arXiv subjects

Xu Shi

Publications and source records attributed to Xu Shi.

At least 19 recordsLinked to original sources

arXiv2026

Differentiable Partitioning with Placement and Hybrid Bonding Terminal Awareness for Optimized 3D Placement

Research on 3D-ICs physical design has expanded rapidly in recent years. Hybrid bonding-enabled 3D integrated circuits (3D-ICs) offer substantial benefits in interconnect scaling and system integration, yet tier assignment remains challenging because it jointly determines 3D wirelength and hybrid bonding terminal (HBT) assignment. This paper presents a differentiable partitioning framework that directly optimizes placement-aware tier assignment for 3D-ICs through gradient-based optimization. Discrete tier assignment is relaxed to continuous probabilities, and a Dual-Max 3D wirelength model is introduced to capture per-tier half-perimeter wirelength (HPWL). In addition, a terminal-aware cutsize penalty selectively suppresses cross-die nets in HBT-congested regions, and a local balance constraint enforces grid-cell density equilibrium across tiers. Experimental results on OpenROAD benchmarks show that our method reduces D2D HPWL by 2.0% on average over two min-cut baselines and by 12.1% over the state-of-the-art 3D placer. We open-source our partition code with 3D placement flow to support reproducibility.

cs.ET↗

arXiv2026

Towards Best Practices for Covariate Adjustment in Regulatory Trials: From Fixed to Data-Adaptive Approaches

While randomization justifies the use of unadjusted effect estimators in randomized trials, there is growing interest in covariate adjustment to improve precision. Adjusting for baseline variables that are prognostic of the outcome can reduce estimator variance, resulting in narrower confidence intervals and increased statistical power. Recent guidance by the U.S. Food and Drug Administration supports fixed adjustment for prognostic covariates using parametric regression models. However, this guidance does not address more flexible approaches using data-adaptive or machine learning methods. We offer our perspectives on covariate adjustment to improve analytic precision. We focus on estimating the average effect for the target population in trials with minimal outcome missingness. We provide a non-technical overview of effect estimators that are unadjusted and effect estimators using fixed versus data-adaptive adjustment. We offer practical suggestions for conducting adjusted analyses that are data-adaptive, fully pre-specified, transparently and reproducibly implemented, robust to model misspecification, and guaranteed to improve precision relative to unadjusted analyses --- all while preserving statistical validity and the causal effect of interest. We hope that sharing our perspectives will foster broader discussion and eventual acceptance of principled, pre-specified, data-adaptive covariate adjustment in randomized trials.

stat.ME↗

arXiv2026

How should we select test-negative controls? A causal perspective in the era of multiplex respiratory testing

The test-negative design (TND) is widely used to estimate vaccine effectiveness (VE) for respiratory pathogens by comparing vaccination odds among test-positive cases versus test-negative controls. A central yet underexplored design element is which test-negative illnesses constitute valid controls. With rapid multiplex PCR panels, investigators can now identify specific non-focal pathogens among test-negative patients, allowing for better characterization of ``test-negative illness'', but also revealing a mixture of control outcomes that may each satisfy or violate causal assumptions. We synthesize recent causal identification results for the TND and show that they imply two distinct interpretations of control selection: 1) a sampling view in which controls represent the source population and 2) a bias-correction view in which controls function as negative control outcomes under equi-confounding. Building on these interpretations, we develop a framework for multiplex-informed control selection. We propose a taxonomy that distinguishes controls that serve primarily as exposure proxies (sharing unmeasured determinants of infection) from those that serve as testing proxies (sharing unmeasured determinants of care-seeking), derive implications for pathogen-specific and pooled estimators, and suggest three practical principles for control selection: vaccine irrelevance, avoidance of entanglement with other interventions, and testing-process comparability. We also formalize nuances introduced by multiplex panels, including co-detections and pan-negative episodes, and outline when standard pooled estimators remain valid versus when alternative estimators are needed. In simulations across 9 scenarios, we demonstrate violations concentrated in a single control pathogen can substantially bias pooled TND estimates, whereas a pre-specified pathogen screening estimator remained unbiased.

stat.ME↗

arXiv2026

Studying Competing Events with Federated Cumulative Incidence Curves

Combining electronic health record (EHR) data from multiple institutions is a valuable strategy for conducting post-market safety surveillance of medical products, but privacy concerns limit sharing individual-level data. We develop a novel federated learning (FL) method for multi-site post-market safety surveillance of medical products using competing risks data. We apply this method to study immune-related adverse events (irAEs) following treatment with immune checkpoint inhibitors (ICIs) in patients with auto-immune disease (AID). We provide an algorithm for constructing non-parametric cumulative incidence curves for competing event types, which can be used to compare exposure groups (e.g. treated and untreated) with no sharing of patient-level data across institutions. We incorporate covariate adjustment via inverse propensity weighting, and informative causal comparison using the area under cumulative incidence curves, known as restricted mean time lost. We apply our method to $N=10,281$ cancer patients with no pre-existing endocrine-related AID receiving ICIs across $K=10$ sites from the OneFlorida+ network, comparing patients with a pre-existing non-endocrine AID to those with no pre-existing AID. After covariate adjustment, we found that patients with a pre-existing non-endocrine AID lost 4.8 [95% CI: 4.3,5.2] months of event-free survival time to endocrine irAEs in the first 18 months following treatment, compared to 3.2 [95% CI: 3.1,3.3] months in the group without prior AID. As patients with prior AID were initially excluded from clinical trials of ICIs, our findings provide important new information to clinicians and patients receiving or considering ICI treatment. Our proposed non-parametric federated algorithm is the first to allow investigators to use some of the most crucial non-parametric tools for conducting postmarket safety surveillance across multiple institutions.

stat.ME↗

arXiv2026

Privacy-preserving causal mediation analysis using distributed electronic health record networks

Electronic health record (EHR) networks provide unprecedented opportunities to study treatment mechanisms at scale, but mediation analyses across institutions are often hindered by privacy and governance constraints that restrict sharing of patient-level data. We developed a privacy-preserving federated mediation framework that enables estimation of natural direct and indirect effects without exchanging individual-level records across participating sites. The proposed approach integrates renewable learning with counterfactual causal mediation analysis, allowing institutions to collaboratively investigate treatment mechanisms using only low-dimensional summary statistics. Both simulation studies and the real-world application demonstrated that the federated estimator closely reproduced pooled-data results while preserving patient privacy. We applied the method to 32,146 patients in the Indiana Network for Patient Care to evaluate the extent to which body mass index (BMI) mediates the effect of GLP-1 receptor agonist on glycated hemoglobin (HbA1c) reduction. The BMI-mediated pathway accounted for only a small proportion of the overall treatment effect, suggesting that most glycemic improvement occurred through mechanisms other than weight loss.

stat.AP↗

arXiv2026

Considerations for the Integration of Randomized Controlled Trials and Real-World Data

As clinical decision-making increasingly moves toward individualized and context-specific treatment recommendations, reliance on any single evidence source, randomized or observational, may be insufficient. Principled integration of randomized controlled trials and real-world data, grounded in explicit causal frameworks, offers a path toward evidence that is both internally credible and externally relevant. In this article, we describe distinct objectives for the integration of randomized controlled trials and real-world data and discuss how these objectives shape key design and analytic considerations, illustrating the resulting choices through example estimands. We highlight practical issues that commonly arise in applied settings, including data relevance and curation, cross-source comparability, estimand specification, and sensitivity analysis. We aim for this article to help readers evaluate and implement principled approaches to integrating randomized controlled trials and real-world data in ways that can support more reliable treatment recommendations while maintaining regulatory-grade evidentiary standards.

stat.ME↗

arXiv2026

Proximal Learning for Trials With External Controls: A Case Study in HIV Prevention

With the advent of effective pre-exposure prophylaxis agents, active-controlled HIV prevention trials have become a common study design. Nevertheless, estimating absolute efficacy relative to a placebo remains important. In this paper, we introduce a novel application of proximal causal inference methods to estimate the counterfactual cumulative HIV incidence under placebo for participants in an active-controlled trial of cabotegravir, using external control data from a placebo-controlled trial with similar eligibility criteria. We leverage baseline sexually transmitted infection status and geographic region as negative control outcome and exposure variables, respectively. We address two key challenges: unmeasured differences in HIV risk between trials and statistical difficulties arising from low HIV incidence rates in both studies. To overcome these challenges, we develop two proximal inference approaches: (1) a semiparametric inverse probability of censoring weighting estimator, and (2) a two-stage regression-based strategy tailored to low-event-rate settings. Our theoretical and numerical investigations demonstrate these methods yield reliable estimates of the counterfactual one-year cumulative HIV incidence under placebo, and provide robust evidence of the superior efficacy of cabotegravir compared with placebo. These findings highlight the potential of proximal inference methods to estimate placebo-controlled effects in both single-arm and active-controlled trials by leveraging external controls.

stat.ME↗

arXiv2026

Doppler Shift Keying Modulation for Uplink Multiple Access over Doubly-Dispersive Channels

The delay-Doppler (DD) domain modulation has been regarded as one of the most competitive candidates to support wireless communications for emerging high-mobility applications in the sixth-generation mobile networks. Unfortunately, most of the existing designs for DD domain modulation suffer from high peak-to-average power ratio (PAPR) and unbearable detection complexity under uplink transmission since large time duration and bandwidth are required to guarantee high DD resolutions. To address these issues, the Doppler shift keying (DSK) modulation based on the orthogonal delay Doppler division multiplexing modulator is proposed in this paper, where the input-output characterization in the DD domain is fully exploited. The principle of the DSK transceiver is first established with the one-hot mapper and low-complexity iterative successive interference cancellation-maximum ratio combining detector for point-to-point scenarios. The proposed scheme is then generalized to the zero auto-correlation sequence-based implementation, which benefits the extension of multi-user (MU) uplink DSK frameworks. For uplink DSK transmission, Zadoff-Chu (ZC) sequences are adopted as the basis sequences. We optimize the assignment of ZC roots to different user equipments (UEs) by minimizing the maximum inter-user interference. This optimization process, which analyzes the root allocation, directly assigns a specific ZC sequence to each UE. The PAPR and bit error rate performance of the proposed DSK modulation with the low-complexity detector is finally verified by extensive simulation results under doubly-dispersive channels, which demonstrates the superiority of DSK modulation especially for uplink multiple access over doubly dispersive channels.

eess.SP↗

arXiv2026

Joint Modeling of Longitudinal EHR Data with Shared Random Effects for Informative Visiting and Observation Processes

Longitudinal electronic health record (EHR) data offer opportunities to study biomarker trajectories; however, association estimates-the primary inferential target-from standard models designed for regular observation times may be biased by a two-stage hierarchical missingness mechanism. The first stage is the visiting process (informative presence), where encounters occur at irregular times driven by patient health status; the second is the observation process (informative observation), where biomarkers are selectively measured during visits. To address these mechanisms, we propose a unified semiparametric joint modeling framework that simultaneously characterizes the visiting, biomarker observation, and longitudinal outcome processes. Central to this framework is a shared subject-specific Gaussian latent variable that captures unmeasured frailty and induces dependence across all components. We develop a three-stage estimation procedure and establish the consistency and asymptotic normality of our estimators. We also introduce a sequential procedure that imputes missing biomarkers prior to adjusting for irregular visiting and examine its performance. Simulation results demonstrate that our method yields unbiased estimates under this mechanism, whereas existing approaches can be substantially biased; notably, methods adjusting only for irregular visiting may exhibit even greater bias than those ignoring both mechanisms. We apply our framework to data from the All of Us Research Program to investigate associations between neighborhood-level socioeconomic status indicators and six blood-based biomarker trajectories, providing a robust tool for outpatient settings where irregular monitoring and selective measurement are prevalent.

stat.ME↗

arXiv2026

InternVLA-A1: Unifying Understanding, Generation and Action for Robotic Manipulation

Prevalent Vision-Language-Action (VLA) models are typically built upon Multimodal Large Language Models (MLLMs) and demonstrate exceptional proficiency in semantic understanding, but they inherently lack the capability to deduce physical world dynamics. Consequently, recent approaches have shifted toward World Models, typically formulated via video prediction; however, these methods often suffer from a lack of semantic grounding and exhibit brittleness in the presence of video prediction errors. To synergize semantic understanding with dynamic predictive capabilities, we present InternVLA-A1. This model employs a unified Mixture-of-Transformers architecture, coordinating three experts for scene understanding, visual foresight generation, and action execution. These components interact seamlessly through a unified masked self attention mechanism. Building upon InternVL3 and Qwen3-VL, we instantiate InternVLA-A1 at 2B and 3B parameter scales. We pre-train these models on heterogeneous data sources over real-world robot data, synthetic simulation data, and human videos, covering over 692M frames. This hybrid training strategy effectively harnesses the diversity of synthetic simulation data while minimizing the sim-to-real gap. We evaluated InternVLA-A1 on 12 real-world robotic tasks and a simulation benchmark. The results show that InternVLA-A1 consistently outperforms prior leading models: compared with pi0.5, it achieves +4.4\% on static manipulation tasks and +2.6\% on the RoboTwin 2.0 simulation benchmark, and delivers a +26.7\% boost on dynamic manipulation tasks.

cs.RO↗

arXiv2025

Adaptive Algorithms for Nonconvex Bilevel Optimization under P{\L} Conditions

Existing methods for nonconvex bilevel optimization (NBO) require prior knowledge of first- and second-order problem-specific parameters (e.g., Lipschitz constants and the Polyak-{\L}ojasiewicz (P{\L}) parameters) to set step sizes, a requirement that poses practical limitations when such parameters are unknown or computationally expensive. We introduce the Adaptive Fully First-order Bilevel Approximation (AF${}^2$BA) algorithm and its accelerated variant, A${}^2$F${}^2$BA, for solving NBO problems under the P{\L} conditions. To our knowledge, these are the first methods to employ fully adaptive step size strategies, eliminating the need for any problem-specific parameters in NBO. We prove that both algorithms achieve $\mathcal{O}(1/\epsilon^2)$ iteration complexity for finding an $\epsilon$-stationary point, matching the iteration complexity of existing well-tuned methods. Furthermore, we show that A${}^2$F${}^2$BA enjoys a near-optimal first-order oracle complexity of $\tilde{\mathcal{O}}(1/\epsilon^2)$, matching the oracle complexity of existing well-tuned methods, and aligning with the complexity of gradient descent for smooth nonconvex single-level optimization when ignoring the logarithmic factors.

math.OC↗

arXiv2025

RSMA-Assited and Transceiver-Coordinated ICI Management for MIMO-OFDM System

High-mobility scenarios are becoming increasingly critical in next-generation communication systems. While multiple-input multiple-output orthogonal frequency division multiplexing (MIMO-OFDM) stands as a prominent technology, its performance in such scenarios is fundamentally limited by Doppler-induced inter-carrier interference (ICI). Rate splitting multiple access (RSMA), recognized as a key multiple access technique for future communications, demonstrates superior interference management capabilities that we leverage to address this challenge. In specific, we propose a novel RSMA-assisted and transceiver-coordinated transmission scheme for ICI management in MIMO-OFDM system: (1) At the receiver side, we develop a hybrid successive interference cancellation (SIC) architecture with dynamic subcarrier clustering, which enables parallel intra-cluster and serial inter-cluster processing to balance complexity and performance. (2) At the transmitter~side, we design a matched hybrid precoding through formulated sum-rate maximization, solved via our proposed augmented boundary-compressed particle swarm optimization (ABC-PSO) algorithm for analog phase optimization and weighted minimum mean-square error (WMMSE)-based digital precoding iteration. Simulation results show that our scheme brings effective ICI suppression and enhanced system capacity with controlled complexity.

eess.SP↗

arXiv2025

Leveraging Channel Knowledge Map for Multi-User Hierarchical Beam Training Under Position Uncertainty

Channel knowledge map (CKM) emerges as a promising framework to acquire location-specific channel information without consuming wireless resources, creating new horizons for advanced wireless network design and optimization. Despite its potential, the practical application of CKM in beam training faces several challenges. On one hand, the user's precise location is typically unavailable prior to beam training, which limits the utility of CKM since its effectiveness relies heavily on accurate input of position data. On the other hand, the intricate interplay among CKM, real-time observations, and training strategies has not been thoroughly studied, leading to suboptimal performance and difficulties in practical implementation. In this paper, we present a framework for CKM-aided beam training that addresses these limitations. For single-user scenario, we propose a reward-motivated beam-potential hierarchical strategy which integrates partial position information and CKM. This strategy models the user equipment (UE) position uncertainty and formulates the hierarchical searching process as a pruned binary search tree. An optimal hierarchical searching strategy with minimal overhead is derived by evaluating the weights and rewards of potential codewords. Furthermore, a low-complexity two-layer lookahead scheme is designed to balance overhead and computational demands. For multi-user scenario, we develop a correlation-driven position-pruning training scheme, where sidelobe gains from inter-user interference are exploited to provide additional side information for overhead reduction, allowing all users to be simultaneously assigned their respective supportive beams. Simulations validate the superior performances of proposed approaches in advancing 6G beam training.

cs.IT↗

arXiv2025

BeamCKM: A Framework of Channel Knowledge Map Construction for Multi-Antenna Systems

The channel knowledge map (CKM) enables efficient construction of high-fidelity mapping between spatial environments and channel parameters via electromagnetic information analysis. Nevertheless, existing studies are largely confined to single-antenna systems, failing to offer dedicated guidance for multi-antenna communication scenarios. To address the inherent conflict between traditional real-value pathloss map and multi-degree-of-freedom (DoF) coherent beamforming in B5G/6G systems, this paper proposes a novel concept of BeamCKM and CKMTransUNet architecture. The CKMTransUNet approach combines a UNet backbone for multi-scale feature extraction with a vision transformer (ViT) module to capture global dependencies among encoded linear vectors, utilizing a composite loss function to characterize the beam propagation characteristics. Furthermore, based on the CKMTransUNet backbone, this paper presents a methodology named M3ChanNet. It leverages the multi-modal learning technique and cross-attention mechanisms to extract intrinsic side information from environmental profiles and real-time multi-beam observations, thereby further improving the map construction accuracy. Simulation results demonstrate that the proposed method consistently outperforms state-of-the-art (SOTA) interpolation methods and deep learning (DL) approaches, delivering superior performance even when environmental contours are inaccurate. For reproducibility, the code is publicly accessible at https://github.com/github-whh/BeamCKM.

eess.SP↗

arXiv2025

InternData-A1: Pioneering High-Fidelity Synthetic Data for Pre-training Generalist Policy

Recent works explore how real and synthetic data contribute to Vision-Language-Action (VLA) models' generalization. While current VLA models have shown the strong effectiveness of large-scale real-robot pre-training, synthetic data has not previously demonstrated comparable capability at scale. This paper provides the first evidence that synthetic data alone can match the performance of the strongest $\pi$-dataset in pre-training a VLA model, revealing the substantial value of large-scale simulation. The resulting model also exhibits surprisingly zero-shot sim-to-real transfer on several challenging tasks. Our synthetic dataset, InternData-A1, contains over 630k trajectories and 7,433 hours across 4 embodiments, 18 skills, 70 tasks, and 227 scenes, covering rigid, articulated, deformable, and fluid-object manipulation. It is generated through a highly autonomous, fully decoupled, and compositional simulation pipeline that enables long-horizon skill composition, flexible task assembly, and heterogeneous embodiments with minimal manual tuning. Using the same architecture as $\pi_0$, we pre-train a model entirely on InternData-A1 and find that it matches the official $\pi_0$ across 49 simulation tasks, 5 real-world tasks, and 4 long-horizon dexterous tasks. We release the dataset and will open-source the generation pipeline to broaden access to large-scale robotic data and to lower the barrier to scalable data creation for embodied AI research.

cs.RO↗

arXiv2025

A New Targeted-Federated Learning Framework for Estimating Heterogeneity of Treatment Effects: A Robust Framework with Applications in Aging Cohorts

Analyzing data from multiple sources offers valuable opportunities to improve the estimation efficiency of causal estimands. However, this analysis also poses many challenges due to population heterogeneity and data privacy constraints. While several advanced methods for causal inference in federated settings have been developed in recent years, many focus on difference-based averaged causal effects and are not designed to study effect modification. In this study, we introduce a novel targeted-federated learning framework to study the heterogeneity of treatment effects (HTEs) for a targeted population by proposing a projection-based estimand. This HTE framework integrates information from multiple data sources without sharing raw data, while accounting for covariate distribution shifts among sources. Our proposed approach is shown to be doubly robust, conveniently supporting both difference-based estimands for continuous outcomes and odds ratio-based estimands for binary outcomes. Furthermore, we develop a communication-efficient bootstrap-based selection procedure to detect non-transportable data sources, thereby enhancing robust information aggregation without introducing bias. The superior performance of the proposed estimator over existing methods is demonstrated through extensive simulation studies, and the utility of our approach has been shown in a real-world data application using nationwide Medicare-linked data.

stat.ME↗

arXiv2025

Time-to-Event Modeling with Pseudo-Observations in Federated Settings

In multi-center clinical research, privacy regulations often prohibit pooling individual-level records, complicating the analysis of time-to-event data. Current federated survival methods frequently require iterative communication or rely strictly on proportional hazards (PH) assumptions or require sensitive survival information. We propose a one-shot federated framework using pseudo-observations derived from a sequentially updated Kaplan-Meier estimator and fitted via a renewable generalized estimating equation. Unlike traditional methods, our approach allows flexible link functions tailored to the target estimand and accommodates non-proportional hazards. To address site-level heterogeneity, we introduce a covariate-wise debiasing procedure that shrinks noise-driven local deviations toward the global estimate while preserving genuine site-specific effects. Simulation studies demonstrate that our framework achieves inferential accuracy comparable to pooled Cox regression and the privacy-preserving One-shot Distributed Algorithm to fit a multicenter Cox proportional hazards model (ODAC) under PH assumptions, while recovering time-varying coefficient trajectories when PH is violated. Furthermore, simulations confirm that the debiasing procedure optimizes the bias-variance trade-off, adaptively balancing global stability with the preservation of genuine site-specific deviations. Applied to pediatric obesity data from the Chicago Area Patient-Centered Outcomes Research Network (CAPriCORN) network ($N=45,865$), the model produced robust estimates of time-invariant and time-varying hazard ratios, offering a flexible, privacy-preserving alternative for collaborative survival research.

stat.AP↗

arXiv2025

Adaptive Proximal Causal Inference with Some Invalid Proxies

Proximal causal inference (PCI) is a recently proposed framework to identify and estimate the causal effect of an exposure on an outcome in the presence of hidden confounders, using observed proxies. Specifically, PCI relies on two types of proxies: a treatment-inducing confounding proxy, related to the outcome only through its association with unmeasured confounders (given treatment and covariates), and an outcome-inducing confounding proxy, related to the treatment only through such association (given covariates). These proxies must satisfy stringent exclusion restrictions - namely, the treatment proxy must not affect the outcome, and the outcome proxy must not be affected by the treatment. To improve identification and potentially efficiency, multiple proxies are often used, raising concerns about bias from exclusion violations. To address this, we introduce necessary and sufficient conditions for identifying causal effects in the presence of many proxies, some potentially invalid. Under a canonical proximal linear structural equations model, we propose a LASSO-based median estimator that jointly selects valid proxies and estimates the causal effect, with theoretical guarantees. Recognizing LASSO's limitations in consistently selecting valid treatment proxies, we develop an adaptive LASSO-based estimator with differential penalization. We show that it is root-n consistent and yields valid confidence intervals when a valid outcome proxy is available. We also extend the approach to settings with many potentially invalid outcome proxies. Theoretical results are supported by simulations and an application assessing the effect of right heart catheterization on 30-day survival in ICU patient.

stat.ME↗