arXiv subjects

Yixuan Pu

Publications and source records attributed to Yixuan Pu.

2 recordsLinked to original sources

arXiv2026

Controlling the phase behaviour of ultraconfined water via bilayer graphene stacking

Water confined within nanoscale capillaries exhibits phase behaviour and transport properties that differ substantially from bulk, and these effects are commonly interpreted as consequences of geometric confinement and reduced dimensionality. Here we show that confinement topology alone is insufficient to predict the behaviour of nanoconfined water. Using machine learning interatomic potentials with first-principles accuracy, we compute the density-temperature phase diagram of water confined within bilayer graphene nanocapillaries and compare AA and AB stacking arrangements, which differ only by a lateral shift of 1.4 {\AA}. Despite this minimal structural change, AA stacking can stabilise different ice polymorphs, can increase the melting temperature by more than 100 K, can enhance proton transfer, and alters the onset of superionic behaviour relative to AB stacking. We trace these effects to stacking-induced changes in the hydrogen-bond network associated with modifications to the lateral free energy landscape and neighbouring O-O separations. Our results demonstrate that even subtle atomistic variations in the confining walls can qualitatively reshape the physical and chemical behaviour of nanoconfined water, with implications for the interpretation and control of fluids under angstrom-scale confinement.

physics.chem-ph↗

arXiv2025

MACE-OFF: Transferable Short Range Machine Learning Force Fields for Organic Molecules

Classical empirical force fields have dominated biomolecular simulation for over 50 years. Although widely used in drug discovery, crystal structure prediction, and biomolecular dynamics, they generally lack the accuracy and transferability required for first-principles predictive modeling. In this paper, we introduce MACE-OFF, a series of short range transferable force fields for organic molecules created using state-of-the-art machine learning technology and first-principles reference data computed with a high level of quantum mechanical theory. MACE-OFF demonstrates the remarkable capabilities of short range models by accurately predicting a wide variety of gas and condensed phase properties of molecular systems. It produces accurate, easy-to-converge dihedral torsion scans of unseen molecules, as well as reliable descriptions of molecular crystals and liquids, including quantum nuclear effects. We further demonstrate the capabilities of MACE-OFF by determining free energy surfaces in explicit solvent, as well as the folding dynamics of peptides.Finally, we simulate a fully solvated small protein, observing accurate secondary structure and vibrational spectrum. These developments enable first-principles simulations of molecular systems for the broader chemistry community at high accuracy and relatively low computational cost.

physics.chem-ph↗