arXiv subjects

Yufeng Liu

Publications and source records attributed to Yufeng Liu.

At least 19 recordsLinked to original sources

arXiv2026

Nonparametric Hypothesis Testing of High-dimensional Clustering With Application to Single-cell RNA Data

Single-cell RNA sequencing studies routinely use clustering to define putative cell types and cell states, yet the observed separation may arise from sampling variability rather than genuine biological heterogeneity. This paper studies formal significance testing of such clustering structure in high-dimensional data. Existing SigClust methods assess clustering significance through Monte Carlo simulation under a Gaussian single-cluster null, but this assumption can be unreliable for normalized gene expression data and other non-Gaussian settings. We propose SigClust-LCP, a nonparametric extension that models a single cluster by a log-concave distribution. To make this approach computationally feasible in moderate to high dimensions, we develop a score-matching estimator for log-concave projection inspired by recent generative modeling ideas. We establish theoretical guarantees for the estimator and for its use in clustering significance testing. Simulations show that SigClust-LCP controls Type-I error more reliably than existing methods across a range of unimodal and mixture distributions while retaining competitive power. In a single-cell RNA sequencing analysis of Hydra cells, the method avoids spurious subclusters within annotated cell populations and supports biologically meaningful separation across lineages and body-axis regions.

stat.ME↗

arXiv2026

When Does Legacy Data Start to Help? Emergent Transfer in Cross-Configuration Robot Learning

Robotic hardware evolves over time, but demonstration data is often tied to a specific sensor and actuator configuration. This raises a practical and underexplored question: when does legacy data begin to benefit an upgraded robot? We study this question on a wheeled humanoid platform across two hardware generations, where both the camera and gripper are changed while the overall morphology remains fixed. Contrary to the common assumption that more cross-configuration data is always helpful, we observe a grokking-like transition: legacy data remains ineffective until the upgraded configuration acquires a minimum level of task competence, after which co-training gains rise sharply before diminishing near saturation. We hypothesize that this task-dependent transition is governed by a transfer threshold and characterize the resulting three-phase pattern. Across real-robot manipulation tasks, we observe all three phases: no measurable benefit at low competence ($10.0\% \rightarrow 10.0\%$), a sharp gain after crossing the threshold ($23.3\% \rightarrow 86.7\%$ on flower insertion), and diminishing returns at high competence ($85.0\% \rightarrow 93.3\%$ on pen insertion). We provide a theoretical account based on gradient alignment and residual policy uncertainty, and derive a phase-aware rule for deciding when to collect more new-hardware data and when to reuse legacy demonstrations. We further validate this three-phase pattern on a mobile dual-arm watering task, with results consistent with our predictions.

cs.RO↗

arXiv2026

A General U-Statistic Framework for High-Dimensional Multiple Change-Point Analysis

High-dimensional change-point analysis is essential in modern statistical inference. However, existing methods are often designed either for specific parameters (e.g., mean or variance) or for particular tasks (e.g., testing or estimation), making them difficult to generalize. Moreover, they typically rely on restrictive distributional assumptions, limiting their robustness to heavy-tailed data. We propose a unified framework for testing, estimating, and inferring multiple change points in high-dimensional data. Our approach leverages a two-sample U-statistic within a moving window, allowing flexible kernel function selection to accommodate structural changes in general parameters such as variance changes or robust statistics. For testing, we develop an L-infinity norm-based statistic with a high-dimensional multiplier bootstrap procedure, achieving minimax-optimal power under sparse alternatives. For estimation, we construct an initial estimator for the change-point number and locations and refine it using the U-statistic Projection Refinement Algorithm (U-PRA), attaining minimax-optimal localization rates. We further derive the asymptotic distribution of refined estimators, enabling valid confidence interval construction. Extensive numerical experiments demonstrate the better performance of our method across various settings, including heavy-tailed distributions. Applications to genomic copy number variation data highlight its practical utility. An R package implementing the proposed method, U-PRA, is publicly available at https://github.com/liubin0145/R-codes-UPRA/.

stat.ME↗

arXiv2026

Navigating User Behavior toward Personalized Multimodal Generation

Modern AIGC pipelines deliver high-fidelity images and videos but presuppose a well-formed creation instruction, while end users rarely articulate visual details, leaving generators misaligned with user demand. We study personalized content generation, which turns a user's interaction history into an executable instruction for downstream synthesis, and identify two obstacles: behavior must be encoded in a form legible to language reasoning, and the model must acquire instruction-writing skill absent from both pretraining and behavior data. We propose NaviGen, which represents each item with a dual identifier coupling a collaborative code and a textual code as a behavioral substrate and a semantic bridge in one token stream. On this representation, a two-stage SFT+RL pipeline first distills preference reasoning and instruction writing from evolutionarily searched supervision, then aligns generation with user intent through hierarchical and self-consistent rewards. Experiments across product, game, and short-video domains show that NaviGen improves personalized image and video generation, strengthens next-item prediction, and yields more specific, relevant, and visually generatable instructions. Our code is released at: https://github.com/iLearn-Lab/NaviGen.

cs.AI↗

arXiv2026

TailorMind: Towards Preference-Aligned Multimodal Content Generation

Personalized content systems depend on available UGC and struggle when suitable content is absent, delayed, or costly to create. Although multimodal generators can synthesize content on demand, how to translate behavioral traces into generation-ready preferences remains underexplored. We study personalized multimodal content generation: creating user-tailored multimodal content without existing item pools or waiting for matching UGC. We propose TailorMind, linking collaborative preference modeling with controllable multimodal generation. TailorMind enriches sparse user histories via hypergraph collaborative filtering and optimizes textual profiles with ranking-error feedback and textual gradient descent. Retrieval-augmented style control grounds outputs in authentic UGC patterns, while cross-modal cohesion reflection reduces semantic drift. We construct TailorBench, a benchmark from three mainstream platforms evaluated along five dimensions: coherence, novelty, aesthetic, hallucination, profiling. Experiments show that TailorMind achieves competitive or stronger coherence, improves novelty and aesthetic quality over representative generation baselines and ground-truth UGC, demonstrating advantages over retrieving available content or comparable UGC, while achieving up to 29% Recall gains in reranking. Our code is released at: https://github.com/iLearn-Lab/TailorMind.

cs.AI↗

arXiv2026

Experimental Asynchronous Measurement-Device-Independent Quantum Cryptographic Conferencing

The quantum cryptographic conferencing (QCC) protocol, which distributes identical secure keys to user groups, is a crucial component of the quantum network. Previous experimental works have implemented the measurement-device-independent (MDI) QCC, of which the key rate in an $N$-user network scales down as $R\sim O(\eta^N)$, respectively. Building on the MDI QCC protocol, the asynchronous MDI (AMDI) QCC protocol theoretically integrates the mode pairing scheme into QCC, significantly boosting the key rate to $R\sim O(\eta)$, which is independent of the number of users, and thus demonstrating greater application potential. Experimentally, in this work, we implement the three-user AMDI QCC network without global phase tracking by adopting the fast Fourier transform-based frequency difference estimation and the phase drift compensation technique. Finally, we achieve a key rate of about $4.470\times10^{-9}$ bits per pulse under a maximum overall loss of about 59.6 dB. This work provides a scalable solution for the development of large-scale quantum communication networks in the future.

quant-ph↗

arXiv2026

Learning Native Continuation for Action Chunking Flow Policies

Action chunking enables Vision Language Action (VLA) models to run in real time, but naive chunked execution often exhibits discontinuities at chunk boundaries. Real-Time Chunking (RTC) alleviates this issue but is external to the policy, leading to spurious multimodal switching and trajectories that are not intrinsically smooth. We propose Legato, a training-time continuation method for action-chunked flow-based VLA policies. Specifically, Legato initializes denoising from a schedule-shaped mixture of known actions and noise, exposing the model to partial action information. Moreover, Legato reshapes the learned flow dynamics to ensure that the denoising process remains consistent between training and inference under per-step guidance. Legato further uses randomized schedule condition during training to support varying inference delays and achieve controllable smoothness. Empirically, Legato produces smoother trajectories and reduces spurious multimodal switching during execution, leading to less hesitation and shorter task completion time. Extensive real-world experiments show that Legato consistently outperforms RTC across five manipulation tasks, achieving approximately 10% improvements in both trajectory smoothness and task completion time.

cs.RO↗

arXiv2026

Prompt-Dependent Ranking of Large Language Models with Uncertainty Quantification

Rankings derived from pairwise comparisons are central to many economic and computational systems. In the context of large language models (LLMs), rankings are typically constructed from human preference data and presented as leaderboards that guide deployment decisions. However, existing approaches rely on point estimates, implicitly treating rankings as fixed objects despite substantial estimation noise and context-dependent performance variation. Acting on such rankings can lead to misallocation and welfare loss when apparent differences are not statistically meaningful. We study prompt-dependent ranking inference under pairwise human preferences and develop a framework for decision-safe rankings with statistically valid uncertainty guarantees. We model preferences using a contextual Bradley-Terry-Luce model in which the latent utility of each model depends on the input prompt. Rather than targeting point estimates of utilities, we directly conduct inference on induced rankings, constructing confidence sets based on simultaneous confidence intervals for pairwise utility differences. This approach yields statistically valid marginal and simultaneous confidence sets for prompt-specific ranks. Our framework connects recent advances in rank inference to contextual preference learning and provides tools for robust ranking-based decision-making. Empirically, using large-scale human preference data from LLM evaluations, we show that rankings vary substantially across prompt characteristics and that many apparent rank differences are not statistically distinguishable. We further demonstrate how uncertainty-aware rankings identify dominance only when supported by the data and otherwise return partial orders.

cs.CL↗

arXiv2026

Beyond Point Estimates: Toward Proper Statistical Inferencing and Reporting of Intraclass Correlation Coefficients

Reporting test-retest reliability using the intraclass correlation coefficient (ICC) has received increasing attention due to the criticisms of poor transparency and replicability in neuroimaging research, as well as many other biomedical studies. Numerous studies have thus evaluated the reliability of their findings by comparing ICCs, however, they often failed to test statistical differences between ICCs or report confidence intervals. Relying solely on point estimates may preclude valid inference about population-level differences and compromise the reliability of conclusions. To address this issue, this study systematically reviewed the use of ICC in articles published in NeuroImage from 2022 to 2024, highlighting the prevalence of misreporting and misuse of ICCs. We further provide practical guidelines for conducting appropriate statistical inference on ICCs. For practitioners in this area, we introduce an online application for statistical testing and sample size estimation when utilizing ICCs. We recalculated confidence intervals and formally tested ICC values reported in the reviewed articles, thereby reassessing the original inferences. Our results demonstrate that exclusive reliance on point estimates could lead to unreliable or even misleading conclusions. Specifically, only two of the eleven reviewed articles provided unequivocally valid statistical inferences based on ICCs, whereas two articles failed to yield any valid inference at all, raising serious concerns about the replicability of findings in this field. These results underscore the urgent need for rigorous inferential frameworks when reporting and interpreting ICCs.

stat.ME↗

arXiv2025

Point What You Mean: Visually Grounded Instruction Policy

Vision-Language-Action (VLA) models align vision and language with embodied control, but their object referring ability remains limited when relying solely on text prompt, especially in cluttered or out-of-distribution (OOD) scenes. In this study, we introduce the Point-VLA, a plug-and-play policy that augments language instructions with explicit visual cues (e.g., bounding boxes) to resolve referential ambiguity and enable precise object-level grounding. To efficiently scale visually grounded datasets, we further develop an automatic data annotation pipeline requiring minimal human effort. We evaluate Point-VLA on diverse real-world referring tasks and observe consistently stronger performance than text-only instruction VLAs, particularly in cluttered or unseen-object scenarios, with robust generalization. These results demonstrate that Point-VLA effectively resolves object referring ambiguity through pixel-level visual grounding, achieving more generalizable embodied control.

cs.CV↗

arXiv2025

The Prevalence of Misreporting and Misinterpreting Correlation Coefficients in Biomedical Literature

Correlation coefficient is widely used in biomedical and biological literature, yet its frequent misuse and misinterpretation undermine the credibility and reproducibility of the scientific findings. We systematically reviewed 1326 records of correlation analyses across 310 articles published in Science, Nature, and Nature Neuroscience in 2022. Our analysis revealed a troubling pattern of poor statistical reporting and inferring: 58.71% (95% CI: [53.23%, 64.19%], 182/310) of studies did not explicitly report sample sizes, and 98.06% (95% CI: [96.53%, 99.60%], 304/310) failed to provide confidence intervals for correlation coefficients. Among 177 articles inferring correlation strength, 45.25% (95% CI: [38.42%, 53.10%], 81/177) relied solely on point estimates, while 53.63% (95% CI: [46.90%, 61.58%], 96/177) drew conclusions based on null hypothesis significance testing. This widespread omission and misuse highlight a systematic gap in both statistic literacy and editorial standards. We advocate clear reporting guidelines mandating effect sizes and confidence intervals in correlation analyses to enhance the transparency, rigor, and reproducibility of quantitative life sciences research.

stat.ME↗

arXiv2025

A Preliminary Exploration of the Differences and Conjunction of Traditional PNT and Brain-inspired PNT

Developing universal Positioning, Navigation, and Timing (PNT) is our enduring goal. Today's complex environments demand PNT that is more resilient, energy-efficient and cognitively capable. This paper asks how we can endow unmanned systems with brain-inspired spatial cognition navigation while exploiting the high precision of machine PNT to advance universal PNT. We provide a new perspective and roadmap for shifting PNT from "tool-oriented" to "cognition-driven". Contributions: (1) multi-level dissection of differences among traditional PNT, biological brain PNT and brain-inspired PNT; (2) a four-layer (observation-capability-decision-hardware) fusion framework that unites numerical precision and brain-inspired intelligence; (3) forward-looking recommendations for future development of brain-inspired PNT.

cs.RO↗

arXiv2025

Do You Need Proprioceptive States in Visuomotor Policies?

Imitation-learning-based visuomotor policies have been widely used in robot manipulation, where both visual observations and proprioceptive states are typically adopted together for precise control. However, in this study, we find that this common practice makes the policy overly reliant on the proprioceptive state input, which causes overfitting to the training trajectories and results in poor spatial generalization. On the contrary, we propose the State-free Policy, removing the proprioceptive state input and predicting actions only conditioned on visual observations. The State-free Policy is built in the relative end-effector action space, and should ensure the full task-relevant visual observations, here provided by dual wide-angle wrist cameras. Empirical results demonstrate that the State-free policy achieves significantly stronger spatial generalization than the state-based policy: in real-world tasks such as pick-and-place, challenging shirt-folding, and complex whole-body manipulation, spanning multiple robot embodiments, the average success rate improves from 0% to 85% in height generalization and from 6% to 64% in horizontal generalization. Furthermore, they also show advantages in data efficiency and cross-embodiment adaptation, enhancing their practicality for real-world deployment. Discover more by visiting: https://statefreepolicy.github.io.

cs.RO↗

arXiv2025

Hub Detection in Gaussian Graphical Models

Graphical models are popular tools for exploring relationships among a set of variables. The Gaussian graphical model (GGM) is an important class of graphical models, where the conditional dependence among variables is represented by nodes and edges in a graph. In many real applications, we are interested in detecting hubs in graphical models, which refer to nodes with a significant higher degree of connectivity compared to non-hub nodes. A typical strategy for hub detection consists of estimating the graphical model, and then using the estimated graph to identify hubs. Despite its simplicity, the success of this strategy relies on the accuracy of the estimated graph. In this paper, we directly target on the estimation of hubs, without the need of estimating the graph. We establish a novel connection between the presence of hubs in a graphical model, and the spectral decomposition of the underlying covariance matrix. Based on this connection, we propose the method of inverse principal components for hub detection (IPC-HD). Both consistency and convergence rates are established for IPC-HD. Our simulation study demonstrates the superior performance and fast computation of the proposed method compared to existing methods in the literature in terms of hub detection. Our application to a prostate cancer gene expression dataset detects several hub genes with close connections to tumor development.

stat.ME↗

arXiv2025

Advancing AI Research Assistants with Expert-Involved Learning

Large language models (LLMs) and large multimodal models (LMMs) promise to accelerate biomedical discovery, yet their reliability remains unclear. We introduce ARIEL (AI Research Assistant for Expert-in-the-Loop Learning), an open-source evaluation and optimization framework that pairs a curated multimodal biomedical corpus with expert-vetted tasks to probe two capabilities: full-length article summarization and fine-grained figure interpretation. Using uniform protocols and blinded PhD-level evaluation, we find that state-of-the-art models generate fluent but incomplete summaries, whereas LMMs struggle with detailed visual reasoning. We later observe that prompt engineering and lightweight fine-tuning substantially improve textual coverage, and a compute-scaled inference strategy enhances visual question answering. We build an ARIEL agent that integrates textual and visual cues, and we show it can propose testable mechanistic hypotheses. ARIEL delineates current strengths and limitations of foundation models, and provides a reproducible platform for advancing trustworthy AI in biomedicine.

cs.AI↗

arXiv2025

Engineering excitonic metal-insulator transitions in ultra-thin doped copper sulfides

Delicate engineering of the bands remains challenging due to complex electronic, structural, and compositional interplay. We demonstrate the formation of distinct metallic and insulating ground states in ultra-thin copper sulfide films by effectively tuning the band structure via changing the composition of Cu and S in the system. Using angle-resolved photoemission spectroscopy (ARPES), we observed a continuous band renormalization and opening of a full gap at low temperatures over a wide range of doping. The electronic origin of this metal-insulator transition is supported by scanning tunneling microscopy (STM) and low energy electron diffraction (LEED) measurements, which show no indication of superlattice modulation and lattice symmetry breaking. The evidence of excitonic insulating phase is further provided by carrier density dependent transitions, a combined effect of electron screening and Coulomb interaction strength. Our findings demonstrate tunability of the band structure of copper sulfides, allowing for new opportunities to study exotic quantum phases.

cond-mat.str-el↗

arXiv2025

Experimental Measurement-Device-Independent Quantum Cryptographic Conferencing

Quantum cryptographic conferencing (QCC) allows sharing secret keys among multiple distant users and plays a crucial role in quantum networks. Because of the fragility and low generation rate of genuine multipartite entangled states required in QCC, realizing and extending QCC with the entanglement-based protocol is challenging. Measurement-device-independent (MDI) QCC, which removes all detector side channels, is a feasible long-distance quantum communication scheme to practically generate multipartite correlation with multiphoton projection measurement. Here we experimentally realize the three-user MDIQCC protocol with four-intensity decoy-state method, in which we employ the polarization encoding and the Greenberger-Horne-Zeilinger state projection measurement. Our work demonstrates the experimental feasibility of the MDI QCC, which lays the foundation for the future realization of quantum networks with multipartite communication tasks.

quant-ph↗

arXiv2025

Asymptotic Inference for Multi-Stage Stationary Treatment Policy with Variable Selection

Dynamic treatment regimes or policies are a sequence of decision functions over multiple stages that are tailored to individual features. One important class of treatment policies in practice, namely multi-stage stationary treatment policies, prescribes treatment assignment probabilities using the same decision function across stages, where the decision is based on the same set of features consisting of time-evolving variables (e.g., routinely collected disease biomarkers). Although there has been extensive literature on constructing valid inference for the value function associated with dynamic treatment policies, little work has focused on the policies themselves, especially in the presence of high-dimensional feature variables. We aim to fill the gap in this work. Specifically, we first estimate the multi-stage stationary treatment policy using an augmented inverse probability weighted estimator for the value function to increase asymptotic efficiency, and further apply a penalty to select important feature variables. We then construct one-step improvements of the policy parameter estimators for valid inference. Theoretically, we show that the improved estimators are asymptotically normal, even if nuisance parameters are estimated at a slow convergence rate and the dimension of the feature variables increases with the sample size. Our numerical studies demonstrate that the proposed method estimates a sparse policy with a near-optimal value function and conducts valid inference for the policy parameters.

stat.ML↗