arXiv subjects

Yansong Shi

Publications and source records attributed to Yansong Shi.

10 recordsLinked to original sources

arXiv2026

Multimodal reasoning for broadly neutralizing antibody discovery from label-free human B cell repertoires across virus families

Discovering broadly neutralizing antibodies (bnAbs) from human natural immune repertoires remains a fundamental challenge in immunology, hindered by: the extreme rarity of bnAb, incomplete understanding of their cellular origins across pathogens, and the inability of existing computational tools to generalize across emerging viral threats. Here we present ImmuneAgent, a closed-loop AI system that integrates multimodal reasoning with continual meta-learning and wet-lab feedback to overcome these barriers. Applied to screen the natural BCR repertoires from vaccinated or infected cohorts, the system achieves a ~55% neutralization antibody discovery rate (60 of 110 cloned candidates) and a ~11% bnAb yield (12 of 110), substantially outperforming a state-of-the-art sequence-based neutralization predictor or cofolding models evaluated at the same cloning budget. Five ImmuneAgent-discovered antibodies conferred 100% in vivo protection against lethal influenza challenge, comparable to the clinical-stage therapeutic MEDI8852. The system recovered the cellular and structural determinants of bnAb activity and identified FCRL5+CD27+ atypical memory B cells as a conserved bnAb reservoir and hydrophobic interface enrichment as a cross-viral structural signature, which generalized to unseen antigens, discovering human metapneumovirus (hMPV) cross-neutralizing and human papillomavirus (HPV)-neutralizing antibodies without antigen-specific sorting. These results validate that ImmuneAgent is a generalizable framework for rapid therapeutic antibody discovery against emerging viral threats.

q-bio.QM↗

arXiv2026

OneStreamer: Unifying Perception, Memory, and Proactive Response in Streaming Video Interaction

Streaming video LLMs must retain evidence before its relevance to future tasks is known and respond when sufficient evidence becomes available. The challenge is to form reusable factual memory without compromising real-time perception. We introduce OneStreamer, which jointly learns query-independent evidence recording and task response through a shared proactive generation process. Its Proactive Hierarchical Caption Memory (PHCM) produces time-grounded local-detail captions and summaries of completed events. Streaming caption targets supervise the interpretation of observed video prefixes during training. At inference, model-generated records complement a recent visual window, providing reusable factual context without revisiting historical visual features. Proactive State Transition Learning (PSTL) reduces the dominance of repeated waiting states by preserving supervision at all output anchors and selecting representative state-change and state-persistence tokens. We further develop a streaming data synthesis pipeline that aligns output content and timing with available evidence. Combining the resulting streaming captions and QA with cleaned open-source data yields OneStreamer-1M, a broad-coverage streaming video interaction dataset with over one million records spanning diverse tasks. Our 4B model achieves the best results among the compared methods across all eight evaluated streaming video understanding benchmarks. Ablations show that retaining generated captions improves historical QA without degrading real-time perception. PSTL also outperforms dense state supervision while supervising only 27.5% of annotated state tokens. Together, these results support proactive generation as a shared learning interface connecting perception, memory formation, and timely response in streaming video interaction.

cs.CV↗

arXiv2026

Benchmarking and Enhancing Skill-Level Memory for Partially Observable Robotic Manipulation

Recent advances in robot learning have enabled manipulation policies to perform increasingly diverse tasks and generalize across environments. However, reliable execution often depends on hidden task states that cannot be determined from current observations alone, making interaction history essential. We introduce $HIDE$, a benchmark for evaluating manipulation memory under partial observability. HIDE comprises 15 tasks covering repetition counting, historical-state recall, and execution-progress tracking, with randomized initial configurations and decision points where similar observations require different actions depending on prior events. We further propose $SEEK$, a framework combining three complementary memory mechanisms to retain historical evidence and track execution state. Evaluations reveal substantial limitations in existing policies on HIDE, while memory augmentation improves task success in both simulation and real-world experiments. Individual mechanisms benefit some tasks but can degrade others; their combination achieves the highest average success rate on HIDE among the evaluated configurations. These findings highlight the importance of maintaining internal representations of hidden task states and matching memory design to task-specific information requirements.

cs.RO↗

arXiv2026

Mitigating Popularity Bias in Recommendation with Global Listwise Learning and Progressive Bi-Weighting

In recommender systems, user feedback typically follows a long-tail distribution, which leads many recommendation algorithms to exacerbate popularity bias by disproportionately favoring popular items. To mitigate this issue, recent studies have employed Inverse Propensity Scoring (IPS) to rebalance training data via reweighting user-item interactions. However, the effectiveness of IPS-based approaches is often constrained by locally unbiased objectives and inaccurate propensity estimation. In this paper, we propose Multinomial Likelihood with Bi-Weighting (Mult-BiW) to address these limitations. First, we introduce a debiasing framework, termed Mult-IPS, which integrates multinomial likelihood with IPS to capture global and unbiased user preferences over the entire item set. Second, we develop a Bi-Weighting (BiW) strategy that jointly leverages propensity scores and a collection model, incorporating a smoothing mechanism to enhance the robustness of propensity estimation. We further provide theoretical analyses that establish an upper bound on the empirical bias and characterize the optimal form of the collection model. Third, to mitigate the adverse effects of aggressive reweighting on representation learning, we design a Progressive Bi-Weighting strategy that gradually transitions from discriminative representation learning to popularity debiasing. Extensive experiments on real-world datasets show that Mult-BiW consistently outperforms state-of-the-art baselines.

cs.IR↗

arXiv2026

VideoChat3: Fully Open Video MLLM for Efficient and Generalist Video Understanding

Recent advances in video understanding have spanned motion, long video, and streaming interaction, driving this field toward real-world applications. Despite this progress, current open-source models remain limited in several ways. They often struggle to generalize across diverse video types, making them effective only in specific domains. High computational demands further restrict their efficiency and scalability. Moreover, most models are only partially open, with key components such as training code, strategy, or datasets unavailable, which hinders reproducibility and slows community-driven development. To address these issues, we introduce VideoChat3, a fully open, efficient, and generalist video-centric MLLM. VideoChat3 advances video understanding through two complementary designs. For efficiency, we introduce Inflated 3D Vision Transformer (I3D-ViT) and Adaptive Frame Resolution for Streaming Video Perception, which enables efficient spatiotemporal representation and reduces the cost of processing video inputs during training and inference. For effectiveness, we develop a scalable video data synthesis pipeline that curates three diverse, high-quality training datasets: VideoChat3-Academic2M, VideoChat3-LV116K, and VideoChat3-OL617K, covering general, long-form, and streaming video scenarios, improving the model's generalization across domains. By integrating these designs, VideoChat3 achieves a rare balance of broad generalization and computational efficiency. Experiments across general, long-form, and streaming benchmarks demonstrate that VideoChat3 surpasses prior open-source models with equal or larger parameter counts with only 4B parameters and higher efficiency.

cs.CV↗

arXiv2026

CoMo: Learning Continuous Latent Motion from Internet Videos for Scalable Robot Learning

Unsupervised learning of latent motion from Internet videos is crucial for robot learning. Existing discrete methods generally mitigate the shortcut learning caused by extracting excessive static backgrounds through vector quantization with a small codebook size. However, they suffer from information loss and struggle to capture more complex and fine-grained dynamics. Moreover, there is an inherent gap between the distribution of discrete latent motion and continuous robot action, which hinders the joint learning of a unified policy. We propose CoMo, which aims to learn more precise continuous latent motion from internet-scale videos. CoMo employs an early temporal difference (Td) mechanism to increase the shortcut learning difficulty and explicitly enhance motion cues. Additionally, to ensure latent motion better captures meaningful foregrounds, we further propose a temporal contrastive learning (Tcl) scheme. Specifically, positive pairs are constructed with a small future frame temporal offset, while negative pairs are formed by directly reversing the temporal direction. The proposed Td and Tcl work synergistically and effectively ensure that the latent motion focuses better on the foreground and reinforces motion cues. Critically, CoMo exhibits strong zeroshot generalization, enabling it to generate effective pseudo action labels for unseen videos. Extensive simulated and real-world experiments show that policies co-trained with CoMo pseudo action labels achieve superior performance with both diffusion and auto-regressive architectures.

cs.CV↗

arXiv2026

RIVER: A Real-Time Interaction Benchmark for Video LLMs

The rapid advancement of multimodal large language models has demonstrated impressive capabilities, yet nearly all operate in an offline paradigm, hindering real-time interactivity. Addressing this gap, we introduce the Real-tIme Video intERaction Bench (RIVER Bench), designed for evaluating online video comprehension. RIVER Bench introduces a novel framework comprising Retrospective Memory, Live-Perception, and Proactive Anticipation tasks, closely mimicking interactive dialogues rather than responding to entire videos at once. We conducted detailed annotations using videos from diverse sources and varying lengths, and precisely defined the real-time interactive format. Evaluations across various model categories reveal that while offline models perform well in single question-answering tasks, they struggle with real-time processing. Addressing the limitations of existing models in online video interaction, especially their deficiencies in long-term memory and future perception, we proposed a general improvement method that enables models to interact with users more flexibly in real time. We believe this work will significantly advance the development of real-time interactive video understanding models and inspire future research in this emerging field. Datasets and code are publicly available at https://github.com/OpenGVLab/RIVER.

cs.CV↗

arXiv2025

TimeSuite: Improving MLLMs for Long Video Understanding via Grounded Tuning

Multimodal Large Language Models (MLLMs) have demonstrated impressive performance in short video understanding. However, understanding long-form videos still remains challenging for MLLMs. This paper proposes TimeSuite, a collection of new designs to adapt the existing short-form video MLLMs for long video understanding, including a simple yet efficient framework to process long video sequence, a high-quality video dataset for grounded tuning of MLLMs, and a carefully-designed instruction tuning task to explicitly incorporate the grounding supervision in the traditional QA format. Specifically, based on VideoChat, we propose our long-video MLLM, coined as VideoChat-T, by implementing a token shuffling to compress long video tokens and introducing Temporal Adaptive Position Encoding (TAPE) to enhance the temporal awareness of visual representation. Meanwhile, we introduce the TimePro, a comprehensive grounding-centric instruction tuning dataset composed of 9 tasks and 349k high-quality grounded annotations. Notably, we design a new instruction tuning task type, called Temporal Grounded Caption, to peform detailed video descriptions with the corresponding time stamps prediction. This explicit temporal location prediction will guide MLLM to correctly attend on the visual content when generating description, and thus reduce the hallucination risk caused by the LLMs. Experimental results demonstrate that our TimeSuite provides a successful solution to enhance the long video understanding capability of short-form MLLM, achieving improvement of 5.6% and 6.8% on the benchmarks of Egoschema and VideoMME, respectively. In addition, VideoChat-T exhibits robust zero-shot temporal grounding capabilities, significantly outperforming the existing state-of-the-art MLLMs. After fine-tuning, it performs on par with the traditional supervised expert models.

cs.CV↗

arXiv2024

InternVideo2: Scaling Foundation Models for Multimodal Video Understanding

We introduce InternVideo2, a new family of video foundation models (ViFM) that achieve the state-of-the-art results in video recognition, video-text tasks, and video-centric dialogue. Our core design is a progressive training approach that unifies the masked video modeling, crossmodal contrastive learning, and next token prediction, scaling up the video encoder size to 6B parameters. At the data level, we prioritize spatiotemporal consistency by semantically segmenting videos and generating video-audio-speech captions. This improves the alignment between video and text. Through extensive experiments, we validate our designs and demonstrate superior performance on over 60 video and audio tasks. Notably, our model outperforms others on various video-related dialogue and long video understanding benchmarks, highlighting its ability to reason and comprehend longer contexts. Code and models are available at https://github.com/OpenGVLab/InternVideo/tree/main/InternVideo2/.

cs.CV↗

arXiv2023

Collaboration and Transition: Distilling Item Transitions into Multi-Query Self-Attention for Sequential Recommendation

Modern recommender systems employ various sequential modules such as self-attention to learn dynamic user interests. However, these methods are less effective in capturing collaborative and transitional signals within user interaction sequences. First, the self-attention architecture uses the embedding of a single item as the attention query, making it challenging to capture collaborative signals. Second, these methods typically follow an auto-regressive framework, which is unable to learn global item transition patterns. To overcome these limitations, we propose a new method called Multi-Query Self-Attention with Transition-Aware Embedding Distillation (MQSA-TED). First, we propose an $L$-query self-attention module that employs flexible window sizes for attention queries to capture collaborative signals. In addition, we introduce a multi-query self-attention method that balances the bias-variance trade-off in modeling user preferences by combining long and short-query self-attentions. Second, we develop a transition-aware embedding distillation module that distills global item-to-item transition patterns into item embeddings, which enables the model to memorize and leverage transitional signals and serves as a calibrator for collaborative signals. Experimental results on four real-world datasets demonstrate the effectiveness of the proposed modules.

cs.IR↗