Yi-Dan Chen | Searcharxiv

arXiv2026

Harmonic-Recycling Rectification Based on Novel Compact Dual-Band Resonator

Harmonic generation during radio frequency (RF)-dc conversion causes performance degradation of a microwave rectifying circuit. To suppress and recycle the harmonic power, this letter proposes a novel compact dual-band resonator (DBR) based on a microstrip coupled transmission line. It presents open-circuits at the second and third harmonic frequencies, which effectively block the higher order harmonic for power recycling. The conventional input cascading filters for harmonic rejection can be eliminated, simplifying the circuit topology and reducing loss. Theoretical analyses were carried out and corresponding equations were formulated for the proposed DBR. For validation, two rectifying circuits with/without the DBR operating at 2.2 GHz were fabricated and tested. Using the proposed DBR at 10 dBm RF power, the suppression of the second and third harmonic powers is enhanced by 18.4 and 7.6 dB, respectively. Besides, an improvement of RF-dc power conversion efficiency (PCE) was observed; specifically, PCE reached 73.2% at 10 dBm compared to 71.6% obtained from an equivalent rectifier.

physics.app-ph↗

arXiv2025

SiCmiR Atlas: Single-Cell miRNA Landscapes Reveals Hub-miRNA and Network Signatures in Human Cancers

microRNA are pivotal post-transcriptional regulators whose single-cell behavior has remained largely inaccessible owing to technical barriers in single-cell small-RNA profiling. We present SiCmiR, a two-layer neural network that predicts miRNA expression profile from only 977 LINCS L1000 landmark genes reducing sensitivity to dropout of single-cell RNA-seq data. Proof-of-concept analyses illustrate how SiCmiR can uncover candidate hub-miRNAs in bulk-seq cell lines and hepatocellular carcinoma, scRNA-seq pancreatic ductal carcinoma and ACTH-secreting pituitary adenoma and extracellular-vesicle-mediated crosstalk in glioblastoma. Trained on 6462 TCGA paired miRNA-mRNA samples, SiCmiR attains state-of-the-art accuracy on held-out cancers and generalizes to unseen cancer types, drug perturbations and scRNA-seq. We next constructed SiCmiR-Atlas, containing 632 public datasets, 9.36 million cells, 726 cell types, which is the first dedicated database of single-cell mature miRNA expression--providing interactive visualization, biomarker identification and cell-type-resolved miRNA-target networks. SiCmiR transforms bulk-derived statistical power into a single-cell view of miRNA biology and provides a community resource SiCmiR Atlas for biomarker discovery. SiCmiR Atlas is avilable at https://awi.cuhk.edu.cn/~SiCmiR/.

q-bio.GN↗