arXiv subjects

Xinwen Xu

Publications and source records attributed to Xinwen Xu.

6 recordsLinked to original sources

arXiv2026

HiST: A Hierarchical Sparse Transformer for Cross-Modal Spatial Transcriptomics Modeling

Spatial transcriptomics (ST) links gene expression with tissue morphology but remains expensive and low-throughput, motivating surrogates that infer expression from routine histology. Whole-slide H&E-to-ST inference pairs a gigapixel image with gene measurements at a sparse, irregular set of locations, making multiscale modeling challenging without incurring dense-grid overhead or quadratic token mixing. We propose HiST, a hierarchical sparse transformer that treats measured locations as a lattice-indexed sparse field and builds a dyadic encoder--decoder directly on the active tissue footprint. HiST combines sparse window attention for local geometric correspondence with resolution-changing operators for rapid multiscale context integration. For a fixed window size, the dominant runtime and memory scale with the number of observed locations rather than the dense slide area. To mitigate slide-specific acquisition variation, HiST adds a bottlenecked global conditioning pathway via a \emph{slide calibration token} that summarizes slide-level context and conditions local representations. On a multi-organ benchmark spanning diverse tissues and acquisition sources, HiST improves predictive performance over recent baselines while reducing runtime and peak memory.

cs.CV↗

arXiv2026

Generative Simulation for Policy Learning in Physical Human-Robot Interaction

Developing autonomous physical human-robot interaction (pHRI) systems is limited by the scarcity of large-scale training data to learn robust robot behaviors for real-world applications. In this paper, we introduce a zero-shot "text2sim2real" generative simulation framework that automatically synthesizes diverse pHRI scenarios from high-level natural-language prompts. Leveraging Large Language Models (LLMs) and Vision-Language Models (VLMs), our pipeline procedurally generates soft-body human models, scene layouts, and robot motion trajectories for assistive tasks. We utilize this framework to autonomously collect large-scale synthetic demonstration datasets and then train vision-based imitation learning policies operating on segmented point clouds. We evaluate our approach through a user study on two physically assistive tasks: scratching and bathing. Our learned policies successfully achieve zero-shot sim-to-real transfer, attaining success rates exceeding 80% and demonstrating resilience to unscripted human motion. Overall, we introduce the first generative simulation pipeline for pHRI applications, automating simulation environment synthesis, data collection, and policy learning. Additional information may be found on our project website: https://rchi-lab.github.io/gen_phri/

cs.RO↗

arXiv2026

Learning Spatial-Preserving Hierarchical Representations for Digital Pathology

Whole slide images (WSIs) pose fundamental computational challenges due to their gigapixel resolution and the sparse distribution of informative regions. Existing approaches often treat image patches independently or reshape them in ways that distort spatial context, thereby obscuring the hierarchical pyramid representations intrinsic to WSIs. We introduce Sparse Pyramid Attention Networks (SPAN), a hierarchical framework that preserves spatial relationships while allocating computation to informative regions. SPAN constructs multi-scale representations directly from single-scale inputs, enabling precise hierarchical modeling of WSI data. We demonstrate SPAN's versatility through two variants: SPAN-MIL for slide classification and SPAN-UNet for segmentation. Comprehensive evaluations across multiple public datasets show that SPAN effectively captures hierarchical structure and contextual relationships. Our results provide clear evidence that architectural inductive biases and hierarchical representations enhance both slide-level and patch-level performance. By addressing key computational challenges in WSI analysis, SPAN provides an effective framework for computational pathology and demonstrates important design principles for large-scale medical image analysis.

cs.CV↗

arXiv2026

Exploiting Label-Independent Regularization from Spatial Dependencies for Whole Slide Image Analysis

Whole slide images, with their gigapixel-scale panoramas of tissue samples, are pivotal for precise disease diagnosis. However, their analysis is hindered by immense data size and scarce annotations. Existing MIL methods face challenges due to the fundamental imbalance where a single bag-level label must guide the learning of numerous patch-level features. This sparse supervision makes it difficult to reliably identify discriminative patches during training, leading to unstable optimization and suboptimal solutions. We propose a spatially regularized MIL framework that leverages inherent spatial relationships among patch features as label-independent regularization signals. Our approach learns a shared representation space by jointly optimizing feature-induced spatial reconstruction and label-guided classification objectives, enforcing consistency between intrinsic structural patterns and supervisory signals. Experimental results on multiple public datasets demonstrate significant improvements over state-of-the-art methods, offering a promising direction.

cs.CV↗

arXiv2025

ProtoVQA: An Adaptable Prototypical Framework for Explainable Fine-Grained Visual Question Answering

Visual Question Answering (VQA) is increasingly used in diverse applications ranging from general visual reasoning to safety-critical domains such as medical imaging and autonomous systems, where models must provide not only accurate answers but also explanations that humans can easily understand and verify. Prototype-based modeling has shown promise for interpretability by grounding predictions in semantically meaningful regions for purely visual reasoning tasks, yet remains underexplored in the context of VQA. We present ProtoVQA, a unified prototypical framework that (i) learns question-aware prototypes that serve as reasoning anchors, connecting answers to discriminative image regions, (ii) applies spatially constrained matching to ensure that the selected evidence is coherent and semantically relevant, and (iii) supports both answering and grounding tasks through a shared prototype backbone. To assess explanation quality, we propose the Visual-Linguistic Alignment Score (VLAS), which measures how well the model's attended regions align with ground-truth evidence. Experiments on Visual7W show that ProtoVQA yields faithful, fine-grained explanations while maintaining competitive accuracy, advancing the development of transparent and trustworthy VQA systems.

cs.CV↗

arXiv2025

Assessing and Mitigating Medical Knowledge Drift and Conflicts in Large Language Models

Large Language Models (LLMs) have great potential in the field of health care, yet they face great challenges in adapting to rapidly evolving medical knowledge. This can lead to outdated or contradictory treatment suggestions. This study investigated how LLMs respond to evolving clinical guidelines, focusing on concept drift and internal inconsistencies. We developed the DriftMedQA benchmark to simulate guideline evolution and assessed the temporal reliability of various LLMs. Our evaluation of seven state-of-the-art models across 4,290 scenarios demonstrated difficulties in rejecting outdated recommendations and frequently endorsing conflicting guidance. Additionally, we explored two mitigation strategies: Retrieval-Augmented Generation and preference fine-tuning via Direct Preference Optimization. While each method improved model performance, their combination led to the most consistent and reliable results. These findings underscore the need to improve LLM robustness to temporal shifts to ensure more dependable applications in clinical practice. The dataset is available at https://huggingface.co/datasets/RDBH/DriftMed.

cs.CL↗