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Yue Jiao

Publications and source records attributed to Yue Jiao.

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Determining the Equivalence of Small Zero-one Reaction Networks

Zero-one reaction networks are pivotal to cellular signaling, and establishing the equivalence of such networks represents a foundational computational challenge in the realm of chemical reaction network research. Herein, we propose a high-efficiency approach for identifying the equivalence of zero-one networks. Its efficiency stems from a set of criteria tailored to judge the equivalence of steady-state ideals derived from zero-one networks, which effectively reduces the computational cost associated with Gröbner basis calculations. Experimental results demonstrate that our proposed method can successfully categorize more than three million networks by their equivalence within a feasible timeframe. Also, our computational results for two important classes of quadratic zero-one networks (3-dimensional with 3 species, 6 reactions; 4-dimensional with 4 species, 5 reactions) show that they have no positive steady states for a generic choice of rate constants, implying these small networks generically exhibit neither multistability nor periodic orbits.

q-bio.MN

Multistability of small zero-one reaction networks

Zero-one biochemical reaction networks play key roles in cell signalling such as signalling pathways regulated by protein phosphorylation. Multistability of reaction networks is a crucial dynamics feature enabling decision-making in cells. It is well known that multistability can be lifted from a "subnetwork" (a network with less species and fewer reactions) to large networks. So, we aim to explore the multistability problem of small zero-one networks. In this work, we prove the following main results: 1. any zero-one network with a one-dimensional stoichiometric subspace admits at most one positive steady state (it must be stable), and all the one-dimensional zero-one networks can be classified according to if they indeed admit a stable positive steady state or not; 2. any two-dimensional zero-one network with up to three species either admits only degenerate positive steady states, or admits at most one positive steady state (it must be stable); 3. the smallest zero-one networks (here, by "smallest", we mean these networks contain species as few as possible) that admit nondegenerate multistationarity/multistability contain three species and five/six reactions, and they are three dimensional. In these proofs, we use the theorems based on the Brouwer degree theory and the theory of real algebraic geometry. Moreover, applying the tools of computational real algebraic geometry, we provide a systematical way for detecting the networks that admit nondegenerate multistationarity/multistability.

math.DS

What Remains of Visual Semantic Embeddings

Zero shot learning (ZSL) has seen a surge in interest over the decade for its tight links with the mechanism making young children recognize novel objects. Although different paradigms of visual semantic embedding models are designed to align visual features and distributed word representations, it is unclear to what extent current ZSL models encode semantic information from distributed word representations. In this work, we introduce the split of tiered-ImageNet to the ZSL task, in order to avoid the structural flaws in the standard ImageNet benchmark. We build a unified framework for ZSL with contrastive learning as pre-training, which guarantees no semantic information leakage and encourages linearly separable visual features. Our work makes it fair for evaluating visual semantic embedding models on a ZSL setting in which semantic inference is decisive. With this framework, we show that current ZSL models struggle with encoding semantic relationships from word analogy and word hierarchy. Our analyses provide motivation for exploring the role of context language representations in ZSL tasks.

cs.CV

Language Models as Zero-shot Visual Semantic Learners

Visual Semantic Embedding (VSE) models, which map images into a rich semantic embedding space, have been a milestone in object recognition and zero-shot learning. Current approaches to VSE heavily rely on static word em-bedding techniques. In this work, we propose a Visual Se-mantic Embedding Probe (VSEP) designed to probe the semantic information of contextualized word embeddings in visual semantic understanding tasks. We show that the knowledge encoded in transformer language models can be exploited for tasks requiring visual semantic understanding.The VSEP with contextual representations can distinguish word-level object representations in complicated scenes as a compositional zero-shot learner. We further introduce a zero-shot setting with VSEPs to evaluate a model's ability to associate a novel word with a novel visual category. We find that contextual representations in language mod-els outperform static word embeddings, when the compositional chain of object is short. We notice that current visual semantic embedding models lack a mutual exclusivity bias which limits their performance.

cs.CV