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Yunjiao Lu

Publications and source records attributed to Yunjiao Lu.

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A statistical procedure to assist dysgraphia detection through dynamic modelling of handwriting

Dysgraphia is a neurodevelopmental condition in which children encounter difficulties in handwriting. Dysgraphia is not a disorder per se, but is secondary to neurodevelopmental disorders, mainly dyslexia, Developmental Coordination Disorder (DCD, also known as dyspraxia) or Attention Deficit Hyperactivity Disorder (ADHD). Since the mastering of handwriting is central for the further acquisition of other skills such as orthograph or syntax, an early diagnosis and handling of dysgraphia is thus essential for the academic success of children. In this paper, we investigated a large handwriting database composed of 36 individual symbols (26 isolated letters of the Latin alphabet written in cursive and the 10 digits) written by 545 children from 6,5 to 16 years old, among which 66 displayed dysgraphia (around 12\%). To better understand the dynamics of handwriting, mathematical models of nonpathological handwriting have been proposed, assuming oscillatory and fluid generation of strokes (Parsimonious Oscillatory Model of Handwriting [André, 2014]). The purpose of this work is to study how such models behave when applied to children dysgraphic handwriting, and whether a lack of fit may help in the diagnosis, using a two-layer classification procedure with different compositions of classification algorithms.

stat.AP

Probabilistic reconstruction of truncated particle trajectories on a closed surface

Investigation of dynamic processes in cell biology very often relies on the observation in two dimensions of 3D biological processes. Consequently, the data are partial and statistical methods and models are required to recover the parameters describing the dynamical processes. In the case of molecules moving over the 3D surface, such as proteins on walls of bacteria cell, a large portion of the 3D surface is not observed in 2D-time microscopy. It follows that biomolecules may disappear for a period of time in a region of interest, and then reappear later. Assuming Brownian motion with drift, we address the mathematical problem of the reconstruction of biomolecules trajectories on a cylindrical surface. A subregion of the cylinder is typically recorded during the observation period, and biomolecules may appear or disappear in any place of the 3D surface. The performance of the method is demonstrated on simulated particle trajectories that mimic MreB protein dynamics observed in 2D time-lapse fluorescence microscopy in rod-shaped bacteria.

stat.AP