arXiv subjects

Xiaojing Guo

Publications and source records attributed to Xiaojing Guo.

3 recordsLinked to original sources

arXiv2026

BRIGHT: A Collaborative Generalist-Specialist Foundation Model for Breast Pathology

Generalist pathology foundation models (PFMs), pretrained on large-scale multi-organ datasets, have demonstrated remarkable predictive capabilities across diverse clinical applications. However, their proficiency on the full spectrum of clinically essential tasks within a specific organ system remains an open question due to the lack of large-scale validation cohorts for a single organ as well as the absence of a tailored training paradigm that can effectively translate broad histomorphological knowledge into the organ-specific expertise required for specialist-level interpretation. In this study, we propose BRIGHT, the first PFM specifically designed for breast pathology, trained on over 51,000 breast whole-slide images derived from a cohort of over 40,000 patients across 19 hospitals. BRIGHT employs a collaborative generalist-specialist framework to capture both universal and organ-specific features. To comprehensively evaluate the performance of PFMs on breast oncology, we curate the largest multi-institutional cohorts to date for downstream task development and evaluation, comprising over 25,000 WSIs across 10 hospitals. The validation cohorts cover the full spectrum of breast pathology across 25 distinct clinical tasks spanning diagnosis, biomarker prediction, treatment response and survival prediction. Extensive experiments demonstrate that BRIGHT outperforms five leading generalist PFMs, achieving state-of-the-art (SOTA) performance in 25 of 25 internal validation tasks and in 4 of 11 external validation tasks with excellent heatmap interpretability. By evaluating on large-scale validation cohorts, this study not only demonstrates BRIGHT's clinical utility in breast oncology but also validates a collaborative generalist-specialist paradigm, providing a scalable template for developing PFMs on a specific organ system, accelerating the translation of foundation models into ...

cs.CV↗

arXiv2026

Enhanced electron injection for efficient proton acceleration and neutron production in femtosecond laser-driven nano-structured targets

Micro- or nano-structured targets are advantageous in enhancing and manipulating laser-proton acceleration, due to the increased absorption of laser energy and onset of direct laser acceleration for high-energy electrons. Here, we experimentally demonstrate that nano-wire-array printed on a flat substrate is an efficient nano-injector of relativistic electrons that leads to a significant boost of laser-driven proton acceleration and neutron production beyond normal geometry. By employing an ultra-intense (2*1021 W/cm2) femtosecond laser pulse to irradiate nano-wire-array targets, protons with cut-off energies of 62.8 MeV are generated, and notably, the energy conversion efficiency from laser to protons reaches up to 9% - 3.5 times higher than that of flat foils. After bombarding a beryllium converter, 1.1*1010 neutrons are produced. Full 3D particle-in-cell simulations have reproduced experimental results and reveal interference mechanisms between the nano-wires and substrate, leading to continuous pumping of electrons from the substrate and standing-wave enhanced re-injection from the wire tip. This efficient injection finally results in the large sheath field and thus high yield of energetic protons and neutrons. Dependence on the wire length and scaling with laser amplitude are further discussed. These results suggest that 3D-printed structures are promising in developing compact laser-driven high-flux proton and neutron sources for numerous applications.

physics.plasm-ph↗

arXiv2025

Towards Computation- and Communication-efficient Computational Pathology

Despite the impressive performance across a wide range of applications, current computational pathology models face significant diagnostic efficiency challenges due to their reliance on high-magnification whole-slide image analysis. This limitation severely compromises their clinical utility, especially in time-sensitive diagnostic scenarios and situations requiring efficient data transfer. To address these issues, we present a novel computation- and communication-efficient framework called Magnification-Aligned Global-Local Transformer (MAG-GLTrans). Our approach significantly reduces computational time, file transfer requirements, and storage overhead by enabling effective analysis using low-magnification inputs rather than high-magnification ones. The key innovation lies in our proposed magnification alignment (MAG) mechanism, which employs self-supervised learning to bridge the information gap between low and high magnification levels by effectively aligning their feature representations. Through extensive evaluation across various fundamental CPath tasks, MAG-GLTrans demonstrates state-of-the-art classification performance while achieving remarkable efficiency gains: up to 10.7 times reduction in computational time and over 20 times reduction in file transfer and storage requirements. Furthermore, we highlight the versatility of our MAG framework through two significant extensions: (1) its applicability as a feature extractor to enhance the efficiency of any CPath architecture, and (2) its compatibility with existing foundation models and histopathology-specific encoders, enabling them to process low-magnification inputs with minimal information loss. These advancements position MAG-GLTrans as a particularly promising solution for time-sensitive applications, especially in the context of intraoperative frozen section diagnosis where both accuracy and efficiency are paramount.

eess.IV↗