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Xinhe Zhang

Publications and source records attributed to Xinhe Zhang.

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BCIJelly: An integrated ecosystem for brain-computer interface research

Brain-computer interface (BCI) research relies on multistage computational pipelines, yet progress remains constrained by fragmented data formats, heterogeneous decoder implementations and hardware-specific deployment toolchains, and researchers lack an integrated workflow. Here, we fill this gap with BCIJelly, a unified computational ecosystem that integrates 18 curated BCI datasets, 15 benchmark decoders and an algorithmic library of 80 reusable modules, an automated architecture search (AAS) procedure, and hardware-aware deployment through the toChip pipeline within a single Python framework. AAS constructs task-specific decoders without manual architecture design. It is further extended into a closed-loop mode guided by a large language model (LLM), which uses task specifications, module descriptions and search history to support multitask and cross-species decoding. The toChip pipeline compiles trained decoders for execution on neuromorphic chips, enabling energy-efficient deployment for BCI systems. An accompanying visualization software provides a graphical interface to the full workflow, making BCIJelly accessible without programming. We validate BCIJelly across five BCI paradigms (motor, visual, speech, emotion and auditory) with recordings from humans, macaques and mice, and single-task, multitask and cross-species decoding settings. BCIJelly establishes a unified and extensible infrastructure that bridges decoder development and hardware-aware deployment for BCI research.

cs.HC

LiFT: Lifted Inter-slice Feature Trajectories for 3D Image Generation from 2D Generators

High-resolution 3D medical image generation remains challenging because fully volumetric models are computationally expensive, while efficient 2D slice generators often fail to preserve anatomical consistency across the third dimension. We propose LiFT, a framework for Lifted inter-slice Feature Trajectories that factorizes 3D volume synthesis into per-slice image generation and inter-slice trajectory learning. Rather than modeling the volumetric distribution end-to-end, LiFT treats a volume as an ordered trajectory in feature space, capturing how anatomical structures appear, transform, and disappear across depth. A tri-planar drifting loss aligns the trajectory of generated slices with the trajectories of real volumes, enabling distributional learning over inter-slice progressions in unconditional generation; in paired translation, a bidirectional $z$-context mixer trained against the registered target supplies through-plane coherence while preserving per-slice fidelity. We evaluate LiFT on BraTS 2023 (unconditional and missing-modality MR) and SynthRAD2023 (MR-to-CT). Across these settings, LiFT preserves per-slice quality, approaches the reported cWDM missing-MR reconstruction quality at $\sim$$135\times$ lower inference cost (without formal equivalence testing), and improves through-plane coherence on MR-to-CT relative to a no-mapper ablation, demonstrating that lightweight inter-slice trajectory learning is a viable route to high-resolution 3D medical synthesis.

cs.CV

Error-In-Variables Methods for Efficient System Identification with Finite-Sample Guarantees

This paper addresses the problem of learning linear dynamical systems from noisy observations. In this setting, existing algorithms either yield biased parameter estimates or have large sample complexities. We resolve these issues by adapting the instrumental variable method and the bias compensation method, originally proposed for error-in-variables models, to our setting. We provide refined non-asymptotic analysis for both methods. Under mild conditions, our algorithms achieve superior sample complexities that match the best-known sample complexity for learning a fully observable system without observation noise.

eess.SY

Benchmarking spike source localization algorithms in high density probes

Estimating neuron location from extracellular recordings is essential for developing advanced brain-machine interfaces. Accurate neuron localization improves spike sorting, which involves detecting action potentials and assigning them to individual neurons. It also helps monitor probe drift, which affects long-term probe reliability. Although several localization algorithms are currently in use, the field is nascent and arguments for using one algorithm over another are largely theoretical or based on visual analysis of clustering results. We present a first-of-its-kind benchmarking of commonly used neuron localization algorithms. We tested these algorithms using two ground truth datasets: a biophysically realistic simulated dataset, and experimental data combining patch-clamp and Neuropixels probes. We systematically evaluate the accuracy, robustness, and runtime of these algorithms in ideal conditions and long-term recording conditions with electrode decay. Our findings highlight significant performance differences; while more complex and physically realistic models perform better in ideal situations, simple heuristics demonstrate superior robustness to noise and electrode degradation in experimental datasets, making them more suitable for long-term neural recordings. This work provides a framework for assessing localization algorithms and developing robust, biologically grounded algorithms to advance the development of brain-machine interfaces.

q-bio.NC

Riemannian Geometry for the classification of brain states with intracortical brain-computer interfaces

This study investigates the application of Riemannian geometry-based methods for brain decoding using invasive electrophysiological recordings. Although previously employed in non-invasive, the utility of Riemannian geometry for invasive datasets, which are typically smaller and scarcer, remains less explored. Here, we propose a Minimum Distance to Mean (MDM) classifier using a Riemannian geometry approach based on covariance matrices extracted from intracortical Local Field Potential (LFP) recordings across various regions during different brain state dynamics. For benchmarking, we evaluated the performance of our approach against Convolutional Neural Networks (CNNs) and Euclidean MDM classifiers. Our results indicate that the Riemannian geometry-based classification not only achieves a superior mean F1 macro-averaged score across different channel configurations but also requires up to two orders of magnitude less computational training time. Additionally, the geometric framework reveals distinct spatial contributions of brain regions across varying brain states, suggesting a state-dependent organization that traditional time series-based methods often fail to capture. Our findings align with previous studies supporting the efficacy of geometry-based methods and extending their application to invasive brain recordings, highlighting their potential for broader clinical use, such as brain computer interface applications.

q-bio.NC

Drift to Remember

Lifelong learning in artificial intelligence (AI) aims to mimic the biological brain's ability to continuously learn and retain knowledge, yet it faces challenges such as catastrophic forgetting. Recent neuroscience research suggests that neural activity in biological systems undergoes representational drift, where neural responses evolve over time, even with consistent inputs and tasks. We hypothesize that representational drift can alleviate catastrophic forgetting in AI during new task acquisition. To test this, we introduce DriftNet, a network designed to constantly explore various local minima in the loss landscape while dynamically retrieving relevant tasks. This approach ensures efficient integration of new information and preserves existing knowledge. Experimental studies in image classification and natural language processing demonstrate that DriftNet outperforms existing models in lifelong learning. Importantly, DriftNet is scalable in handling a sequence of tasks such as sentiment analysis and question answering using large language models (LLMs) with billions of parameters on a single Nvidia A100 GPU. DriftNet efficiently updates LLMs using only new data, avoiding the need for full dataset retraining. Tested on GPT-2 and RoBERTa, DriftNet is a robust, cost-effective solution for lifelong learning in LLMs. This study not only advances AI systems to emulate biological learning, but also provides insights into the adaptive mechanisms of biological neural systems, deepening our understanding of lifelong learning in nature.

cs.AI

Self-Convinced Prompting: Few-Shot Question Answering with Repeated Introspection

While large language models (LLMs) such as ChatGPT and PaLM have demonstrated remarkable performance in various language understanding and generation tasks, their capabilities in complex reasoning and intricate knowledge utilization still fall short of human-level proficiency. Recent studies have established the effectiveness of prompts in steering LLMs towards generating desired outputs. Building on these insights, we introduce a novel framework that harnesses the potential of large-scale pre-trained language models, to iteratively enhance performance of the LLMs. Our framework incorporates three components: \textit{Normal CoT}, a \textit{Convincer}, and an \textit{Answerer}. It processes the output of a typical few-shot chain-of-thought prompt, assesses the correctness of the response, scrutinizes the answer, refines the reasoning, and ultimately produces a new solution. Experimental results on the 7 datasets of miscellaneous problems validate the efficacy of the Self-Convince framework, achieving substantial improvements compared to the baselines. This study contributes to the burgeoning body of research focused on integrating pre-trained language models with tailored prompts and iterative refinement processes to augment their performance in complex tasks.

cs.CL