guided image insertion. Its key idea is to decouple category-specific expertise learning from cross-category capability consolidation. InsertFuse first trains specialized experts for different insertion categories and then introduces Insertion On-Policy Distillation (IOPD) to consolidate their capabilities into a single student. By querying the matched expert at states visited by the student, IOPD preserves category-specific insertion behavior while mitigating the cross-category interference caused by direct joint training. To improve spatial control, we propose Token-Aligned Geometry Conditioning (TAGC), which maps mask-derived geometric cues to the visual token grid, and Region-Balanced Flow Matching, which separately normalizes prediction errors inside and outside the insertion region to prevent background-dominated and scale-dependent supervision. We further introduce Reference CFG to isolate and strengthen the guidance induced by the visual reference under fixed scene and geometry conditions, with IOPD transferring this enhanced supervision into the unified student. Extensive experiments on the public AnyInsertion benchmark and our multi-category test set demonstrate state-of-the-art performance on most metrics, showing strong reference fidelity and generation quality across diverse insertion categories.

cs.CV↗
arXiv2026

STEP-OPD: Rethinking Output Targets and Internal Dynamics in On-Policy Distillation for Diffusion Models

On-policy distillation (OPD) has become an effective approach for consolidating multiple task-specialized image generation models into a single student. However, existing OPD methods optimize the student mainly to match the teacher's output velocity, making the teacher the upper limit of the optimization objective. While output-level supervision alone leaves the student's blockwise representation evolution underconstrained, which weakens the transfer of capabilities that must be progressively developed across layers. We propose STEP-OPD, an on-policy distillation framework for image generation that extends the student's learning target beyond the teacher and introduces explicit constraints on its internal representation evolution. Instead of treating the teacher as the final target, we use the velocity difference between each task-specific teacher and the shared base model as a direction for further learning and add a scaled version of this difference to the teacher velocity. In addition, we align the direction and magnitude of representation changes between the student and teacher, enabling the student to learn how representations are progressively transformed across network blocks. Experiments on compositional alignment, text rendering, and human preference show that our method consistently improves Standard OPD methods. In particular, it increases the GenEval score of DiffusionOPD from 0.927 to 0.961, while also improving OCR and all preference-based metrics. The resulting unified student surpasses the corresponding single-task teachers across all three capability groups, showing that output extrapolation enables beyond-teacher learning. And representation change alignment provides complementary guidance for the student's internal transformations.

cs.CV↗
arXiv2026

Rarity-Aware Discrete Diffusion with Spatially Consistent Decoding for Photo-Realistic Image Super-Resolution

Continuous diffusion models have become the dominant paradigm for photo-realistic image Super-Resolution (SR), but they typically formulate reconstruction as continuous signal-level denoising and incorporate semantic priors through external conditioning modules. This makes it less direct to exploit the unified token-based scaling paradigm of modern multimodal models. Autoregressive models provide a more native semantic representation by modeling images as discrete visual tokens, yet their causal decoding is inefficient for high-resolution reconstruction. Discrete diffusion offers a promising middle ground by enabling non-causal, parallel prediction over visual tokens. However, directly adapting discrete diffusion to SR remains non-trivial due to two task-specific challenges: (1) the long-tailed distribution of visual tokens, which under-represents rare but perceptually critical textures; and (2) spatially inconsistent parallel decoding, which may introduce isolated artifacts. To address these issues, we propose DiMOO-SR, a rarity-aware multimodal discrete diffusion framework for photo-realistic image SR. During training, Inverse Frequency Sampling (IFS) prioritizes under-represented but information-rich tokens. During inference, Spatial Consistency Ranking (SCR) refines token confidence using local neighborhood agreement to improve structural coherence. Extensive experiments on widely used real-world SR benchmarks demonstrate that DiMOO-SR achieves competitive perceptual quality with only a few parallel decoding steps, highlighting the potential of discrete diffusion for generative image super-resolution. The code will be released upon publication.

cs.CV↗
arXiv2026

From Open Loop to Closed Loop: A Test-Time Iterative Optimization Framework for Reference-Consistent Image Generation

While controllable image generation has made significant strides by incorporating visual reference conditions, existing methods predominantly operate as open-loop systems. They inject control signals in a strictly feed-forward manner, failing to guarantee strict fidelity to the reference due to the absence of active feedback and error correction mechanisms. To address this fundamental limitation, we propose a novel test-time iterative optimization framework that reformulates reference-consistent generation as a closed-loop dynamic tracking problem. By treating the pre-trained generative model as a control plant, our framework employs a sensor-controller architecture driven by a modified Proportional-Integral-Derivative (PID) algorithm. This mechanism iteratively optimizes the latent control signals at test time based on the sensed discrepancy between the generated output and the reference target. Notably, this approach is entirely training-free, model-agnostic, and integrates seamlessly around existing diffusion pipelines. Extensive evaluations across ID-preserving, pose-controlled, and depth-controlled generation tasks validate the universality of our method. Empirical results demonstrate improvements over computation-matched open-loop baselines, achieving relative performance gains of up to 25.36\% for facial similarity, alongside spatial error reductions of up to 27.71\% for pose alignment and 28.50\% for depth consistency. More broadly, this work offers a new conceptual perspective: it demonstrates that controllable generation can be effectively managed as a dynamic feedback system, bringing the rigorous principles of classical control theory into the optimization of generative models. Code is available at https://github.com/zzdrill/From-Open-Loop-to-Closed-Loop.

cs.CV↗
arXiv2026

FUMO: Prior-Modulated Diffusion for Single Image Reflection Removal

Single image reflection removal (SIRR) is challenging in real scenes, where reflection strength varies spatially and reflection patterns are tightly entangled with transmission structures. This paper presents a diffusion model with prior modulation framework (FUMO) that introduces explicit priors for spatially adaptive conditioning and structurally faithful restoration. Two priors are extracted directly from the mixed image, an intensity prior that estimates spatial reflection severity and a high-frequency prior that captures detail-sensitive responses via multi-scale residual aggregation. We propose a coarse-to-fine training paradigm. In the first stage, these cues are combined to gate the conditional residual injections, focusing the conditioning on regions that are both reflection-dominant and structure-sensitive. In the second stage, a fine-grained refinement network corrects local misalignment and sharpens fine details in the image space. Experiments conducted on both standard benchmarks and challenging images in the wild demonstrate competitive quantitative results and consistently improved perceptual quality. The code is released at https://github.com/Lucious-Desmon/FUMO.

cs.CV↗
arXiv2026

A First-Principles Derivation of LLM Policy Optimization: From Expected Reward to GRPO and Its Structural Extensions

Policy gradient algorithms for language models optimize the same objective $J(θ) = \mathbb{E}*{τ\sim p*θ(τ)}[R(τ)]$, which has exactly two factors: the trajectory probability $p_θ(τ)$ and the reward $R(τ)$. Every method from REINFORCE to PPO to GRPO and their descendants modifies one or both factors to address a specific failure in the preceding formulation. Existing surveys organize these methods by domain or chronology, which obscures the rationale behind each design choice and the precise location of its intervention within the gradient estimator. This survey revisits the landscape of LLM policy optimization from $J(θ)$ on first principles and uses the trajectory side, induced by $p_θ(τ)$, and the reward side, induced by $R(τ)$, as the two axes along which methods are located. It covers the path from REINFORCE and PPO to GRPO, as well as post-GRPO variants, Agentic RL, and GRPO-OPD. The resulting framework is unified, diagnostic, and extensible: it analyzes methods from a shared objective, identifies which side each method modifies and why, and applies the same trajectory and reward axes across these settings. Across these settings, the framework also exposes compound failures that no single-side fix resolves and that therefore require joint design of the trajectory side and the reward side. The boundary cases and coupled failures identified by this map mark where existing solutions run out and provide a principled starting point for designing the next generation of LLM policy optimization algorithms.

cs.AI↗
arXiv2026

Sketch Then Paint: Hierarchical Reinforcement Learning for Diffusion Multi-Modal Large Language Models

Diffusion Multi-Modal Large Language Models (dMLLMs) are powerful for image generation, but optimizing them through reinforcement learning (RL) remains a major challenge. One primary difficulty is that a single image can be generated through many different unmasking sequences, which makes calculating importance ratios often intractable. Additionally, existing methods tend to ignore the hierarchical generation process of dMLLMs, where early tokens define the global layout and later tokens focus on local details. By assigning uniform rewards to all tokens, these current methods fail to reflect the actual contribution of each token to the final image. To address these issues, we propose Hierarchical Token GRPO (HT-GRPO), which integrates this hierarchy directly into the policy optimization process. Our approach features a Sketch-Then-Paint training scheme that organizes updates into three distinct stages: global, structure, and refinement. We also use a prompt-conditioned estimator to calculate importance ratios starting from a fully masked state. Furthermore, we introduce a Hierarchical Credit Assignment mechanism that prioritizes key structural tokens to ensure accurate reward propagation. Experiments using two popular dMLLM backbones, MMaDA and Lumina-DiMOO, demonstrate that HT-GRPO achieves substantial gains on the GenEval and DPG benchmarks. Evaluations across six additional metrics confirm significant improvements in image quality, aesthetics, and human preference.

cs.AI↗
arXiv2026

PVRF: All-in-one Adverse Weather Removal via Prior-modulated and Velocity-constrained Rectified Flow

Adverse weather removal (AWR) in real-world images remains challenging due to heterogeneous and unseen degradations, while distortion-driven training often yields overly smooth results. We propose PVRF, a unified framework that integrates zero-shot soft weather perceptions with velocity-constrained rectified-flow refinement. PVRF introduces an AWR-specific question answering module (AWR-QA) that uses frozen vision--language models (VLMs) to estimate soft probabilities of weather types and low-level attribute scores. These perceptions condition restoration networks via attribute-modulated normalization (AMN) and weather-weighted adapters (WWA), producing an anchor estimate for refinement. We then learn a terminal-consistent residual rectified flow with perception-adaptive source perturbation and a terminal-consistent velocity parameterization to stabilize learning near the terminal regime. Extensive experiments show that PVRF improves both fidelity and perceptual quality over state-of-the-art baselines, with strong cross-dataset generalization on single and combined degradations. Code will be released at https://github.com/dongw22/PVRF.

cs.CV↗
arXiv2026

MULTIBENCH++: A Unified and Comprehensive Multimodal Fusion Benchmarking Across Specialized Domains

Although multimodal fusion has made significant progress, its advancement is severely hindered by the lack of adequate evaluation benchmarks. Current fusion methods are typically evaluated on a small selection of public datasets, a limited scope that inadequately represents the complexity and diversity of real-world scenarios, potentially leading to biased evaluations. This issue presents a twofold challenge. On one hand, models may overfit to the biases of specific datasets, hindering their generalization to broader practical applications. On the other hand, the absence of a unified evaluation standard makes fair and objective comparisons between different fusion methods difficult. Consequently, a truly universal and high-performance fusion model has yet to emerge. To address these challenges, we have developed a large-scale, domain-adaptive benchmark for multimodal evaluation. This benchmark integrates over 30 datasets, encompassing 15 modalities and 20 predictive tasks across key application domains. To complement this, we have also developed an open-source, unified, and automated evaluation pipeline that includes standardized implementations of state-of-the-art models and diverse fusion paradigms. Leveraging this platform, we have conducted large-scale experiments, successfully establishing new performance baselines across multiple tasks. This work provides the academic community with a crucial platform for rigorous and reproducible assessment of multimodal models, aiming to propel the field of multimodal artificial intelligence to new heights.

cs.LG↗
arXiv2026

Prism: Efficient Test-Time Scaling via Hierarchical Search and Self-Verification for Discrete Diffusion Language Models

Inference-time compute has re-emerged as a practical way to improve LLM reasoning. Most test-time scaling (TTS) algorithms rely on autoregressive decoding, which is ill-suited to discrete diffusion language models (dLLMs) due to their parallel decoding over the entire sequence. As a result, developing effective and efficient TTS methods to unlock dLLMs' full generative potential remains an underexplored challenge. To address this, we propose Prism (Pruning, Remasking, and Integrated Self-verification Method), an efficient TTS framework for dLLMs that (i) performs Hierarchical Trajectory Search (HTS) which dynamically prunes and reallocates compute in an early-to-mid denoising window, (ii) introduces Local branching with partial remasking to explore diverse implementations while preserving high-confidence tokens, and (iii) replaces external verifiers with Self-Verified Feedback (SVF) obtained via self-evaluation prompts on intermediate completions. Across four mathematical reasoning and code generation benchmarks on three dLLMs, including LLaDA 8B Instruct, Dream 7B Instruct, and LLaDA 2.0-mini, our Prism achieves a favorable performance-efficiency trade-off, matching best-of-N performance with substantially fewer function evaluations (NFE). The code is released at https://github.com/viiika/Prism.

cs.LG↗
arXiv2026

DVFace: Spatio-Temporal Dual-Prior Diffusion for Video Face Restoration

Video face restoration aims to enhance degraded face videos into high-quality results with realistic facial details, stable identity, and temporal coherence. Recent diffusion-based methods have brought strong generative priors to restoration and enabled more realistic detail synthesis. However, existing approaches for face videos still rely heavily on generic diffusion priors and multi-step sampling, which limit both facial adaptation and inference efficiency. These limitations motivate the use of one-step diffusion for video face restoration, yet achieving faithful facial recovery alongside temporally stable outputs remains challenging. In this paper, we propose, DVFace, a one-step diffusion framework for real-world video face restoration. Specifically, we introduce a spatio-temporal dual-codebook design to extract complementary spatial and temporal facial priors from degraded videos. We further propose an asymmetric spatio-temporal fusion module to inject these priors into the diffusion backbone according to their distinct roles. Evaluation on various benchmarks shows that DVFace delivers superior restoration quality, temporal consistency, and identity preservation compared to recent methods. Code: https://github.com/zhengchen1999/DVFace.

cs.CV↗
arXiv2026

Q-Agent: Quality-Driven Chain-of-Thought Image Restoration Agent through Robust Multimodal Large Language Model

Image restoration (IR) often faces various complex and unknown degradations in real-world scenarios, such as noise, blurring, compression artifacts, and low resolution, etc. Training specific models for specific degradation may lead to poor generalization. To handle multiple degradations simultaneously, All-in-One models might sacrifice performance on certain types of degradation and still struggle with unseen degradations during training. Existing IR agents rely on multimodal large language models (MLLM) and a time-consuming rolling-back selection strategy neglecting image quality. As a result, they may misinterpret degradations and have high time and computational costs to conduct unnecessary IR tasks with redundant order. To address these, we propose a Quality-Driven agent (Q-Agent) via Chain-of-Thought (CoT) restoration. Specifically, our Q-Agent consists of robust degradation perception and quality-driven greedy restoration. The former module first fine-tunes MLLM, and uses CoT to decompose multi-degradation perception into single-degradation perception tasks to enhance the perception of MLLMs. The latter employs objective image quality assessment (IQA) metrics to determine the optimal restoration sequence and execute the corresponding restoration algorithms. Experimental results demonstrate that our Q-Agent achieves superior IR performance compared to existing All-in-One models.

eess.IV↗
arXiv2026

dMLLM-TTS: Self-Verified and Efficient Test-Time Scaling for Diffusion Multi-Modal Large Language Models

Diffusion Multi-modal Large Language Models (dMLLMs) have recently emerged as a novel architecture unifying image generation and understanding. However, developing effective and efficient Test-Time Scaling (TTS) methods to unlock their full generative potential remains an underexplored challenge. To address this, we propose dMLLM-TTS, a novel framework operating on two complementary scaling axes: (1) trajectory exploration scaling to enhance the diversity of generated hypotheses, and (2) iterative refinement scaling for stable generation. Conventional TTS approaches typically perform linear search across these two dimensions, incurring substantial computational costs of O(NT) and requiring an external verifier for best-of-N selection. To overcome these limitations, we propose two innovations. First, we design an efficient hierarchical search algorithm with O(N+T) complexity that adaptively expands and prunes sampling trajectories. Second, we introduce a self-verified feedback mechanism that leverages the dMLLMs' intrinsic image understanding capabilities to assess text-image alignment, eliminating the need for external verifier. Extensive experiments on the GenEval benchmark across three representative dMLLMs (e.g., Lumina-DiMOO, MMaDA, Muddit) show that our framework substantially improves generation quality while achieving up to 6x greater efficiency than linear search. Project page: https://github.com/Alpha-VLLM/Lumina-DiMOO.

cs.CV↗