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Xinyue Guo

Publications and source records attributed to Xinyue Guo.

7 recordsLinked to original sources

Beyond Gene Reconstruction: Learning Cell Representations through Complementary Transcriptomic Views

The rapid growth of single-cell transcriptomic data has enabled the development of foundation models pretrained primarily by reconstructing masked expression values. This objective encourages these models to learn gene dependencies but does not directly optimize whole-cell representations, which are essential for many downstream tasks. To bridge this gap, we propose a contrastive pretraining framework that learns cell representations through complementary transcriptomic views. Since standard contrastive learning is not readily applicable to single-cell pretraining, we introduce specific adaptations along three dimensions --- co-expression-guided gene partitioning, expression-aware contrast-set construction, and competence-gated contrastive onset. Specifically, we first construct two complementary views of each cell by partitioning its genes according to their co-expression structure. Then, to prevent the model from using gene-set identity as a shortcut, we construct hard negatives by permuting expression values while keeping gene identities unchanged. Finally, we introduce a competence-aware controller to determine how the contrastive objective is applied. Experiments on cell-type annotation and gene regulatory network inference demonstrate competitive transfer under the evaluated protocols. In the six-network GRN evaluation, our method records the highest mean AUROC and AUPRC point estimates among the compared variants, while the highest-scoring variant differs across individual networks. These results establish complementary-view contrastive learning as an effective direction for single-cell pretraining beyond gene reconstruction.

cs.LG

No Hidden Prompts Needed! You Can Game AI Peer Review with Presentation-Only Revisions

As AI-generated reviews move from experimental tools into peer-review infrastructure, most robustness concerns have focused on explicit attacks such as hidden instructions and prompt injection. We study a harder and more policy-relevant failure mode: no hidden text, no prompt injection, and no changes to methods, experiments, figures, equations, proofs, or numerical results. The attacker modifies only presentation-level content, such as the abstract, contribution framing, related work, discussion, and narrative structure. We introduce adversarial repackaging: a closed-loop attack that uses AI-reviewer feedback to search for presentation-level revisions while keeping the scientific evidence fixed. Across three mainstream AI reviewers, adversarial repackaging achieves a 75.1% attack success rate and a mean score gain of +1.21/10. The effect is not explained by ordinary prose polishing. We also reveal that strategies that change how the reviewer interprets the paper, such as related-work repositioning and analytical discussion expansion, substantially outperform surface edits such as local polishing, table formatting, and algorithm boxes. Our analysis reveals two deeper structural failure modes. First, AI reviewers are easier to impress than to convince: highlighting strengths reliably increases perceived merit, while attempts to dissolve weaknesses frequently backfire. Second, AI reviewers can confuse the appearance of addressing a limitation with actually resolving it, allowing unchanged evidence to be reinterpreted as stronger scientific contribution. These results show that the deployment risk is not only malicious hidden instructions, but the emergence of paper presentation itself as an optimization surface. We release a contamination-free rolling benchmark and attack framework for testing whether AI reviewers remain anchored to scientific content under presentation-only edits.

cs.CL

ControlFoley: Unified and Controllable Video-to-Audio Generation with Cross-Modal Conflict Handling

Recent advances in video-to-audio (V2A) generation enable high-quality audio synthesis from visual content, yet achieving robust and fine-grained controllability remains challenging. Existing methods suffer from weak textual controllability under visual-text conflict and imprecise stylistic control due to entangled temporal and timbre information in reference audio. Moreover, the lack of standardized benchmarks limits systematic evaluation. We propose ControlFoley, a unified multimodal V2A framework that enables precise control over video, text, and reference audio. We introduce a joint visual encoding paradigm that integrates CLIP with a spatio-temporal audio-visual encoder to improve alignment and textual controllability. We further propose temporal-timbre decoupling to suppress redundant temporal cues while preserving discriminative timbre features. In addition, we design a modality-robust training scheme with unified multimodal representation alignment (REPA) and random modality dropout. We also present VGGSound-TVC, a benchmark for evaluating textual controllability under varying degrees of visual-text conflict. Extensive experiments demonstrate state-of-the-art performance across multiple V2A tasks, including text-guided, text-controlled, and audio-controlled generation. ControlFoley achieves superior controllability under cross-modal conflict while maintaining strong synchronization and audio quality, and shows competitive or better performance compared to an industrial V2A system. Code, models, datasets, and demos are available at: https://github.com/xiaomi-research/controlfoley.

cs.MM

AV-Edit: Multimodal Generative Sound Effect Editing via Audio-Visual Semantic Joint Control

Sound effect editing-modifying audio by adding, removing, or replacing elements-remains constrained by existing approaches that rely solely on low-level signal processing or coarse text prompts, often resulting in limited flexibility and suboptimal audio quality. To address this, we propose AV-Edit, a generative sound effect editing framework that enables fine-grained editing of existing audio tracks in videos by jointly leveraging visual, audio, and text semantics. Specifically, the proposed method employs a specially designed contrastive audio-visual masking autoencoder (CAV-MAE-Edit) for multimodal pre-training, learning aligned cross-modal representations. These representations are then used to train an editorial Multimodal Diffusion Transformer (MM-DiT) capable of removing visually irrelevant sounds and generating missing audio elements consistent with video content through a correlation-based feature gating training strategy. Furthermore, we construct a dedicated video-based sound editing dataset as an evaluation benchmark. Experiments demonstrate that the proposed AV-Edit generates high-quality audio with precise modifications based on visual content, achieving state-of-the-art performance in the field of sound effect editing and exhibiting strong competitiveness in the domain of audio generation.

cs.MM

MultiSoundGen: Video-to-Audio Generation for Multi-Event Scenarios via SlowFast Contrastive Audio-Visual Pretraining and Direct Preference Optimization

Current video-to-audio (V2A) methods struggle in complex multi-event scenarios (video scenarios involving multiple sound sources, sound events, or transitions) due to two critical limitations. First, existing methods face challenges in precisely aligning intricate semantic information together with rapid dynamic features. Second, foundational training lacks quantitative preference optimization for semantic-temporal alignment and audio quality. As a result, it fails to enhance integrated generation quality in cluttered multi-event scenes. To address these core limitations, this study proposes a novel V2A framework: MultiSoundGen. It introduces direct preference optimization (DPO) into the V2A domain, leveraging audio-visual pretraining (AVP) to enhance performance in complex multi-event scenarios. Our contributions include two key innovations: the first is SlowFast Contrastive AVP (SF-CAVP), a pioneering AVP model with a unified dual-stream architecture. SF-CAVP explicitly aligns core semantic representations and rapid dynamic features of audio-visual data to handle multi-event complexity; second, we integrate the DPO method into V2A task and propose AVP-Ranked Preference Optimization (AVP-RPO). It uses SF-CAVP as a reward model to quantify and prioritize critical semantic-temporal matches while enhancing audio quality. Experiments demonstrate that MultiSoundGen achieves state-of-the-art (SOTA) performance in multi-event scenarios, delivering comprehensive gains across distribution matching, audio quality, semantic alignment, and temporal synchronization. Demos are available at https://v2aresearch.github.io/MultiSoundGen/.

cs.MM

MeanFlow-Accelerated Multimodal Video-to-Audio Synthesis via One-Step Generation

A key challenge in synthesizing audios from silent videos is the inherent trade-off between synthesis quality and inference efficiency in existing methods. For instance, flow matching based models rely on modeling instantaneous velocity, inherently require an iterative sampling process, leading to slow inference speeds. To address this efficiency bottleneck, we introduce a MeanFlow-accelerated model that characterizes flow fields using average velocity, enabling one-step generation and thereby significantly accelerating multimodal video-to-audio (VTA) synthesis while preserving audio quality, semantic alignment, and temporal synchronization. Furthermore, a scalar rescaling mechanism is employed to balance conditional and unconditional predictions when classifier-free guidance (CFG) is applied, effectively mitigating CFG-induced distortions in one step generation. Since the audio synthesis network is jointly trained with multimodal conditions, we further evaluate it on text-to-audio (TTA) synthesis task. Experimental results demonstrate that incorporating MeanFlow into the network significantly improves inference speed without compromising perceptual quality on both VTA and TTA synthesis tasks.

cs.SD

Atomistic Structure of Transient Switching States in Ferroelectric AlScN

We resolve the microscopic mechanism of polarization switching in wurtzite ferroelectric AlScN by integrating advanced thin-film fabrication, ferroelectric switching dynamics characterizations, high-resolution scanning transmission electron microscopy (STEM), and large-scale molecular dynamics simulations enabled by a deep neural network-based interatomic potential. Contrary to earlier interpretations proposing a transient nonpolar intermediate phase, we demonstrate that the broad transitional regions previously observed in STEM images are projection artifacts resulting from the intrinsic three-dimensional zigzag morphology of 180$^\circ$ domain walls, which are a characteristic form of inversion domain boundary. This is further confirmed by STEM imaging of strategically prepared, partially switched Al$_{0.75}$Sc$_{0.25}$N thin films. Our simulations reveal that switching proceeds through collective, column-by-column atomic displacements, directly explaining the emergence of zigzag-shaped domain walls, and is consistent with the nucleation-limited switching behavior observed in experimental switching dynamic measurements. Furthermore, we show that increasing Sc content systematically lowers domain wall energy and associated nucleation barrier, thereby reducing the switching field in agreement with experimental trends. These findings establish a direct connection between local domain wall structure, switching kinetics, and macroscopic ferroelectric behavior.

cond-mat.mtrl-sci