Yoshihiro Shibuya | Searcharxiv

arXiv2026

Processing-in-memory for genomics workloads

Low-cost, high-throughput DNA and RNA sequencing (HTS) data is the backbone of the life sciences. Genome sequencing is now becoming a part of Predictive, Preventive, Personalized, and Participatory (termed 'P4') medicine. All genomic data are currently processed in energy-hungry computer clusters and centers, necessitating data transfer, consuming substantial energy, and wasting valuable time. Therefore, there is a need for fast, energy-efficient, and cost-efficient technologies that enable genomics research without requiring data centers and cloud platforms. We recently launched the BioPIM Project to leverage emerging processing-in-memory (PIM) technologies to enable energy- and cost-efficient analysis of bioinformatics workloads. The BioPIM Project focuses on co-designing algorithms and data structures commonly used in genomics with several PIM architectures to achieve the highest cost, energy, and time savings.

q-bio.GN↗

arXiv2023

Locality-Preserving Minimal Perfect Hashing of k-mers

Minimal perfect hashing is the problem of mapping a static set of $n$ distinct keys into the address space $\{1,\ldots,n\}$ bijectively. It is well-known that $n\log_2(e)$ bits are necessary to specify a minimal perfect hash function (MPHF) $f$, when no additional knowledge of the input keys is to be used. However, it is often the case in practice that the input keys have intrinsic relationships that we can exploit to lower the bit complexity of $f$. For example, consider a string and the set of all its distinct $k$-mers as input keys: since two consecutive $k$-mers share an overlap of $k-1$ symbols, it seems possible to beat the classic $\log_2(e)$ bits/key barrier in this case. Moreover, we would like $f$ to map consecutive $k$-mers to consecutive addresses, as to also preserve as much as possible their relationship in the codomain. This is a useful feature in practice as it guarantees a certain degree of locality of reference for $f$, resulting in a better evaluation time when querying consecutive $k$-mers. Motivated by these premises, we initiate the study of a new type of locality-preserving MPHF designed for $k$-mers extracted consecutively from a collection of strings. We design a construction whose space usage decreases for growing $k$ and discuss experiments with a practical implementation of the method: in practice, the functions built with our method can be several times smaller and even faster to query than the most efficient MPHFs in the literature.

cs.DS↗