arXiv subjects

Yuanyuan Dang

Publications and source records attributed to Yuanyuan Dang.

3 recordsLinked to original sources

arXiv2025

Transcranial Photoacoustic Imaging for Human Intracranial Pressure Evaluation

Photoacoustic imaging (PAI), by combining high optical contrast with ultrasonic resolution, offers a promising noninvasive approach for dynamic monitoring of cerebral vasculature. However, transcranial PAI still faces significant challenges due to strong attenuation of both optical and acoustic signals by the skull. In this study, we propose a multi-wavelength photoacoustic tomography system and method for intracranial pressure (ICP) assessment, enabling visualization of cross-sectional structures of the middle cerebral artery (MCA) through the human temporal bone. By utilizing multi-wavelength excitation in the near-infrared-I (NIR-I) window, quantitative maps of blood oxygen saturation ($\mathbf{sO_2}$) are reconstructed, and the relationship between oxygenation dynamics and ICP variations is established. Experimental results demonstrate that the proposed system can successfully capture dynamic $\mathbf{sO_2}$ fluctuations in the MCA despite skull attenuation, revealing its characteristic responses to ICP changes. This work provides a high-precision, noninvasive imaging tool for early stroke diagnosis, cerebral vascular function assessment, and neurointerventional guidance, highlighting the clinical translational potential of PAI in neuroscience.

physics.med-ph↗

arXiv2021

Empowering Patients Using Smart Mobile Health Platforms: Evidence From A Randomized Field Experiment

With today's technological advancements, mobile phones and wearable devices have become extensions of an increasingly diffused and smart digital infrastructure. In this paper, we examine mobile health (mHealth) platforms and their health and economic impacts on the outcomes of chronic disease patients. We partnered with a major mHealth firm that provides one of the largest mHealth apps in Asia specializing in diabetes care. We designed a randomized field experiment based on detailed patient health activities (e.g., exercises, sleep, food intake) and blood glucose values from 1,070 diabetes patients over several months. We find the adoption of the mHealth app leads to an improvement in health behavior, which leads to both short term metrics (reduction in patients' blood glucose and glycated hemoglobin levels) and longer-term metrics (hospital visits and medical expenses). Patients who adopted the mHealth app undertook more exercise, consumed healthier food, walked more steps and slept for longer times. They also were more likely to substitute offline visits with telehealth. A comparison of mobile vs. PC version of the same app demonstrates that mobile has a stronger effect than PC in helping patients make these behavioral modifications with respect to diet, exercise and lifestyle, which leads to an improvement in their healthcare outcomes. We also compared outcomes when the platform facilitates personalized health reminders to patients vs. generic reminders. Surprisingly, we find personalized mobile messages with patient-specific guidance can have an inadvertent (smaller) effect on patient app engagement and lifestyle changes, leading to a lower health improvement. However, they are more like to encourage a substitution of offline visits by telehealth. Overall, our findings indicate the massive potential of mHealth technologies and platform design in achieving better healthcare outcomes.

econ.GN↗

arXiv2018

Prognostication of chronic disorders of consciousness using brain functional networks and clinical characteristics

Disorders of consciousness are a heterogeneous mixture of different diseases or injuries. Although some indicators and models have been proposed for prognostication, any single method when used alone carries a high risk of false prediction. This study aimed to develop a multidomain prognostic model that combines resting state functional MRI with three clinical characteristics to predict one year outcomes at the single-subject level. The model discriminated between patients who would later recover consciousness and those who would not with an accuracy of around 90% on three datasets from two medical centers. It was also able to identify the prognostic importance of different predictors, including brain functions and clinical characteristics. To our knowledge, this is the first implementation reported of a multidomain prognostic model based on resting state functional MRI and clinical characteristics in chronic disorders of consciousness. We therefore suggest that this novel prognostic model is accurate, robust, and interpretable.

q-bio.NC↗