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Yunus Alapan

Publications and source records attributed to Yunus Alapan.

7 recordsLinked to original sources

Membrane-based Acoustic Microrobots

Acoustic microrobots have emerged as a promising frontier for targeted drug delivery and minimally invasive medicine due to their high-power density and biocompatibility. Despite wide-ranging designs, conventional acoustic microrobots mostly rely on air microbubbles trapped within confined microcavities within the robot body, which suffer from limited operational longevity due to rapid gas dissolution and resultant shifts in resonance frequency. In this paper, we propose a robust, membrane-based acoustic microrobot that overcomes these limitations by employing a thin flexible Polydimethylsiloxane (PDMS) membrane bonded over confined microcavities for microstreaming. The introduced design physically prevents gas diffusion, ensuring stable performance over extended periods at high actuation voltages. We systematically characterized the membrane-based acoustic actuator longevity, demonstrating consistent streaming and propulsion for over 24 hours of continuous operation. In addition, by embedding magnetic microparticles into the structural body, these actuators were successfully employed as microswimmers with directional control using low-intensity (2 mT) external magnetic fields. Finally, we demonstrate the scalability of the proposed design architecture down to ~100 um. This membrane-based approach establishes a reliable framework for the development of high-endurance acoustic microactuators and microrobots capable of performing long-term tasks.

cs.RO

Shape-programmable Magnetic Soft Membranes for Mechanically Active Microchannels

The capability to encode spatially distinct magnetization patterns within soft materials enables remote control over complex deformations. This characteristic is especially important for microfluidic platforms, where limited dynamic control of channel boundaries and laminar flow conditions usually restrict fluid transport and interactions. The present study introduces a shape-programmable magnetic soft membrane actuator as an active microchannel component that can dynamically modulate its shape under magnetic fields and therefore the microfluidic environment. The membrane is magnetically programmed using a template-based approach, which allows it to be controllably deformed in the form of a sinusoid under the influence of an external magnetic field. The membrane's integration into a microchannel converts a passive channel wall into a dynamically changeable interface, allowing active fluid manipulation and enhancing micromixing in laminar flow conditions. The proposed approach establishes a versatile platform for wirelessly controlled deformable interfaces in next-generation microfluidic and lab-on-chip systems.

cs.RO

Programmable magnetic soft robots with controlled locomotion and directional liquid cargo release

Magnetically programmable soft elastomers enable complex shape morphing and locomotion dynamics in small scale soft robots under external magnetic fields. Benefiting from their programmed deformation and wireless actuation capabilities, magnetic soft robots have emerged as promising platforms for targeted drug delivery, especially in human gastrointestinal tract. However, achieving controlled directional liquid cargo release toward desired tissue interface while preserving the encoded shape morphing and locomotion capabilities remain a significant challenge. Here, we report a new design strategy that employs an optimized magnetization profile to enable controlled directional release of aqueous cargo without compromising shape morphing and locomotion capabilities. Magnetic soft robots with a specific spatially distributed magnetization profile allow directional alignment of the release interface with the orientation of the external magnetic field. This orientation control ensures active alignment of the release interface toward the intestinal wall prior to drug release. An interconnected microporous elastomer is embedded within the robot for aqueous cargo storage, while a thin microcrystalline wax layer seals the release opening hole to isolate the stored liquid cargo from external environment during transport. Triggered release is achieved by mechanically rupturing the wax sealing layer under a higher magnitude external magnetic field. Controlled directional flipping, locomotion, and triggered release are decoupled through external magnetic field's direction and strength. The controlled directional release strategy reported here integrates directional targeted liquid cargo release, shape morphing, and locomotion, which establishes the groundwork for target drug delivery in gastrointestinal tract applications.

cs.RO

Biocompatible carbon nitride-based light-driven microswimmer propulsion in biological and ionic media with responsive on-demand drug delivery

We propose two-dimensional organic poly(heptazine imide) (PHI) carbon nitride microparticles as light-driven microswimmers in various ionic and biological media. Their demonstrated high-speed (15-23 $μ$m/s) swimming in multi-component ionic solutions with concentrations up to 1 M and without dedicated fuels is unprecedented, overcoming one of the bottlenecks of previous light-driven microswimmers. Such high ion tolerance is attributed to a favorable interplay between the particle's textural and structural nanoporosity and optoionic properties, facilitating ionic interactions in solutions with high salinity. Biocompatibility of the microswimmers is validated by cell viability tests with three different cell types and primary cells. The nanopores of the swimmers are loaded with a model cancer drug, doxorubicin (DOX), in high (185%) loading efficiency without passive release. Controlled drug release is reported in different pH conditions and can be triggered on-demand also by illumination. Light-triggered, boosted release of DOX and its active degradation products is demonstrated in oxygen-poor conditions using the intrinsic, environmentally sensitive and light-induced charge storage properties of PHI, which could enable future theranostic applications in oxygen-deprived tumor regions. These organic PHI microswimmers simultaneously solve the current light-driven microswimmer challenges of high ion tolerance, fuel-free high-speed propulsion in biological media, biocompatibility and controlled on-demand cargo release towards their biomedical, environmental and other potential future applications.

cond-mat.soft

Cohesive self-organization of mobile microrobotic swarms

Mobile microrobots are envisioned to be useful in a wide range of high-impact applications, many of which requiring cohesive group formation to maintain self-bounded swarms in the absence of confining boundaries. Cohesive group formation relies on a balance between attractive and repulsive interactions between agents. We found that a balance of magnetic dipolar attraction and multipolar repulsion between self-assembled particle chain microrobots enable their self-organization into cohesive clusters. Self-organized microrobotic clusters translate above a solid substrate via a hydrodynamic self-propulsion mechanism. Cluster velocity increases with cluster size, resulting from collective hydrodynamic effects. Clustering is promoted by the strength of cohesive interactions and hindered by heterogeneities of individual microrobots. Scalability of cohesive interactions allows formation of larger groups, whose internal spatiotemporal organization undergoes a transition from solid-like ordering to liquid-like behavior with increasing cluster size. Our work elucidates the dynamics of clustering under cohesive interactions, and presents an approach for addressing operation of microrobots as localized teams.

cond-mat.soft

Programmable collective behavior in dynamically self-assembled mobile microrobotic swarms

Collective control of mobile microrobotic swarms is indispensable for their potential high-impact applications in targeted drug delivery, medical diagnostics, parallel micromanipulation, and environmental sensing and remediation. Lack of on-board computational and sensing capabilities in current microrobotic systems necessitates use of physical interactions among individual microrobots for local physical communication and cooperation. Here, we show that mobile microrobotic swarms with well-defined collective behavior can be designed by engineering magnetic interactions among individual units. Microrobots, consisting of a linear chain of self-assembled magnetic microparticles, locomote on surfaces in response to a precessing magnetic field. Control over the direction of precessing magnetic field allows engineering attractive and repulsive interactions among microrobots and, thus, collective order with well-defined spatial organization and parallel operation over macroscale distances (~1 cm). These microrobotic swarms can be guided through confined spaces, while preserving microrobot morphology and function. These swarms can further achieve directional transport of large cargoes on surfaces and small cargoes in bulk fluids. Described design approach, exploiting physical interactions among individual robots, enables facile and rapid formation of self-organized and reconfigurable microrobotic swarms with programmable collective order.

cond-mat.soft

Thermocapillary-driven fluid flow within microchannels

Surface tension gradients induce Marangoni flow, which may be exploited for fluid transport. At the micrometer scale, these surface-driven flows can be more significant than those driven by pressure. By introducing fluid-fluid interfaces on the walls of microfluidic channels, we use surface tension gradients to drive bulk fluid flows. The gradients are specifically induced through thermal energy, exploiting the temperature dependence of a fluid-fluid interface to generate thermocapillary flow. In this report, we provide the design concept for a biocompatible, thermocapillary microchannel capable of being powered by solar irradiation. Using temperature gradients on the order of degrees Celsius per centimeter, we achieve fluid velocities on the order of millimeters per second. Following experimental observations, fluid dynamic models, and numerical simulation, we find that the fluid velocity is linearly proportional to the provided temperature gradient, enabling full control of the fluid flow within the microchannels.

physics.flu-dyn