Micromechanical statistical model links induced nematic order to mechanical response in fiber networks
Contractile cells and external loads reorganize the fibrous extracellular matrix, aligning and compacting fibers over distances far exceeding a cell's size, strongly affecting bioprocesses such as wound healing, angiogenesis and tumor invasion. We develop a continuum micromechanical theory that links, at every material point, the load-induced orientational order to the mechanical response that the reoriented network then exhibits. The network is described statistically, by the probability density of fiber orientations, and deforms affinely, so that a single-fiber stress-strain law is carried into the network stress, with the deformation set self-consistently by mechanical equilibrium. Critical to realistic biological relevant conditions, this theory allows both geometrical and material nonlinearities. Applied to a two-dimensional network under uniaxial stretch, the theory collapses onto a single anisotropy parameter that governs the orientation distribution, the nematic order, the Poisson ratio, and the densification of fibers. Our theory reveals that induced order and densification are highly positively correlated, and in the case of uniaxial stretch they collapse onto a nearly universal curve, independent of the single-fiber stiffness behavior. For a contracting cell, we find that buckling controls how far nematic orientational order and densification propagate. We find an algebraic decay of deformations with distance and solve for the dependence of the power-law exponent on the buckled-reduced stiffness of a single fiber. We validate our theory by comparison with non-affine discrete fiber-network simulations.