SearcharxivSearch

arXiv subjects

Ximo Gual-Arnau

Publications and source records attributed to Ximo Gual-Arnau.

5 recordsLinked to original sources

An efficient heuristic for geometric analysis of cell deformations

Sickle cell disease causes erythrocytes to become sickle-shaped, affecting their movement in the bloodstream and reducing oxygen delivery. It has a high global prevalence and places a significant burden on healthcare systems, especially in resource-limited regions. Automated classification of sickle cells in blood images is crucial, allowing the specialist to reduce the effort required and avoid errors when quantifying the deformed cells and assessing the severity of a crisis. Recent studies have proposed various erythrocyte representation and classification methods. Since classification depends solely on cell shape, a suitable approach models erythrocytes as closed planar curves in shape space. This approach employs elastic distances between shapes, which are invariant under rotations, translations, scaling, and reparameterizations, ensuring consistent distance measurements regardless of the curves' position, starting point, or traversal speed. While previous methods exploiting shape space distances had achieved high accuracy, we refined the model by considering the geometric characteristics of healthy and sickled erythrocytes. Our method proposes (1) to employ a fixed parameterization based on the major axis of each cell to compute distances and (2) to align each cell with two templates using this parameterization before computing distances. Aligning shapes to templates before distance computation, a concept successfully applied in areas such as molecular dynamics, and using a fixed parameterization, instead of minimizing distances across all possible parameterizations, simplifies calculations. This strategy achieves 96.03\% accuracy rate in both supervised classification and unsupervised clustering. Our method ensures efficient erythrocyte classification, maintaining or improving accuracy over shape space models while significantly reducing computational costs.

cs.LG

Biarchetype analysis: simultaneous learning of observations and features based on extremes

We introduce a novel exploratory technique, termed biarchetype analysis, which extends archetype analysis to simultaneously identify archetypes of both observations and features. This innovative unsupervised machine learning tool aims to represent observations and features through instances of pure types, or biarchetypes, which are easily interpretable as they embody mixtures of observations and features. Furthermore, the observations and features are expressed as mixtures of the biarchetypes, which makes the structure of the data easier to understand. We propose an algorithm to solve biarchetype analysis. Although clustering is not the primary aim of this technique, biarchetype analysis is demonstrated to offer significant advantages over biclustering methods, particularly in terms of interpretability. This is attributed to biarchetypes being extreme instances, in contrast to the centroids produced by biclustering, which inherently enhances human comprehension. The application of biarchetype analysis across various machine learning challenges underscores its value, and both the source code and examples are readily accessible in R and Python at https://github.com/aleixalcacer/JA-BIAA.

stat.ME

Classification of geometrical objects by integrating currents and functional data analysis. An application to a 3D database of Spanish child population

This paper focuses on the application of Discriminant Analysis to a set of geometrical objects (bodies) characterized by currents. A current is a relevant mathematical object to model geometrical data, like hypersurfaces, through integration of vector fields along them. As a consequence of the choice of a vector-valued Reproducing Kernel Hilbert Space (RKHS) as a test space to integrate hypersurfaces, it is possible to consider that hypersurfaces are embedded in this Hilbert space. This embedding enables us to consider classification algorithms of geometrical objects. A method to apply Functional Discriminant Analysis in the obtained vector-valued RKHS is given. This method is based on the eigenfunction decomposition of the kernel. So, the novelty of this paper is the reformulation of a size and shape classification problem in Functional Data Analysis terms using the theory of currents and vector-valued RKHS. This approach is applied to a 3D database obtained from an anthropometric survey of the Spanish child population with a potential application to online sales of children's wear.

stat.ME

Generalized Linear Models for Geometrical Current predictors. An application to predict garment fit

The aim of this paper is to model an ordinal response variable in terms of vector-valued functional data included on a vector-valued RKHS. In particular, we focus on the vector-valued RKHS obtained when a geometrical object (body) is characterized by a current and on the ordinal regression model. A common way to solve this problem in functional data analysis is to express the data in the orthonormal basis given by decomposition of the covariance operator. But our data present very important differences with respect to the usual functional data setting. On the one hand, they are vector-valued functions, and on the other, they are functions in an RKHS with a previously defined norm. We propose to use three different bases: the orthonormal basis given by the kernel that defines the RKHS, a basis obtained from decomposition of the integral operator defined using the covariance function, and a third basis that combines the previous two. The three approaches are compared and applied to an interesting problem: building a model to predict the fit of children's garment sizes, based on a 3D database of the Spanish child population.

stat.AP

Unsupervised classification of children's bodies using currents

Object classification according to their shape and size is of key importance in many scientific fields. This work focuses on the case where the size and shape of an object is characterized by a current}. A current is a mathematical object which has been proved relevant to the modeling of geometrical data, like submanifolds, through integration of vector fields along them. As a consequence of the choice of a vector-valued Reproducing Kernel Hilbert Space (RKHS) as a test space for integrating manifolds, it is possible to consider that shapes are embedded in this Hilbert Space. A vector-valued RKHS is a Hilbert space of vector fields; therefore, it is possible to compute a mean of shapes, or to calculate a distance between two manifolds. This embedding enables us to consider size-and-shape classification algorithms. These algorithms are applied to a 3D database obtained from an anthropometric survey of the Spanish child population with a potential application to online sales of children's wear.

stat.ME