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Yunyi Kang

Publications and source records attributed to Yunyi Kang.

2 recordsLinked to original sources

Partially Observable Markov Decision Process Framework for Operating Condition Optimization Using Real-Time Degradation Signals

In many engineering systems, proper predictive maintenance and operational control are essential to increase efficiency and reliability while reducing maintenance costs. However, one of the major challenges is that many sensors are used for system monitoring. Analyzing these sensors simultaneously for better predictive maintenance optimization is often very challenging. In this paper, we propose a systematic decision-making framework to improve the system performance in manufacturing practice, considering the real-time degradation signals generated by multiple sensors. Specifically, we propose a partially observed Markov decision process (POMDP) model to generate the optimal capacity and predictive maintenance policies, given the fact that the observation of the system state is imperfect. Such work provides a systematic approach that focuses on jointly controlling the operating conditions and preventive maintenance utilizing the real-time machine deterioration signals by incorporating the degradation constraint and non-observable states. We apply this technique to the bearing degradation data and NASA aircraft turbofan engine dataset, demonstrating the effectiveness of the proposed method.

stat.AP

Multi-species network inference improves gene regulatory network reconstruction for early embryonic development in Drosophila

Gene regulatory network inference uses genome-wide transcriptome measurements in response to genetic, environmental or dynamic perturbations to predict causal regulatory influences between genes. We hypothesized that evolution also acts as a suitable network perturbation and that integration of data from multiple closely related species can lead to improved reconstruction of gene regulatory networks. To test this hypothesis, we predicted networks from temporal gene expression data for 3,610 genes measured during early embryonic development in six Drosophila species and compared predicted networks to gold standard networks of ChIP-chip and ChIP-seq interactions for developmental transcription factors in five species. We found that (i) the performance of single-species networks was independent of the species where the gold standard was measured; (ii) differences between predicted networks reflected the known phylogeny and differences in biology between the species; (iii) an integrative consensus network which minimized the total number of edge gains and losses with respect to all single-species networks performed better than any individual network. Our results show that in an evolutionarily conserved system, integration of data from comparable experiments in multiple species improves the inference of gene regulatory networks. They provide a basis for future studies on the numerous multi-species gene expression datasets for other biological processes available in the literature.

q-bio.GN