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Yangyang Yu

Publications and source records attributed to Yangyang Yu.

38 records · Page 3Linked to original sources

Actively learning a Bayesian matrix fusion model with deep side information

High-dimensional deep neural network representations of images and concepts can be aligned to predict human annotations of diverse stimuli. However, such alignment requires the costly collection of behavioral responses, such that, in practice, the deep-feature spaces are only ever sparsely sampled. Here, we propose an active learning approach to adaptively sampling experimental stimuli to efficiently learn a Bayesian matrix factorization model with deep side information. We observe a significant efficiency gain over a passive baseline. Furthermore, with a sequential batched sampling strategy, the algorithm is applicable not only to small datasets collected from traditional laboratory experiments but also to settings where large-scale crowdsourced data collection is needed to accurately align the high-dimensional deep feature representations derived from pre-trained networks.

cs.AI↗

Transition behavior of the seizure dynamics modulated by the astrocyte inositol triphosphate noise

Epilepsy is a neurological disorder with recurrent seizures of complexity and randomness. Until now, the mechanism of epileptic randomness has not been fully elucidated. Inspired by the recent finding that astrocyte GTPase-activating protein (G-protein)-coupled receptors could be involved in stochastic epileptic seizures, we proposed a neuron-astrocyte network model, incorporating the noise of the astrocytic second messager, inositol triphosphate (IP3) which is modulated by the G-protein)-coupled receptor activation. Based on this model, we have statistically analysed the transitions of epileptic seizures by performing tens of simulation trials. Our simulation results show that the increase of the IP3 noise intensity induces the depolarization-block epileptic seizures together with an increase in neuronal firing frequency. Meanwhile, a bistable state of neuronal firing emerges under certain noise intensity, during which the neuronal firing pattern switches between regular sparse spiking and epileptic seizure states. This random presence of epileptic seizures is absent when the noise intensity continues to increase, accompanying with an increase in the epileptic depolarization block duration. The simulation results also shed light on the fact that calcium signals in astrocytes play significant roles in the pattern formations of the epileptic seizure. Our results provide a potential pathway for understanding the epileptic randomness.

q-bio.NC↗