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Yossi Matias

Publications and source records attributed to Yossi Matias.

At least 19 recordsLinked to original sources

Improving Entrepreneurial Skills by Practicing with AI

Durable skills like critical thinking, creativity, and collaboration are essential for innovation, yet teaching them remains difficult. In this work, we focus on the entrepreneurial domain, where these skills and others are required, and ask whether AI can be used as a tool for improving entrepreneurial proficiency. As a first step towards this challenge, we present an extension of Vantage, a platform developed at Google Research, adapted to serve as an interactive practice environment for entrepreneurship. Vantage pairs students with simulated AI peers engineered to navigate realistic business scenarios and challenge learners to exercise key skills. In a randomized controlled trial (RCT) embedded in summer entrepreneurship programs run by The Network for Teaching Entrepreneurship (NFTE), students using Vantage scored significantly higher on their Capstone Business Plans than control students with access to standard AI tools. These preliminary findings suggest that orchestrated AI peers can meaningfully support short-term performance on tasks requiring complex, durable skills.

cs.CY↗

A prospective randomized study of patient-centered AI for clinical visit preparation

Patients often arrive at brief, time-constrained clinical visits unsure of what to expect or ask, and millions of adults now turn to general-purpose AI chatbots to prepare beforehand. Yet whether conversational AI improves visit readiness remains unclear. We designed a large language model (LLM)-based visit preparation agent to guide patients before an appointment by gathering clinical context, setting visit expectations, providing relevant health information, building a prioritized list of questions for their clinician, and generating a summary. In a prospective consented randomized study in the Google Health app, 802 U.S. adults held 866 health-related conversations with the visit preparation agent (standard or concise variant) or a minimally prompted control chatbot built on the same LLM. The visit preparation agent significantly outperformed the control across blinded clinician evaluations and patient self-reports. In clinician reviews of completed sessions (n = 272), the agent achieved a 16.6% higher rate of comprehensive preparation (67.2% vs. 50.6%; P < 0.05) and an 8.5% higher rate of alignment with patients' health context (98.9% vs. 90.4%; P < 0.01), while maintaining high medical safety and appropriateness across all study arms. Patient post-surveys (n = 460) showed 16.8% higher visit preparedness (73.8% vs. 57.0%; P < 0.01), 14.3% higher confidence in knowing what to ask (81.4% vs. 67.1%; P < 0.01), and 12.0% higher overall satisfaction (74.0% vs. 62.0%; P < 0.05). Clinician and participant metrics were not significantly correlated, indicating that expert review and patient self-assessment capture complementary dimensions of patient-facing AI. These findings suggest that LLM chatbots can safely help patients prepare for clinical visits, with greater benefit when following a structured workflow, and motivate future studies on in-visit communication and clinical outcomes.

cs.HC↗

Semantic Representation for Agentic Self-Play in Automated Laboratories

Navigating complex, high-dimensional biological search spaces necessitates scalable physical and computational intelligence to explore beyond local optima through iterative self-play across ideation, experimentation, and automation. Translating experimental designs into reliable physical execution remains bottlenecked by static laboratory automation and unmodeled physical variability. To address this, we introduce VERified Infrastructure for Discovery Laboratories, or VERID, a foundational infrastructure designed to bridge the gap between the high-level reasoning of artificial intelligence (AI) agents and complex, error-prone physical realities of wet labs. VERID is a persistent, high-fidelity semantic digital twin of the laboratory workcell that provides four core services: queryable introspection for agentic reasoning, time-compressed simulation for protocol validation, comprehensive trace persistence for a complete scientific record, and a framework for safe execution. We present three case studies using aqueous dye and deionized water mixtures to validate the optical and fluidic foundations of VERID. These studies demonstrate how VERID enables pre-emptive detection of critical errors in experimental protocols, stateful mid-run error recovery and post-hoc identification of subtle physical failures. The simulation functions as a discrete accounting engine, allowing agents to safely and inexpensively explore experimental designs in silico and refine experimental strategies through iterative self-play. VERID also captures structured multimodal experimental data for downstream analysis, knowledge mining and agent training. We argue that this semantic layer is an essential prerequisite for deploying autonomous agents in the biochemical and biomedical sciences, ensuring data integrity, operational safety, and paving the way for tackling previously intractable grand challenges in biology.

cs.RO↗

Agent-guided epitope excision enables economical de novo binder design

De novo protein design campaigns remain bottlenecked by the inference compute time required to generate and rank candidates, limiting wider functional exploration. Here, we introduce and evaluate an epitope excision approach that truncates targets to local interface windows to accelerate both backbone diffusion and structure prediction. Across 15 targets and 3,666 designs, excised windows closely reproduced full-target binding interfaces (median CαRMSD of 0.37 Å) and made it practical to design binders against the 719-residue extracellular domain of fibroblast activation protein alpha (FAP) by cutting RFdiffusion and AlphaFold3 GPU time by ~ 88% in one of the epitopes. Pairing this workflow with an agentic optimization loop allowed the system to autonomously identify catalytic-site targeting strategies. Under a fixed compute budget, a human-in-the-loop (HITL) workflow raised the computational hit rate from 5.06% to 9.33% while further cutting GPU hours by ~ 42%. We also found that omitting target multiple sequence alignments during refolding roughly substantially increased the apparent yield. Wet-lab validation with yeast display identified nanomolar binders from the generated designs with the HITL and the fully autonomous agent (human-out-of-the-loop, HOOTL) arms recovering more enriched designs than the PI-alone baseline. Together, target excision and agent-guided search offer a practical way to scale de novo binder design to large, therapeutically relevant proteins.

q-bio.BM↗

Planetary Geospatial Foundation Models: A New Paradigm for Global Public Health

The efficacy of traditional disease prediction is limited by spatial gaps and temporal lags, which impact the timing and targets of resource deployments. Outbreaks escalate undetected, chronic disease burdens are quantified years later, and at-risk populations in data-sparse regions remain unaddressed. Planetary geospatial foundation models complement existing epidemiological workflows to provide operational improvements, encoding multimodal search, mobility, and environmental signals into generalizable place representations. As illustrations of this complementarity, we present independent global health case studies of Google Earth AI's Population Dynamics Foundation Model (PDFM) -- a foundation model for geospatial inference -- across four domains (vaccine-preventable, communicable, noncommunicable, maternal mental health), five tasks (spatial extrapolation, interpolation/nowcasting, probabilistic forecasting, prospective forecasting, risk stratification), and four countries (USA, Canada, Mexico, and the Democratic Republic of the Congo). Across these case studies, PDFM addresses critical surveillance gaps across domains: improving US-Canada border MMR vaccination coverage predictions by capturing cross-border behavioral spillovers domestic models miss; nowcasting cardiovascular disease to accelerate data availability; enhancing short-term municipal Mexican dengue forecasts for timely outbreak vector control; improving forecasts of cholera hotspots; and adding a transferable signal to individual-level postpartum-depression risk prediction in US states the model had never seen, while not replacing individual socioeconomic data or closing demographic screening gaps. Together, these results showcase capabilities of geospatial foundation models for public health surveillance.

cs.LG↗

Aptamers as a sandbox for lab-in-the-loop agentic molecular discovery

Despite breakthroughs in AI-driven molecular generation, existing discovery pipelines operate largely in silico, with wet-lab feedback reserved for validation rather than iterative improvement. Whether large language model (LLM)-based reasoning agents can accelerate de novo discovery by iterating with lab data remains unproven. Here we use protein-binding aptamer design as a sandbox (1-2 week cycles, \$1-\$3 per candidate) to demonstrate a wet lab in a closed loop with AI systems. We tasked agentic pipelines with developing aptamer binders against $α$-thrombin and myoglobin across three design-test-improve cycles ($\sim$1,000 candidates per round; $\sim$4,400 constructs). Statistically significant, bead-corrected on-target hit rates among new candidates rose across rounds from 0.0% in Round 1 to 26.0% in Round 2 and 42.1% in Round 3 on $α$-thrombin (37.1% excluding literature motif descendants), and from 10.2% in Round 1 to 3.7% in Round 2 and 33.5% in Round 3 on myoglobin. Single-clone bead-binding titrations of eight full-length $α$-thrombin candidates confirmed concordance with pooled sequencing enrichment (Pearson $r = 0.90$). In these assays, literature-derived motifs engineered by the agents to reduce off-target reactivity in the pooled screen reached apparent affinities of $K_D = 24.6$--$133$ nM, whereas de novo scaffolds showed low-micromolar binding ($K_D > 1\ μ$M). We also report how our pipelines used myoglobin binding data to exploit the G-quadruplex binder space, diagnose cross-reactivity as on-target specificity dropped from 75.0% to 19.1%, and recover by developing strategies that restored specificity to 72.4%. We demonstrate that empirical lab data is more valuable than existing computational proxies, showing how iterative experimental feedback enables AI agents to diagnose assay artifacts and refine molecular designs across rounds.

q-bio.BM↗

Google Earth AI Geospatial Reasoning Agent: Capabilities and a Systematic Evaluation

Google Earth AI is a family of geospatial AI models, together with an agent that orchestrates them. We present this agent, Google Earth AI's Geospatial Reasoning agent (GRA), a Gemini-powered research system that combines geospatial data sources, foundation models, and tools to answer questions about our planet. GRA organizes these into modular domain skills and pairs them with upfront geospatial planning to decompose complex queries into multi-stage workflows. Evaluating such systems is hard: real-world problems admit multiple valid workflows, require data discovery across large catalogs, and rely on evolving ground truth. We introduce two benchmarks and release their development splits. GeoExpertQueries poses complex analytical problems grounded in practitioner use cases and refined by geospatial experts; each is paired with a consensus golden workflow from three independent experts and scored by a human-validated, tool-agnostic autorater. GeoKTools consists of templated queries with deterministic reference solvers that systematically vary the number of required tool types. We also use two external benchmarks, CBGB and UnivEARTH; the latter we find to be saturated. To isolate the contribution of GRA's tools and its agentic orchestration, we compare four configurations, each with Gemini 3.1 Pro and 3.8 Flash: a standalone LLM, the LLM with basic tools, the LLM with GRA's skills and tools but without its upfront planning and execution guidance, and GRA itself. With at most basic tools, an advanced model recovers much of the answer on templated queries but satisfies only a small fraction of the expert workflows on open-ended problems; GRA performs well on both. The largest step comes from GRA's skills and tools; on open-ended problems, its planning and execution guidance add a further gain with Gemini 3.8 Flash, letting Flash match or exceed Pro at lower cost.

cs.AI↗

ResidencyRL: Reinforcement Learning in Simulated Clinical Environments

In medical education, physicians convert academic knowledge into clinical expertise through residency: years of training across thousands of encounters, with diverse sources of feedback and progressively greater autonomy. Much of clinical reasoning relies on the patient encounter, a dialogue in which a clinician elicits history, refines diagnostic hypotheses, and decides management under uncertainty. While large language models (LLMs) excel on static medical benchmarks, methods to optimize the full sequence of clinical decisions remain underdeveloped. We present ResidencyRL, a reinforcement learning (RL) method for training clinical artificial intelligence (AI) agents through simulated multi-turn clinical encounters (up to 60 dialogue turns and 8 tool calls per trajectory). ResidencyRL pairs the policy agent with LLM simulators capable of complex, adversarial behaviors, training against a structured reward aligned to diagnostic accuracy, management quality, communication, documentation, and safety. On held-out evaluations, the ResidencyRL agent improves diagnostic accuracy by 7.0% under adversarial conditions (88.0% vs. 81.0%) and reduces missed red flag rates by 31%, demonstrating rigorous mitigation of premature closure. Blinded expert clinicians validated these gains, preferring the trained agent in 87.6% of side-by-side comparisons. The procedural competencies transfer to unseen benchmarks: the agent outperforms the base model across all six clinical axes of the AMIE multi-visit benchmark, and shows consistent directional improvements on AgentClinic and CRAFT-MD. Our findings demonstrate that sequential clinical decision-making can be effectively learned through multi-turn RL in simulation, yielding robust, generalizable capabilities, paving the way towards clinical mastery. Prospective validation with real-world workflows remains necessary to establish clinical utility.

cs.AI↗

Evaluating Alignment of Behavioral Dispositions in LLMs

As people turn to LLMs for social advice, understanding their behavior in such contexts becomes essential. In this work, we focus on behavioral dispositions: the underlying tendencies that shape responses in social contexts. We introduce STAR, a framework for studying how closely the dispositions expressed by LLMs align with those of humans. STAR builds on established psychological questionnaires, adapting their items into realistic advice-seeking scenarios, as self-report may not transfer to actual advisory behavior. Using STAR, we construct a dataset of 23k scenarios, each validated by 3 raters and annotated with preferences from 10 participants. Across 25 LLMs, we find that (1) when human consensus is high, frontier models can fail to reflect it in 15-20% of cases, and smaller models fail at substantially higher rates; (2) when humans disagree, LLM recommendations are substantially less diverse than human choices, both within individual models and even across models from different providers, potentially narrowing the range of options users are guided toward; (3) LLMs' self-reported values are poor predictors of their recommendations. To support future research we make our dataset and code publicly available.

cs.CL↗

Planetary Prediction Engine: Autonomous Geospatial Prediction via Intelligent Data Selection and Foundation Model Embeddings

Addressing critical global challenges, from food security and disaster risk to disease outbreaks and socio-economic vulnerability, demands high-fidelity geospatial modeling. However, building predictive planetary models remains bottlenecked by a fragmented data ecosystem, requiring manual data retrieval, multimodal data curation and fusion along with iterative model selection. We present the Planetary Prediction Engine (PPE), an autonomous AI system that executes this end-to-end workflow directly from natural-language queries. PPE synthesizes multimodal datasets on the fly, retrieving spatiotemporally relevant covariates across open-web and Earth observation platforms (Data Commons, Google Earth Engine) and fusing them with geospatial foundation model embeddings (PDFM, AlphaEarth). Simultaneously, it searches over task-tailored model architecture families with automated overfitting guards. Across diverse tasks, geographies, and scientific domains, PPE consistently outperforms state-of-the-art or manually tuned expert baselines. For US spatial regression, PPE improves mean $R^2$ across 21 CDC health indicators (76.8% vs. 60.0%), FEMA national risk indices (64.9% vs. 60.0%), and the Social Vulnerability Index (66.2% vs. 58.6%). For spatial downscaling in data-scarce settings, PPE integrates localized proxies to double baseline accuracy in Nigerian food security indicators ($R^2$ of 66.1% vs. 31.5%). For epidemiological nowcasting of the 2026 DRC Bundibugyo Ebola outbreak, PPE achieves a Recall@10 of 83.3% (identifying 15 of 18 newly invaded health zones across five weekly forecasts), a +10.3 percentage-point improvement over the public state-of-the-art modeling (~73%). By combining autonomous multimodal planetary data discovery with targeted model optimization, PPE lowers the technical barrier to planetary-scale analytics, enabling rapid, customized, expert-level deployment.

cs.AI↗

Harnessing Generative UI for Education: Tailored Learning Interactives

It is well established that students learn best through active engagement, particularly via interactive experiences tied to real-world concepts. Creating such experiences, however, typically requires labor-intensive design, costly development, and continuous teacher guidance to achieve measurably effective outcomes. Recent advances in generative UI open the door for a future of practice where the creation of tailored interactive experiences is automated. However, off-the-shelf models lack optimization for pedagogical precision and learning principles, often yielding unsatisfactory results for complex pedagogical constructs. To address these limitations, we present learning interactives, a structured framework leveraging the generative UI capabilities of Gemini to construct effective customized interactive simulations. We evaluate our approach through both an initial study with educators as well as a pedagogical rating of a varied set of simulations by expert teachers.

cs.CY↗

Verifiable Social Reasoning for LLM Assistants

LLM assistants are widely used for daily social advice, yet evaluating their social reasoning in such consultation settings remains challenging since (i) it requires setups where the assistant learns about social situations from subjective user narratives, and (ii) social properties, such as others' intentions, typically lack verifiable ground truth. To address these challenges, we introduce Fuse, a multi-agent simulation framework for studying user-mediated social reasoning. In Fuse, a target agent with a hidden motive interacts with other agents including one representing the user, who then consults the evaluated assistant to infer the target's motive, providing verifiable ground truth by construction. Simulation faithfulness is validated through a human study with 24k annotations. We apply Fuse to 12 LLMs and demonstrate its analytical utility by systematically isolating key factors, showing that (i) user mediation compounds the inherent difficulty of social reasoning; (ii) LLMs exhibit systematic sensitivity to biased user framing; (iii) models can require more details than humans need to reach a correct prediction; and (iv) longer conversations do not always improve performance despite providing opportunities for clarifying questions. We open-source Fuse and a dataset with 21k examples.

cs.AI↗

Towards Scalable Measurement of Durable Skills

Durable skills, such as collaboration, creativity and critical thinking, are instrumental to success in the modern workforce. Yet, measuring these skills remains a persistent challenge. Moreover, because what is not measured is often not taught, these skills are often overlooked in mainstream educational curricula. Designing effective assessments for these skills necessitates balancing two often-conflicting requirements: ecological validity and psychometric rigor. On the one hand, the assessment environment should emulate natural real-world human interaction between humans. On the other hand, it should be scalable, controllable and reproducible. Here we argue that LLMs can be used to better capture both of these aims. Concretely, we develop a framework where the subject converses with AI teammates in a way that resembles human-human interaction for authenticity, while also offering the psychometric control required for informative and robust assessment. Importantly, the AI participants not only act as teammates but also, in an "Executive LLM" setup, steer the conversation towards eliciting a high density of observable evidence for skill proficiency. We complement this with an AI evaluator that can be used to measure skill proficiency in such interactions. We evaluate our assessment protocol based on transcripts of interactions of human participants with our AI framework, for multiple durable skills. For the skill of creativity, we further demonstrate the efficacy of an autorater for evaluating complex tasks performed by real students. Our analysis shows that the use of the Executive LLM significantly increases elicited evidence and that LLM-automated scoring of conversations largely agrees with that of expert annotators. This research demonstrates the utility of orchestrated LLMs approaches for measuring complex social and cognitive constructs in a scalable and controllable manner.

cs.HC↗

Patients With Personality: Realistic Patient Simulation through Controlled Diversity and Selective Disclosure

Simulating realistic patient interactions is a key requirement to testing clinical applications of LLMs at scale without time-consuming and expensive user studies. However, existing approaches often lack realism and controllability, often oversharing information unprompted, and failing to capture the wide variability of patient behavior. Here, we introduce PatientsWithPersonality (PWP), a patient simulation framework that generates realistic yet diverse virtual patient responses through explicit personality parametrization over a latent patient state. Grounded in HEXACO, a six-dimensional personality space used to quantify and parameterize human behavioral traits, our approach enables fine-grained control over conversational style, cooperativeness, and information disclosure within a unified framework. In a clinician evaluation, PWP is judged nearly as realistic as recorded human actors and clearly ahead of prior simulators, while being flagged as "too informative" far less often. Conditioning on HEXACO axes yields personas whose configured traits are recoverable by both clinicians and an autorater, span a substantially wider behavioral footprint than the closest baseline, and prevent oversharing. Altogether, our framework paves the way for more accurate and informative LLM benchmarking through our realistic and steerable patient simulator.

cs.HC↗

Towards Expert-level Medical AI for Real-time Video Consultations

Audio-visual interaction is the standard for patient-physician consultations, enabling natural communication and effective assessment of illness through non-verbal cues. While text-based AI has shown promise, it discards essential perceptual dimensions and limits patients who cannot articulate symptoms in writing. Early efforts to extend medical AI to audio-visual interaction have demonstrated feasibility but not reached clinician-level performance. Here, we provide the first demonstration of expert-level AI in real-time clinical video consultations using AMIE (Articulate Medical Intelligence Explorer) in a video configuration. AMIE (Video) is a Gemini-based multi-agent system integrating low-latency dialogue, clinical reasoning, and real-time audio-visual perception. To guide development, we established a taxonomy and automated evaluations for clinical audio-visual cues in telehealth settings. In a randomized Objective Structured Clinical Examination (OSCE) study with 30 primary care physicians (PCPs), 15 patient actors and 100 clinical scenarios, we compared AMIE (Video), its text-only counterpart AMIE (Text), and PCPs consulting via video. Clinical evaluators rated AMIE (Video) on par or better than PCPs in history-taking, diagnosis, management, and physical observation and examination. Patient actors preferred AMIE's approach to assessing and explaining conditions, while PCPs were preferred for rapport and partnership building. In modality ablation, patient actors preferred AMIE (Video)'s interface over text chat for communicative effectiveness, convenience, and feeling understood. Limitations remain in fine anatomical precision, subtle affective nuances, and high-frequency movements. While further research is needed before real-world translation, these results mark an important milestone toward AI systems capable of augmenting care across the sensory complexity of clinical practice.

cs.AI↗

Accelerating scientific discovery with Co-Scientist

Scientific discovery is driven by scientists generating novel hypotheses for complex problems that undergo rigorous experimental validation. To augment this process, we introduce Co-Scientist, a multi-agent AI system built on Gemini for structured scientific thinking and hypothesis generation. Co-Scientist aims to help scientists discover new original knowledge. Conditioned on their research objectives and prior scientific evidence, it formulates demonstrably novel research hypotheses for experimental verification. The system's design involves agents continuously generating, critiquing and refining hypotheses accelerated by scaling test-time compute. Key contributions include: (1) a multi-agent architecture with an asynchronous task execution framework for flexible compute scaling; (2) a tournament evolution process for self-improving hypotheses generation. Automated evaluations show continued benefits of test-time compute scaling, improving hypothesis quality over time. While general purpose, we focus the validation in three biomedical applications: drug repurposing, novel target discovery, and explaining mechanisms of anti-microbial resistance. Specifically, Co-Scientist helped identify new drug repurposing candidates and synergistic combination therapies for acute myeloid leukemia, which were validated through in vitro experiments. These real-world validations demonstrate the potential of Co-Scientist to accelerate scientific discovery and usher in an era of AI empowered scientists.

cs.AI↗

Towards Automating Scientific Review with Google's Paper Assistant Tool

Artificial intelligence is driving a revolution in scientific discovery, accelerating everything from hypothesis generation to mathematical theorem proving. However, this rapid acceleration is creating a systemic challenge: traditional human peer review cannot scale to match the influx of AI-assisted science. Ultimately, to resolve this tension, we must also deploy AI to accelerate the verification and review process itself. To frame the discussion around this transition, we propose a taxonomy consisting of four progressive levels of AI-human collaboration in scientific evaluation, and discuss various trade-offs involved with each. As a step toward this future, we introduce the Paper Assistant Tool (PAT), an agentic AI framework built for deep scientific review and verification. PAT ingests full scientific manuscripts and produces a comprehensive evaluation, checking theoretical results, validating experiments, suggesting improvements, and identifying potential flaws. By utilizing inference scaling techniques, PAT is able to identify deeper issues than a single model call alone, achieving a 34% improvement over zero-shot recall on mathematical errors in the SPOT benchmark. Pilot deployments of PAT as a pre-submission tool for authors at two major Computer Science conferences -- STOC and ICML -- demonstrate its ability to identify critical errors and suggest substantive improvements to research papers. By catching errors early, PAT eases the cognitive burden placed on referees, while preserving their control over the outcomes of the review process.

cs.LG↗

Evaluating the Utility of Personal Health Records in Personalized Health AI

Patient-managed Personal Health Records (PHRs) promises to empower patients to better understand their health; but information in the record is complex, potentially hindering insights. In this study, we assess the potential of large language models (LLMs, Gemini 3.0 Flash) to provide helpful answers to user health queries, when provided clinical data from PHRs as context. A total of 2,257 user queries were drawn from 3 different distributions to represent patient questions: shorter web search queries, longer questions derived from templates of chatbot conversations, and questions patients asked to their healthcare team (patient calls). Queries were matched with de-identified PHRs (from a pool of 1,945). Gemini responses were generated (1) without PHR context; (2) with a basic summary of demographics, conditions, and medications; (3) with full, extensive clinical notes. For evaluation, we leveraged an existing rating framework (SHARP), and developed a new framework for specific error modes when interpreting PHRs. Evaluation was performed using autoraters for the full set, and with clinician ratings for a subset (n=95), with both sets of raters knowing the full PHR context. We see significant improvements in the helpfulness of answers to all question types with PHR data (p < 0.001, paired t-test). We also observe potential gains in safety, accuracy, relevance and personalization of answers. Our PHR evaluation framework further identifies gaps in LLM understanding of particular aspects of complex PHRs, such as temporal disorientation, and rare but meaningful confabulations. These results suggest potential for PHR data to help people with a wide range of user needs; and provide a framework for monitoring for gaps in LLM answers based on PHR context. This study motivates further work to assess and realize potential benefits to users from understanding their health records.

cs.AI↗