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Yuan-chin Ivan Chang

Publications and source records attributed to Yuan-chin Ivan Chang.

22 records · Page 2Linked to original sources

Active Learning Via Sequential Design and Uncertainty Sampling

Classification is an important task in many fields including biomedical research and machine learning. Traditionally, a classification rule is constructed based a bunch of labeled data. Recently, due to technological innovation and automatic data collection schemes, we easily encounter with data sets containing large amounts of unlabeled samples. Because to label each of them is usually costly and inefficient, how to utilize these unlabeled data in a classifier construction process becomes an important problem. In machine learning literature, active learning or semi-supervised learning are popular concepts discussed under this situation, where classification algorithms recruit new unlabeled subjects sequentially based on the information learned from previous stages of its learning process, and these new subjects are then labeled and included as new training samples. From a statistical aspect, these methods can be recognized as a hybrid of the sequential design and stochastic approximation procedure. In this paper, we study sequential learning procedures for building efficient and effective classifiers, where only the selected subjects are labeled and included in its learning stage. The proposed algorithm combines the ideas of Bayesian sequential optimal design and uncertainty sampling. Computational issues of the algorithm are discussed. Numerical results using both synthesized data and real examples are reported.

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Sequential Estimation in Item Calibration with A Two-Stage Design

In this paper we apply a two-stage sequential design to item calibration problems under a three-parameter logistic model assumption. The measurement errors of the estimates of the latent trait levels of examinees are considered in our procedure. Moreover, a sequential procedure is employed to guarantee that the estimates of the parameters reach a prescribed accuracy criterion when the iteration is stopped, which fully takes the advantage of sequential design. Statistical properties of both the item parameter estimates and the sequential procedure are discussed. We compare the performance of the proposed method with that of the procedures based on some conventional designs using numerical studies.

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Sequential estimation for covariate-adjusted response-adaptive designs

In clinical trials, a covariate-adjusted response-adaptive (CARA) design allows a subject newly entering a trial a better chance of being allocated to a superior treatment regimen based on cumulative information from previous subjects, and adjusts the allocation according to individual covariate information. Since this design allocates subjects sequentially, it is natural to apply a sequential method for estimating the treatment effect in order to make the data analysis more efficient. In this paper, we study the sequential estimation of treatment effect for a general CARA design. A stopping criterion is proposed such that the estimates satisfy a prescribed precision when the sampling is stopped. The properties of estimates and stopping time} are obtained under the proposed stopping rule. In addition, we show that the asymptotic properties of the allocation function, under the proposed stopping rule, are the same as those obtained in the non-sequential/fixed sample size counterpart. We then illustrate the performance of the proposed procedure with some simulation results using logistic models. The properties, such as the coverage probability of treatment effect, correct allocation proportion and average sample size, for diverse combinations of initial sample sizes and tuning parameters in the utility function are discussed.

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Evaluating the diagnostic powers of variables and their linear combinations when the gold standard is continuous

The receiver operating characteristic (ROC) curve is a very useful tool for analyzing the diagnostic/classification power of instruments/classification schemes as long as a binary-scale gold standard is available. When the gold standard is continuous and there is no confirmative threshold, ROC curve becomes less useful. Hence, there are several extensions proposed for evaluating the diagnostic potential of variables of interest. However, due to the computational difficulties of these nonparametric based extensions, they are not easy to be used for finding the optimal combination of variables to improve the individual diagnostic power. Therefore, we propose a new measure, which extends the AUC index for identifying variables with good potential to be used in a diagnostic scheme. In addition, we propose a threshold gradient descent based algorithm for finding the best linear combination of variables that maximizes this new measure, which is applicable even when the number of variables is huge. The estimate of the proposed index and its asymptotic property are studied. The performance of the proposed method is illustrated using both synthesized and real data sets.

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