arXiv subjects

Yi Chang

Publications and source records attributed to Yi Chang.

At least 73 records · Page 4Linked to original sources

arXiv2026

LLM as an Algorithmist: Enhancing Anomaly Detectors via Programmatic Synthesis

Existing anomaly detection (AD) methods for tabular data usually rely on some assumptions about anomaly patterns, leading to inconsistent performance in real-world scenarios. While Large Language Models (LLMs) show remarkable reasoning capabilities, their direct application to tabular AD is impeded by fundamental challenges, including difficulties in processing heterogeneous data and significant privacy risks. To address these limitations, we propose LLM-DAS, a novel framework that repositions the LLM from a ``data processor'' to an ``algorithmist''. Instead of being exposed to raw data, our framework leverages the LLM's ability to reason about algorithms. It analyzes a high-level description of a given detector to understand its intrinsic weaknesses and then generates detector-specific, data-agnostic Python code to synthesize ``hard-to-detect'' anomalies that exploit these vulnerabilities. This generated synthesis program, which is reusable across diverse datasets, is then instantiated to augment training data, systematically enhancing the detector's robustness by transforming the problem into a more discriminative two-class classification task. Extensive experiments on 36 TAD benchmarks show that LLM-DAS consistently boosts the performance of mainstream detectors. By bridging LLM reasoning with classic AD algorithms via programmatic synthesis, LLM-DAS offers a scalable, effective, and privacy-preserving approach to patching the logical blind spots of existing detectors.

cs.LG↗

arXiv2026

High-Quality and Efficient Turbulence Mitigation with Events

Turbulence mitigation (TM) is highly ill-posed due to the stochastic nature of atmospheric turbulence. Most methods rely on multiple frames recorded by conventional cameras to capture stable patterns in natural scenarios. However, they inevitably suffer from a trade-off between accuracy and efficiency: more frames enhance restoration at the cost of higher system latency and larger data overhead. Event cameras, equipped with microsecond temporal resolution and efficient sensing of dynamic changes, offer an opportunity to break the bottleneck. In this work, we present EHETM, a high-quality and efficient TM method inspired by the superiority of events to model motions in continuous sequences. We discover two key phenomena: (1) turbulence-induced events exhibit distinct polarity alternation correlated with sharp image gradients, providing structural cues for restoring scenes; and (2) dynamic objects form spatiotemporally coherent ``event tubes'' in contrast to irregular patterns within turbulent events, providing motion priors for disentangling objects from turbulence. Based on these insights, we design two complementary modules that respectively leverage polarity-weighted gradients for scene refinement and event-tube constraints for motion decoupling, achieving high-quality restoration with few frames. Furthermore, we construct two real-world event-frame turbulence datasets covering atmospheric and thermal cases. Experiments show that EHETM outperforms SOTA methods, especially under scenes with dynamic objects, while reducing data overhead and system latency by approximately 77.3% and 89.5%, respectively. Our code is available at: https://github.com/Xavier667/EHETM.

cs.CV↗

arXiv2026

NEC-Diff: Noise-Robust Event-RAW Complementary Diffusion for Seeing Motion in Extreme Darkness

High-quality imaging of dynamic scenes in extremely low-light conditions is highly challenging. Photon scarcity induces severe noise and texture loss, causing significant image degradation. Event cameras, featuring a high dynamic range (120 dB) and high sensitivity to motion, serve as powerful complements to conventional cameras by offering crucial cues for preserving subtle textures. However, most existing approaches emphasize texture recovery from events, while paying little attention to image noise or the intrinsic noise of events themselves, which ultimately hinders accurate pixel reconstruction under photon-starved conditions. In this work, we propose NEC-Diff, a novel diffusion-based event-RAW hybrid imaging framework that extracts reliable information from heavily noisy signals to reconstruct fine scene structures. The framework is driven by two key insights: (1) combining the linear light-response property of RAW images with the brightness-change nature of events to establish a physics-driven constraint for robust dual-modal denoising; and (2) dynamically estimating the SNR of both modalities based on denoising results to guide adaptive feature fusion, thereby injecting reliable cues into the diffusion process for high-fidelity visual reconstruction. Furthermore, we construct the REAL (Raw and Event Acquired in Low-light) dataset which provides 47,800 pixel-aligned low-light RAW images, events, and high-quality references under 0.001-0.8 lux illumination. Extensive experiments demonstrate the superiority of NEC-Diff under extreme darkness. The project are available at: https://github.com/jinghan-xu/NEC-Diff.

cs.CV↗

arXiv2026

Deep Tabular Representation Corrector

Tabular data have been playing a mostly important role in diverse real-world fields, such as healthcare, engineering, finance, etc. The recent success of deep learning has fostered many deep networks (e.g., Transformer, ResNet) based tabular learning methods. Generally, existing deep tabular machine learning methods are along with the two paradigms, i.e., in-learning and pre-learning. In-learning methods need to train networks from scratch or impose extra constraints to regulate the representations which nonetheless train multiple tasks simultaneously and make learning more difficult, while pre-learning methods design several pretext tasks for pre-training and then conduct task-specific fine-tuning, which however need much extra training effort with prior knowledge. In this paper, we introduce a novel deep Tabular Representation Corrector, TRC, to enhance any trained deep tabular model's representations without altering its parameters in a model-agnostic manner. Specifically, targeting the representation shift and representation redundancy that hinder prediction, we propose two tasks, i.e., (i) Tabular Representation Re-estimation, that involves training a shift estimator to calculate the inherent shift of tabular representations to subsequently mitigate it, thereby re-estimating the representations and (ii) Tabular Space Mapping, that transforms the above re-estimated representations into a light-embedding vector space via a coordinate estimator while preserves crucial predictive information to minimize redundancy. The two tasks jointly enhance the representations of deep tabular models without touching on the original models thus enjoying high efficiency. Finally, we conduct extensive experiments on state-of-the-art deep tabular machine learning models coupled with TRC on various tabular benchmarks which have shown consistent superiority.

cs.LG↗

arXiv2026

ClarEval: A Benchmark for Evaluating Clarification Skills of Code Agents under Ambiguous Instructions

To integrate seamlessly into real-world software engineering, Code Agents must evolve from passive instruction followers into proactive collaborative partners. However, current evaluation paradigms predominantly reward "guessing" user intent under ideal conditions, neglecting the agent's ability to align with users through dialogue--a critical trait for collaborative intelligence. In this work, we propose a paradigm shift in evaluation to drive this transition. We introduce ClarEval, a framework designed to assess an agent's "Collaborative Quotient" by simulating the inherent ambiguity of human communication. By systematically injecting three types of realistic ambiguity (missing goals, premises, and ambiguous terminology) into standard tasks, we force agents to step out of their "generator" role and engage in requirement elicitation. To quantify this capability, we propose a metric suite led by Average Turns to Clarify (ATC) and Key Question Coverage (KQC), which measure not just the correctness of the generated code, but the efficiency and precision of the collaboration. Our experiments on eleven state-of-the-art agents reveal a stark reality: while models like GPT-5-Coder excel at coding, they often lack the strategic communication skills required for efficient partnership. ClarEval thus serves as a crucial roadmap for bridging the gap between strong coders and capable collaborators.The code is available at https://github.com/JialinLi13/ClarEval

cs.SE↗

arXiv2026

Fix Before Search: Benchmarking Agentic Query Visual Pre-processing in Multimodal Retrieval-augmented Generation

Multimodal Retrieval-Augmented Generation (MRAG) has emerged as a key paradigm for grounding MLLMs with external knowledge. While query pre-processing (e.g., rewriting) is standard in text-based RAG, existing MRAG pipelines predominantly treat visual inputs as static and immutable, implicitly assuming they are noise-free. However, real-world visual queries are often ``imperfect'' -- suffering from geometric distortions, quality degradation, or semantic ambiguity -- leading to catastrophic retrieval failures. To address this gap, we propose V-QPP-Bench, the first comprehensive benchmark dedicated to Visual Query Pre-processing (V-QPP). We formulate V-QPP as an agentic decision-making task where MLLMs must autonomously diagnose imperfections and deploy perceptual tools to refine queries. Our extensive evaluation across 46,700 imperfect queries and diverse MRAG paradigms reveals three critical insights: (1) Vulnerability -- visual imperfections severely degrade both retrieval recall and end-to-end MRAG performance; (2) Restoration Potential \& Bottleneck -- while oracle preprocessing recovers near-perfect performance, off-the-shelf MLLMs struggle with tool selection and parameter prediction without specialized training; and (3) Training Enhancement -- supervised fine-tuning enables compact models to achieve comparable or superior performance to larger proprietary models, demonstrating the benchmark's value for developing robust MRAG systems The code is available at https://github.com/phycholosogy/VQQP_Bench

cs.IR↗

arXiv2026

Paper2Data: Large-Scale LLM Extraction and Metadata Structuring of Global Urban Data from Scientific Literature

Urban data support a wide range of applications across multiple disciplines. However, at the global scale, there is no unified platform for urban data discovery. As a result, researchers often have to manually search through websites or scientific literature to identify relevant datasets. To address this problem, we curate an open urban data discovery portal, \textit{UrbanDataMiner}, which supports dataset-level search and filtering over more than 60{,}000 urban datasets extracted from over 15{,}000 Nature-affiliated publications. \textit{UrbanDataMiner} is enabled by \textit{Paper2Data}, a novel large-scale LLM-driven pipeline that automatically identifies dataset mentions in scientific papers and structures them using a unified urban data metadata schema. Human-annotated evaluation demonstrates that \textit{Paper2Data} achieves high recall (approximately 90\%) in dataset identification and high field-level precision (above 80\%). In addition, \textit{UrbanDataMiner} can retrieve over 9\% of datasets that are not easily discoverable through general-purpose search engines such as Google. Overall, our work provides the first large-scale, literature-derived infrastructure for urban data discovery and enables more systematic and reusable data-driven research across disciplines. Our code and data are publicly available\footnote{https://github.com/Yourunwen/Paper2Data}.

cs.IR↗

arXiv2026

Graph-based Agent Memory: Taxonomy, Techniques, and Applications

Memory emerges as the core module in the Large Language Model (LLM)-based agents for long-horizon complex tasks (e.g., multi-turn dialogue, game playing, scientific discovery), where memory can enable knowledge accumulation, iterative reasoning and self-evolution. Among diverse paradigms, graph stands out as a powerful structure for agent memory due to the intrinsic capabilities to model relational dependencies, organize hierarchical information, and support efficient retrieval. This survey presents a comprehensive review of agent memory from the graph-based perspective. First, we introduce a taxonomy of agent memory, including short-term vs. long-term memory, knowledge vs. experience memory, non-structural vs. structural memory, with an implementation view of graph-based memory. Second, according to the life cycle of agent memory, we systematically analyze the key techniques in graph-based agent memory, covering memory extraction for transforming the data into the contents, storage for organizing the data efficiently, retrieval for retrieving the relevant contents from memory to support reasoning, and evolution for updating the contents in the memory. Third, we summarize the open-sourced libraries and benchmarks that support the development and evaluation of self-evolving agent memory. We also explore diverse application scenarios. Finally, we identify critical challenges and future research directions. This survey aims to offer actionable insights to advance the development of more efficient and reliable graph-based agent memory systems. All the related resources, including research papers, open-source data, and projects, are collected for the community in https://github.com/DEEP-PolyU/Awesome-GraphMemory.

cs.AI↗

arXiv2026

PRISM: Purified Representation and Integrated Semantic Modeling for Generative Sequential Recommendation

Generative Sequential Recommendation (GSR) has emerged as a promising paradigm, reframing recommendation as an autoregressive sequence generation task over discrete Semantic IDs (SIDs), typically derived via codebook-based quantization. Despite its great potential in unifying retrieval and ranking, existing GSR frameworks still face two critical limitations: (1) impure and unstable semantic tokenization, where quantization methods struggle with interaction noise and codebook collapse, resulting in SIDs with ambiguous discrimination; and (2) lossy and weakly structured generation, where reliance solely on coarse-grained discrete tokens inevitably introduces information loss and neglects items' hierarchical logic. To address these issues, we propose a novel generative recommendation framework, PRISM, with Purified Representation and Integrated Semantic Modeling. Specifically, to ensure high-quality tokenization, we design a Purified Semantic Quantizer that constructs a robust codebook via adaptive collaborative denoising and hierarchical semantic anchoring mechanisms. To compensate for information loss during quantization, we further propose an Integrated Semantic Recommender, which incorporates a dynamic semantic integration mechanism to integrate fine-grained semantics and enforces logical validity through a semantic structure alignment objective. PRISM consistently outperforms state-of-the-art baselines across four real-world datasets, demonstrating substantial performance gains, particularly in high-sparsity scenarios.

cs.IR↗

arXiv2026

AGGC: Adaptive Group Gradient Clipping for Stabilizing Large Language Model Training

To stabilize the training of Large Language Models (LLMs), gradient clipping is a nearly ubiquitous heuristic used to alleviate exploding gradients. However, traditional global norm clipping erroneously presupposes gradient homogeneity across different functional modules, leading to an adverse "spill-over" effect where volatile parameters force unnecessary scaling on stable ones. To overcome this, we propose Adaptive Group-wise Gradient Clipping (AGGC). AGGC partitions parameters into groups based on functional types and regulates each according to its historical behavior using an Exponential Moving Average (EMA). Specifically, it constructs an adaptive interval to simultaneously mitigate gradient explosion and vanishing, while employing a time-dependent scheduling mechanism to balance exploration and convergence. Experiments on LLaMA 2-7B, Mistral-7B, and Gemma-7B models show that AGGC consistently outperforms LoRA and frequently surpasses Full Fine-Tuning. On the GSM8K benchmark, Mistral-7B fine-tuned with AGGC achieves an accuracy of 72.93%, exceeding LoRA's 69.5%. AGGC also effectively stabilizes Reinforcement Learning with Verifiable Rewards (RLVR), enhancing the logic deduction of Qwen 2.5 and Llama 3.2 models. Experimental results demonstrate that AGGC effectively addresses the limitations of traditional gradient clipping methods, particularly in overcoming gradient heterogeneity, by utilizing a modular, adaptive clipping strategy to stabilize the training process. Due to its lightweight design, AGGC can be seamlessly integrated into existing post-training pipelines with negligible overhead.

cs.LG↗

arXiv2026

A Simple Unified Uncertainty-Guided Framework for Offline-to-Online Reinforcement Learning

Offline reinforcement learning (RL) provides a promising solution to learning an agent fully relying on a data-driven paradigm. However, constrained by the limited quality of the offline dataset, its performance is often sub-optimal. Therefore, it is desired to further finetune the agent via extra online interactions before deployment. Unfortunately, offline-to-online RL can be challenging due to two main challenges: constrained exploratory behavior and state-action distribution shift. In view of this, we propose a Simple Unified uNcertainty-Guided (SUNG) framework, which naturally unifies the solution to both challenges with the tool of uncertainty. Specifically, SUNG quantifies uncertainty via a VAE-based state-action visitation density estimator. To facilitate efficient exploration, SUNG presents a practical optimistic exploration strategy to select informative actions with both high value and high uncertainty. Moreover, SUNG develops an adaptive exploitation method by applying conservative offline RL objectives to high-uncertainty samples and standard online RL objectives to low-uncertainty samples to smoothly bridge offline and online stages. SUNG achieves state-of-the-art online finetuning performance when combined with different offline RL methods, across various environments and datasets in D4RL benchmark. Codes are made publicly available in https://github.com/guosyjlu/SUNG.

cs.LG↗

arXiv2026

Adapting Depth Anything to Adverse Imaging Conditions with Events

Robust depth estimation under dynamic and adverse lighting conditions is essential for robotic systems. Currently, depth foundation models, such as Depth Anything, achieve great success in ideal scenes but remain challenging under adverse imaging conditions such as extreme illumination and motion blur. These degradations corrupt the visual signals of frame cameras, weakening the discriminative features of frame-based depths across the spatial and temporal dimensions. Typically, existing approaches incorporate event cameras to leverage their high dynamic range and temporal resolution, aiming to compensate for corrupted frame features. However, such specialized fusion models are predominantly trained from scratch on domain-specific datasets, thereby failing to inherit the open-world knowledge and robust generalization inherent to foundation models. In this work, we propose ADAE, an event-guided spatiotemporal fusion framework for Depth Anything in degraded scenes. Our design is guided by two key insights: 1) Entropy-Aware Spatial Fusion. We adaptively merge frame-based and event-based features using an information entropy strategy to indicate illumination-induced degradation. 2) Motion-Guided Temporal Correction. We resort to the event-based motion cue to recalibrate ambiguous features in blurred regions. Under our unified framework, the two components are complementary to each other and jointly enhance Depth Anything under adverse imaging conditions. Extensive experiments have been performed to verify the superiority of the proposed method. Our code will be released upon acceptance.

cs.CV↗

arXiv2025

LLM Meeting Decision Trees on Tabular Data

Tabular data have been playing a vital role in diverse real-world fields, including healthcare, finance, etc. With the recent success of Large Language Models (LLMs), early explorations of extending LLMs to the domain of tabular data have been developed. Most of these LLM-based methods typically first serialize tabular data into natural language descriptions, and then tune LLMs or directly infer on these serialized data. However, these methods suffer from two key inherent issues: (i) data perspective: existing data serialization methods lack universal applicability for structured tabular data, and may pose privacy risks through direct textual exposure, and (ii) model perspective: LLM fine-tuning methods struggle with tabular data, and in-context learning scalability is bottle-necked by input length constraints (suitable for few-shot learning). This work explores a novel direction of integrating LLMs into tabular data throughough logical decision tree rules as intermediaries, proposes a decision tree enhancer with LLM-derived rule for tabular prediction, DeLTa. The proposed DeLTa avoids tabular data serialization, and can be applied to full data learning setting without LLM fine-tuning. Specifically, we leverage the reasoning ability of LLMs to redesign an improved rule given a set of decision tree rules. Furthermore, we provide a calibration method for original decision trees via new generated rule by LLM, which approximates the error correction vector to steer the original decision tree predictions in the direction of ``errors'' reducing. Finally, extensive experiments on diverse tabular benchmarks show that our method achieves state-of-the-art performance.

cs.LG↗

arXiv2025

Infrared UAV Target Tracking with Dynamic Feature Refinement and Global Contextual Attention Knowledge Distillation

Unmanned aerial vehicle (UAV) target tracking based on thermal infrared imaging has been one of the most important sensing technologies in anti-UAV applications. However, the infrared UAV targets often exhibit weak features and complex backgrounds, posing significant challenges to accurate tracking. To address these problems, we introduce SiamDFF, a novel dynamic feature fusion Siamese network that integrates feature enhancement and global contextual attention knowledge distillation for infrared UAV target (IRUT) tracking. The SiamDFF incorporates a selective target enhancement network (STEN), a dynamic spatial feature aggregation module (DSFAM), and a dynamic channel feature aggregation module (DCFAM). The STEN employs intensity-aware multi-head cross-attention to adaptively enhance important regions for both template and search branches. The DSFAM enhances multi-scale UAV target features by integrating local details with global features, utilizing spatial attention guidance within the search frame. The DCFAM effectively integrates the mixed template generated from STEN in the template branch and original template, avoiding excessive background interference with the template and thereby enhancing the emphasis on UAV target region features within the search frame. Furthermore, to enhance the feature extraction capabilities of the network for IRUT without adding extra computational burden, we propose a novel tracking-specific target-aware contextual attention knowledge distiller. It transfers the target prior from the teacher network to the student model, significantly improving the student network's focus on informative regions at each hierarchical level of the backbone network. Extensive experiments on real infrared UAV datasets demonstrate that the proposed approach outperforms state-of-the-art target trackers under complex backgrounds while achieving a real-time tracking speed.

cs.CV↗

arXiv2025

Don't Take the Premise for Granted: Evaluating the Premise Critique Ability of Large Language Models

Large language models (LLMs) have witnessed rapid advancements, demonstrating remarkable capabilities. However, a notable vulnerability persists: LLMs often uncritically accept flawed or contradictory premises, leading to inefficient reasoning and unreliable outputs. This emphasizes the significance of possessing the \textbf{Premise Critique Ability} for LLMs, defined as the capacity to proactively identify and articulate errors in input premises. Most existing studies assess LLMs' reasoning ability in ideal settings, largely ignoring their vulnerabilities when faced with flawed premises. Thus, we introduce the \textbf{Premise Critique Bench (PCBench)}, designed by incorporating four error types across three difficulty levels, paired with multi-faceted evaluation metrics. We conducted systematic evaluations of 15 representative LLMs. Our findings reveal: (1) Most models rely heavily on explicit prompts to detect errors, with limited autonomous critique; (2) Premise critique ability depends on question difficulty and error type, with direct contradictions being easier to detect than complex or procedural errors; (3) Reasoning ability does not consistently correlate with the premise critique ability; (4) Flawed premises trigger overthinking in reasoning models, markedly lengthening responses due to repeated attempts at resolving conflicts. These insights underscore the urgent need to enhance LLMs' proactive evaluation of input validity, positioning premise critique as a foundational capability for developing reliable, human-centric systems. The code is available at https://github.com/MLGroupJLU/Premise_Critique.

cs.CL↗

arXiv2025

Blur-Robust Detection via Feature Restoration: An End-to-End Framework for Prior-Guided Infrared UAV Target Detection

Infrared unmanned aerial vehicle (UAV) target images often suffer from motion blur degradation caused by rapid sensor movement, significantly reducing contrast between target and background. Generally, detection performance heavily depends on the discriminative feature representation between target and background. Existing methods typically treat deblurring as a preprocessing step focused on visual quality, while neglecting the enhancement of task-relevant features crucial for detection. Improving feature representation for detection under blur conditions remains challenging. In this paper, we propose a novel Joint Feature-Domain Deblurring and Detection end-to-end framework, dubbed JFD3. We design a dual-branch architecture with shared weights, where the clear branch guides the blurred branch to enhance discriminative feature representation. Specifically, we first introduce a lightweight feature restoration network, where features from the clear branch serve as feature-level supervision to guide the blurred branch, thereby enhancing its distinctive capability for detection. We then propose a frequency structure guidance module that refines the structure prior from the restoration network and integrates it into shallow detection layers to enrich target structural information. Finally, a feature consistency self-supervised loss is imposed between the dual-branch detection backbones, driving the blurred branch to approximate the feature representations of the clear one. Wealso construct a benchmark, named IRBlurUAV, containing 30,000 simulated and 4,118 real infrared UAV target images with diverse motion blur. Extensive experiments on IRBlurUAV demonstrate that JFD3 achieves superior detection performance while maintaining real-time efficiency.

cs.CV↗

arXiv2025

Spatio-Temporal Context Learning with Temporal Difference Convolution for Moving Infrared Small Target Detection

Moving infrared small target detection (IRSTD) plays a critical role in practical applications, such as surveillance of unmanned aerial vehicles (UAVs) and UAV-based search system. Moving IRSTD still remains highly challenging due to weak target features and complex background interference. Accurate spatio-temporal feature modeling is crucial for moving target detection, typically achieved through either temporal differences or spatio-temporal (3D) convolutions. Temporal difference can explicitly leverage motion cues but exhibits limited capability in extracting spatial features, whereas 3D convolution effectively represents spatio-temporal features yet lacks explicit awareness of motion dynamics along the temporal dimension. In this paper, we propose a novel moving IRSTD network (TDCNet), which effectively extracts and enhances spatio-temporal features for accurate target detection. Specifically, we introduce a novel temporal difference convolution (TDC) re-parameterization module that comprises three parallel TDC blocks designed to capture contextual dependencies across different temporal ranges. Each TDC block fuses temporal difference and 3D convolution into a unified spatio-temporal convolution representation. This re-parameterized module can effectively capture multi-scale motion contextual features while suppressing pseudo-motion clutter in complex backgrounds, significantly improving detection performance. Moreover, we propose a TDC-guided spatio-temporal attention mechanism that performs cross-attention between the spatio-temporal features from the TDC-based backbone and a parallel 3D backbone. This mechanism models their global semantic dependencies to refine the current frame's features. Extensive experiments on IRSTD-UAV and public infrared datasets demonstrate that our TDCNet achieves state-of-the-art detection performance in moving target detection.

cs.CV↗

arXiv2025

Biological Regulatory Network Inference through Circular Causal Structure Learning

Biological networks are pivotal in deciphering the complexity and functionality of biological systems. Causal inference, which focuses on determining the directionality and strength of interactions between variables rather than merely relying on correlations, is considered a logical approach for inferring biological networks. Existing methods for causal structure inference typically assume that causal relationships between variables can be represented by directed acyclic graphs (DAGs). However, this assumption is at odds with the reality of widespread feedback loops in biological systems, making these methods unsuitable for direct use in biological network inference. In this study, we propose a new framework named SCALD (Structural CAusal model for Loop Diagram), which employs a nonlinear structure equation model and a stable feedback loop conditional constraint through continuous optimization to infer causal regulatory relationships under feedback loops. We observe that SCALD outperforms state-of-the-art methods in inferring both transcriptional regulatory networks and signaling transduction networks. SCALD has irreplaceable advantages in identifying feedback regulation. Through transcription factor (TF) perturbation data analysis, we further validate the accuracy and sensitivity of SCALD. Additionally, SCALD facilitates the discovery of previously unknown regulatory relationships, which we have subsequently confirmed through ChIP-seq data analysis. Furthermore, by utilizing SCALD, we infer the key driver genes that facilitate the transformation from colon inflammation to cancer by examining the dynamic changes within regulatory networks during the process.

q-bio.MN↗