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Yuhua Fu

Publications and source records attributed to Yuhua Fu.

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CAVE: A Structured Credit Assignment Approach for Fragmented Visual Evidence Reasoning

Vision-Language Models (VLMs) have achieved strong performance on general multimodal reasoning, yet remain challenged in integrating nonlocal visual information to support semantically underdetermined visual reasoning. We describe this challenge as Fragmented Visual Reasoning. To this end, we propose Credit Assignment for Visual Evidence (CAVE), a structured process-reward method based on GRPO for interleaved visual reasoning. Specifically, CAVE evaluates the contribution of intermediate steps at the action level via three complementary reasoning process signals: belief update, evidence acquisition, and adaptive focus control, thereby guiding the model to optimize each reasoning action and learn more reliable visual reasoning strategies. Meanwhile, we construct TRACER-Bench, which covers four nonlocal and semantically confusable reasoning dimensions and provides key intermediate evidence to supervise reasoning paths. Experiments demonstrate that CAVE substantially improves performance on tasks requiring fragmented visual evidence integration, covering both public benchmarks and our newly introduced TRACER-Bench, while retaining competitive performance on general multimodal evaluations. Further analyses reveal that CAVE effectively improves the visual reasoning capacity and exhibits stronger robustness under longer-range and deeper cross-region dependencies.

cs.CV

Bridging the genotype-phenotype gap with generative artificial intelligence

The genotype-phenotype gap is a persistent barrier to complex trait genetic dissection, worsened by the explosive growth of genomic data (1.5 billion variants identified in the UK Biobank WGS study) alongside persistently scarce and subjective human-defined phenotypes. Digital phenotyping offers a potential solution, yet existing tools fail to balance scalable non-manual phenotype generation and biological interpretability of these quantitative traits. Here we report AIPheno, the first generative AI-driven "phenotype sequencer" that bridges this gap. It enables high-throughput, unsupervised extraction of digital phenotypes from imaging data and unlocks their biological meaning via generative network analysis. AIPheno transforms imaging modalities into a rich source of quantitative traits, dramatically enhancing cross-species genetic discovery, including novel loci such as CCBE1 (humans), KITLG-TMTC3 (domestic pigeons), and SOD2-IGF2R (swine). Critically, its generative module decodes AI-derived phenotypes by synthesizing variant-specific images to yield actionable biological insights. For example, it clarifies how the OCA2-HERC2 locus pleiotropically links pigmentation to retinal vascular traits via vascular visibility modulation. Integrating scalable non-manual phenotyping, enhanced genetic discovery power, and generative mechanistic decoding, AIPheno establishes a transformative closed-loop paradigm. This work addresses the longstanding genotype-phenotype imbalance, redefines digital phenotype utility, and accelerates translation of genetic associations into actionable understanding with profound implications for human health and agriculture.

q-bio.QM