arXiv subjects

Xiaolu Guo

Publications and source records attributed to Xiaolu Guo.

4 recordsLinked to original sources

arXiv2025

Using Context to Improve Word Segmentation

An important step in understanding how children acquire languages is studying how infants learn word segmentation. It has been established in previous research that infants may use statistical regularities in speech to learn word segmentation. The research of Goldwater et al., demonstrated that incorporating context in models improves their ability to learn word segmentation. We implemented two of their models, a unigram and bigram model, to examine how context can improve statistical word segmentation. The results are consistent with our hypothesis that the bigram model outperforms the unigram model at predicting word segmentation. Extending the work of Goldwater et al., we also explored basic ways to model how young children might use previously learned words to segment new utterances.

cs.CL↗

arXiv2025

Reconstructing Noisy Gene Regulation Dynamics Using Extrinsic-Noise-Driven Neural Stochastic Differential Equations

Proper regulation of cell signaling and gene expression is crucial for maintaining cellular function, development, and adaptation to environmental changes. Reaction dynamics in cell populations is often noisy because of (i) inherent stochasticity of intracellular biochemical reactions (``intrinsic noise'') and (ii) heterogeneity of cellular states across different cells that are influenced by external factors (``extrinsic noise''). In this work, we introduce an extrinsic-noise-driven neural stochastic differential equation (END-nSDE) framework that utilizes the Wasserstein distance to accurately reconstruct SDEs from trajectory data from a heterogeneous population of cells (extrinsic noise). We demonstrate the effectiveness of our approach using both simulated and experimental data from three different systems in cell biology: (i) circadian rhythms, (ii) RPA-DNA binding dynamics, and (iii) NF$κ$B signaling process. Our END-nSDE reconstruction method can model how cellular heterogeneity (extrinsic noise) modulates reaction dynamics in the presence of intrinsic noise. It also outperforms existing time-series analysis methods such as recurrent neural networks (RNNs) and long short-term memory networks (LSTMs). By inferring cellular heterogeneities from data, our END-nSDE reconstruction method can reproduce noisy dynamics observed in experiments. In summary, the reconstruction method we propose offers a useful surrogate modeling approach for complex biophysical processes, where high-fidelity mechanistic models may be impractical.

q-bio.QM↗

arXiv2022

The Nonequilibrium Mechanism of Noise Enhancer synergizing with Activator in HIV Latency Reactivation

Noise-modulating chemicals can synergize with transcriptional activators in reactivating latent HIV to eliminate latent HIV reservoirs. To understand the underlying biomolecular mechanism, we investigate a previous two-gene-state model and identify two necessary conditions for the synergy: an assumption of inhibition effect of transcription activators on noise enhancers; and frequent transitions to the gene non-transcription-permissive state. We then develop a loop-four-gene-state model with Tat transcription/translation and find that drug synergy is mainly determined by the magnitude and direction of energy input into the genetic regulatory kinetics of the HIV promoter. The inhibition effect of transcription activators is actually a phenomenon of energy dissipation in the nonequilibrium gene transition system. Overall, the loop-four-state model demonstrates that energy dissipation plays a crucial role in HIV latency reactivation, which might be useful for improving drug effects and identifying other synergies on lentivirus latency reactivation.

q-bio.SC↗

arXiv2016

City traffic forecasting using taxi GPS data: A coarse-grained cellular automata model

City traffic is a dynamic system of enormous complexity. Modeling and predicting city traffic flow remains to be a challenge task and the main difficulties are how to specify the supply and demands and how to parameterize the model. In this paper we attempt to solve these problems with the help of large amount of floating car data. We propose a coarse-grained cellular automata model that simulates vehicles moving on uniform grids whose size are much larger compared with the microscopic cellular automata model. The car-car interaction in the microscopic model is replaced by the coupling between vehicles and coarse-grained state variables in our model. To parameterize the model, flux-occupancy relations are fitted from the historical data at every grids, which serve as the coarse-grained fundamental diagrams coupling the occupancy and speed. To evaluate the model, we feed it with the historical travel demands and trajectories obtained from the floating car data and use the model to predict road speed one hour into the future. Numerical results show that our model can capture the traffic flow pattern of the entire city and make reasonable predictions. The current work can be considered a prototype for a model-based forecasting system for city traffic.

cs.OH↗