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Yonghyun Kwon

Publications and source records attributed to Yonghyun Kwon.

6 recordsLinked to original sources

MEC-Cox: Machine-Learning-Assisted Generalized Entropy Calibration for ATT Marginal Hazard-Ratio Estimation

Externally controlled survival trials are increasingly used when concurrent randomized controls are infeasible, particularly in oncology and rare-disease settings with time-to-event endpoints. We target an average-treatment-effect-on-the-treated (ATT)-type marginal hazard-ratio estimand, comparing treatment with counterfactual control in the treated trial population, and estimate it using inverse-probability-weighted (IPW) Cox regression. Valid inference is challenging because IPW Cox regression depends on the weights through both event contributions and risk-set averages, making flexible machine-learning nuisance estimation difficult to incorporate directly. Building on machine-learning-assisted generalized entropy calibration (MEC) by Lee and Kim (2026), we propose MEC-Cox for ATT-weighted IPW Cox regression. The method begins with normalized source-propensity-score odds weights for external controls and then applies Bregman calibration to balance cross-fitted prognostic summaries between external controls and treated trial patients. The calibration basis may include control-survival predictions, Cox linear predictors, penalized-survival-model predictions, or other prognostic-score summaries. MEC-updated weights therefore play a dual role as source-transport and prognostic-score balancing weights. We establish consistency, characterize a calibration-induced efficiency gain, and develop a stacked sandwich variance estimator. Simulations show that MEC-Cox can reduce bias, increase efficiency, and improve coverage through flexible machine-learning-assisted adjustment.

stat.ML

Sample-split REGression SREG: A robust estimator for high-dimensional survey data

Model-assisted regression estimation is fundamental in survey sampling for incorporating auxiliary information. However, when the auxiliary dimension grows with the sample size, the standard Generalized regression (GREG) estimator can exhibit non-negligible bias under informative sampling, even when the working model is correctly specified. This failure stems from the double use of sampled outcomes simultaneously for fitting the regression and for forming the residual correction. We propose a sample-split REGression (SREG) estimator based on K-fold cross-fitting that eliminates this bias by pairing each unit's residual with an out-of-fold prediction. The resulting estimator is first-order equivalent to the oracle difference estimator under a weak prediction-norm consistency requirement, without requiring root-n consistent estimation of regression coefficients. We establish asymptotic normality and prove consistency of a variance estimator based on cross-fitted residuals. The key conditional fluctuation assumption is verified for simple random, stratified, and rejective sampling. Simulations demonstrate that SREG effectively removes high-dimensional bias while maintaining competitive efficiency.

stat.ME

Bregman projection for calibration estimation in Survey Sampling

Calibration weighting is a fundamental tool in survey sampling for incorporating auxiliary population information into design-based estimators. Classical formulations measure distance between calibrated and design weights on the multiplicative ratio scale. We develop a unified framework based on Bregman divergence defined directly on the weight vector. The framework reveals a primal--dual symmetry in which both the weight-space and multiplier-space optimization problems are themselves Bregman projections, and the calibrated weights satisfy a generalized Pythagorean decomposition with respect to the constraint manifold. The resulting estimator is asymptotically equivalent to a debiased prediction estimator whose regression coefficient depends explicitly on the Bregman generator, in contrast to the generalized regression estimator equivalent of classical calibration. Exploiting this dependence, we identify a contrast-entropy generator that achieves design-optimality under Poisson sampling. Two extensions are developed: cross-fitted estimation under non-probability sampling, yielding doubly robust inference under standard product-rate conditions; and a regularized extension whose Lagrangian dual produces a H\"older-conjugate penalty for soft balance under high-dimensional auxiliary variables. Simulations and an analysis of National Oceanic and Atmospheric Administration (NOAA)'s Large Pelagics Intercept Survey illustrate the framework.

stat.ME

A General Approach for Calibration Weighting under Missing at Random

We propose a unified class of calibration weighting methods based on weighted generalized entropy to handle missing at random (MAR) data with improved stability and efficiency. The proposed generalized entropy calibration (GEC) formulates weight construction as a convex optimization program that unifies entropy-based approaches and generalized regression weighting. Double robustness is achieved by augmenting standard covariate balancing with a debiasing constraint tied to the propensity score model and a Neyman-orthogonal constraint that removes first-order sensitivity to nuisance estimation. Selection of the weights on the entropy function can lead to the optimal calibration estimator under a correctly specified outcome regression model. The proposed GEC weighting ha a nice geometric characterization: the GEC solution is the Bregman projection of the initial weights onto a constraint set, which yields a generalized Pythagorean identity and a nested decomposition that quantifies the incremental distance paid for additional constraints. We also develop a high-dimensional extension with soft calibration and a projection calibration constraint that preserves doubly robust inference. Two simulation studies are presented to compare the performance of the proposed method with the existing methods.

stat.ME

Generalized entropy calibration for analyzing voluntary survey data

Statistical analysis of voluntary survey data is an important area of research in survey sampling. We consider a unified approach to voluntary survey data analysis under the assumption that the sampling mechanism is ignorable. Generalized entropy calibration is introduced as a unified tool for calibration weighting to control the selection bias. We first establish the relationship between the generalized calibration weighting and its dual expression for regression estimation. The dual relationship is critical in identifying the implied regression model and developing model selection for calibration weighting. Also, if a linear regression model for an important study variable is available, then two-step calibration method can be used to smooth the final weights and achieve the statistical efficiency. Asymptotic properties of the proposed estimator are investigated. Results from a limited simulation study are also presented.

stat.ME

Debiased calibration estimation using generalized entropy in survey sampling

Incorporating the auxiliary information into the survey estimation is a fundamental problem in survey sampling. Calibration weighting is a popular tool for incorporating the auxiliary information. The calibration weighting method of Deville and Sarndal (1992) uses a distance measure between the design weights and the final weights to solve the optimization problem with calibration constraints. This paper introduces a novel framework that leverages generalized entropy as the objective function for optimization, where design weights play a role in the constraints to ensure design consistency, rather than being part of the objective function. This innovative calibration framework is particularly attractive due to its generality and its ability to generate more efficient calibration weights compared to traditional methods based on Deville and Sarndal (1992). Furthermore, we identify the optimal choice of the generalized entropy function that achieves the minimum variance across various choices of the generalized entropy function under the same constraints. Asymptotic properties, such as design consistency and asymptotic normality, are presented rigorously. The results from a limited simulation study are also presented. We demonstrate a real-life application using agricultural survey data collected from Kynetec, Inc.

stat.ME