arXiv subjects

Yiqing Lyu

Publications and source records attributed to Yiqing Lyu.

4 recordsLinked to original sources

arXiv2026

DynImmune-BERT: Dynamic Immune Repertoire Modeling with Neural ODE Driven Continuous Transformers

Longitudinal T cell receptor repertoires contain signals of clonal expansion, contraction, disappearance, and reappearance after immune perturbation. Static repertoire language models usually summarize a sample as a bag of sequences, so the sampling interval, sequencing depth, and clone presence pattern are only weakly represented. This paper presents DynImmune-BERT, a continuous time repertoire model for patient level immune status prediction. The method combines depth adaptive centered log ratio initialization, clone presence gated Neural ordinary differential equation dynamics, bounded neighborhood self attention, event based state restart, and a hybrid transport objective that supervises dominant and rare clone mass. A low rank meta adapter initializes reappearing clonotypes while keeping the parameter count independent of the number of observed clones. The evaluation separates literature reported baselines from internally controlled temporal comparisons, reports uncertainty for small external cohorts, adds calibration and threshold diagnostics, and visualizes latent clone trajectories and attention neighborhoods. The results indicate that event aware temporal modeling can complement strong static encoders when longitudinal repertoire structure is available, while small external cohorts and protocol differences require cautious interpretation.

cs.LG↗

arXiv2026

Dep-LLM: Training-Free Depression Diagnosis via Evidence-Guided Structured Multi-factor with Reliable LLM Reasoning

Automatic Depression Detection (ADD) from clinical interviews is a pivotal task in computational mental health, yet it remains challenging due to two critical obstacles: 1) difficulty in modeling complex but sparsely distributed depression clues within lengthy, multi-topic clinical interviews, leading to superficial and unreliable reasoning; 2) scarcity of labeled data due to clinical privacy, together with high cost of training and fine-tuning, limiting the deployment of supervised ADD systems. To jointly address these challenges, we propose Dep-LLM, a training-free framework that mirrors the step-by-step reasoning of clinical psychiatrists and operates entirely on frozen off-the-shelf foundation LLMs. Dep-LLM comprises three stages. First, a Chain-of-Thought (CoT) Depression Multi-factor Analysis module structurally decomposes the long dialogue into five clinically aligned themes and produces evidence-grounded rationales, effectively handling long-context dependencies. Second, we introduce Confidence Analysis and Modulation module that quantifies the epistemic reliability from token-level entropy of each rationale and applies an intra-label and inter-theme modulation that amplifies trustworthy signals while suppressing uncertain ones without extra training. Third, a Collaborative Multi-factor Prediction module dynamically integrates multi-factor signals weighted by confidence into the final diagnosis. Extensive experiments on the DAIC-WOZ and E-DAIC datasets demonstrate the effectiveness and generalizability of Dep-LLM: it surpasses zero-shot baseline on nearly all 21 foundation LLMs across 9 metrics such as accuracy, macro F1 and weighted-average F1, and further outperforms state-of-the-art supervised domain-specific LLMs as well as the latest closed-source commercial LLMs, while requiring no extra training.

cs.CL↗

arXiv2026

NeuroSymb-MRG: Differentiable Abductive Reasoning with Active Uncertainty Minimization for Radiology Report Generation

Automatic generation of radiology reports seeks to reduce clinician workload while improving documentation consistency. Existing methods that adopt encoder-decoder or retrieval-augmented pipelines achieve progress in fluency but remain vulnerable to visual-linguistic biases, factual inconsistency, and lack of explicit multi-hop clinical reasoning. We present NeuroSymb-MRG, a unified framework that integrates NeuroSymbolic abductive reasoning with active uncertainty minimization to produce structured, clinically grounded reports. The system maps image features to probabilistic clinical concepts, composes differentiable logic-based reasoning chains, decodes those chains into templated clauses, and refines the textual output via retrieval and constrained language-model editing. An active sampling loop driven by rule-level uncertainty and diversity guides clinician-in-the-loop adjudication and promptbook refinement. Experiments on standard benchmarks demonstrate consistent improvements in factual consistency and standard language metrics compared to representative baselines.

cs.CV↗

arXiv2025

Predicting Depression in Screening Interviews from Interactive Multi-Theme Collaboration

Automatic depression detection provides cues for early clinical intervention by clinicians. Clinical interviews for depression detection involve dialogues centered around multiple themes. Existing studies primarily design end-to-end neural network models to capture the hierarchical structure of clinical interview dialogues. However, these methods exhibit defects in modeling the thematic content of clinical interviews: 1) they fail to capture intra-theme and inter-theme correlation explicitly, and 2) they do not allow clinicians to intervene and focus on themes of interest. To address these issues, this paper introduces an interactive depression detection framework. This framework leverages in-context learning techniques to identify themes in clinical interviews and then models both intra-theme and inter-theme correlation. Additionally, it employs AI-driven feedback to simulate the interests of clinicians, enabling interactive adjustment of theme importance. PDIMC achieves absolute improvements of 35\% and 12\% compared to the state-of-the-art on the depression detection dataset DAIC-WOZ, which demonstrates the effectiveness of modeling theme correlation and incorporating interactive external feedback.

cs.CL↗