arXiv subjects

Xinran Li

Publications and source records attributed to Xinran Li.

At least 73 records · Page 4Linked to original sources

arXiv2024

Sensitivity Analysis for Quantiles of Hidden Biases in Matched Observational Studies

Causal conclusions from observational studies may be sensitive to unmeasured confounding. In such cases, a sensitivity analysis is often conducted, which tries to infer the minimum amount of hidden biases or the minimum strength of unmeasured confounding needed in order to explain away the observed association between treatment and outcome. If the needed bias is large, then the treatment is likely to have significant effects. The Rosenbaum sensitivity analysis is a modern approach for conducting sensitivity analysis in matched observational studies. It investigates what magnitude the maximum of hidden biases from all matched sets needs to be in order to explain away the observed association. However, such a sensitivity analysis can be overly conservative and pessimistic, especially when investigators suspect that some matched sets may have exceptionally large hidden biases. In this paper, we generalize Rosenbaum's framework to conduct sensitivity analysis on quantiles of hidden biases from all matched sets, which are more robust than the maximum. Moreover, the proposed sensitivity analysis is simultaneously valid across all quantiles of hidden biases and is thus a free lunch added to the conventional sensitivity analysis. The proposed approach works for general outcomes, general matched studies and general test statistics. In addition, we demonstrate that the proposed sensitivity analysis also works for bounded null hypotheses when the test statistic satisfies certain properties. An R package implementing the proposed approach is available online.

stat.ME↗

arXiv2024

Text-Driven Tumor Synthesis

Tumor synthesis can generate examples that AI often misses or over-detects, improving AI performance by training on these challenging cases. However, existing synthesis methods, which are typically unconditional -- generating images from random variables -- or conditioned only by tumor shapes, lack controllability over specific tumor characteristics such as texture, heterogeneity, boundaries, and pathology type. As a result, the generated tumors may be overly similar or duplicates of existing training data, failing to effectively address AI's weaknesses. We propose a new text-driven tumor synthesis approach, termed TextoMorph, that provides textual control over tumor characteristics. This is particularly beneficial for examples that confuse the AI the most, such as early tumor detection (increasing Sensitivity by +8.5%), tumor segmentation for precise radiotherapy (increasing DSC by +6.3%), and classification between benign and malignant tumors (improving Sensitivity by +8.2%). By incorporating text mined from radiology reports into the synthesis process, we increase the variability and controllability of the synthetic tumors to target AI's failure cases more precisely. Moreover, TextoMorph uses contrastive learning across different texts and CT scans, significantly reducing dependence on scarce image-report pairs (only 141 pairs used in this study) by leveraging a large corpus of 34,035 radiology reports. Finally, we have developed rigorous tests to evaluate synthetic tumors, including Text-Driven Visual Turing Test and Radiomics Pattern Analysis, showing that our synthetic tumors is realistic and diverse in texture, heterogeneity, boundaries, and pathology.

eess.IV↗

arXiv2024

Learn How to Query from Unlabeled Data Streams in Federated Learning

Federated learning (FL) enables collaborative learning among decentralized clients while safeguarding the privacy of their local data. Existing studies on FL typically assume offline labeled data available at each client when the training starts. Nevertheless, the training data in practice often arrive at clients in a streaming fashion without ground-truth labels. Given the expensive annotation cost, it is critical to identify a subset of informative samples for labeling on clients. However, selecting samples locally while accommodating the global training objective presents a challenge unique to FL. In this work, we tackle this conundrum by framing the data querying process in FL as a collaborative decentralized decision-making problem and proposing an effective solution named LeaDQ, which leverages multi-agent reinforcement learning algorithms. In particular, under the implicit guidance from global information, LeaDQ effectively learns the local policies for distributed clients and steers them towards selecting samples that can enhance the global model's accuracy. Extensive simulations on image and text tasks show that LeaDQ advances the model performance in various FL scenarios, outperforming the benchmarking algorithms.

cs.LG↗

arXiv2024

Randomization-based Z-estimation for evaluating average and individual treatment effects

Randomized experiments have been the gold standard for drawing causal inference. The conventional model-based approach has been one of the most popular ways for analyzing treatment effects from randomized experiments, which is often carried through inference for certain model parameters. In this paper, we provide a systematic investigation of model-based analyses for treatment effects under the randomization-based inference framework. This framework does not impose any distributional assumptions on the outcomes, covariates and their dependence, and utilizes only randomization as the "reasoned basis". We first derive the asymptotic theory for Z-estimation in completely randomized experiments, and propose sandwich-type conservative covariance estimation. We then apply the developed theory to analyze both average and individual treatment effects in randomized experiments. For the average treatment effect, we consider three estimation strategies: model-based, model-imputed, and model-assisted, where the first two can be sensitive to model misspecification or require specific ways for parameter estimation. The model-assisted approach is robust to arbitrary model misspecification and always provides consistent average treatment effect estimation. We propose optimal ways to conduct model-assisted estimation using generally nonlinear least squares for parameter estimation. For the individual treatment effects, we propose to directly model the relationship between individual effects and covariates, and discuss the model's identifiability, inference and interpretation allowing model misspecification.

stat.ME↗

arXiv2024

Kaleidoscope: Learnable Masks for Heterogeneous Multi-agent Reinforcement Learning

In multi-agent reinforcement learning (MARL), parameter sharing is commonly employed to enhance sample efficiency. However, the popular approach of full parameter sharing often leads to homogeneous policies among agents, potentially limiting the performance benefits that could be derived from policy diversity. To address this critical limitation, we introduce \emph{Kaleidoscope}, a novel adaptive partial parameter sharing scheme that fosters policy heterogeneity while still maintaining high sample efficiency. Specifically, Kaleidoscope maintains one set of common parameters alongside multiple sets of distinct, learnable masks for different agents, dictating the sharing of parameters. It promotes diversity among policy networks by encouraging discrepancy among these masks, without sacrificing the efficiencies of parameter sharing. This design allows Kaleidoscope to dynamically balance high sample efficiency with a broad policy representational capacity, effectively bridging the gap between full parameter sharing and non-parameter sharing across various environments. We further extend Kaleidoscope to critic ensembles in the context of actor-critic algorithms, which could help improve value estimations.Our empirical evaluations across extensive environments, including multi-agent particle environment, multi-agent MuJoCo and StarCraft multi-agent challenge v2, demonstrate the superior performance of Kaleidoscope compared with existing parameter sharing approaches, showcasing its potential for performance enhancement in MARL. The code is publicly available at \url{https://github.com/LXXXXR/Kaleidoscope}.

cs.LG↗

arXiv2024

Mamba-Enhanced Text-Audio-Video Alignment Network for Emotion Recognition in Conversations

Emotion Recognition in Conversations (ERCs) is a vital area within multimodal interaction research, dedicated to accurately identifying and classifying the emotions expressed by speakers throughout a conversation. Traditional ERC approaches predominantly rely on unimodal cues\-such as text, audio, or visual data\-leading to limitations in their effectiveness. These methods encounter two significant challenges: 1) Consistency in multimodal information. Before integrating various modalities, it is crucial to ensure that the data from different sources is aligned and coherent. 2) Contextual information capture. Successfully fusing multimodal features requires a keen understanding of the evolving emotional tone, especially in lengthy dialogues where emotions may shift and develop over time. To address these limitations, we propose a novel Mamba-enhanced Text-Audio-Video alignment network (MaTAV) for the ERC task. MaTAV is with the advantages of aligning unimodal features to ensure consistency across different modalities and handling long input sequences to better capture contextual multimodal information. The extensive experiments on the MELD and IEMOCAP datasets demonstrate that MaTAV significantly outperforms existing state-of-the-art methods on the ERC task with a big margin.

cs.CV↗

arXiv2024

3Dπ: Three-Dimensional Positron Imaging, A Novel Total-Body PET Scanner Using Xenon-Doped Liquid Argon Scintillator

Objective: This paper introduces a novel PET imaging methodology called 3-dimensional positron imaging (3Dπ), which integrates total-body (TB) coverage, time-of-flight (TOF) technology, ultra-low dose imaging capabilities, and ultra-fast readout electronics inspired by emerging technology from the DarkSide collaboration. Approach: The study evaluates the performance of 3Dπ using Monte Carlo simulations based on NEMA NU 2-2018 protocols. The methodology employs a homogenous, monolithic scintillator composed of liquid argon (LAr) doped with xenon (Xe) with silicon photomultipliers (SiPM) operating at cryogenic temperatures. Main results: Significant enhancements in system performance are observed, with the 3Dπ system achieving a noise equivalent count rate (NECR) of 3.2 Mcps which is approximately two times higher than uEXPLORER's peak NECR (1.5 Mcps) at 17.3 (kBq/mL). Spatial resolution measurements show an average FWHM of 2.7 mm across both axial positions. The system exhibits superior sensitivity, with values reaching 373 kcps/MBq with a line source at the center of the field of view. Additionally, 3Dπ achieves a TOF resolution of 151 ps at 5.3 kBq/mL, highlighting its potential to produce high-quality images with reduced noise levels. Significance: The study underscores the potential of 3Dπ in improving PET imaging performance, offering the potential for shorter scan times and reduced radiation exposure for patients. The Xe-doped LAr offers advantages such as fast scintillation, enhanced light yield, and cost-effectiveness. Future research will focus on optimizing system geometry and further refining reconstruction algorithms to exploit the strengths of 3Dπ for clinical applications.

physics.med-ph↗

arXiv2024

A Stress Induced Source of Phonon Bursts and Quasiparticle Poisoning

The performance of superconducting qubits is degraded by a poorly characterized set of energy sources breaking the Cooper pairs responsible for superconductivity, creating a condition often called ``quasiparticle poisoning". Both superconducting qubits and low threshold dark matter calorimeters have observed excess bursts of quasiparticles or phonons that decrease in rate with time. Here, we show that a silicon crystal glued to its holder exhibits a rate of low-energy phonon events that is more than two orders of magnitude larger than in a functionally identical crystal suspended from its holder in a low-stress state. The excess phonon event rate in the glued crystal decreases with time since cooldown, consistent with a source of phonon bursts which contributes to quasiparticle poisoning in quantum circuits and the low-energy events observed in cryogenic calorimeters. We argue that relaxation of thermally induced stress between the glue and crystal is the source of these events.

physics.ins-det↗

arXiv2024

Context-aware Communication for Multi-agent Reinforcement Learning

Effective communication protocols in multi-agent reinforcement learning (MARL) are critical to fostering cooperation and enhancing team performance. To leverage communication, many previous works have proposed to compress local information into a single message and broadcast it to all reachable agents. This simplistic messaging mechanism, however, may fail to provide adequate, critical, and relevant information to individual agents, especially in severely bandwidth-limited scenarios. This motivates us to develop context-aware communication schemes for MARL, aiming to deliver personalized messages to different agents. Our communication protocol, named CACOM, consists of two stages. In the first stage, agents exchange coarse representations in a broadcast fashion, providing context for the second stage. Following this, agents utilize attention mechanisms in the second stage to selectively generate messages personalized for the receivers. Furthermore, we employ the learned step size quantization (LSQ) technique for message quantization to reduce the communication overhead. To evaluate the effectiveness of CACOM, we integrate it with both actor-critic and value-based MARL algorithms. Empirical results on cooperative benchmark tasks demonstrate that CACOM provides evident performance gains over baselines under communication-constrained scenarios. The code is publicly available at https://github.com/LXXXXR/CACOM.

cs.LG↗

arXiv2024

Observation of Heat Pumping Effect by Radiative Shuttling

Heat shuttling phenomenon is characterized by the presence of a non-zero heat flow between two bodies without net thermal bias on average. It was initially predicted in the context of nonlinear heat conduction within atomic lattices coupled to two time-oscillating thermostats. Recent theoretical works revealed an analog of this effect for heat exchanges mediated by thermal photons between two solids having a temperature dependent emissivity. In this paper, we present the experimental proof of this effect using systems made with composite materials based on phase change materials. By periodically modulating the temperature of one of two solids we report that the system akin to heat pumping with a controllable heat flow direction. Additionally, we demonstrate the effectiveness of a simultaneous modulation of two temperatures to control both the strength and direction of heat shuttling by exploiting the phase delay between these temperatures. These results show that this effect is promising for an active thermal management of solid-state technology, to cool down solids, to insulate them from their background or to amplify heat exchanges.

physics.app-ph↗

arXiv2024

Transient Measurement of Near-field Thermal Radiation between Macroscopic Objects

The involvement of evanescent waves in the near-field regime could greatly enhance the spontaneous thermal radiation, offering a unique opportunity to study nanoscale photon-phonon interaction. However, accurately characterizing this subtle phenomenon is very challenging. This paper proposes a transient all-optical method for rapidly characterizing near-field radiative heat transfer (NFRHT) between macroscopic objects, using the first law of thermodynamics. Significantly, a full measurement at a fixed gap distance is completed within tens of seconds. By simplifying the configuration, the transient all-optical method achieves high measurement accuracy and reliable reproducibility. The proposed method can effectively analyze the NFRHT in various material systems, including SiO2, SiC, and Si, which involve different phonon or plasmon polaritons. Experimental observations demonstrate significant super-Planckian radiation, which arises from the near-field coupling of bounded surface modes. Furthermore, the method achieves excellent agreement with theory, with a minimal discrepancy of less than 2.7% across a wide temperature range. This wireless method could accurately characterize the NFRHT for objects with different sizes or optical properties, enabling the exploration of both fundamental interests and practical applications.

physics.optics↗

arXiv2024

Radiative Thermal Transistor

Developing thermal analogues of field-effect transistor could open the door to a low-power and even zero-power communication technology working with heat rather than electricity. These solid-sate devices could also find many applications in the field of active thermal management in numerous technologies (microelectronic, building science, energy harvesting,conversion,...). Recent theoretical works has suggested that a photonic transistor made with three terminals can in principle be used to switch, modulate, and even amplify heat flux through exchange of thermal photons. Here, we report an experimental demonstration of thermal transistor effect using a non-contact system composed by a temperature-controlled metal-insulator-based material interacting in far-field regime with two blackbodies held at two different temperatures. We demonstrate that, with a tiny change in the temperature of the active layer, the heat flux received by the cold blackbody can be drastically modified. An amplification parameter of heat flux over 20 is reported.

physics.app-ph↗

arXiv2024

Some theoretical foundations for the design and analysis of randomized experiments

Neyman[106]'s seminal work in 1923 has been a milestone in statistics over the century, which has motivated many fundamental statistical concepts and methodology. In this review, we delve into Neyman[106]'s groundbreaking contribution and offer technical insights into the design and analysis of randomized experiments. We shall review the basic setup of completely randomized experiments and the classical approaches for inferring the average treatment effects. We shall in particular review more efficient design and analysis of randomized experiments by utilizing pretreatment covariates, which move beyond Neyman's original work without involving any covariate. We then summarize several technical ingredients regarding randomizations and permutations that have been developed over the century, such as permutational central limit theorems and Berry-Esseen bounds, and elaborate on how these technical results facilitate the understanding of randomized experiments. The discussion is also extended to other randomized experiments including rerandomization, stratified randomized experiments, matched pair experiments, cluster randomized experiments, etc.

math.ST↗

arXiv2024

A Federated Online Restless Bandit Framework for Cooperative Resource Allocation

Restless multi-armed bandits (RMABs) have been widely utilized to address resource allocation problems with Markov reward processes (MRPs). Existing works often assume that the dynamics of MRPs are known prior, which makes the RMAB problem solvable from an optimization perspective. Nevertheless, an efficient learning-based solution for RMABs with unknown system dynamics remains an open problem. In this paper, we study the cooperative resource allocation problem with unknown system dynamics of MRPs. This problem can be modeled as a multi-agent online RMAB problem, where multiple agents collaboratively learn the system dynamics while maximizing their accumulated rewards. We devise a federated online RMAB framework to mitigate the communication overhead and data privacy issue by adopting the federated learning paradigm. Based on this framework, we put forth a Federated Thompson Sampling-enabled Whittle Index (FedTSWI) algorithm to solve this multi-agent online RMAB problem. The FedTSWI algorithm enjoys a high communication and computation efficiency, and a privacy guarantee. Moreover, we derive a regret upper bound for the FedTSWI algorithm. Finally, we demonstrate the effectiveness of the proposed algorithm on the case of online multi-user multi-channel access. Numerical results show that the proposed algorithm achieves a fast convergence rate of $\mathcal{O}(\sqrt{T\log(T)})$ and better performance compared with baselines. More importantly, its sample complexity decreases with the number of agents.

cs.LG↗

arXiv2024

Individual Contributions as Intrinsic Exploration Scaffolds for Multi-agent Reinforcement Learning

In multi-agent reinforcement learning (MARL), effective exploration is critical, especially in sparse reward environments. Although introducing global intrinsic rewards can foster exploration in such settings, it often complicates credit assignment among agents. To address this difficulty, we propose Individual Contributions as intrinsic Exploration Scaffolds (ICES), a novel approach to motivate exploration by assessing each agent's contribution from a global view. In particular, ICES constructs exploration scaffolds with Bayesian surprise, leveraging global transition information during centralized training. These scaffolds, used only in training, help to guide individual agents towards actions that significantly impact the global latent state transitions. Additionally, ICES separates exploration policies from exploitation policies, enabling the former to utilize privileged global information during training. Extensive experiments on cooperative benchmark tasks with sparse rewards, including Google Research Football (GRF) and StarCraft Multi-agent Challenge (SMAC), demonstrate that ICES exhibits superior exploration capabilities compared with baselines. The code is publicly available at https://github.com/LXXXXR/ICES.

cs.LG↗

arXiv2024

Local Observability of VINS and LINS

This work analyzes unobservable directions of Vision-aided Inertial Navigation System (VINS) and Lidar-aided Inertial Navigation System (LINS) nonlinear model. Under the assumption that there exist two features observed by the camera without occlusion, the unobservable directions of VINS are uniformly globally translation and global rotations about the gravity vector. The unobservable directions of LINS are same as VINS, while only one feature need to be observed. Also, a constraint in Observability-Constrained VINS (OC-VINS) is proved.

eess.SY↗

arXiv2024

The role of randomization inference in unraveling individual treatment effects in early phase vaccine trials

Randomization inference is a powerful tool in early phase vaccine trials when estimating the causal effect of a regimen against a placebo or another regimen. Randomization-based inference often focuses on testing either Fisher's sharp null hypothesis of no treatment effect for any participant or Neyman's weak null hypothesis of no sample average treatment effect. Many recent efforts have explored conducting exact randomization-based inference for other summaries of the treatment effect profile, for instance, quantiles of the treatment effect distribution function. In this article, we systematically review methods that conduct exact, randomization-based inference for quantiles of individual treatment effects (ITEs) and extend some results to a special case where naïve participants are expected not to exhibit responses to highly specific endpoints. These methods are suitable for completely randomized trials, stratified completely randomized trials, and a matched study comparing two non-randomized arms from possibly different trials. We evaluate the usefulness of these methods using synthetic data in simulation studies. Finally, we apply these methods to HIV Vaccine Trials Network Study 086 (HVTN 086) and HVTN 205 and showcase a wide range of application scenarios of the methods. R code that replicates all analyses in this article can be found in first author's GitHub page at https://github.com/Zhe-Chen-1999/ITE-Inference.

stat.ME↗

arXiv2023

ProsDectNet: Bridging the Gap in Prostate Cancer Detection via Transrectal B-mode Ultrasound Imaging

Interpreting traditional B-mode ultrasound images can be challenging due to image artifacts (e.g., shadowing, speckle), leading to low sensitivity and limited diagnostic accuracy. While Magnetic Resonance Imaging (MRI) has been proposed as a solution, it is expensive and not widely available. Furthermore, most biopsies are guided by Transrectal Ultrasound (TRUS) alone and can miss up to 52% cancers, highlighting the need for improved targeting. To address this issue, we propose ProsDectNet, a multi-task deep learning approach that localizes prostate cancer on B-mode ultrasound. Our model is pre-trained using radiologist-labeled data and fine-tuned using biopsy-confirmed labels. ProsDectNet includes a lesion detection and patch classification head, with uncertainty minimization using entropy to improve model performance and reduce false positive predictions. We trained and validated ProsDectNet using a cohort of 289 patients who underwent MRI-TRUS fusion targeted biopsy. We then tested our approach on a group of 41 patients and found that ProsDectNet outperformed the average expert clinician in detecting prostate cancer on B-mode ultrasound images, achieving a patient-level ROC-AUC of 82%, a sensitivity of 74%, and a specificity of 67%. Our results demonstrate that ProsDectNet has the potential to be used as a computer-aided diagnosis system to improve targeted biopsy and treatment planning.

eess.IV↗