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Young-Ho Lee

Publications and source records attributed to Young-Ho Lee.

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Real-time feedback control of ELM frequency using divertor gas puffing and its effects on tungsten-induced radiation and plasma performance in KSTAR

The edge-localized mode (ELM) frequency ($f_{\mathrm{ELM}}$) was successfully controlled in real time on KSTAR using a proportional-integral (PI) feedback controller, employing a $\mathrm{D}_2$ divertor gas puff as the actuator under tungsten lower-divertor conditions. The controller accurately tracked a two-step target---a 30 Hz increase in $f_{\mathrm{ELM}}$ for 4 s, followed by a 30 Hz decrease for 3 s---yielding mean and median absolute percentage errors of approximately 13% and 12%, respectively. Compared to a reference discharge, the actively controlled shot did not exhibit a significant drop in volume-integrated core radiation, confirming that excessive gas use merely degrades overall plasma performance. However, when contrasted with the exponential increase in core radiation observed in the absence of divertor gas puffing, these results underscore the critical need for real-time optimization. Specifically, divertor gas commands must be actively managed to maintain an $f_{\mathrm{ELM}}$ sufficient for flushing tungsten from the core while maximizing global plasma performance.

physics.plasm-ph

Computational fluid dynamic simulation of hull reservoir wave energy device

This paper presents a Computational Fluid Dynamics (CFD) analysis of a wave energy device called the Hull Reservoir Wave Energy Converter (HRWEC). The device consists of a floating hull and a flap connected to the shaft of power take-off system (PTO), which is integral to the hull structure. It is unique due to its ability to convert wave energy by utilizing the pitch motion of the hull and rotating flap due to the internal water movement in the hull. Due to the complexity of the internal fluid dynamics, a CFD-based analysis was considered most appropriate. The CFD investigation of the dynamics of the device was done under regular wave conditions by using the ANSYS-AQWA and ANSYS FLUENT. Relative pitch angle variation, the hydrodynamic coefficients, which determine the degree of power extraction, were obtained from simulated results. A simulation was designed exhibiting complete system dynamics for different configurations varying on internal water height. Excellent convergence was observed,and an optimum configuration was identified. It is expected to validate the simulation results through experiments in the foreseeable future.

physics.flu-dyn

Graphene quantum dots prevent alpha-synucleinopathy in Parkinson's disease

While the emerging evidence indicates that the pathogenesis of Parkinson's disease (PD) is strongly correlated to the accumulation of alpha-synuclein (α-syn) aggregates, there has been no clinical success in anti-aggregation agents for the disease to date. Here we show that graphene quantum dots (GQDs) exhibit anti-amyloid activity via direct interaction with α-syn. Employing biophysical, biochemical, and cell-based assays as well as molecular dynamics (MD) simulation, we find that GQDs have notable potency in not only inhibiting fibrillization of α-syn but also disaggregating mature fibrils in a time-dependent manner. Remarkably, GQDs rescue neuronal death and synaptic loss, reduce Lewy body (LB)/Lewy neurite (LN) formation, ameliorate mitochondrial dysfunctions, and prevent neuron-to-neuron transmission of α-syn pathology induced by α-syn preformed fibrils (PFFs) in neurons. In addition, in vivo administration of GQDs protects against α-syn PFFs-induced loss of dopamine neurons, LB/LN pathology, and behavioural deficits through the penetration of the blood-brain barrier (BBB). The finding that GQDs function as an anti-aggregation agent provides a promising novel therapeutic target for the treatment of PD and related α-synucleinopathies.

physics.med-ph