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Yefeng Zheng

Publications and source records attributed to Yefeng Zheng.

At least 19 recordsLinked to original sources

Test-Time Adaptation for ECG Classification via SQI-Gated Self-Training and Beat-Rhythm Consistency

Deep learning models for electrocardiogram (ECG) classification often suffer from significant performance degradation when deployed in unseen domains due to shifts in acquisition devices and patient populations. Test-time adaptation (TTA) offers a practical solution by adapting models using only unlabeled data at inference time. However, existing TTA methods often underperform on ECG tasks, since naive online updates ignore the hierarchical beat-rhythm structure of cardiac cycles and are vulnerable to signal artifacts, which leads to unstable adaptation and model drift. We propose BeatRhythm-TTA, an ECG-tailored TTA framework that explicitly accounts for ECG's noisy observations and structured beat-rhythm semantics under domain shift. First, to handle pervasive ECG artifacts, we introduce a Signal Quality Index (SQI)-gated adaptation scheme that selectively filters out low-quality signals to prevent harmful updates. Second, to leverage ECG's beat-rhythm semantics, we enforce dual-level consistency so the model preserves beat morphology and rhythm dynamics while adapting to shifted acquisition conditions. Extensive experiments on multi-label ECG diagnosis across three adaptation protocols, using PTB-XL as the source domain and CPSC2018/Georgia as two target domains, demonstrate the effectiveness of our method, yielding an average +2.70% relative improvement in Macro-F1 over the best competing method.

cs.LG

Volumetric Radiology AI in the Era of Multimodal Large Language Models

Advances in multimodal large language models (MLLMs) are extending radiological artificial intelligence (AI) beyond task-specific image analysis toward multimodal understanding and reasoning. Volumetric radiology, however, presents a fundamental representational mismatch: clinical interpretation often requires full-volume spatial context and acquisition-dependent quantitative information, whereas current MLLMs are commonly conditioned on selected two-dimensional (2D) images, compressed visual representations, or report-derived text. Reliable volumetric radiology AI therefore requires representations that preserve task-relevant three-dimensional (3D) information and systems that can access, verify, and integrate this information across clinical workflows. In this Review, we examine more than 200 publications through July 2026. We organize the literature around volumetric representation and multimodal understanding at the model level, agentic orchestration at the system level, and their links to clinical applications and evaluation. We review volumetric foundation models, language alignment and compression strategies, and agentic systems that extend MLLMs through planning, tools, memory, and workflow interaction. We distinguish settings in which selected 2D views or report-mediated reasoning may suffice from those that warrant native volumetric modeling. We also introduce a Claim-Design-Validation framework to assess whether technical, workflow, and clinical claims are matched by appropriate design and validation. Across the literature, native volumetric modeling and agentic capabilities depend on the spatial, quantitative, contextual, and workflow requirements of the intended task. Clinical credibility requires faithful volumetric representation, traceable system behavior, claim-aligned validation, and clearly defined human oversight in realistic workflows.

cs.AI

Open-Linguistic Concept Unified Learning for Cross-Site Interpretable Dermatology Image Diagnosis

Human-interpretable computer-aided diagnosis is crucial for clinical decision making. Concept-based models excel by providing transparent reasoning and enabling post-hoc, clinician-in-the-loop interventions. However, their rigid dataset-specific adaptation inherently restricts cross-site generalization. Applying them across diverse modalities, such as dermoscopic and clinical photographs, is challenging due to heterogeneous concept taxonomies varying in availability, granularity, and semantics across cohorts. Consequently, adapting Foundation Vision-Language Models (FVLMs) demands costly label engineering and repeated post-training. Existing intervention mechanisms remain rigidly tied to predefined concepts, lacking adaptability and hindering scalable dermatology CAD deployment. To address these bottlenecks, we propose UniCon, an open-linguistic unified concept learning framework for multimodal interpretable vision-language diagnosis. UniCon resolves these challenges through three contributions: (1) A shared semantic representation space via a unified concept prototype codebook, seamlessly coordinating heterogeneous concept systems across modalities without dataset-specific retraining. (2) Open-linguistic based multi-faceted semantic specifications to overcome sparse textual label limitations, improving boundary sensitivity in uncertain clinical contexts. (3) A robust, cross-site adjustable intervention interface powered by reliability-gated bottleneck aggregation, enabling consistent reasoning and transferable clinician corrections. Extensive experiments demonstrate that beyond securing top-tier diagnostic accuracy, UniCon successfully bridges disparate clinical taxonomies, unlocking unprecedented cross-site intervention capabilities. Code is available at https://github.com/wuchengyu123/UniCon.

cs.CV

GUI-Lens: Coarse-to-Fine Cropping for GUI Grounding with General-Purpose VLMs

GUI grounding maps natural-language instructions to click locations and is essential for reliable GUI agents. The task remains difficult on high-resolution, densely populated interfaces because a vision-language model (VLM) may recognize a requested control without locating it precisely enough for interaction. Most existing methods provide various forms of localization assistance, but still rely on a direct click prediction, allowing visual ambiguity or an inaccurate initial estimate to propagate to the final result. In this paper, we introduce GUI-Lens, a coarse-to-fine grounding framework that allows a general-purpose VLM to determine the target through active visual observations. Specifically, GUI-Lens extracts OCR text and detected UI components from the screenshot and presents their positions as coordinate references. Using the instruction, the current view, and these references, the VLM selects the region and scale of the next view, which is cropped and enlarged to provide finer visual details. This process continues over successively focused views until the target is determined. Proposed crops and clicks are checked against the instruction throughout the process, and the final local position is mapped back to the original screen coordinates. Experiments on four GUI grounding benchmarks and three general-purpose VLM backends show that GUI-Lens improves overall grounding accuracy by up to 24.9 percentage points and achieves state-of-the-art performance with GPT-5.5.

cs.CV

CoDe-SSM: Context-Detail Decoupled State Space Model for Efficient UHD Image Restoration

Ultra-high-definition (UHD) image restoration must balance the aggregation of spatially recurring degradation cues with the preservation of localized image structures. Compact aggregation can reduce redundant processing but may attenuate edges, textures, and other fine structures. Existing approaches manage UHD restoration cost through downsampling, window partitioning, or cluster-based token reduction; yet many of them do not explicitly retain information that is poorly represented by shared aggregation. In this study, we propose a Context-Detail Decoupled State Space Model (CoDe-SSM) for UHD restoration, which processes aggregated context and clustering residuals in separate pathways. The context modeling pathway, implemented by the Global Cluster Scan Module (GCSM), aggregates features into $K$ input-dependent cluster centers and applies selective SSM reasoning over the resulting fixed-order sequence, enabling cross-region context sharing while decoupling computational cost from spatial resolution. The detail recovery pathway, implemented by the Local High-Frequency Module (LHFM), processes the clustering residual with an input-derived high-frequency mask and a sparse mixture of convolutional experts. Extensive experiments on five UHD benchmarks and five degradation types demonstrate that our explicit context-detail decoupling strategy yields substantial gains in restoration quality while maintaining desirable efficiency.

cs.CV

A Sliced-Wasserstein Framework on Correlation Matrices for EEG Decoding

Electroencephalography (EEG) offers noninvasive, millisecond resolution recordings of neuronal activity and is widely used in neuroscience and healthcare. Many EEG decoding pipelines rely on covariance descriptors for their robustness to noise, but such representations are sensitive to channel-wise scaling. Recent studies have therefore advocated full-rank correlation matrices as a scale-invariant alternative for EEG decoding. In this paper, we study Sliced-Wasserstein (SW) discrepancies for probability distributions on the manifold of full-rank correlation matrices. We adopt the pullback-Euclidean formulation of SW, referred to as Pullback Euclidean Metric Sliced-Wasserstein (PEMSW), and instantiate it under two recently introduced correlation geometries, \textit{i.e.}, the Off-Log Metric (OLM) and Log-Scaled Metric (LSM). This yields two Correlation Sliced-Wasserstein (CorSW) discrepancies with closed-form slicing coordinates and efficient computation through one-dimensional Wasserstein distances. Building on CorSW, we further develop a domain generalization (DG) framework for EEG decoding. Experiments on three EEG datasets demonstrate improved generalization under distribution shifts, with low training overhead and no additional inference cost. The source code is available at github.com/ChenHu-ML/CorSW.

cs.LG

Bridging Auxiliary Constraints to Resolve Instruction Following in Large Reasoning Models

Large Reasoning Models (LRMs) have demonstrated impressive capabilities in many tasks, yet they struggle with reliably following multiple instructions, either by failing to satisfy individual constraints or by struggling to balance competing constraints simultaneously. We formalize this challenge as the Constraint Adherence Problem (CAP). This paper introduces a novel framework that addresses CAP by representing instructions as a structured knowledge graph of constraints. Our approach, Constraint Relationship Graph Completion (CRGC), explicitly models relationships between constraints, identifies adherence challenges, and discovers ``bridge constraints'' that help the model better focus on and reconcile requirements. Bridge constraints act as auxiliary instructions that make primary constraints more salient and compatible. Unlike existing approaches that enhance instruction following through general training methods, CRGC specifically improves constraint satisfaction by leveraging the model's own knowledge to create better pathways for generation. Experiments across three popular instruction following datasets demonstrate that our approach reduces constraint violations by 39% compared to standard prompting while maintaining reasoning abilities of large reasoning models.

cs.AI

VoxShield: Protecting 3D Medical Datasets from Unauthorized Training via Frequency-Aware Inter-Slice Disruption

The release of public 3D medical image segmentation (MIS) datasets accelerates clinical research but simultaneously heightens risks of unauthorized AI model training. While Unlearnable Examples (UE) offer protection by injecting imperceptible perturbations to prevent effective model learning, existing methods primarily target 2D scenarios. They neglect the volumetric spatial correlations and inter-slice anatomical consistency inherent in 3D medical volumes, which serve as critical learning priors for 3D segmentation networks. To bridge this gap, we propose VoxShield, a UE framework that explicitly targets the volumetric inductive biases of 3D networks. Our core insight is that by systematically dismantling the cross-slice continuity that 3D architectures rely on, we can fundamentally impair their spatial aggregation process. Specifically, we introduce an Inter-Slice Frequency Consistency Disruption mechanism that maximizes the spectral divergence between adjacent slices, injecting structural incoherence along the $z$-axis. Complementing this structural attack, a Semantic Prediction Disruption module is incorporated. By maximizing the $\ell_1$ divergence between clean and perturbed logits, it forces the injected noise to penetrate the entire network and corrupt the final semantic mapping. Experiments on BraTS19 and FLARE21 demonstrate that VoxShield successfully degrades 3D segmentation performance, reducing the DSC from 80.0% to near 0.0% and from 88.6% to 6.8%, respectively. All protections are achieved with minimal perturbation ($\epsilon=4/255$) to preserve high visual fidelity. The code is available at https://github.com/KK266299/VoxShield.

cs.CV

VISTA: Variance-Gated Inter-Sequence Test-Time Adaptation for Multi-Sequence MRI Segmentation

Deploying multi-sequence magnetic resonance imaging (MRI) segmentation models to new clinical environments is challenging due to variations in scanners and acquisition protocols. Although existing TTA methods handle basic per-modality shifts, they often fail under a fundamental dual-shift problem, as their adaptation signals fail to capture modality-interaction shifts that disrupt inter-sequence consistency. To address this, we propose Variance-gated Inter-Sequence Test-time Adaptation (VISTA), a source-free framework that tackles modality-interaction shifts. First, we design an Inter-Sequence Intervention Generator (ISIG) that generates a set of consistency probes by swapping low-frequency spectra and entropy-localized patches across sequences, preserving anatomical semantics while challenging inter-sequence dependencies. Second, we introduce Cross-View Disagreement-Aware Pseudo Labeling (CDPL), which establishes a voxel-wise reliability metric using cross-view disagreement variance to dynamically gate self-training and enforce interventional consistency, encouraging the network to rely on robust anatomical semantics. Extensive experiments adapting from standard adult MRI (BraTS-GLI-Pre) to African low-field (BraTS-SSA) and pediatric (BraTS-PED) cohorts show improved performance over competing methods under clinical shifts, achieving absolute Dice improvements of +1.89% (SSA) and +2.82% (PED) over the source model. The code is available at https://github.com/dzp2095/VISTA.

cs.CV

AdapTime: Enabling Adaptive Temporal Reasoning in Large Language Models

Large language models have demonstrated strong reasoning capabilities in general knowledge question answering. However, their ability to handle temporal information remains limited. To address this limitation, existing approaches often involve external tools or manual verification and are tailored to specific scenarios, leading to poor generalizability. Moreover, these methods apply a fixed pipeline to all questions, overlooking the fact that different types of temporal questions require distinct reasoning strategies, which leads to unnecessary processing for simple cases and inadequate reasoning for complex ones. To this end, we propose AdapTime, an adaptive temporal reasoning method that dynamically executes reasoning steps based on the input context. Specifically, it involves three temporal reasoning actions: reformulate, rewrite and review, with an LLM planner guiding the reasoning process. AdapTime integrates seamlessly with state-of-the-art LLMs and significantly enhances their temporal reasoning capabilities without relying on external support. Extensive experiments demonstrate the effectiveness of our approach.

cs.CL

MultiDx: A Multi-Source Knowledge Integration Framework towards Diagnostic Reasoning

Diagnostic prediction and clinical reasoning are critical tasks in healthcare applications. While Large Language Models (LLMs) have shown strong capabilities in commonsense reasoning, they still struggle with diagnostic reasoning due to limited domain knowledge. Existing approaches often rely on internal model knowledge or static knowledge bases, resulting in knowledge insufficiency and limited adaptability, which hinder their capacity to perform diagnostic reasoning. Moreover, these methods focus solely on the accuracy of final predictions, overlooking alignment with standard clinical reasoning trajectories. To this end, we propose MultiDx, a two-stage diagnostic reasoning framework that performs differential diagnosis by analyzing evidence collected from multiple knowledge sources. Specifically, it first generates suspected diagnoses and reasoning paths by leveraging knowledge from web search, SOAP-formatted case, and clinical case database. Then it integrates multi-perspective evidence through matching, voting, and differential diagnosis to generate the final prediction.~Extensive experiments on two public benchmarks demonstrate the effectiveness of our approach.

cs.CL

Tandem: Riding Together with Large and Small Language Models for Efficient Reasoning

Recent advancements in large language models (LLMs) have catalyzed the rise of reasoning-intensive inference paradigms, where models perform explicit step-by-step reasoning before generating final answers. While such approaches improve answer quality and interpretability, they incur substantial computational overhead due to the prolonged generation sequences. In this paper, we propose Tandem, a novel collaborative framework that synergizes large and small language models (LLMs and SLMs) to achieve high-quality reasoning with significantly reduced computational cost. Specifically, the LLM serves as a strategic coordinator, efficiently generating a compact set of critical reasoning insights. These insights are then used to guide a smaller, more efficient SLM in executing the full reasoning process and delivering the final response. To balance efficiency and reliability, Tandem introduces a cost-aware termination mechanism that adaptively determines when sufficient reasoning guidance has been accumulated, enabling early stopping of the LLM's generation. Experiments on mathematical reasoning and code generation benchmarks demonstrate that Tandem reduces computational costs by approximately 40% compared to standalone LLM reasoning, while achieving superior or competitive performance. Furthermore, the sufficiency classifier trained on one domain transfers effectively to others without retraining. The code is available at: https://github.com/Applied-Machine-Learning-Lab/ACL2026_Tandem.

cs.AI

Radiology Report Generation for Low-Quality X-Ray Images

Vision-Language Models (VLMs) have significantly advanced automated Radiology Report Generation (RRG). However, existing methods implicitly assume high-quality inputs, overlooking the noise and artifacts prevalent in real-world clinical environments. Consequently, current models exhibit severe performance degradation when processing suboptimal images. To bridge this gap, we propose a robust report generation framework explicitly designed for image quality variations. We first introduce an Automated Quality Assessment Agent (AQAA) to identify low-quality samples within the MIMIC-CXR dataset and establish the Low-quality Radiology Report Generation (LRRG) benchmark. To tackle degradation-induced shifts, we propose a novel Dual-loop Training Strategy leveraging bi-level optimization and gradient consistency. This approach ensures the model learns quality-agnostic diagnostic features by aligning gradient directions across varying quality regimes. Extensive experiments demonstrate that our approach effectively mitigates model performance degradation caused by image quality deterioration. The code and data will be released upon acceptance.

cs.CV

Guaranteeing Knowledge Integration with Joint Decoding for Retrieval-Augmented Generation

Retrieval-Augmented Generation (RAG) significantly enhances Large Language Models (LLMs) by providing access to external knowledge. However, current research primarily focuses on retrieval quality, often overlooking the critical ''integration bottleneck'': even when relevant documents are retrieved, LLMs frequently fail to utilize them effectively due to conflicts with their internal parametric knowledge. In this paper, we argue that implicitly resolving this conflict in a single generation pass is suboptimal. We introduce GuarantRAG, a framework that explicitly decouples reasoning from evidence integration. First, we generate an ''Inner-Answer'' based solely on parametric knowledge to capture the model's reasoning flow. Second, to guarantee faithful evidence extraction, we generate a ''Refer-Answer'' using a novel Contrastive DPO objective. This objective treats the parametric Inner-Answer as a negative constraint and the retrieved documents as positive ground truth, forcing the model to suppress internal hallucinations in favor of external evidence during this phase. Finally, rather than naive concatenation or using the DPO trained model directly, we propose a joint decoding mechanism that dynamically fuses the logical coherence of the Inner-Answer with the factual precision of the Refer-Answer at the token level. Experiments on five QA benchmarks demonstrate that GuarantRAG improves accuracy by up to 12.1% and reduces hallucinations by 16.3% compared to standard and dynamic RAG baselines.

cs.CL

Bi-CRCL: Bidirectional Conservative-Radical Complementary Learning with Pre-trained Foundation Models for Class-incremental Medical Image Analysis

Class-incremental learning (CIL) in medical image-guided diagnosis requires retaining prior diagnostic knowledge while adapting to newly emerging disease categories, which is critical for scalable clinical deployment. This problem is particularly challenging due to heterogeneous data and privacy constraints that prevent memory replay. Although pretrained foundation models (PFMs) have advanced general-domain CIL, their potential in medical imaging remains underexplored, where domain-specific adaptation is essential yet difficult due to anatomical complexity and inter-institutional heterogeneity. To address this gap, we conduct a systematic benchmark of recent PFM-based CIL methods and propose Bidirectional Conservative-Radical Complementary Learning (Bi-CRCL), a dual-learner framework inspired by complementary learning systems. Bi-CRCL integrates a conservative learner that preserves prior knowledge through stability-oriented updates and a radical learner that rapidly adapts to new categories via plasticity-oriented learning. A bidirectional interaction mechanism enables forward transfer and backward consolidation, allowing continual integration of new knowledge while mitigating catastrophic forgetting. During inference, outputs from both learners are adaptively fused for robust predictions. Experiments on five medical imaging datasets demonstrate consistent improvements over state-of-the-art methods under diverse settings, including cross-dataset shifts and varying task configurations.

cs.CV

InViC: Intent-aware Visual Cues for Medical Visual Question Answering

Medical visual question answering (Med-VQA) aims to answer clinically relevant questions grounded in medical images. However, existing multimodal large language models (MLLMs) often exhibit shortcut answering, producing plausible responses by exploiting language priors or dataset biases while insufficiently attending to visual evidence. This behavior undermines clinical reliability, especially when subtle imaging findings are decisive. We propose a lightweight plug-in framework, termed Intent-aware Visual Cues (InViC), to explicitly enhance image-based answer generation in medical VQA. InViC introduces a Cue Tokens Extraction (CTE) module that distills dense visual tokens into a compact set of K question-conditioned cue tokens, which serve as structured visual intermediaries injected into the LLM decoder to promote intent-aligned visual evidence. To discourage bypassing of visual information, we further design a two-stage fine-tuning strategy with a cue-bottleneck attention mask. In Stage I, we employ an attention mask to block the LLM's direct view of raw visual features, thereby funneling all visual evidence through the cue pathway. In Stage II, standard causal attention is restored to train the LLM to jointly exploit the visual and cue tokens. We evaluate InViC on three public Med-VQA benchmarks (VQA-RAD, SLAKE, and ImageCLEF VQA-Med 2019) across multiple representative MLLMs. InViC consistently improves over zero-shot inference and standard LoRA fine-tuning, demonstrating that intent-aware visual cues with bottlenecked training is a practical and effective strategy for improving trustworthy Med-VQA.

cs.CV

Topology-Guided Biomechanical Profiling: A White-Box Framework for Opportunistic Screening of Spinal Instability on Routine CT

Routine oncologic computed tomography (CT) presents an ideal opportunity for screening spinal instability, yet prophylactic stabilization windows are frequently missed due to the complex geometric reasoning required by the Spinal Instability Neoplastic Score (SINS). Automating SINS is fundamentally hindered by metastatic osteolysis, which induces topological ambiguity that confounds standard segmentation and black-box AI. We propose Topology-Guided Biomechanical Profiling (TGBP), an auditable white-box framework decoupling anatomical perception from structural reasoning. TGBP anchors SINS assessment on two deterministic geometric innovations: (i) canal-referenced partitioning to resolve posterolateral boundary ambiguity, and (ii) context-aware morphometric normalization via covariance-based oriented bounding boxes (OBB) to quantify vertebral collapse. Integrated with auxiliary radiomic and large language model (LLM) modules, TGBP provides an end-to-end, interpretable SINS evaluation. Validated on a multi-center, multi-cancer cohort ($N=482$), TGBP achieved 90.2\% accuracy in 3-tier stability triage. In a blinded reader study ($N=30$), TGBP significantly outperformed medical oncologists on complex structural features ($\kappa=0.857$ vs.\ $0.570$) and prevented compounding errors in Total Score estimation ($\kappa=0.625$ vs.\ $0.207$), democratizing expert-level opportunistic screening.

q-bio.QM

Step-CoT: Stepwise Visual Chain-of-Thought for Medical Visual Question Answering

Chain-of-thought (CoT) reasoning has advanced medical visual question answering (VQA), yet most existing CoT rationales are free-form and fail to capture the structured reasoning process clinicians actually follow. This work asks: Can traceable, multi-step reasoning supervision improve reasoning accuracy and the interpretability of Medical VQA? To this end, we introduce Step-CoT, a large-scale medical reasoning dataset with expert-curated, structured multi-step CoT aligned to clinical diagnostic workflows, implicitly grounding the model's reasoning in radiographic evidence. Step-CoT comprises more than 10K real clinical cases and 70K VQA pairs organized around diagnostic workflows, providing supervised intermediate steps that guide models to follow valid reasoning trajectories. To effectively learn from Step-CoT, we further introduce a teacher-student framework with a dynamic graph-structured focusing mechanism that prioritizes diagnostically informative steps while filtering out less relevant contexts. Our experiments show that using Step-CoT can improve reasoning accuracy and interpretability. Benchmark: github.com/hahaha111111/Step-CoT. Dataset Card: huggingface.co/datasets/fl-15o/Step-CoT

cs.CV