arXiv subjects

Yichao Zhang

Publications and source records attributed to Yichao Zhang.

At least 19 recordsLinked to original sources

arXiv2026

From Bench-to-Bedside: A Review of Clinical Trials in Drug Discovery and Development

Clinical trials bridge basic research and clinical application, serving as essential steps in drug development. This review examines clinical trial phases (Phase I [safety assessment], Phase II [efficacy evaluation], Phase III [large-scale validation], and Phase IV [post-marketing surveillance]), highlighting the distinct characteristics and interconnections. Major challenges are identified, including ethical compliance, participant recruitment, and ensuring diversity and representativeness in trial populations, while proposing evidence-based mitigation strategies. To address these challenges, innovative technologies, such as artificial intelligence, big data analytics, and digital health tools, are transforming trial design and implementation, enhancing efficiency and data quality. Looking forward, the review explores how emerging therapies, including gene therapy and immunotherapy, are reshaping trial design requirements and emphasizes the growing importance of regulatory harmonization and global collaboration. Clinical trials remain central to advancing innovative drug development and improving patient outcomes.

cs.CY↗

arXiv2026

From In Silico to In Vitro: A Comprehensive Guide to Validating Bioinformatics Findings

Translating computational predictions into experimentally validated biological knowledge remains one of the central challenges in modern bioinformatics. This review critically examines how in silico findings can be prioritized, tested, and interpreted through experimental validation. We organize the validation process around three recurring challenges: the specificity gap between genome-wide computational predictions and single-target experimental assays; the reproducibility-translatability tension, in which results validated in one model system may not generalize to another; and the scale-depth trade-off between high-throughput candidate discovery and the low-throughput nature of mechanistic validation. Rather than presenting an encyclopedic catalogue of techniques, we compare the strengths, limitations, and common failure modes of major validation approaches, including qPCR, RNA-seq, Western blotting, co-immunoprecipitation, luciferase reporter assays, CRISPR perturbation, and functional phenotypic assays. We also provide structured comparison tables for gene expression, protein-protein interaction, non-coding RNA, regulatory element, and pathway validation, together with decision-making frameworks to guide method selection according to prediction type, biological context, evidence stringency, throughput, and resource constraints. Case studies from cancer genomics, drug target discovery, miRNA regulation, and neurological disease illustrate how multi-step validation workflows can strengthen causal inference and reduce false-positive interpretation. Finally, we discuss how emerging technologies, including CRISPR screens, single-cell and spatial multi-omics, and AI-assisted experimental design, may reshape validation practice by improving scalability, context specificity, and reproducibility.

q-bio.GN↗

arXiv2026

Scalable Attention for 5G NR Channel Estimation

Attention-based neural estimators achieve strong channel-estimation accuracy, but the computational cost of global attention over the time-frequency resource grid grows quadratically with the number of subcarriers, and these estimators are typically tied to a single resource allocation. This paper proposes Channel Estimation Attention (CHEA), a low-complexity channel estimator for 5G New Radio (5G NR) multi-user multiple-input multiple-output (MU-MIMO). CHEA replaces global attention with a multi-resolution windowed design: a high-resolution encoder preserves local pilot detail, a low-resolution encoder captures wider frequency-domain context, and a local cross-attention decoder transfers this coarse context back to the high-resolution pilot tokens. A per-Physical Resource Block (PRB) upsampling module then reconstructs the channel over the full slot. Because every attention operation is confined to a fixed-size window and reconstruction is performed per PRB, the cost of CHEA scales linearly with the number of subcarriers, and a single trained model supports different PRB allocations without retraining. On a standard-compliant Physical Uplink Shared Channel (PUSCH), CHEA achieves the lowest Mean Squared Error (MSE) among conventional and state-of-the-art neural estimators, while requiring 2.8$\times$ to 22.0$\times$ lower operations than existing attention-based estimators.

eess.SP↗

arXiv2026

Learning-Based Automated Adversarial Red-Teaming for Robustness Evaluation of Large Language Models

Red-teaming is becoming a central part of large language model (LLM) safety evaluation, yet current practice still relies heavily on expert-written prompts or fixed benchmark suites. This creates a gap between what is easy to test and what deployed models can actually do: failures may be rare, context-sensitive, and distributed across many threat categories. We study automated red-teaming as a constrained adversarial search problem and introduce a learning-driven framework that couples category-aware attack generation with hierarchical vulnerability detection. The method starts from curated safety seeds, expands them through meta-prompt-guided and evolutionary search, and scores the resulting prompt--response pairs with lexical, semantic, and behavioral detectors. Across six threat categories on GPT-OSS-20B, the framework discovers 47 validated vulnerabilities, including 21 high-severity cases and 12 novel attack patterns. Under matched query budgets, it achieves a 3.9$\times$ higher discovery rate than manual expert red-teaming while maintaining 89\% detection accuracy and full category coverage. Ablations show that the gains do not come from more prompts alone: diversity constraints prevent template collapse, coverage constraints prevent category blind spots, and semantic detection recovers failures missed by lexical rules. These results suggest that red-teaming can be made more scalable and reproducible when treated as adaptive search rather than as a static checklist.

cs.CR↗

arXiv2026

AOI: Context-Aware Multi-Agent Operations via Dynamic Scheduling and Hierarchical Memory Compression

Cloud-native systems have made operational work both more powerful and harder to automate: incidents unfold across microservices, logs and metrics arrive faster than operators can inspect them, and recovery actions must be coordinated without losing the causal context that makes them safe. We present AOI (AI-Oriented Operations), a context-aware multi-agent framework for autonomous IT operations. AOI separates operational responsibility across an Observer, a read-only Probe, and a guarded Executor, and connects them through dynamic scheduling and a hierarchical memory system with LLM-based context compression. This design turns long-running incident response into an iterative loop of observation, evidence gathering, safe intervention, and memory update. Across AIOpsLab simulations and real-world Loghub-derived scenarios, AOI improves task success to 94.2\%, reduces mean time to resolution by 34.4\% relative to the strongest baseline, and compresses operational context by 72.4\% while preserving 92.8\% of diagnostic information. Ablations show that these gains come from the combination of agent specialization, adaptive scheduling, and memory-aware compression rather than from any single module alone. The results suggest that autonomous operations systems can move beyond alert classification toward reliable, context-preserving recovery in complex infrastructure.

cs.MA↗

arXiv2026

Jailbreaking and Mitigation of Vulnerabilities in Large Language Models

Large Language Models (LLMs) have transformed artificial intelligence by advancing natural language understanding and generation, enabling applications across fields beyond healthcare, software engineering, and conversational systems. Despite these advancements in the past few years, LLMs have shown considerable vulnerabilities, particularly to prompt injection and jailbreaking attacks. This review analyzes the state of research on these vulnerabilities and presents available defense strategies. We roughly categorize attack approaches into prompt-based, model-based, multimodal, and multilingual, covering techniques such as adversarial prompting, backdoor injections, and cross-modality exploits. We also review various defense mechanisms, including prompt filtering, transformation, alignment techniques, multi-agent defenses, and self-regulation, evaluating their strengths and shortcomings. We also discuss key metrics and benchmarks used to assess LLM safety and robustness, noting challenges like the quantification of attack success in interactive contexts and biases in existing datasets. Identifying current research gaps, we suggest future directions for resilient alignment strategies, advanced defenses against evolving attacks, automation of jailbreak detection, and consideration of ethical and societal impacts. This review emphasizes the need for continued research and cooperation within the AI community to enhance LLM security and ensure their safe deployment.

cs.CR↗

arXiv2026

Disentangling Generation and Regression in Stochastic Interpolants for Controllable Image Restoration

Recent advances in Image Restoration (IR) have been largely driven by generative methods such as Diffusion Models and Flow Matching, which excel in synthesizing realistic textures while suffering from slow multi-step inference and compromised pixel fidelity. In contrast, classical regression-based IR methods excel precisely in these aspects, offering single-step efficiency and high pixel-level reconstruction fidelity. To bridge this gap, we propose DiSI, a unified framework that Disentangles the underlying Stochastic Interpolant process into independent generation and regression components. This decoupling endows DiSI with remarkable versatility, enabling a continuous and controllable transition from a pure regression process to a fully generative one. Technically, we instantiate this framework with two specific sampling trajectories, accompanied by a unified sampler for high-quality, few-step inference on arbitrary trajectories. Furthermore, we design a dual-branch U-Net style transformer network in pixel space, using a dedicated branch to enhance conditional guidance while ensuring high throughput. Extensive experiments demonstrate that DiSI efficiently achieves competitive results on various IR tasks, while uniquely offering the inference-time flexibility to control the distortion-perception trade-off within a single model.

cs.CV↗

arXiv2026

SSDA: Bridging Spectral and Structural Gaps via Dual Adaptation for Vision-Based Time Series Forecasting

Large vision models (LVMs) have recently proven to be surprisingly effective time series forecasters, simply by rendering temporal data as images. This success, how ever, rests on a largely unexamined premise: the rendered time series images are sufficiently close to natural images for knowledge in pre-trained models to transfer effectively. We argue that two gaps still remain, i.e., spectral and structural gaps, fundamentally limiting the potential of LVMs for time series forecasting. Spectrally, we systematically reveal that rendered time series images exhibit a markedly shallower power spectrum than the natural images LVMs are pre-trained to recognize. Structurally, reshaping 1D temporal sequences into 2D grids fabricates spurious spatial adjacencies while severing genuine temporal continuities, misleading the spatial inductive biases of pre-trained LVMs. To bridge these gaps, we propose SSDA, a dual-branch network that spectrally and structurally adapts to unlock the full potential of LVMs for time series forecasting. At the data level, a Spectral Magnitude Aligner (SMA) applies 2D FFT to selectively enhance the magnitude spectrum toward natural-image statistics while preserving phase. At the model level, a Structural-Guided Low-Rank Adaptation (SG-LoRA) injects position-aware temporal encodings into patch embeddings and adapts at tention via low-rank updates. The two branches are further adaptively fused to produce the final forecast. Extensive experiments on seven real-world benchmarks demonstrate that SSDA consistently outperforms strong LVM- and LLM-based baselines under both full-shot and few-shot settings. Code is publicly available at https://anonymous.4open.science/r/SSDA-8C5B.

cs.CV↗

arXiv2026

Accelerating Precise End-to-End Simulation: Latency-Sensitive Many-core System Modeling

Modern large language model workloads put increasing demands on parallel compute capability and on-chip memory capacity, while also stressing fine-grained data movement and synchronization. These trends motivate exploring and designing many-core accelerators with tightly coupled scratchpad memory (SPM) for scalable compute and predictable, explicitly managed data access. However, this architectural shift raises two challenges: cycle-accurate register-transfer level (RTL) simulation becomes prohibitively slow as system complexity grows, and performance estimation requires precise modeling of latency-sensitive interconnect behavior. This paper presents a fast yet accurate end-to-end modeling approach for latency-sensitive many-core architectures, targeting large-scale instances such as TeraNoC with 1024 cores and a 4MiB globally shared L1 SPM. The approach captures timing behavior of latency-sensitive SPM accesses across multiple interconnect scales, while abstracting non-essential hardware details. Across diverse benchmarks, the model tracks a cycle-accurate RTL golden model with errors below 7%, while delivering up to 115x faster simulation. The framework also provides detailed profiling across processing elements and interconnect, enabling efficient end-to-end software development and hardware design exploration. Two case studies demonstrate its practicality: profiling-guided optimization of FlashAttention-2 to reduce interconnect stalls and synchronization overhead, and design space exploration of network-on-chip (NoC) router remapping to alleviate traffic imbalance and improve throughput.

cs.AR↗

arXiv2026

AdaMamba: Adaptive Frequency-Gated Mamba for Long-Term Time Series Forecasting

Accurate long-term time series forecasting (LTSF) requires the capture of complex long-range dependencies and dynamic periodic patterns. Recent advances in frequency-domain analysis offer a global perspective for uncovering temporal characteristics. However, real-world time series often exhibit pronounced cross-domain heterogeneity where variables that appear synchronized in the time domain can differ substantially in the frequency domain. Existing frequency-based LTSF methods often rely on implicit assumptions of cross-domain homogeneity, which limits their ability to adapt to such intricate variability. To effectively integrate frequency-domain analysis with temporal dependency learning, we propose AdaMamba, a novel framework that endogenizes adaptive and context-aware frequency analysis within the Mamba state-space update process. Specifically, AdaMamba introduces an interactive patch encoding module to capture inter-variable interaction dynamics. Then, we develop an adaptive frequency-gated state-space module that generates input-dependent frequency bases, and generalizes the conventional temporal forgetting gate into a unified time-frequency forgetting gate. This allows dynamic calibration of state transitions based on learned frequency-domain importance, while preserving Mamba's capability in modeling long-range dependencies. Extensive experiments on seven public LTSF benchmarks and two domain-specific datasets demonstrate that AdaMamba consistently outperforms state-of-the-art methods in forecasting accu racy while maintaining competitive computational efficiency. The code of AdaMamba is available at https://github.com/XDjiang25/AdaMamba.

cs.AI↗

arXiv2026

An Adaptive Spatiotemporal Clustering Framework for 3D Ocean Subsurface Temperature Reconstruction

The reconstruction of ocean subsurface temperature (OST) using satellite remote sensing data holds significant scientific value for advancing the understanding of ocean dynamics and climate variability. However, the scarcity of subsurface observations, combined with the high degree of nonlinearity and spatiotemporal heterogeneity in subsurface processes, poses substantial challenges to the accuracy and generalization capability of traditional reconstruction methods. To address these limitations, this study proposes an adaptive framework that could capture both vertical structural dependencies and temporal variation patterns of OST via spatio-temporal clustering. By incorporating this framework with various deep learning models, e.g., dual-path convolutional neural networks (DP-CNN), Attention U-Net, and Vision Transformer (ViT), the OST field can be accurately reconstructed at a global scale only using surface observations, i.e., sea surface temperature (SST), sea surface salinity (SSS), sea surface height (SSH), and sea surface wind (SSW). Experimental results demonstrate that multiple deep learning methods using the proposed framework largely outperform their original counterparts, yielding improvements in RMSE ranging from 12.4\% to 27.2\%. This study provides a reliable solution for subsurface temperature reconstruction, offering important implications for meteorological modeling and climate change assessment.

physics.ao-ph↗

arXiv2026

One Pass for All: A Discrete Diffusion Model for Knowledge Graph Triple Set Prediction

Knowledge Graphs (KGs) are composed of triples, and the goal of Knowledge Graph Completion (KGC) is to infer the missing factual triples. Traditional KGC tasks predict missing elements in a triple given one or two of its elements. As a more realistic task, the Triple Set Prediction (TSP) task aims to infer the set of missing triples conditioned only on the observed knowledge graph, without assuming any partial information about the missing triples. Existing TSP methods predict the set of missing triples in a triple-by-triple manner, falling short in capturing the dependencies among the predicted triples to ensure consistency. To address this issue, we propose a novel discrete diffusion model termed DiffTSP that treats TSP as a generative task. DiffTSP progressively adds noise to the KG through a discrete diffusion process, achieved by masking relational edges. The reverse process then gradually recovers the complete KG conditioned on the incomplete graph. To this end, we design a structure-aware denoising network that integrates a relational context encoder with a relational graph diffusion transformer for knowledge graph generation. DiffTSP can generate the complete set of triples in a one-pass manner while ensuring the dependencies among the predicted triples. Our approach achieves state-of-the-art performance on three public datasets. Code: https://github.com/ADMIS-TONGJI/DiffTSP.

cs.AI↗

arXiv2026

TensorPool: A 3D-Stacked 8.4TFLOPS/4.3W Many-Core Domain-Specific Processor for AI-Native Radio Access Networks

The upcoming integration of AI in the physical layer (PHY) of 6G radio access networks (RAN) will enable a higher quality of service in challenging transmission scenarios. However, deeply optimized AI-Native PHY models impose higher computational complexity compared to conventional baseband, challenging deployment under the sub-msec real-time constraints typical of modern PHYs. Additionally, following the extension to terahertz carriers, the upcoming densification of 6G cell-sites further limits the power consumption of base stations, constraining the budget available for compute ($\leq$ 100W). The desired flexibility to ensure long term sustainability and the imperative energy-efficiency gains on the high-throughput tensor computations dominating AI-Native PHYs can be achieved by domain-specialization of many-core programmable baseband processors. Following the domain-specialization strategy, we present TensorPool, a cluster of 256 RISCV32IMAF programmable cores, accelerated by 16 256 MACs/cycle (FP16) tensor engines with low-latency access to 4MiB of L1 scratchpad for maximal data-reuse. Implemented in TSMC's N7, TensorPool achieves 3643~MACs/cycle (89% tensor-unit utilization) on tensor operations for AI-RAN, 6$\times$ more than a core-only cluster without tensor acceleration, while simultaneously improving GOPS/W/mm$^2$ efficiency by 9.1$\times$. Further, we show that 3D-stacking the computing blocks of TensorPool to better unfold the tensor engines to L1-memory routing provides 2.32$\times$ footprint improvement with no frequency degradation, compared to a 2D implementation.

cs.AR↗

arXiv2026

Millimeter-Scale, Atomically Controlled 2D Topological Insulators Revealed by Multimodal Spectroscopy

Quantum spin Hall insulators, or synonymously known as 2D topological insulators, are crucial 2D systems hosting topologically protected edge states. The working temperature of this topological quantum phase is dictated by the inverted bandgap. However, the previously identified large-gap 2D topological insulators are either extremely chemically unstable, or cannot be made with atomistic precision over macroscopic scales. Here, we establish two-quintuple-layer Bi2Te3 and MnBi2Te4/Bi2Te3 heterostructures as atomically controlled, millimeter-scale 2D topological insulators, enabled by precision layer-by-layer growth that yields a carpet-like morphology extending coherently over macroscopic distances. This carpet-like growth mode renders the films amenable to mechanical exfoliation and subsequent wet or dry transfer. Multimodal spectroscopies and microscopies reveal the integer-layer tuned electronic structure of (Bi2Te3)n with excellent agreement to theory. Photon-energy-dependent photoemission and time-resolved photoemission identify band inversion and band dynamics, respectively, while scanning tunneling spectroscopy resolves topological edge states, characteristic of the 2D topological insulator phase. Thickness- and photon-energy-dependent photoemission further validates MnBi2Te4/Bi2Te3 as a robust 2D topological insulator. The large inverted gaps of ~100 meV in (Bi2Te3)2 and ~150 meV in MnBi2Te4/Bi2Te3 suggest operation near ambient temperature. These results define a scalable materials platform for next-generation, low-loss quantum and energy-efficient devices.

cond-mat.mtrl-sci↗

arXiv2026

TeraPool: A Physical Design Aware, 1024 RISC-V Cores Shared-L1-Memory Scaled-up Cluster Design with High Bandwidth Main Memory Link

Shared L1-memory clusters of streamlined instruction processors (processing elements - PEs) are commonly used as building blocks in modern, massively parallel computing architectures (e.g. GP-GPUs). Scaling out these architectures by increasing the number of clusters incurs computational and power overhead, caused by the requirement to split and merge large data structures in chunks and move chunks across memory hierarchies via the high-latency global interconnect. Scaling up the cluster reduces buffering, copy, and synchronization overheads. However, the complexity of a fully connected cores-to-L1-memory crossbar grows quadratically with PE-count, posing a major physical implementation challenge. We present TeraPool, a physically implementable, >1000 floating-point-capable RISC-V PEs scaled-up cluster design, sharing a Multi-MegaByte >4000-banked L1 memory via a low latency hierarchical interconnect (1-7/9/11 cycles, depending on target frequency). Implemented in 12nm FinFET technology, TeraPool achieves near-gigahertz frequencies (910MHz) typical, 0.80 V/25C. The energy-efficient hierarchical PE-to-L1-memory interconnect consumes only 9-13.5pJ for memory bank accesses, just 0.74-1.1x the cost of a FP32 FMA. A high-bandwidth main memory link is designed to manage data transfers in/out of the shared L1, sustaining transfers at the full bandwidth of an HBM2E main memory. At 910MHz, the cluster delivers up to 1.89 single precision TFLOP/s peak performance and up to 200GFLOP/s/W energy efficiency (at a high IPC/PE of 0.8 on average) in benchmark kernels, demonstrating the feasibility of scaling a shared-L1 cluster to a thousand PEs, four times the PE count of the largest clusters reported in literature.

cs.DC↗

arXiv2025

From Word Vectors to Multimodal Embeddings: Techniques, Applications, and Future Directions For Large Language Models

Word embeddings and language models have transformed natural language processing (NLP) by facilitating the representation of linguistic elements in continuous vector spaces. This review visits foundational concepts such as the distributional hypothesis and contextual similarity, tracing the evolution from sparse representations like one-hot encoding to dense embeddings including Word2Vec, GloVe, and fastText. We examine both static and contextualized embeddings, underscoring advancements in models such as ELMo, BERT, and GPT and their adaptations for cross-lingual and personalized applications. The discussion extends to sentence and document embeddings, covering aggregation methods and generative topic models, along with the application of embeddings in multimodal domains, including vision, robotics, and cognitive science. Advanced topics such as model compression, interpretability, numerical encoding, and bias mitigation are analyzed, addressing both technical challenges and ethical implications. Additionally, we identify future research directions, emphasizing the need for scalable training techniques, enhanced interpretability, and robust grounding in non-textual modalities. By synthesizing current methodologies and emerging trends, this survey offers researchers and practitioners an in-depth resource to push the boundaries of embedding-based language models.

cs.CL↗

arXiv2025

From Pixels to Prose: Advancing Multi-Modal Language Models for Remote Sensing

Remote sensing has evolved from simple image acquisition to complex systems capable of integrating and processing visual and textual data. This review examines the development and application of multi-modal language models (MLLMs) in remote sensing, focusing on their ability to interpret and describe satellite imagery using natural language. We cover the technical underpinnings of MLLMs, including dual-encoder architectures, Transformer models, self-supervised and contrastive learning, and cross-modal integration. The unique challenges of remote sensing data--varying spatial resolutions, spectral richness, and temporal changes--are analyzed for their impact on MLLM performance. Key applications such as scene description, object detection, change detection, text-to-image retrieval, image-to-text generation, and visual question answering are discussed to demonstrate their relevance in environmental monitoring, urban planning, and disaster response. We review significant datasets and resources supporting the training and evaluation of these models. Challenges related to computational demands, scalability, data quality, and domain adaptation are highlighted. We conclude by proposing future research directions and technological advancements to further enhance MLLM utility in remote sensing.

cs.CV↗

arXiv2025

AutoSurvey2: Empowering Researchers with Next Level Automated Literature Surveys

The rapid growth of research literature, particularly in large language models (LLMs), has made producing comprehensive and current survey papers increasingly difficult. This paper introduces autosurvey2, a multi-stage pipeline that automates survey generation through retrieval-augmented synthesis and structured evaluation. The system integrates parallel section generation, iterative refinement, and real-time retrieval of recent publications to ensure both topical completeness and factual accuracy. Quality is assessed using a multi-LLM evaluation framework that measures coverage, structure, and relevance in alignment with expert review standards. Experimental results demonstrate that autosurvey2 consistently outperforms existing retrieval-based and automated baselines, achieving higher scores in structural coherence and topical relevance while maintaining strong citation fidelity. By combining retrieval, reasoning, and automated evaluation into a unified framework, autosurvey2 provides a scalable and reproducible solution for generating long-form academic surveys and contributes a solid foundation for future research on automated scholarly writing. All code and resources are available at https://github.com/annihi1ation/auto_research.

cs.AI↗