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Xuelin Huang

Publications and source records attributed to Xuelin Huang.

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SurvFM enables tabular foundation models for right-censored survival prediction

General-purpose tabular foundation models can be adapted across prediction tasks, but right censoring leaves many event times unknown and prevents their direct use as regression labels. SurvFM converts censored follow-up into observation-level targets for restricted mean survival time (RMST), the expected event-free time accumulated up to a chosen horizon. These targets allow multiple tabular foundation models to predict RMST without architectural modification. In simulations with known RMST, SurvFM achieved leading RMST accuracy and competitive discrimination across heterogeneous settings. Its targets were more accurate than simpler outcome constructions, with larger gains as censoring increased. Across 55 public datasets, SurvFM models remained in the leading performance band under full and restricted training. Models fitted in either of two public myelodysplastic syndrome cohorts retained competitive performance in the other without refitting. SurvFM separates censoring handling from prediction architecture, allowing advances in general-purpose tabular prediction to enter survival analysis without model-specific redesign.

stat.ME

Comparison of Effect Size Measures for Mediation Analysis of Survival Outcomes with Application to the Framingham Heart Study

There is an increasing trend of research in mediation analysis for survival outcomes. Such analyses help researchers to better understand how exposure affects disease outcomes through mediators. However, due to censored observations in survival outcomes, it is not straightforward to extend mediation analysis from linear models to survival outcomes. In this article, we extend a mediation effect size measure based on $R^2$ in linear regression to survival outcomes. Due to multiple definitions of $R^2$ for survival models, we compare and evaluate five $R^2$ measures for mediation analysis. Based on extensive simulations, we recommend two $R^2$ measures with good operating characteristics. We illustrate the utility of the $R^2$-based mediation measures by analyzing the mediation effects of multiple lifestyle risk factors on the relationship between environmental exposures and time to coronary heart disease and all-cause mortality in the Framingham Heart Study.

stat.ME

Evidence synthesis with reconstructed survival data

We present a general approach to synthesizing evidence of time-to-event endpoints in meta-analyses of aggregate data (AD). Our work goes beyond most previous meta-analytic research by using reconstructed survival data as a source of information. A Bayesian multilevel regression model, called the "meta-analysis of reconstructed survival data" (MARS), is introduced, by modeling and integrating reconstructed survival information with other types of summary data, to estimate the hazard ratio function and survival probabilities. The method attempts to reduce selection bias, and relaxes the presumption of proportional hazards in individual clinical studies from the conventional approaches restricted to hazard ratio estimates. Theoretically, we establish the asymptotic consistency of MARS, and investigate its relative efficiency with respect to the individual participant data (IPD) meta-analysis. In simulation studies, the MARS demonstrated comparable performance to IPD meta-analysis with minor deviation from the true values, suggesting great robustness and efficiency achievable in AD meta-analysis with finite sample. Finally, we applied MARS in a meta-analysis of acute myeloid leukemia to assess the association of minimal residual disease with survival, to help respond to FDA's emerging concerns on translational use of surrogate biomarker in drug development of hematologic malignancies.

stat.ME