arXiv subjects

Xu Chu

Publications and source records attributed to Xu Chu.

111 records · Page 7Linked to original sources

arXiv2018

Multi-Label Robust Factorization Autoencoder and its Application in Predicting Drug-Drug Interactions

Drug-drug interactions (DDIs) are a major cause of preventable hospitalizations and deaths. Predicting the occurrence of DDIs helps drug safety professionals allocate investigative resources and take appropriate regulatory action promptly. Traditional DDI prediction methods predict DDIs based on the similarity between drugs. Recently, researchers revealed that predictive performance can be improved by better modeling the interactions between drug pairs with bilinear forms. However, the shallow models leveraging bilinear forms suffer from limitations on capturing complicated nonlinear interactions between drug pairs. To this end, we propose Multi-Label Robust Factorization Autoencoder (abbreviated to MuLFA) for DDI prediction, which learns a representation of interactions between drug pairs and has the capability of characterizing complicated nonlinear interactions more precisely. Moreover, a novel loss called CuXCov is designed to effectively learn the parameters of MuLFA. Furthermore, the decoder is able to generate high-risk chemical structures of drug pairs for specific DDIs, assisting pharmacists to better understand the relationship between drug chemistry and DDI. Experimental results on real-world datasets demonstrate that MuLFA consistently outperforms state-of-the-art methods; particularly, it increases 21:3% predictive performance compared to the best baseline for top 50 frequent DDIs.We also illustrate various case studies to demonstrate the efficacy of the chemical structures generated by MuLFA in DDI diagnosis.

cs.LG↗

arXiv2017

Motif-based Rule Discovery for Predicting Real-valued Time Series

Time series prediction is of great significance in many applications and has attracted extensive attention from the data mining community. Existing work suggests that for many problems, the shape in the current time series may correlate an upcoming shape in the same or another series. Therefore, it is a promising strategy to associate two recurring patterns as a rule's antecedent and consequent: the occurrence of the antecedent can foretell the occurrence of the consequent, and the learned shape of consequent will give accurate predictions. Earlier work employs symbolization methods, but the symbolized representation maintains too little information of the original series to mine valid rules. The state-of-the-art work, though directly manipulating the series, fails to segment the series precisely for seeking antecedents/consequents, resulting in inaccurate rules in common scenarios. In this paper, we propose a novel motif-based rule discovery method, which utilizes motif discovery to accurately extract frequently occurring consecutive subsequences, i.e. motifs, as antecedents/consequents. It then investigates the underlying relationships between motifs by matching motifs as rule candidates and ranking them based on the similarities. Experimental results on real open datasets show that the proposed approach outperforms the baseline method by 23.9%. Furthermore, it extends the applicability from single time series to multiple ones.

cs.AI↗

arXiv2017

HoloClean: Holistic Data Repairs with Probabilistic Inference

We introduce HoloClean, a framework for holistic data repairing driven by probabilistic inference. HoloClean unifies existing qualitative data repairing approaches, which rely on integrity constraints or external data sources, with quantitative data repairing methods, which leverage statistical properties of the input data. Given an inconsistent dataset as input, HoloClean automatically generates a probabilistic program that performs data repairing. Inspired by recent theoretical advances in probabilistic inference, we introduce a series of optimizations which ensure that inference over HoloClean's probabilistic model scales to instances with millions of tuples. We show that HoloClean scales to instances with millions of tuples and find data repairs with an average precision of ~90% and an average recall of above ~76% across a diverse array of datasets exhibiting different types of errors. This yields an average F1 improvement of more than 2x against state-of-the-art methods.

cs.DB↗