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Xueqin Yan

Publications and source records attributed to Xueqin Yan.

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Effects of realistic laser intensity and phase distribution on high-charge laser wakefield acceleration

Laser wakefield acceleration (LWFA) can produce relativistic electron beams and various secondary particles in centimeter-long plasmas, making it a valuable particle source with important applications in many disciplines. In this work, we examine the effects of non-ideal transverse intensity and phase distribution of laser pulses on LWFA through both experimental measurements and particle-in-cell simulations. The complex transverse profile of the 75 TW laser pulses reduces the self-focused intensity in plasma compared with a transversely Gaussian laser. Furthermore, the sheath structure of the nonlinear plasma wake excited by realistic laser pulses is wider and more complicated than that of a Gaussian laser. These hinder the injection of the plasma electrons. As the laser pulse propagates through the plasma, its intensity profile gradually becomes elliptical and drives a plasma wake with a sharp sheath near the azimuths of the major axis, leading to an injection. When using a realistic laser profile in simulations, both the charge and energy of injected electrons closely match experimental results ($\sim200$ pC of charge and $\sim 200$ MeV peak energy), whereas the Gaussian laser simulations produce much higher charge ($\sim500$ pC). Our findings reveal the difference in injection dynamics between LWFA driven by non-ideal laser pulses and those driven by Gaussian pulses, and are useful for applications of LWFA which demand high-charge electron beams.

physics.plasm-ph

Current Views on Mechanisms of the FLASH Effect in Cancer Radiotherapy

FLASH radiotherapy (FLASH-RT) is a new modality of radiotherapy by delivering doses with ultra-high dose rates. FLASH-RT has the ability to suppress tumor growth while sparing normal tissues, known as the FLASH effect. Although FLASH effect has proved valid in various models by different ionizing radiations, the exact underlying mechanism is still unclear. This article summarizes mainstream hypotheses of FLASH effect at physicochemical and biological levels, including oxygen depletion and free radical reactions, nuclear and mitochondria damage, as well as immune response. These hypotheses contribute reasonable explanations to the FLASH effect, and are interconnected according to the chronological order of the organism's response to ionizing radiation. By collating the existing consensus, evidence, and hypotheses, this article provides a comprehensive overview of potential mechanisms of FLASH effect and practical guidance for future investigation in the field of FLASH-RT.

physics.med-ph