arXiv subjects

Yaojun Hu

Publications and source records attributed to Yaojun Hu.

12 recordsLinked to original sources

arXiv2026

SeVeR: Selective Visual Exposure and Retrieval for 3D Medical Image Question Answering

Volumetric medical VQA requires reasoning over long and redundant 3D visual token sequences, especially in multi-sequence MRI where complementary modalities provide diverse diagnostic cues but expose the decoder to many repeated anatomical regions. To investigate reasoning under multi-sequence visual redundancy, we first introduce BreMRIs-VQA, a clinically curated breast MRI benchmark with 1.19M QA pairs from 71.0K sequences and 12.9K patients, covering both free-text and multiple-choice questions. We further propose SeVeR, a selective visual exposure framework that compresses dense volumes into modality-wise prototypes and retrieves complementary multi-level evidence with change-aware gated attention during decoding, trained with a marginal-utility self-consistency objective that suppresses unhelpful retrieval. Experiments on BreMRIs-VQA and public benchmarks show that SeVeR improves both discriminative and generative performance while exposing substantially fewer visual tokens.

cs.CV↗

arXiv2026

D3O: Dynamic Distribution Distillation for Ordinal Regression

Ordinal regression is widely used in scenarios where labels are discrete yet inherently ordered. In practice, however, ordinal labels are often obtained by discretizing underlying continuous semantics through subjective human judgment, resulting in ambiguous boundaries and annotation noise. Such uncertainty challenges existing methods that rely on fixed supervision targets, which may reinforce biased ordering under subjective annotations. To address this limitation, we propose D3O, a dynamic distribution distillation framework that replaces static supervision with training-driven evolution of ordinal label distributions via self-distillation. Specifically, we introduce a contrastive ordinal-aware label enhancement module that leverages vision-language alignment to recover refined label distributions capturing both inter-class ambiguity and instance-level uncertainty. Furthermore, we design a CDF-based cross-layer interaction distillation mechanism to propagate cumulative ordinal structure across network hierarchy, ensuring consistent ordinal geometry in intermediate representations. Extensive experiments on four general ordinal regression tasks demonstrate that our proposed D3O consistently outperforms existing approaches, particularly under severe class imbalance and noisy supervision. These results highlight the effectiveness of dynamic supervision in learning robust ordinal representations beyond fixed targets. The code will be publicly available.

cs.CV↗

arXiv2026

HyperVLP: Enhancing Hierarchical Surgical Video-Language Pre-training in Hyperbolic Space

Surgical vision-language foundation models typically adopt educational materials, such as surgical lecture videos, to transfer surgical knowledge encoded in language into visual representations. These knowledge are multi-dimensional and hierarchical: fine-grained action cues appear in narration, mid-level key steps are summarized in subsection headings, and global procedural context, such as patient history and surgical strategy, is described in abstract texts. Prior work largely collapses these heterogeneous signals into a single flat embedding space, implicitly assuming independence across hierarchy levels. However, this is suboptimal because it ignores cross-level semantic containment, e.g., actions belong to steps, steps compose phases, weakens long-range dependency modeling. To this end, we propose a hyperbolic surgical video-language pre-training framework that explicitly preserves the hierarchical structure by mitigating structural false negatives induced by procedural context and enforcing semantic consistency between parent phases and their constituent child steps. Extensive experiments on multiple surgical benchmarks show consistent gains in zero- and few-shot phase recognition across procedures and institutions.

cs.CV↗

arXiv2026

BreastGPT: A Multimodal Large Language Model for the Full Spectrum of Breast Cancer Clinical Routine

Breast cancer remains a leading cause of cancer-related mortality among women. Its clinical management requires multimodal reasoning across a clinical workflow that spans \textit{screening}, \textit{diagnosis} and \textit{treatment planning}, where each stage involves distinct imaging modalities, task objectives, and reasoning patterns. However, constrained by data scarcity and model versatility, existing medical MLLMs are typically evaluated on isolated modalities or narrow task families, limiting their ability to support workflow-level clinical reasoning. In this work, we first introduce \textbf{BreastStage}, a workflow-aligned breast imaging instruction corpus comprising 1.86M instruction-following pairs curated from 17 sub-datasets across 5 imaging modalities and 136 task templates. Its held-out split, \textbf{BreastStage-Bench}, provides a comprehensive benchmark for evaluating multimodal reasoning across the breast cancer care continuum. Building on this corpus, we propose \textbf{BreastGPT}, a unified MLLM equipped with a dual-branch visual encoder and concept-preserving token compression to bridge the scale gap between standard radiology and gigapixel pathology. On BreastStage-Bench, BreastGPT achieves 75.66\% closed-ended accuracy and 89.92\% open-ended score, outperforming both general-purpose and medical-specific MLLMs across clinical stages and task formats. These results suggest that workflow-aligned data and cross-scale visual modeling are critical for clinically grounded medical MLLMs. All data, code, and model checkpoints are released at https://yangyy-liu.github.io/BreastGPT.io.

cs.CV↗

arXiv2025

NEF-NET+: Adapting Electrocardio panorama in the wild

Conventional multi-lead electrocardiogram (ECG) systems capture cardiac signals from a fixed set of anatomical viewpoints defined by lead placement. However, certain cardiac conditions (e.g., Brugada syndrome) require additional, non-standard viewpoints to reveal diagnostically critical patterns that may be absent in standard leads. To systematically overcome this limitation, Nef-Net was recently introduced to reconstruct a continuous electrocardiac field, enabling virtual observation of ECG signals from arbitrary views (termed Electrocardio Panorama). Despite its promise, Nef-Net operates under idealized assumptions and faces in-the-wild challenges, such as long-duration ECG modeling, robustness to device-specific signal artifacts, and suboptimal lead placement calibration. This paper presents NEF-NET+, an enhanced framework for realistic panoramic ECG synthesis that supports arbitrary-length signal synthesis from any desired view, generalizes across ECG devices, and compensates for operator-induced deviations in electrode placement. These capabilities are enabled by a newly designed model architecture that performs direct view transformation, incorporating a workflow comprising offline pretraining, device calibration tuning steps as well as an on-the-fly calibration step for patient-specific adaptation. To rigorously evaluate panoramic ECG synthesis, we construct a new Electrocardio Panorama benchmark, called Panobench, comprising 5367 recordings with 48-view per subject, capturing the full spatial variability of cardiac electrical activity. Experimental results show that NEF-NET+ delivers substantial improvements over Nef-Net, yielding an increase of around 6 dB in PSNR in real-world setting. The code and Panobench will be released in a subsequent publication.

eess.SP↗

arXiv2024

AnyECG: Foundational Models for Multitask Cardiac Analysis in Real-World Settings

Electrocardiogram (ECG), a non-invasive and affordable tool for cardiac monitoring, is highly sensitive in detecting acute heart attacks. However, due to the lengthy nature of ECG recordings, numerous machine learning methods have been developed for automated heart disease detection to reduce human workload. Despite these efforts, performance remains suboptimal. A key obstacle is the inherent complexity of ECG data, which includes heterogeneity (e.g., varying sampling rates), high levels of noise, demographic-related pattern shifts, and intricate rhythm-event associations. To overcome these challenges, this paper introduces AnyECG, a foundational model designed to extract robust representations from any real-world ECG data. Specifically, a tailored ECG Tokenizer encodes each fixed-duration ECG fragment into a token and, guided by proxy tasks, converts noisy, continuous ECG features into discrete, compact, and clinically meaningful local rhythm codes. These codes encapsulate basic morphological, frequency, and demographic information (e.g., sex), effectively mitigating signal noise. We further pre-train the AnyECG to learn rhythmic pattern associations across ECG tokens, enabling the capture of cardiac event semantics. By being jointly pre-trained on diverse ECG data sources, AnyECG is capable of generalizing across a wide range of downstream tasks where ECG signals are recorded from various devices and scenarios. The experimental results show that AnyECG achieves an average performance improvement of 6% across four critical tasks-anomaly detection, arrhythmia classification, corrupted lead generation, and ultra-long ECG recognition. AnyECG learns common ECG rhythm from data and significantly outperforms state-of-the-art methods in each of these tasks.

eess.SP↗

arXiv2024

DrugCLIP: Contrastive Drug-Disease Interaction For Drug Repurposing

Bringing a novel drug from the original idea to market typically requires more than ten years and billions of dollars. To alleviate the heavy burden, a natural idea is to reuse the approved drug to treat new diseases. The process is also known as drug repurposing or drug repositioning. Machine learning methods exhibited huge potential in automating drug repurposing. However, it still encounter some challenges, such as lack of labels and multimodal feature representation. To address these issues, we design DrugCLIP, a cutting-edge contrastive learning method, to learn drug and disease's interaction without negative labels. Additionally, we have curated a drug repurposing dataset based on real-world clinical trial records. Thorough empirical studies are conducted to validate the effectiveness of the proposed DrugCLIP method.

cs.LG↗

arXiv2024

TrialBench: Multi-Modal Artificial Intelligence-Ready Clinical Trial Datasets

Clinical trials are pivotal for developing new medical treatments but typically carry risks such as patient mortality and enrollment failure that waste immense efforts spanning over a decade. Applying artificial intelligence (AI) to predict key events in clinical trials holds great potential for providing insights to guide trial designs. However, complex data collection and question definition requiring medical expertise have hindered the involvement of AI thus far. This paper tackles these challenges by presenting a comprehensive suite of 23 meticulously curated AI-ready datasets covering multi-modal input features and 8 crucial prediction challenges in clinical trial design, encompassing prediction of trial duration, patient dropout rate, serious adverse event, mortality rate, trial approval outcome, trial failure reason, drug dose finding, design of eligibility criteria. Furthermore, we provide basic validation methods for each task to ensure the datasets' usability and reliability. We anticipate that the availability of such open-access datasets will catalyze the development of advanced AI approaches for clinical trial design, ultimately advancing clinical trial research and accelerating medical solution development.

cs.LG↗

arXiv2024

Fair Evaluation of Federated Learning Algorithms for Automated Breast Density Classification: The Results of the 2022 ACR-NCI-NVIDIA Federated Learning Challenge

The correct interpretation of breast density is important in the assessment of breast cancer risk. AI has been shown capable of accurately predicting breast density, however, due to the differences in imaging characteristics across mammography systems, models built using data from one system do not generalize well to other systems. Though federated learning (FL) has emerged as a way to improve the generalizability of AI without the need to share data, the best way to preserve features from all training data during FL is an active area of research. To explore FL methodology, the breast density classification FL challenge was hosted in partnership with the American College of Radiology, Harvard Medical School's Mass General Brigham, University of Colorado, NVIDIA, and the National Institutes of Health National Cancer Institute. Challenge participants were able to submit docker containers capable of implementing FL on three simulated medical facilities, each containing a unique large mammography dataset. The breast density FL challenge ran from June 15 to September 5, 2022, attracting seven finalists from around the world. The winning FL submission reached a linear kappa score of 0.653 on the challenge test data and 0.413 on an external testing dataset, scoring comparably to a model trained on the same data in a central location.

eess.IV↗

arXiv2024

Personalized Heart Disease Detection via ECG Digital Twin Generation

Heart diseases rank among the leading causes of global mortality, demonstrating a crucial need for early diagnosis and intervention. Most traditional electrocardiogram (ECG) based automated diagnosis methods are trained at population level, neglecting the customization of personalized ECGs to enhance individual healthcare management. A potential solution to address this limitation is to employ digital twins to simulate symptoms of diseases in real patients. In this paper, we present an innovative prospective learning approach for personalized heart disease detection, which generates digital twins of healthy individuals' anomalous ECGs and enhances the model sensitivity to the personalized symptoms. In our approach, a vector quantized feature separator is proposed to locate and isolate the disease symptom and normal segments in ECG signals with ECG report guidance. Thus, the ECG digital twins can simulate specific heart diseases used to train a personalized heart disease detection model. Experiments demonstrate that our approach not only excels in generating high-fidelity ECG signals but also improves personalized heart disease detection. Moreover, our approach ensures robust privacy protection, safeguarding patient data in model development.

cs.LG↗

arXiv2024

Small Models are LLM Knowledge Triggers on Medical Tabular Prediction

Recent development in large language models (LLMs) has demonstrated impressive domain proficiency on unstructured textual or multi-modal tasks. However, despite with intrinsic world knowledge, their application on structured tabular data prediction still lags behind, primarily due to the numerical insensitivity and modality discrepancy that brings a gap between LLM reasoning and statistical tabular learning. Unlike textual or vision data (e.g., electronic clinical notes or medical imaging data), tabular data is often presented in heterogeneous numerical values (e.g., CBC reports). This ubiquitous data format requires intensive expert annotation, and its numerical nature limits LLMs' capability to effectively transfer untapped domain expertise. In this paper, we propose SERSAL, a general self-prompting method by synergy learning with small models to enhance LLM tabular prediction in an unsupervised manner. Specifically, SERSAL utilizes the LLM's prior outcomes as original soft noisy annotations, which are dynamically leveraged to teach a better small student model. Reversely, the outcomes from the trained small model are used to teach the LLM to further refine its real capability. This process can be repeatedly applied to gradually distill refined knowledge for continuous progress. Comprehensive experiments on widely used medical domain tabular datasets show that, without access to gold labels, applying SERSAL to OpenAI GPT reasoning process attains substantial improvement compared to linguistic prompting methods, which serves as an orthogonal direction for tabular LLM, and increasing prompting bonus is observed as more powerful LLMs appear.

cs.CL↗

arXiv2022

Asymmetric Dual-Decoder U-Net for Joint Rain and Haze Removal

This work studies the joint rain and haze removal problem. In real-life scenarios, rain and haze, two often co-occurring common weather phenomena, can greatly degrade the clarity and quality of the scene images, leading to a performance drop in the visual applications, such as autonomous driving. However, jointly removing the rain and haze in scene images is ill-posed and challenging, where the existence of haze and rain and the change of atmosphere light, can both degrade the scene information. Current methods focus on the contamination removal part, thus ignoring the restoration of the scene information affected by the change of atmospheric light. We propose a novel deep neural network, named Asymmetric Dual-decoder U-Net (ADU-Net), to address the aforementioned challenge. The ADU-Net produces both the contamination residual and the scene residual to efficiently remove the rain and haze while preserving the fidelity of the scene information. Extensive experiments show our work outperforms the existing state-of-the-art methods by a considerable margin in both synthetic data and real-world data benchmarks, including RainCityscapes, BID Rain, and SPA-Data. For instance, we improve the state-of-the-art PSNR value by 2.26/4.57 on the RainCityscapes/SPA-Data, respectively. Codes will be made available freely to the research community.

cs.CV↗