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Yuanhong Bi

Publications and source records attributed to Yuanhong Bi.

2 recordsLinked to original sources

Topology-Biased Resource Constraints Shape Synchronization Pathways in Hindmarsh-Rose Oscillator Networks

In oscillator networks sustained by finite resources, synchronization can depend on both the total resource and its spatial distribution. We study a duplex system whose activity layer consists of chaotic Hindmarsh--Rose oscillators and whose transport layer redistributes a conserved resource through a degree-biased Markov process. The stationary resource field is characterized analytically, and its existence, uniqueness, and convergence are established. By embedding this field into a local adaptive feedback law, the available resource is converted into node-dependent dissipation, for which Lyapunov analysis guarantees convergence to the synchronization manifold. Numerical results show that topology bias reorganizes the transient route to synchronization. Weak bias produces an almost collective contraction, whereas intermediate bias creates a hub-initiated recruitment hierarchy that extends toward middle-degree and peripheral nodes. Under stronger bias, the degree hierarchy becomes more pronounced while peripheral recruitment slows because adaptive dissipation is concentrated on structurally privileged nodes. Across the explored parameter range, this localization--coverage tradeoff is accompanied by a non-monotonic synchronization response at fixed total resource. The largest Lyapunov exponent remains positive after synchronization and the correlation dimension changes only modestly, consistent with suppression of transverse deviations while chaotic motion is retained on the synchronization manifold.

nlin.AO

Bifurcation analysis and potential landscape of the p53-Mdm2 oscillator regulated by the co-activator PDCD5

Dynamics of p53 is known to play important roles in the regulation of cell fate decisions in response to various stresses, and PDCD5 functions as a co-activator of p53 to modulate the p53 dynamics. In the present paper, we investigate how p53 dynamics are modulated by PDCD5 during the DNA damage response using methods of bifurcation analysis and potential landscape. Our results reveal that p53 activities can display rich dynamics under different PDCD5 levels, including monostability, bistability with two stable steady states, oscillations, and co-existence of a stable steady state and an oscillatory state. Physical properties of the p53 oscillations are further shown by the potential landscape, in which the potential force attracts the system state to the limit cycle attractor, and the curl flux force drives the coherent oscillation along the cyclic. We also investigate the effect of PDCD5 efficiency on inducing the p53 oscillations. We show that Hopf bifurcation is induced by increasing the PDCD5 efficiency, and the system dynamics show clear transition features in both barrier height and energy dissipation when the efficiency is close to the bifurcation point. This study provides a global picture of how PDCD5 regulates p53 dynamics via the interaction with the p53-Mdm2 oscillator and can be helpful in understanding the complicate p53 dynamics in a more complete p53 pathway.

q-bio.MN