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Yishun Zhu

Publications and source records attributed to Yishun Zhu.

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OceanMoE: Structured Conditional Sparse Computation for Long-Horizon Multivariate Ocean Forecasting

Multivariate ocean forecasting must exploit shared evolution in a coupled ocean system while adapting to the heterogeneous statistical and dynamical characteristics of different prediction variables and locations. Fully shared models may lack the flexibility to handle this heterogeneity, whereas fully independent models discard the common ocean context shared across variables. The key question is how to retain shared context in a unified model while allowing computation to specialize according to the prediction target and local state. We propose OceanMoE, a structured conditional sparse Mixture-of-Experts framework that combines sharing and specialization for multivariate ocean forecasting. OceanMoE fuses cross-variable information to construct target-specific local representations and uses them to perform content-conditioned sparse routing at each spatial location, with the number of active experts adapted to router confidence. In the decoder, routing is augmented with a learned geographic bias parameterized by spherical-harmonic spatial bases, while shared residual and seasonal pathways provide common cross-variable and month-dependent context. Experiments on long-horizon autoregressive ORAS5 forecasting show that OceanMoE lowers aggregate forecasting error in both evaluated settings and maintains lower geometric-mean normalized RMSE than the corresponding baselines over most later rollout months. Routing analyses further show that expert allocation varies with prediction targets and spatial locations. These results support structured conditional computation as a modeling strategy for balancing shared ocean context with adaptive specialization.

cs.LG

Spatial Transcriptomics as Images for Large-Scale Pretraining

Spatial Transcriptomics (ST) profiles thousands of gene expression values at discrete spots with precise coordinates on tissue sections, preserving spatial context essential for clinical and pathological studies. With rising sequencing throughput and advancing platforms, the expanding data volumes motivate large-scale ST pretraining. However, the fundamental unit for pretraining, i.e., what constitutes a single training sample, remains ill-posed. Existing choices fall into two camps: (1) treating each spot as an independent sample, which discards spatial dependencies and collapses ST into single-cell transcriptomics; and (2) treating an entire slide as a single sample, which produces prohibitively large inputs and drastically fewer training examples, undermining effective pretraining. To address this gap, we propose treating spatial transcriptomics as croppable images. Specifically, we define a multi-channel image representation with fixed spatial size by cropping patches from raw slides, thereby preserving spatial context while substantially increasing the number of training samples. Along the channel dimension, we define gene subset selection rules to control input dimensionality and improve pretraining stability. Extensive experiments show that the proposed image-like dataset construction for ST pretraining consistently improves downstream performance, outperforming conventional pretraining schemes. Ablation studies verify that both spatial patching and channel design are necessary, establishing a unified, practical paradigm for organizing ST data and enabling large-scale pretraining.

cs.CV