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Yizhou Chen

Publications and source records attributed to Yizhou Chen.

At least 19 recordsLinked to original sources
arXiv2026

VLM- and LLM-Driven Multi-Agent System for PET Image Denoising

Positron emission tomography (PET) imaging suffers from limited spatial resolution and low signal-to-noise ratio, which can compromise quantitative accuracy and lesion detectability. Deep learning-based denoising methods have demonstrated strong potential for improving PET image quality. However, their practical deployment in real-world settings remains challenging, often requiring multiple specialized models and expert interventions, such as identifying motion-induced misregistration artifacts, estimating noise levels to select an appropriate denoiser, and performing lesion-focused quantitative assessment after denoising. Recent advances in vision-language models (VLMs) for image quality understanding and large language models (LLMs) for contextual reasoning provide new opportunities for automated, decision-driven workflows. Inspired by expert workflows for PET image quality enhancement, we propose an VLM- and LLM-driven multi-agent PET denoising framework that dynamically assesses image quality and lesion status, autonomously selects optimal denoising models and parameters, and enables closed-loop feedback with rollback mechanisms. Experiments were conducted on Siemens Biograph Vision Quadra PET/CT data with 1/20 and 1/50 low-dose settings. Individual module evaluations demonstrated the reliability of the agentic components, while the complete framework achieved higher PSNR and SSIM than UNet, GAN, and DDPM baselines at both dose levels. These preliminary results demonstrate the feasibility of using a closed-loop multi-agent framework to adapt PET denoising strategies to different image conditions.

eess.IV↗
arXiv2026

CausalRepair: Bridging the Causality Gap in Large Language Model-Based Automated Program Repair via Dual-Slicing

Automated Program Repair (APR) has recently benefited from Large Language Models (LLMs), yet their effectiveness heavily depends on repair context. Existing LLM-based APR methods suffer from a causality gap: test contexts can be noisy or incomplete, while source contexts derived from static analysis often contain irrelevant and unexecuted code, misleading LLMs from identifying the true root cause. To address this issue, we propose CausalRepair, a conversation-driven APR framework based on minimal causal context, i.e., the essential dependencies required to explain a failure. CausalRepair employs a dual-slicing strategy: context-aware static slicing purifies test semantics, while execution-trace-based dynamic slicing captures precise runtime dependencies in source code. Together, they construct compact, causally relevant contexts to guide iterative repair. We evaluate CausalRepair on Defects4J V1.2, V2.0, and Defects4J-Trans using DeepSeek-V3. CausalRepair correctly fixes 313 bugs on Defects4J, outperforming state-of-the-art approaches such as ReinFix and TSAPR, while reducing the average repair cost to $0.029 per bug.

cs.SE↗
arXiv2026

Decompose and Reorganize: Planning with Primitives and Visuomotor Policies Learned from Demonstrations

Successfully automating dexterous, long-horizon robotic manipulation requires frameworks capable of both high-level reasoning and fine-grained execution. Traditional task and motion planning (TAMP), while excellent at symbolic planning, is often brittle in contact-rich operations. Simultaneously, imitation learning (IL), while effective in manipulation tasks with visual feedback, is limited by its low capability in spatial generalization and multi-stage operation. To reconcile their complementary strengths and limitations, we propose DR-LfD (Decomposed and Reorganized Skills Learned from Demonstrations), a framework that seamlessly integrates visuomotor policies into a TAMP-gated decision-making system. Based on contact relationships, DR-LfD decomposes human demonstrations into atomic skills, which are reproduced as visuomotor policies or object-centric primitives. The initiation, termination, and constraints of the visuomotor policies are carefully modeled and implemented in a TAMP-compatible form, enabling reorganization of skills learned from different sources. DR-LfD transforms the learning problem from one requiring exponential demonstration data over possible skill sequences to one whose demonstration burden scales with the number of distinct skill types, with limited data for each skill. Through comprehensive real-world and simulation benchmarking across diverse scenarios, we demonstrate the strong performance of DR-LfD on tasks involving multiple steps, unseen setups, and physical constraints. Project website: https://dr-lfd.github.io/DR-LfD-website.

cs.RO↗
arXiv2026

Rethinking Scientific Discovery in the Agentic Era

Artificial intelligence has advanced scientific discovery, but most AI4Science systems remain fragmented tools that rely on humans to coordinate problem formulation, literature grounding, model use, simulation, validation, and knowledge reuse. This paper presents \textbf{SCION (Scientific Collaborative Innovation with Agentic Organizational Nexus)}, an agentic scientific operating system that acts as an \textbf{organizational nexus}. Through a Science Agent serving as a \textbf{Meta-Harness}, SCION connects scientific tasks, tools, agents, artifacts, and memory, transforming research into an executable, auditable, and reusable operational process. At its core is the \textbf{Research Execution Plan (REP)}, which compiles high-level scientific intent into staged objectives, dependencies, verification checkpoints, tool requirements, expected artifacts, and fallback conditions. SCION further integrates hierarchical multi-agent execution, profile-driven specialization, selective context construction, governed delegation, and layered epistemic memory to support long-horizon scientific work. We formulate discovery under SCION as \textbf{Target-conditioned Inverse Search} and extend it to hidden-target settings through batch active search under finite experimental budgets. Applications in materials analysis, molecule design, and protein or antibody screening, together with experiments on scientific reading, idea generation, molecule generation, and antibody screening, show that SCION outperforms existing autonomous research-agent baselines, especially in decomposition, verification, refinement, and memory reuse. Overall, SCION shifts AI from isolated tools toward a coordinated operational layer for traceable and reusable scientific innovation.

cs.CL↗
arXiv2026

Keypose Exploration: Efficient Automatic Trajectory Labelling and Cross-Embodiment Policy Transfer

Keypose-based manipulation decomposes tasks into critical waypoints to simplify policy learning for long-horizon tasks, but existing approaches rely on task-specific heuristics or manual annotation to extract keyposes from demonstrations. We present an automatic trajectory labelling pipeline for grasp-related tasks. This pipeline combines vision-language models (VLMs) for semantic event detection with classical trajectory analysis for precise temporal alignment, requiring VLM inference only on one single demo among repeating ones per task. Using the labelled data, we train a keypose-guided Diffusion Policy (DP) that exploits keypose conditioning to intervene demonstration distributions. We explore the possibility to apply this property for cross-embodiment transfer: candidate keyposes are sampled and filtered via a reachability map, steering the policy toward kinematically feasible keyposes for the target robot. As a preliminary feasibility study, experiments on two robomimic tasks show that the labelled data produces policies matching a standard DP baseline, and that reachability-filtered keypose conditioning may benefit zero-shot transfer on the multimodal insertion task when feasible candidates are available.

cs.RO↗
arXiv2026

Semantically Structured Mixture-of-Experts for Compositional Robotic Manipulation

Diffusion-based policies have established a new standard for precise robotic manipulation but face a critical scalability bottleneck: high-performance models are computationally expensive, while lightweight alternatives often fail to generalize across diverse multi-task environments. Mixture-of-Experts (MoE) architectures offer a promising path to efficiency by activating only a subset of parameters. However, existing MoE routing mechanisms typically rely on low-level noise or latent statistics, ignoring the compositional nature of manipulation tasks. This can fragment reusable behaviors across experts, limiting interpretability and transferability. We introduce Semantically Structured Mixture-of-Experts Diffusion Policy (SMoDP) for compositional robotic manipulation, a framework that grounds expert specialization in semantic task structure. SMoDP leverages a lightweight, inference-time skill predictor, supervised by offline annotations from Vision-Language Models (VLMs), to route action chunks to experts specialized for specific behavioral phases. To ensure robust assignment, we propose a dual contrastive alignment strategy that grounds multi-modal observations in language-defined skill semantics (Inter-modal) while enforcing routing consistency across visually distinct but functionally related behaviors (Intra-modal). Our approach outperforms representative diffusion and MoE-based baselines on multi-task benchmarks with significantly improved parameter efficiency and demonstrates effective compositional transfer to novel tasks through parameter-efficient fine-tuning. Project website: https://deng-cy20.github.io/SMoDP/

cs.RO↗
arXiv2026

HumanSplatHMR: Closing the Loop Between Human Mesh Recovery and Gaussian Splatting Avatar

Accurately recovering human pose and appearance from video is an essential component of scene reconstruction, with applications to motion capture, motion prediction, virtual reality, and digital twinning. Despite significant interest in building realistic human avatars from video, this paper demonstrates that existing methods do not accurately recover the 3D geometry of humans. ViT-based approaches are not consistently reliable and can overfit to 2D views, while NeRF- and Gaussian Splatting-based avatars treat pose and appearance separately, limiting rendering generalization to new poses. To resolve these shortcomings, this paper proposes HumanSplatHMR, a joint optimization framework that refines 3D human poses while simultaneously learning a high-fidelity avatar for novel-view and novel-pose synthesis. Our key insight is to close the loop between geometric pose estimation and differentiable rendering. Unlike prior human avatar methods that rely on accurate human pose obtained through motion capture systems or offline refinement, which are impractical in in-the-wild scenarios, our approach uses only human mesh estimates from a state-of-the-art human pose estimator to better reflect real-world conditions. Therefore, instead of using the human pose only as a deformation prior, HumanSplatHMR backpropagates photometric, segmentation, and depth losses through a differentiable renderer to the pose parameters and global position. This coupling refines the global 3D pose over time, improving accuracy and alignment while producing better renderings from novel views. Experiments show consistent improvements over pose recovery baselines that omit image-level refinement and avatar baselines that decouple pose estimation from avatar reconstruction.

cs.CV↗
arXiv2026

DebugRepair: Enhancing LLM-Based Automated Program Repair via Self-Directed Debugging

Automated Program Repair (APR) has benefited from the code understanding and generation capabilities of Large Language Models (LLMs). Existing feedback-based APR methods iteratively refine candidate patches using test execution feedback and have shown promising results. However, most rely on outcome-level failure symptoms, such as stack traces, which show how failures are observed but fail to expose the intermediate runtime states critical for root-cause analysis. As a result, LLMs often infer bug causes without sufficient runtime evidence, leading to incorrect patches. To address this limitation, we propose DebugRepair, a self-directed debugging framework for LLM-based APR. DebugRepair enhances patch refinement with intermediate runtime evidence collected through simulated debugging. It consists of three components: test semantic purification, simulated instrumentation, and debugging-driven conversational repair. Together, they reduce noisy test context, collect runtime traces through targeted debugging statements with rule-based fallback, and progressively refine candidate patches using prior attempts and newly observed runtime states. We evaluate DebugRepair on three benchmarks across Java and Python. Experiments show that DebugRepair achieves state-of-the-art performance against 15 approaches. With GPT-3.5, it correctly fixes 224 bugs on Defects4J, outperforming prior SOTA LLM-based methods by 26.2%. With DeepSeek-V3, it correctly fixes 295 Defects4J bugs, surpassing the second-best baseline by 59 bugs. Across five additional backbone LLMs, DebugRepair improves repair performance by 51.3% over vanilla settings. Ablation studies further confirm the effectiveness of all components.

cs.SE↗
arXiv2026

Search-Induced Issues in Web-Augmented LLM Code Generation: Detecting and Repairing Error-Inducing Pages

Web-augmented large language models (LLMs) offer promising capabilities for automatic code generation. However, integrating live web search exposes models to unreliable or malicious content, leading to Search-Induced Issues (SII), a novel failure mode in which external pages mislead LLMs into producing incorrect code. This paper presents a comprehensive empirical study of the prevalence and impact of SII across three commercial search APIs and six advanced LLMs. Our analysis reveals that all evaluated web-augmented LLMs are vulnerable to SII, with root causes arising from either misaligned specifications or flawed code implementations in the searched Error-Inducing Pages (EIPs). To address this challenge, we propose Sherlock, an automated framework that enables LLM service providers to proactively safeguard web-augmented generation systems at scale. Sherlock operates as a continuous pipeline that first detects potential SII instances, then debugs them to identify the responsible EIPs and pinpoint their root causes, and finally repairs them by either annotating misaligned content or replacing erroneous code snippets with evaluated solutions from trusted sources. Experiments show that Sherlock identifies EIPs with an F1 score of up to 95% and repairs 71% to 100% of affected generations across the evaluated models, with modest computational overhead. Our findings and framework provide practical guidance for improving the reliability of web-augmented LLM-based code generation systems in real-world software engineering scenarios.

cs.SE↗
arXiv2026

TrackDeform3D: Markerless and Autonomous 3D Keypoint Tracking and Dataset Collection for Deformable Objects

Structured 3D representations such as keypoints and meshes offer compact, expressive descriptions of deformable objects, jointly capturing geometric and topological information useful for downstream tasks such as dynamics modeling and motion planning. However, robustly extracting such representations remains challenging, as current perception methods struggle to handle complex deformations. Moreover, large-scale 3D data collection remains a bottleneck: existing approaches either require prohibitive data collection efforts, such as labor-intensive annotation or expensive motion capture setups, or rely on simplifying assumptions that break down in unstructured environments. As a result, large-scale 3D datasets and benchmarks for deformable objects remain scarce. To address these challenges, this paper presents an affordable and autonomous framework for collecting 3D datasets of deformable objects using only RGB-D cameras. The proposed method identifies 3D keypoints and robustly tracks their trajectories, incorporating motion consistency constraints to produce temporally smooth and geometrically coherent data. TrackDeform3D is evaluated against several state-of-the-art tracking methods across diverse object categories and demonstrates consistent improvements in both geometric and tracking accuracy. Using this framework, this paper presents a high-quality, large-scale dataset consisting of 6 deformable objects, totaling 110 minutes of trajectory data. Project page: https://roahmlab.github.io/trackDeform3D-core-tracking/

cs.CV↗
arXiv2026

TheraAgent: Multi-Agent Framework with Self-Evolving Memory and Evidence-Calibrated Reasoning for PET Theranostics

PET theranostics is transforming precision oncology, yet treatment response varies substantially; many patients receiving 177Lu-PSMA radioligand therapy (RLT) for metastatic castration-resistant prostate cancer (mCRPC) fail to respond, demanding reliable pre-therapy prediction. While LLM-based agents have shown remarkable potential in complex medical diagnosis, their application to PET theranostic outcome prediction remains unexplored, which faces three key challenges: (1) data and knowledge scarcity: RLT was only FDA-approved in 2022, yielding few training cases and insufficient domain knowledge in general LLMs; (2) heterogeneous information integration: robust prediction hinges on structured knowledge extraction from PET/CT, laboratory tests, and free-text clinical documentation; (3) evidence-grounded reasoning: clinical decisions must be anchored in trial evidence rather than LLM hallucinations. In this paper, we present TheraAgent, to our knowledge, the first agentic framework for PET theranostics, with three core innovations: (1) Multi-Expert Feature Extraction with Confidence-Weighted Consensus, where three specialized experts process heterogeneous inputs with uncertainty quantification; (2) Self-Evolving Agentic Memory (SEA-Mem), which learns prognostic patterns from accumulated cases, enabling case-based reasoning from limited data; (3) Evidence-Calibrated Reasoning, integrating a curated theranostics knowledge base to ground predictions in VISION/TheraP trial evidence. Evaluated on 35 real patients and 400 synthetic cases, TheraAgent achieves 75.7% overall accuracy on real patients and 87.0% on synthetic cases, outperforming MDAgents and MedAgent-Pro by over 20%. These results highlight a promising blueprint for trustworthy AI agents in PET theranostics, enabling trial-calibrated, multi-source decision support. Code will be released upon acceptance.

cs.AI↗
arXiv2026

Learning Unified Distance Metric for Heterogeneous Attribute Data Clustering

Datasets composed of numerical and categorical attributes (also called mixed data hereinafter) are common in real clustering tasks. Differing from numerical attributes that indicate tendencies between two concepts (e.g., high and low temperature) with their values in well-defined Euclidean distance space, categorical attribute values are different concepts (e.g., different occupations) embedded in an implicit space. Simultaneously exploiting these two very different types of information is an unavoidable but challenging problem, and most advanced attempts either encode the heterogeneous numerical and categorical attributes into one type, or define a unified metric for them for mixed data clustering, leaving their inherent connection unrevealed. This paper, therefore, studies the connection among any-type of attributes and proposes a novel Heterogeneous Attribute Reconstruction and Representation (HARR) learning paradigm accordingly for cluster analysis. The paradigm transforms heterogeneous attributes into a homogeneous status for distance metric learning, and integrates the learning with clustering to automatically adapt the metric to different clustering tasks. Differing from most existing works that directly adopt defined distance metrics or learn attribute weights to search clusters in a subspace. We propose to project the values of each attribute into unified learnable multiple spaces to more finely represent and learn the distance metric for categorical data. HARR is parameter-free, convergence-guaranteed, and can more effectively self-adapt to different sought number of clusters $k$. Extensive experiments illustrate its superiority in terms of accuracy and efficiency.

cs.LG↗
arXiv2026

BiKC+: Bimanual Hierarchical Imitation with Keypose-Conditioned Coordination-Aware Consistency Policies

Robots are essential in industrial manufacturing due to their reliability and efficiency. They excel in performing simple and repetitive unimanual tasks but still face challenges with bimanual manipulation. This difficulty arises from the complexities of coordinating dual arms and handling multi-stage processes. Recent integration of generative models into imitation learning (IL) has made progress in tackling specific challenges. However, few approaches explicitly consider the multi-stage nature of bimanual tasks while also emphasizing the importance of inference speed. In multi-stage tasks, failures or delays at any stage can cascade over time, impacting the success and efficiency of subsequent sub-stages and ultimately hindering overall task performance. In this paper, we propose a novel keypose-conditioned coordination-aware consistency policy tailored for bimanual manipulation. Our framework instantiates hierarchical imitation learning with a high-level keypose predictor and a low-level trajectory generator. The predicted keyposes serve as sub-goals for trajectory generation, indicating targets for individual sub-stages. The trajectory generator is formulated as a consistency model, generating action sequences based on historical observations and predicted keyposes in a single inference step. In particular, we devise an innovative approach for identifying bimanual keyposes, considering both robot-centric action features and task-centric operation styles. Simulation and real-world experiments illustrate that our approach significantly outperforms baseline methods in terms of success rates and operational efficiency. Implementation codes can be found at https://github.com/JoanaHXU/BiKC-plus.

cs.RO↗
arXiv2025

Artificial intelligence for simplified patient-centered dosimetry in radiopharmaceutical therapies

KEY WORDS: Artificial Intelligence (AI), Theranostics, Dosimetry, Radiopharmaceutical Therapy (RPT), Patient-friendly dosimetry KEY POINTS - The rapid evolution of radiopharmaceutical therapy (RPT) highlights the growing need for personalized and patient-centered dosimetry. - Artificial Intelligence (AI) offers solutions to the key limitations in current dosimetry calculations. - The main advances on AI for simplified dosimetry toward patient-friendly RPT are reviewed. - Future directions on the role of AI in RPT dosimetry are discussed.

physics.med-ph↗
arXiv2025

GramTrans: A Better Code Representation Approach in Code Generation

Code generation has shown great promise in assisting software development. A fundamental yet underexplored question is how the choice of code representation affects model performance. While existing studies employ various representations, such as treating code as plain text, grammar rule sequences, or syntax tree sequences, they lack a principled understanding of the relationship between parsing difficulty and model effectiveness. This paper proposes a conjecture: the easier a representation is to parse, the better performance the model achieves. We formalize this idea using grammar classes, where representations in simpler classes (e.g., LL(1)) are easier to parse. Through a controlled experiment on a Python-based DSL, we show that parsing difficulty strongly correlates with model performance. Motivated by this finding, we present GramTrans, a general approach that automatically transforms a context-free language into a representation within the LL(1) class. GramTrans introduces a novel hierarchical conflict elimination algorithm, enabling a flexible trade-off between syntactic simplicity and token efficiency. We evaluate GramTrans on both Python and Java using three code generation models: StarCoder 1B, DeepSeek-Coder 1.3B, and Qwen2.5 1.5B. Across multiple benchmarks, GramTrans consistently delivers significant improvements over baseline representations. Furthermore, our analysis of existing representations reconfirms the strong alignment between parsing difficulty and model performance, providing additional support for the conjecture.

cs.SE↗
arXiv2025

BagIt! An Adaptive Dual-Arm Manipulation of Fabric Bags for Object Bagging

Bagging tasks, commonly found in industrial scenarios, are challenging considering deformable bags' complicated and unpredictable nature. This paper presents an automated bagging system from the proposed adaptive Structure-of-Interest (SOI) manipulation strategy for dual robot arms. The system dynamically adjusts its actions based on real-time visual feedback, removing the need for pre-existing knowledge of bag properties. Our framework incorporates Gaussian Mixture Models (GMM) for estimating SOI states, optimization techniques for SOI generation, motion planning via Constrained Bidirectional Rapidly-exploring Random Tree (CBiRRT), and dual-arm coordination using Model Predictive Control (MPC). Extensive experiments validate the capability of our system to perform precise and robust bagging across various objects, showcasing its adaptability. This work offers a new solution for robotic deformable object manipulation (DOM), particularly in automated bagging tasks. Video of this work is available at https://youtu.be/6JWjCOeTGiQ.

cs.RO↗
arXiv2025

SViP: Sequencing Bimanual Visuomotor Policies with Object-Centric Motion Primitives

Imitation learning (IL), particularly when leveraging high-dimensional visual inputs for policy training, has proven intuitive and effective in complex bimanual manipulation tasks. Nonetheless, the generalization capability of visuomotor policies remains limited, especially when small demonstration datasets are available. Accumulated errors in visuomotor policies significantly hinder their ability to complete long-horizon tasks. To address these limitations, we propose SViP, a framework that seamlessly integrates visuomotor policies into task and motion planning (TAMP). SViP partitions human demonstrations into bimanual and unimanual operations using a semantic scene graph monitor. Continuous decision variables from the key scene graph are employed to train a switching condition generator. This generator produces parameterized scripted primitives that ensure reliable performance even when encountering out-of-the-distribution observations. Using only 20 real-world demonstrations, we show that SViP enables visuomotor policies to generalize across out-of-distribution initial conditions without requiring object pose estimators. For previously unseen tasks, SViP automatically discovers effective solutions to achieve the goal, leveraging constraint modeling in TAMP formulism. In real-world experiments, SViP outperforms state-of-the-art generative IL methods, indicating wider applicability for more complex tasks. Project website: https://sites.google.com/view/svip-bimanual

cs.RO↗
arXiv2025

Establishing Reliability Metrics for Reward Models in Large Language Models

The reward model (RM) that represents human preferences plays a crucial role in optimizing the outputs of large language models (LLMs), e.g., through reinforcement learning from human feedback (RLHF) or rejection sampling. However, a long challenge for RM is its uncertain reliability, i.e., LLM outputs with higher rewards may not align with actual human preferences. Currently, there is a lack of a convincing metric to quantify the reliability of RMs. To bridge this gap, we propose the \textit{\underline{R}eliable at \underline{$\eta$}} (RETA) metric, which directly measures the reliability of an RM by evaluating the average quality (scored by an oracle) of the top $\eta$ quantile responses assessed by an RM. On top of RETA, we present an integrated benchmarking pipeline that allows anyone to evaluate their own RM without incurring additional Oracle labeling costs. Extensive experimental studies demonstrate the superior stability of RETA metric, providing solid evaluations of the reliability of various publicly available and proprietary RMs. When dealing with an unreliable RM, we can use the RETA metric to identify the optimal quantile from which to select the responses.

cs.AI↗