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Youhua Liu

Publications and source records attributed to Youhua Liu.

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S$^2$GR: Stepwise Semantic-Guided Reasoning in Latent Space for Generative Recommendation

Generative Recommendation (GR) has emerged as a transformative paradigm with its end-to-end generation advantages. However, existing GR methods primarily focus on direct Semantic ID (SID) generation from interaction sequences, failing to activate deeper reasoning capabilities analogous to those in large language models and thus limiting performance potential. We identify two critical limitations in current reasoning-enhanced GR approaches: (1) Strict sequential separation between reasoning and generation steps creates imbalanced computational focus across hierarchical SID codes, degrading quality for SID codes; (2) Generated reasoning vectors lack interpretable semantics, while reasoning paths suffer from unverifiable supervision. In this paper, we propose stepwise semantic-guided reasoning in latent space (S$^2$GR), a novel reasoning enhanced GR framework. First, we establish a robust semantic foundation via codebook optimization, integrating item co-occurrence relationship to capture behavioral patterns, and load balancing and uniformity objectives that maximize codebook utilization while reinforcing coarse-to-fine semantic hierarchies. Our core innovation introduces the stepwise reasoning mechanism inserting thinking tokens before each SID generation step, where each token explicitly represents coarse-grained semantics supervised via contrastive learning against ground-truth codebook cluster distributions ensuring physically grounded reasoning paths and balanced computational focus across all SID codes. Extensive experiments demonstrate the superiority of S$^2$GR, and online A/B test confirms efficacy on large-scale industrial short video platform.

cs.IR

Sequential Wnt Agonist then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis

Tissue fibrosis compromises organ function and occurs as a potential long-term outcome in response to acute tissue injuries. Currently, lack of mechanistic understanding prevents effective prevention and treatment of the progression from acute injury to fibrosis. Here, we combined quantitative experimental studies with a mouse kidney injury model and a computational approach to determine how the physiological consequences are determined by the severity of ischemia injury, and to identify how to manipulate Wnt signaling to accelerate repair of ischemic tissue damage while minimizing fibrosis. The study reveals that Wnt-mediated memory of prior injury contributes to fibrosis progression, and ischemic preconditioning reduces the risk of death but increases the risk of fibrosis. Furthermore, we validated the prediction that sequential combination therapy of initial treatment with a Wnt agonist followed by treatment with a Wnt antagonist can reduce both the risk of death and fibrosis in response to acute injuries.

q-bio.TO