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Yue Yang

Publications and source records attributed to Yue Yang.

At least 217 records · Page 12Linked to original sources

Modeling Three-dimensional Invasive Solid Tumor Growth in Heterogeneous Microenvironment under Chemotherapy

A systematic understanding of the evolution and growth dynamics of invasive solid tumors in response to different chemotherapy strategies is crucial for the development of individually optimized oncotherapy. Here, we develop a hybrid three-dimensional (3D) computational model that integrates pharmacokinetic model, continuum diffusion-reaction model and discrete cell automaton model to investigate 3D invasive solid tumor growth in heterogeneous microenvironment under chemotherapy. Specifically, we consider the effects of heterogeneous environment on drug diffusion, tumor growth, invasion and the drug-tumor interaction on individual cell level. We employ the hybrid model to investigate the evolution and growth dynamics of avascular invasive solid tumors under different chemotherapy strategies. Our simulations reproduce the well-established observation that constant dosing is generally more effective in suppressing primary tumor growth than periodic dosing, due to the resulting continuous high drug concentration. In highly heterogeneous microenvironment, the malignancy of the tumor is significantly enhanced, leading to inefficiency of chemotherapies. The effects of geometrically-confined microenvironment and non-uniform drug dosing are also investigated. Our computational model, when supplemented with sufficient clinical data, could eventually lead to the development of efficient in silico tools for prognosis and treatment strategy optimization.

q-bio.TO↗

Neutrino Flavour Evolution Through Fluctuating Matter

A neutrino propagating through fluctuating matter can experience large amplitude transitions between its states. Such transitions occur in supernovae and compact object mergers due to turbulent matter profiles and neutrino self-interactions. In this paper we study, both numerically and analytically, three-flavour neutrino transformation through fluctuating matter built from two and three Fourier modes. We find flavor transformation effects which cannot occur with just two flavours. For the case of two Fourier modes we observe the equivalent of "induced transparency" from quantum optics whereby transitions between a given pair of states are suppressed due to the presence of a resonant mode between another pair. When we add a third Fourier mode we find a new effect whereby the third mode can manipulate the transition probabilities of the two mode case so as to force complete transparency or, alternatively, restore "opacity" meaning the perturbative Hamiltonian regains its ability to induce neutrino flavour transitions. In both applications we find analytic solutions are able to match the amplitude and wavenumber of the numerical results to within a few percent. We then consider a case of turbulence and show how the theory can be used to understand the very different response of a neutrino to what appears to be two, almost identical, instances of turbulence.

quant-ph↗

OPARC: Optimal and Precise Array Response Control Algorithm -- Part I: Fundamentals

In this paper, the problem of how to optimally and precisely control array response levels is addressed. By using the concept of the optimal weight vector from the adaptive array theory and adding virtual interferences one by one, the change rule of the optimal weight vector is found and a new formulation of the weight vector update is thus devised. Then, the issue of how to precisely control the response level of one single direction is investigated. More specifically, we assign a virtual interference to a direction such that the response level can be precisely controlled. Moreover, the parameters, such as, the interference-to-noise ratio (INR), can be figured out according to the desired level. Additionally, the parameter optimization is carried out to obtain the maximal array gain. The resulting scheme is called optimal and precise array response control (OPARC) in this paper. To understand it better, its properties are given, and its comparison with the existing accurate array response control ($ {\textrm A}^2\textrm{RC} $) algorithm is provided. Finally, simulation results are presented to verify the effectiveness and superiority of the proposed OPARC.

eess.SP↗

OPARC: Optimal and Precise Array Response Control Algorithm -- Part II: Multi-points and Applications

In this paper, the optimal and precise array response control (OPARC) algorithm proposed in Part I of this two paper series is extended from single point to multi-points. Two computationally attractive parameter determination approaches are provided to maximize the array gain under certain constraints. In addition, the applications of the multi-point OPARC algorithm to array signal processing are studied. It is applied to realize array pattern synthesis (including the general array case and the large array case), multi-constraint adaptive beamforming and quiescent pattern control, where an innovative concept of normalized covariance matrix loading (NCL) is proposed. Finally, simulation results are presented to validate the superiority and effectiveness of the multi-point OPARC algorithm.

eess.SP↗

Effects of the Mach number on the evolution of vortex-surface fields in compressible Taylor--Green flows

We investigate the evolution of vortex-surface fields (VSFs) in compressible Taylor--Green flows at Mach numbers ($Ma$) ranging from 0.5 to 2.0 using direct numerical simulation. The formulation of VSFs in incompressible flows is extended to compressible flows, and a mass-based renormalization of VSFs is used to facilitate characterizing the evolution of a particular vortex surface. The effects of the Mach number on the VSF evolution are different in three stages. In the early stage, the jumps of the compressive velocity component near shocklets generate sinks to contract surrounding vortex surfaces, which shrink vortex volume and distort vortex surfaces. The subsequent reconnection of vortex surfaces, quantified by the minimal distance between approaching vortex surfaces and the exchange of vorticity fluxes, occurs earlier and has a higher reconnection degree for larger $Ma$ owing to the dilatational dissipation and shocklet-induced reconnection of vortex lines. In the late stage, the positive dissipation rate and negative pressure work accelerate the loss of kinetic energy and suppress vortex twisting with increasing $Ma$.

physics.flu-dyn↗

GR Effects in Supernova Neutrino Flavor Transformation

The strong gravitational field around a proto-neutron star can modify the neutrino flavor transformations that occur above the neutrinosphere via three General Relativistic (GR) effects: time dilation, energy redshift, and trajectory bending. Depending on the compactness of the central object, the neutrino self-interaction potential is up to three times as large as that without GR principally due to trajectory bending which increases the intersection angles between different neutrino trajectories, and time dilation which changes the fluxes. We determine whether GR effects are important for flavor transformation during the different epochs of a supernova by using multi-angle flavor transformation calculations and consider a density profile and neutrino spectra representative of both the accretion and cooling phases. We find the GR effects are smaller during the accretion phase due to low compactness of the proto-neutron star and merely delay the decoherence; the neutrino bipolar oscillations during the cooling phase are also delayed due to the GR effects but the delay may be more important because the delay occurs at radii where it might alter the nucleosynthesis in the neutrino driven wind.

astro-ph.HE↗

Exploiting ITO colloidal nanocrystals for ultrafast pulse generation

Dynamical materials that capable of responding to optical stimuli have always been pursued for designing novel photonic devices and functionalities, of which the response speed and amplitude as well as integration adaptability and energy effectiveness are especially critical. Here we show ultrafast pulse generation by exploiting the ultrafast and sensitive nonlinear dynamical processes in tunably solution-processed colloidal epsilon-near-zero (ENZ) transparent conducting oxide (TCO) nanocrystals (NCs), of which the potential respond response speed is >2 THz and modulation depth is ~23% pumped at ~0.7 mJ/cm2, benefiting from the highly confined geometry in addition to the ENZ enhancement effect. These ENZ NCs may offer a scalable and printable material solution for dynamic photonic and optoelectronic devices.

cond-mat.mtrl-sci↗

Real-Time Optical flow-based Video Stabilization for Unmanned Aerial Vehicles

This paper describes the development of a novel algorithm to tackle the problem of real-time video stabilization for unmanned aerial vehicles (UAVs). There are two main components in the algorithm: (1) By designing a suitable model for the global motion of UAV, the proposed algorithm avoids the necessity of estimating the most general motion model, projective transformation, and considers simpler motion models, such as rigid transformation and similarity transformation. (2) To achieve a high processing speed, optical-flow based tracking is employed in lieu of conventional tracking and matching methods used by state-of-the-art algorithms. These two new ideas resulted in a real-time stabilization algorithm, developed over two phases. Stage I considers processing the whole sequence of frames in the video while achieving an average processing speed of 50fps on several publicly available benchmark videos. Next, Stage II undertakes the task of real-time video stabilization using a multi-threading implementation of the algorithm designed in Stage I.

cs.CV↗

OFDM demodulation using virtual time reversal processing in underwater acoustic communication

The extremely long underwater channel delay spread causes severe inter-symbol interference (ISI) for underwater acoustic communications. Passive time reversal processing (PTRP) can effectively reduce the channel time dispersion in a simple way via convolving the received packet with a time reversed probe signal. However the probe signal itself may introduce extra noise and interference (self-correlation of the probe signal). In this paper, we propose a virtual time reversal processing (VTRP) for single input single output (SISO) Orthogonal Frequency Division Multiplexing (OFDM) systems. It convolves the received packet with the reversed estimated channel, instead of the probe signal to reduce the interference. Two sparse channel estimation methods, matching pursuit (MP), and basis pursuit de-noising (BPDN), are adopted to estimate the channel impulse response (CIR). We compare the performance of VTRP with the PTRP and without any time reversal processing through MATLAB simulations and the pool experiments. The results reveal that VTRP has outstanding performance over time-invariant channels.

cs.IT↗

PCF Scheme for Periodic Data Transmission in Smart Metering Network with Cognitive Radio

The next generation Advanced Metering Infrastructure (AMI), with the aid of two-way Smart Metering Network (SMN), is expected to support many advanced functions. In this work, we focus on the application of remote periodic energy consumption reporting, which is a fundamental and significant component of Demand Response and Load Management. In order to support this periodic application with satisfactory communication performance, a well-suited Media Access Control (MAC) protocol needs to be designed. Because the number of Smart Meters (communication nodes) involved in SMN are much larger than that in today's local area networks, the traditional taking-turns MAC protocol, such as Point Coordination Function (PCF) in WiFi is unlikely to perform well. In order to solve this problem, we propose a modified PCF scheme with the combination of Cognitive Radio technology, in which the Smart Meters may use the free channels (white space) to report energy consumption data to the Local Collector when the Primary Users are not occupying the channels. We also conduct comprehensive throughput analysis on the proposed scheme. The numerical results and simulation results through NS-3 show that the PCF scheme with Cognitive Radio significantly outperform the traditional one in a densely populated network like SMN.

cs.NI↗

A semi-automatic computer-aided method for surgical template design

This paper presents a generalized integrated framework of semi-automatic surgical template design. Several algorithms were implemented including the mesh segmentation, offset surface generation, collision detection, ruled surface generation, etc., and a special software named TemDesigner was developed. With a simple user interface, a customized template can be semi- automatically designed according to the preoperative plan. Firstly, mesh segmentation with signed scalar of vertex is utilized to partition the inner surface from the input surface mesh based on the indicated point loop. Then, the offset surface of the inner surface is obtained through contouring the distance field of the inner surface, and segmented to generate the outer surface. Ruled surface is employed to connect inner and outer surfaces. Finally, drilling tubes are generated according to the preoperative plan through collision detection and merging. It has been applied to the template design for various kinds of surgeries, including oral implantology, cervical pedicle screw insertion, iliosacral screw insertion and osteotomy, demonstrating the efficiency, functionality and generality of our method.

cs.GR↗

Evolution of material surfaces in the temporal transition in channel flow

We report a Lagrangian study on the evolution of material surfaces in the K-type temporal transitional channel flow. Based on the Eulerian velocity field from the DNS, a backward-particle-tracking method is applied to solve the transport equation of the Lagrangian scalar field, and then the iso-surfaces of the Lagrangian field can be extracted as material surfaces in the evolution. Three critical issues for Lagrangian investigations on the evolution of coherent structures using material surfaces are addressed. First, the initial scalar field is uniquely determined based on proposed criteria, so that the initial material surfaces can be approximated as vortex surfaces, and keep invariant in the initial laminar state. Second, the evolution of typical material surfaces initially from different wall distances is presented, and then the influential material surface with the maximum deformation is identified. Large vorticity variations with the maximum curvature growth of vortex lines are also observed on this surface. Moreover, crucial events in the transition can be characterized in a Lagrangian approach by conditional statistics on the material surfaces. Finally, the influential material surface, which is initially a vortex surface, is demonstrated as a surrogate of the vortex surface before significant topological changes of vortical structures. Therefore, this material surface can be used to elucidate the continuous evolution of vortical structures in transitional wall-bounded flows in a Lagrangian perspective. The evolution of the influential material surface is divided into three stages: the formation of a triangular bulge from an initially disturbed streamwise-spanwise sheet, rolling up of the vortex sheet near the bulge ridges with the vorticity intensification, and the generation and evolution of signature hairpin-like structures with self-induced dynamics of vortex filaments.

physics.flu-dyn↗

MAC Protocols Design for Smart Metering Network

The new generation of power metering system - i.e. Advanced Metering Infrastructure (AMI) - is expected to enable remote reading, control, demand response and other advanced functions, based on the integration of a new two-way communication network, which will be referred as Smart Metering Network (SMN). In this paper, we focus on the design principles of multiple access control (MAC) protocols for SMN. First, we list several AMI applications and its benefits to the current power grid and user experience. Next, we introduces several features of SMN relevant to the design choice of the MAC protocols, including the SMN architecture and candidate communication technologies. After that, we propose some performance evaluation metrics, such as scalability issue, traffic types, delay and etc, and give a survey of the associated research issues for the SMN MAC protocols design. In addition, we also note progress within the new IEEE standardization task group (IEEE 802.11ah TG) currently working to create SMN standards, especially in the MAC protocols aspect.

cs.NI↗

Dose conversion coefficients for Chinese reference adult male and female voxel phantoms from idealized neutron exposures

A new set of fluence-to-dose conversion coefficients based on the Chinese reference adult voxel phantoms CRAM and CRAF are presented for six idealized external neutron exposures from 10-8 MeV to 20 MeV. The voxel phantoms CRAM and CRAF were adjusted from the previous phantoms CNMAN and CNWM respectively, and the masses of individual organs have been adjusted to the Chinese reference data. The calculation of organ-absorbed doses and effective doses were performed with the Monte Carlo transport code MCNPX. The resulting dose conversion coefficients were compared with those published in ICRP Publication 116, which represents the reference Caucasian. The organ-absorbed dose conversion coefficients of most organs are in good agreement with the results in ICRP Publication 116, however, obvious discrepancies are observed for some organs and certain geometries. For neutrons with energies above 2 MeV, the effective dose conversion coefficients of Chinese reference adult are almost identical to those of ICRP Publication 116 in AP, PA, ROT and ISO geometries. When energies range from 10-8 MeV to 1 MeV, differences are within 10% in AP (5%), PA (8%) and ROT (-4%) geometries. However, relatively large discrepancies are shown in lateral and ISO geometries when energies are below 1 MeV, with differences of -15% for LLAT, -20% for RLAT and -12% for ISO, respectively.

physics.med-ph↗

Spectrally enhancing near-field radiative transfer between gold gratings by exciting magnetic polariton in nanometric vacuum gaps

In the present work, we theoretically demonstrate that near field radiative transport between one dimensional periodic grating microstructures separated by nanometer vacuum gaps can be spectrally enhanced by exciting magnetic polariton. Fluctuational electrodynamics that incorporates scattering matrix theory with rigorous coupled wave analysis is employed to exactly calculate the near field radiative flux between two gold gratings. Besides the well known coupled surface plasmon polaritons, the radiative flux can be also spectrally enhanced due to magnetic polariton, which is excited in the gap between gold ridges. The mechanisms of magnetic polariton in the near field radiative transport are elucidated in detail, while the unusual enhancement cannot be predicted by either the Derjaguin or effective medium approximations. The effects of vacuum gap distance and grating geometry parameters between the two gratings are investigated. The findings will open up a new way to control near field radiative transfer by magnetic polariton with micro or nanostructured metamaterials.

cond-mat.mes-hall↗

Performance Analysis of a Near-Field Thermophotovoltaic Device with a Metallodielectric Selective Emitter and Electrical Contacts for the Photovoltaic Cell

A near-field thermophotovoltaic (TPV) system with a multilayer emitter of alternate tungsten and alumina layer is proposed in this paper. The fluctuational electrodynamics along with the dyadic Green function for a multilayered structure is applied to calculate the spectral heat flux, and the charge transport equations are solved to get the photocurrent generation and electrical power output. The spectral heat flux is much enhanced when plain tungsten emitter is replaced with multilayer emitter. The mechanism of surface plasmon polariton coupling in the tungsten thin film, which is responsible for the heat flux enhancement, is analyzed. In addition, the invalidity of effective medium theory to predict the optical properties of multilayer structure in near-field radiation is discussed. The tungsten and alumina layer thicknesses are optimized to match the spectral heat flux with the bandgap of TPV cell. Practically, with a gold reflector placed on the back of TPV cell, which also acts as the back electrode, and a 5-nm-thick indium tin oxide (ITO) layer as the front contact, when the emitter and receiver temperature are respectively set as 2000 K and 300 K, the conversion efficiency and electrical power output can be achieved to 23.7% and 0.31 MW/m2 at a vacuum gap distance of 100 nm.

cond-mat.mes-hall↗

Extraordinary Photon Transport by Near-Field Coupling of a Nanostructured Metamaterial with a Graphene-Covered Plate

Coupled surface plasmon/phonon polaritons and hyperbolic modes are known to enhance radiative transport across nanometer vacuum gaps but usually require identical materials. It becomes crucial to achieve strong near-field energy transfer between dissimilar materials for applications like near-field thermophotovoltaic and thermal rectification. In this work, we theoretically demonstrate extraordinary near-field radiative transport between a nanostructured metamaterial emitter and a graphene-covered planar receiver. Strong near-field coupling with two orders of magnitude enhancement in the spectral heat flux is achieved at the gap distance of 20 nm. By carefully selecting the graphene chemical potential and doping levels of silicon nanohole emitter and silicon plate receiver, the total near-field radiative heat flux can reach about 500 times higher than the far-field blackbody limit between 400 K and 300 K. The physical mechanisms are elucidated by the near-field surface plasmon coupling with fluctuational electrodynamics and dispersion relations. The effects of graphene chemical potential, emitter and receiver doping levels, and vacuum gap distance on the near-field coupling and radiative transfer are analyzed in detail.

cond-mat.mes-hall↗

Tunable subwavelength strong absorption by graphene wrapped dielectric particles

The optical absorption properties of graphene wrapped dielectric particles have been investigated by using Mie scattering theory and exact multi-scattering method. It is shown that subwavelength strong absorption in infrared spectra can take place in such systems due to the excitation of plasmon resonance in graphene. The absorption characteristics and efficiency are tunable by varying Fermi level and damping constant of graphene, or by changing size and dielectric constant of small particles. For a cluster of these particles, the absorption characteristics are also affected by the separation distance between them. These extreme light resonances and absorptions in graphene wrapped nanostructures have great potential for opto-electronic devices.

physics.optics↗