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Xiaoxiao Li

Publications and source records attributed to Xiaoxiao Li.

At least 19 recordsLinked to original sources

SlideBank: A Persistent Hierarchical Evidence Bank for Consistent Whole-Slide Reasoning

Whole-slide images (WSIs) are challenging for vision-language reasoning because diagnostically relevant morphology is sparse, heterogeneous, and distributed across gigapixel-scale images and multiple spatial resolutions. Existing WSI models and pathology agents can aggregate slide features or actively acquire evidence, but the information retained after exploration is often difficult to access semantically while preserving its connection to the original visual evidence. We introduce SlideBank, a training-free framework that represents each WSI as a persistent, concept-indexed, and spatially grounded evidence bank. SlideBank performs question-independent coarse-to-fine exploration to identify informative regions and multi-scale views, converts them into explicit morphological observations, and grounds pathology signals to their supporting patches and WSI coordinates. At inference time, questions are routed to relevant signals and evidence scales, and the linked global, regional, and patch evidence is integrated through confidence-based cross-level consensus. Experiments on WSI-VQA and SlideBench-BCNB show that with Patho-R1, SlideBank reaches 52.77% on WSI-VQA and with Quilt-LLaVA, it reaches 50.92% average accuracy on SlideBench-BCNB, while structured signal-guided retrieval consistently outperforms random evidence sampling. Reusing the same bank across repeated queries further achieves over 99% rephrasing consistency and substantially reduces amortized inference cost through persistent evidence reuse.

cs.AI

APIFlow-Bench: Measuring Whether Agents Survive Long, Dependent API Workflows

Tool-using agents are commonly evaluated by a single bit: whether an end-to-end workflow completed. This metric fails to distinguish failures that matter in production, such as expired credentials, malformed payloads, or correct execution followed by incorrect final delivery. We introduce APIFlow-Bench, a fully auditable benchmark for long-horizon, dependent REST-API workflows that decomposes performance into seven engineering capabilities and requires agents to produce answers supported by the actual call path. We generate synthetic API worlds forward, subtask by subtask; each subtask is admitted only after a zero-LLM self-test triad verifies its grader and an oracle establishes solvability, and an adversarial audit identified and fixed six grader exploits. Grading is deterministic and provenance-sensitive: a state check traces a mock-minted canary through the API data flow to the response the answer must originate from, and a typed answer card is verified field by field. We release all answer keys and 44,362 unredacted execution transcripts. Across 19 frontier and open-weight models under one neutral scaffold, we find: (1) longer dependency chains degrade success, from 93% on individual subtasks to 74% on clean 20-subtask chains and 61% when including the 8% of chain trials that a model-consensus screen flags as passed by no model; (2) reliability separates models more than best-case capability, with best-of-five spanning seven points but all-five-of-five reliability spanning 44 points; (3) the independent-error account of compounding failure does not fit the data: pass rates on 20-subtask chains are 33 percentage points above the product of subtask-level rates, and on the clean slice 77% of failing runs reached the correct final state and failed only at delivery.

cs.AI

Toward Federated Large Language Models in Medicine: A Parameter-Efficient Framework for Privacy-Preserving, Multi-Institutional Adaptation

Large language models (LLMs) are increasingly adapted for medical applications, but most are trained using data from a single institution because privacy and governance constraints prevent multi-institutional data sharing. As a result, these models often generalize poorly across heterogeneous healthcare systems. We address this gap by introducing Fed-MedLoRA and Fed-MedLoRA+, a parameter-efficient federated framework for collaborative LLM adaptation across healthcare institutions. Fed-MedLoRA transmits only low-rank adapters rather than full model weights, reducing communication overhead. We also evaluate a privacy-preserving variant that applies Gaussian perturbation to transmitted adapter updates. Fed-MedLoRA+ further incorporates adaptive aggregation to better address cross-site heterogeneity in patient populations, annotation practices, and disease distributions. We evaluate the framework on clinical information extraction across five independent patient cohorts totaling 42,198 entities and 41,570 relations, and compare it with zero-shot and fine-tuned LLMs, domain-specific BERT models, and federated baselines. Across all settings, the proposed methods consistently improve extraction performance and generalize better to heterogeneous cohorts. In a real-world case study using clinical notes from the Yale New Haven Health System, the framework demonstrates strong performance under low-resource new-site deployment. These results suggest that federated, parameter-efficient LLM adaptation is feasible, scalable, and effective for multi-institutional clinical deployment.

cs.CL

Can Generalist Vision Language Models (VLMs) Rival Specialist Medical VLMs? Benchmarking and Strategic Insights

Vision Language Models (VLMs) have shown promise in automating image diagnosis and interpretation in clinical settings. However, developing specialist medical VLMs requires substantial computational resources and carefully curated datasets, and it remains unclear under which conditions generalist and specialist medical VLMs each perform best. This study highlights the complementary strengths of specialist medical and generalist VLMs. Specialists remain valuable in modality-aligned use cases, but we find that efficiently fine-tuned generalist VLMs can achieve comparable or even superior performance in most tasks, particularly when transferring to unseen or rare OOD medical modalities. These results suggest that generalist VLMs, rather than being constrained by their lack of specialist medical pretraining, may offer a scalable and cost-effective pathway for advancing clinical AI development.

eess.IV

DeCo-MIL: Debiased Counterfactual Reasoning for Long-Tailed Whole Slide Image Analysis

Multiple instance learning (MIL) is widely used for weakly supervised whole slide image (WSI) analysis. However, under long-tailed distributions, MIL-based WSI analysis faces a nested dual long-tail: an inter-slide class long tail and an intra-slide long tail of instance-level discriminative evidence. The two long tails are coupled: tail classes have few training slides, while their limited diagnostic evidence is concentrated in a few patches and obscured by abundant within-bag redundancy. This coupling biases models toward head classes and degrades rare-class recognition. To address this, we propose DeCo-MIL for long-tailed WSI analysis, which jointly alleviates the nested dual long-tail through frequency-debiased counterfactual reasoning. For the inner long tail, DeCo-MIL clusters patches into tissue-morphology anchors, replaces each anchor with its matched normal prototype to perform a counterfactual intervention, and estimates its counterfactual contribution to the ground-truth class using class-frequency-corrected predictions. These contributions guide redundancy masking to preserve scarce discriminative instances. For the outer long tail, DeCo-MIL constructs anchor-stratified pseudo-bags from redundancy-reduced bags and combines tail-aware oversampling with consistency regularization, increasing effective supervision for tail classes while preserving tissue-morphology composition. Extensive experiments on three long-tailed WSI benchmarks demonstrate that DeCo-MIL achieves state-of-the-art performance in both tail-class recognition and overall classification.

cs.CV

CoEvoSkills: Self-Evolving Agent Skills via Co-Evolutionary Verification

Anthropic proposes the concept of skills for LLM agents to tackle multi-step professional tasks that simple tool invocations cannot address. A tool is a single, self-contained function, whereas a skill is a structured bundle of interdependent multi-file artifacts. Currently, skill generation is not only label-intensive due to manual authoring, but also may suffer from human--machine cognitive misalignment, which can lead to degraded agent performance, as evidenced by evaluations on SkillsBench. Therefore, we aim to enable agents to autonomously generate skills. However, existing self-evolving methods designed for tools cannot be directly applied to skills due to their increased complexity. To address these issues, we propose CoEvoSkills, a self-evolving skills framework that enables agents to autonomously construct complex, multi-file skill packages. Specifically, CoEvoSkills couples a Skill Generator that iteratively refines skills with a Surrogate Verifier that co-evolves to provide informative and actionable feedback without access to ground-truth test content. On SkillsBench, CoEvoSkills outperforms five baselines on both Claude Code and Codex, and generalizes strongly to six additional LLMs. The code is publicly available at https://github.com/Zhang-Henry/CoEvoSkills.

cs.AI

MESA:Task-Adaptive Multi-Structure Evidence Selection for Long-Horizon Agent Memory

Long-horizon agents accumulate trajectories spanning hundreds of interleaved reasoning, action, and observation steps, where answering a query may depend on evidence buried far back in the history. External memory stores such trajectories as structured representations, yet each structure provides a distinct and incomplete view. Existing multi-memory systems either read a fixed set of structures for every query, inflating context and introducing noise, or route each query to a single structure, preventing the composition of complementary evidence. A controlled analysis on AMA-Bench shows that the optimal memory configuration is typically neither a single structure nor the full union, but a tailored composition of multiple structural memories that varies with query and task demands. Motivated by these findings, we formulate structure-level dynamic selection: selecting and fusing a query-adaptive subset from a library of specialized memory structures. We propose MESA (a Multi-structure Evidence Selection framework for long-horizon Agent), which builds five complementary structure views of each trajectory and learns from end-to-end answer-level feedback to select and fuse a query-specific subset for a frozen answer model. To learn under this weak supervision, MESA employs harness optimization with prior-guided search and UCB-guided scheduling to balance exploration and exploitation. On AMA-Bench, MESA outperforms the strongest baseline by 8.5% while using 41% fewer evidence tokens than the all-structure alternative.

cs.AI

Location-Aware Fine-Grained Representation Learning for Medical Vision Foundation Models

Fine-grained visual representations are essential for medical image analysis, particularly when diagnostically relevant evidence is subtle and spatially localized. Modern transformer-based medical vision encoders must therefore learn patch-level representations that are both clinically meaningful and spatially consistent. Without these properties, large vision-language models (LVLMs) operate on an ambiguous visual foundation, limiting their ability to generate clinically reliable and spatially grounded responses. However, existing training strategies for medical vision encoders rarely achieve both objectives. Image-text alignment provides clinically meaningful supervision primarily at the image level, leaving the spatial localization of diagnostic evidence weakly constrained. In contrast, self-supervised learning promotes spatial consistency but lacks the semantic supervision needed to distinguish visually similar yet clinically distinct regions. To address this gap, we present LoFi, a medical vision foundation model built on location-aware fine-grained representation learning. LoFi trains a vision encoder with a lightweight large language model under grounding and grounded captioning objectives. Because these objectives require predicting location from clinical text and vice versa, spatial consistency emerges without any explicit patch-level regularization. To enable training at scale, we construct MedG, a large-scale medical grounding dataset of 4.48M image-text-box triplets curated from 84 datasets spanning 7 modalities. Across phrase grounding, visual question answering, and region-based organ classification under perturbations, LoFi consistently outperforms general-purpose and medical vision foundation models as well as state-of-the-art LVLMs. Code is available at https://github.com/myeongkyunkang/lofi-medg.

cs.CV

CPInj: Uncovering Prompt Injection Risks in Textual Collaborative Prompt Optimization

Textual Collaborative Prompt Optimization (TCPO) extends TextGrad (Yuksekgonul et al., 2025) to a decentralized setting by allowing multiple clients to jointly improve prompts for large language models (LLMs) while keeping their data locally. Its reliance on free-form textual updating and aggregation introduces a new and largely unexplored attack surface, i.e., malicious instructions can be injected into local prompts and propagated through server-side prompt aggregation. Unlike conventional prompt injection attacks, attacking TCPO targets the collaborative optimization loop in TCPO. This setting is more challenging because malicious instructions must survive aggregation, persist through subsequent benign prompt optimization, and evade server-side defenses. To expose this risk, we propose Collaborative Prompt Injection (CPInj) attack that contaminates the aggregated global prompt with malicious instructions, degrades downstream task performance, resists purification by prompt optimization on benign clients, and evades advanced detection-based defenses on the server. We find that current defense methods are ineffective against CPInj. We further propose Anchored Purification Aggregation (APAgg), a defense-oriented aggregation that purifies malicious instructions without severely degrading TCPO utility. We conduct extensive experiments across three LLM families and five reasoning tasks in math, logic, and medicine, and demonstrate that our proposed attack reveals a critical vulnerability in TCPO. Although we take a first step toward mitigation, the attack remains highly effective and far from fully resolved, calling for more robust defense for TCPO.

cs.CR

Rethinking Artificial Intelligence in Medical Imaging: Assumptions, Reality, and Reframing

Medical imaging has served as primary proving ground for clinical artificial intelligence (AI), yet a decade of intense research has not translated into proportionate bedside impact. We argue that this gap is not primarily a product of insufficient algorithmic performance, inadequate regulation, or limited explainability. Rather, it reflects a structural misalignment, between how AI systems are designed and evaluated, and how clinical decisions are made. This Perspective identifies six interconnected dimensions of this misalignment: the dominance of pixel-only models in a multimodal clinical world; the erosion of physician trust through opaque and inflexible systems; the unfulfilled promise of foundation models in data-sparse medical domains; the persistent bottleneck of non-shareable, under-curated datasets; the gap between validated algorithms and deployable clinical platforms; and the failure of prediction-centric AI to generate actionable clinical guidance. For each dimension, we reframe the problem and propose a path forward, culminating in a vision of agentic, physician-aligned AI that extends, rather than replaces, clinical judgment.

physics.med-ph

Transsion's Speaker-Attributed Multilingual ASR System for the MLC-SLM 2026 Challenge

This paper presents the Transsion Speech Team submission to Task 1 of the MLC-SLM 2026 Challenge, which focuses on speaker-attributed transcription for multilingual conversational speech. We propose a cascaded framework consisting of three components: a speaker diarization module, a long-form multilingual ASR module, and a speaker-transcription fusion module. The diarization module is built upon DiariZen and produces speaker-homogeneous segments through local speaker activity estimation and global speaker clustering. The ASR module is based on Qwen3-Omni and generates multilingual transcriptions, while an external CTC-based alignment model provides precise word- and character-level timestamps. Finally, the fusion module combines diarization outputs with timestamped transcriptions to generate speaker-attributed STM outputs. Experimental results on the official evaluation set demonstrate the effectiveness of the proposed framework. The submitted system achieves a tcpMER of 15.41% and ranks second among all participating teams.

cs.CL

The tttAI System for the TSA-ASR Task of the SmartGlasses Challenge 2026

This paper presents the tttAI system submitted to the TSA-ASR task of the SmartGlasses Challenge 2026, evaluated on both two-person dialogues (Track 1) and multi-party meetings (Track 2). The task requires time-stamped speaker-attributed speech recognition from smart-glasses recordings. This is particularly challenging due to long-form audio, multiple speakers, and frequent overlapping speech. We proposed a cascaded architecture consisting of speaker diarization, overlap detection, target-speaker extraction, post-processing, and automatic speech recognition. The diarization module extracts features via WavLM-Large, performs frame-wise speaker classification with a Conformer encoder, and then generates global speaker segments through embedding clustering. For overlapped regions, we apply a WeSep-based target-speaker extraction model with ECAPA-TDNN speaker embeddings. When the extraction is unreliable, a dominant-speaker fallback strategy is used. The final system uses FireRedASR2-AED with the first microphone channel. The submitted system has a total parameter count of approximately 1.53B. On Track 1, our system achieves a tcpCER of 7.10%. On Track 2, it achieves a tcpCER of 34.04% and ranks second on the leaderboard.

eess.AS

TextResNet: Decoupling and Routing Optimization Signals in Compound AI Systems via Deep Residual Tuning

Textual Gradient-style optimizers (TextGrad) enable gradient-like feedback propagation through compound AI systems. However, they do not work well for deep chains. The root cause of this limitation stems from the Semantic Entanglement problem in these extended workflows. In standard textual backpropagation, feedback signals mix local critiques with upstream contexts, leading to Attribution Ambiguity. To address this challenge, we propose TextResNet, a framework that reformulates the optimization process to achieve precise signal routing via four key innovations. Firstly, in the forward pass, it enforces Additive Semantic Deltas to preserve an Identity Highway for gradient flow. Secondly, in the backward pass, it introduces Semantic Gradient Decomposition via a Semantic Projector to disentangle feedback into causally independent subspaces. Thirdly, it implements Causal Routing, which routes projected signals to their specific components. Finally, it performs Density-Aware Optimization Scheduling to leverage the disentangled signals to dynamically allocate resources to key system bottlenecks. Our results show that TextResNet not only achieves superior performance compared to TextGrad, but also exhibits remarkable stability for agentic tasks in compound AI systems where baselines collapse. Code is available at https://github.com/JeanDiable/TextResNet.

cs.LG

When RAG Hurts: Diagnosing and Mitigating Attention Distraction in Retrieval-Augmented LVLMs

While Retrieval-Augmented Generation (RAG) is one of the dominant paradigms for enhancing Large Vision-Language Models (LVLMs) on knowledge-based VQA tasks, recent work attributes RAG failures to insufficient attention towards the retrieved context, proposing to reduce the attention allocated to image tokens. In this work, we identify a distinct failure mode that previous study overlooked: Attention Distraction (AD). When the retrieved context is sufficient (highly relevant or including the correct answer), the retrieved text suppresses the visual attention globally, and the attention on image tokens shifts away from question-relevant regions. This leads to failures on questions the model could originally answer correctly without the retrieved text. To mitigate this issue, we propose MAD-RAG, a training-free intervention that decouples visual grounding from context integration through a dual-question formulation, combined with attention mixing to preserve image-conditioned evidence. Extensive experiments on OK-VQA, E-VQA, and InfoSeek demonstrate that MAD-RAG consistently outperforms existing baselines across different model families, yielding absolute gains of up to 4.76%, 9.20%, and 6.18% over the vanilla RAG baseline. Notably, MAD-RAG rectifies up to 74.68% of failure cases with negligible computational overhead.

cs.CV

UltraVR: A Diagnostic Ultra-Resolution Image-VQA Benchmark for Evidence-Grounded Reasoning

Vision-language models (VLMs) excel on visual question answering and multimodal reasoning benchmarks. Yet their capability on ultra-resolution images - where critical evidence is tiny, subtle, spatially distant, or distributed - remains unclear. Existing evaluations largely report final-answer accuracy, offering limited insight into whether models acquire and integrate the necessary visual evidence. We introduce UltraVR, a diagnostic benchmark for evidence-grounded visual reasoning over ultra-resolution images. UltraVR spans four high-value scenarios: CCTV surveillance, remote sensing (RS), whole-slide image (WSI) pathology, and industrial anomaly detection (AD). These domains pose complementary challenges: fine-grained object grounding in crowded CCTV scenes, long-range spatial comparison in RS, multi-scale evidence navigation in WSI, and subtle irregularity detection in repetitive industrial layouts. Beyond standard QA triples, each instance includes a structured ground-truth chain of thought with step-level questions, intermediate answers, and reasoning labels. These labels decompose reasoning into evidence grounding, local perception, quantification, evidence integration, and decision inference, enabling process-level diagnosis over black-box scoring. Using UltraVR, we evaluate frontier VLMs and show that current models remain far from reliable on ultra-resolution reasoning. Importantly, the structured annotations allow us to localize failures across the visual-to-decision pipeline: errors concentrate in evidence grounding and local perception, while downstream inference often recovers when intermediate visual facts are supplied. These findings demonstrate UltraVR as a diagnostic testbed for measuring not only whether VLMs answer correctly, but where their ultra-resolution reasoning process breaks.

cs.CV

ChWDTA: Channel-wise Wavelet-Domain Transformer Attention and Entropy Modeling for Learned Image Compression

State-of-the-art learned image compression (LIC) schemes are increasingly based on hybrid CNN-transformer architectures. To further improve rate-distortion performance, we introduce channel-wise wavelet transforms into both the transformer and entropy-coding components. First, we propose a channel-wise wavelet-domain transformer attention (ChWDTA) mechanism. ChWDTA keeps the efficient windowed spatial self-attention used in modern LIC backbones, but computes the Q/K/V projections on channel-wise wavelet-transformed features before mapping the attention output back with the inverse transform. The resulting Channel-wise Wavelet-Domain Transformer Block (ChWDTB) therefore preserves the spatial tokenization pattern of windowed attention while sparsifying the channel covariance seen by the attention projections. Second, in the entropy-coding stage, we introduce a channel-wise wavelet packet (ChWP) decomposition that produces four equal-sized subbands, which better fit channel-wise slice-based autoregressive entropy modeling. When each channel-wise subband is divided into two slices, we use eight slices for entropy coding. With this configuration, the proposed scheme obtains BD-rate reductions of -17.82%, -19.15%, and -22.56% on the Kodak, CLIC Professional Validation, and Tecnick test sets, respectively. Even when each channel-wise subband is coded as a single slice, the scheme still retains most of the coding gains with lower complexity. The results confirm the advantage of introducing wavelet transform in CNN-transformer-based LIC schemes.

eess.IV

RVCBench: Benchmarking the Robustness of Voice Cloning Across Modern Audio Generation Models

Modern voice cloning, also known as zero-shot text-to-speech (TTS), can synthesize speech that closely matches a target speaker from only seconds of reference audio, enabling applications such as personalized speech interfaces and dubbing. In practice, these systems often face noisy reference audio, imperfect text prompts, multilingual and long-form generation, post-processing, and adversarial perturbations, all of which can weaken robustness. Despite rapid progress in codec-token language models and diffusion-based TTS, robustness under realistic deployment shifts remains underexplored. This paper introduces RVCBench, a comprehensive dataset and benchmark for evaluating robustness in voice cloning. RVCBench provides task-aligned tests covering controlled text-audio pairing, multilingual and long-form scenarios, expressive prompts, post-processing conditions, and passive or proactive audio perturbations. Across 18 robustness evaluations, 225 speakers, and 14,370 utterances, RVCBench supports unified evaluation of input sensitivity, generation stability, output resilience, perturbation robustness, speaker similarity, and deepfake detectability. We evaluate 18 representative open-source voice cloning models and reveal systematic vulnerabilities in content consistency, speaker similarity, long-form stability, post-processing resilience, adversarial robustness, and detector-facing separability. We release the code and dataset to support reproducible evaluation and future research on robust voice cloning, speech synthesis, and audio generation. Code: https://github.com/Nanboy-Ronan/RVCBench. Dataset: https://huggingface.co/datasets/Nanboy/RVCBench.

cs.SD

DUCX: Decomposing Unfairness in Tool-Using Chest X-ray Agents

Fairness in medical agents is becoming critical as tool-using clinical AI systems orchestrate specialized vision and language modules for tasks such as chest X-ray question answering. While these medical AI agents can improve flexibility, their added pipeline complexity also creates new pathways for demographic bias beyond standalone models. We present DUCK, Decomposing Unfairness in Chest X-ray agents, a systematic audit of fairness in tool-using chest X-ray agents instantiated with MedRAX. To localize where disparities arise, we introduce a stage-wise fairness decomposition that separates end-to-end bias from three agent-specific sources: tool exposure bias, or utility gaps conditioned on tool presence; tool transition bias, or subgroup differences in tool-routing patterns; and model reasoning bias, or subgroup differences in synthesis behaviors. Extensive experiments on tool-using agentic frameworks across five driver backbones reveal that demographic gaps persist in end-to-end performance, with equalized odds up to 20.79% and the lowest fairness-utility tradeoff down to 28.65%. Intermediate behaviors, including tool usage, transition patterns, and reasoning traces, exhibit distinct subgroup disparities that are not predictable from end-to-end evaluation alone. For example, conditioned on segmentation-tool availability, the subgroup utility gap reaches as high as 50%. Our findings underscore the need for process-level fairness auditing and debiasing to ensure the equitable deployment of clinical agentic systems. Code: https://github.com/Nanboy-Ronan/DUCK.

cs.CV